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The map label for this gene is ribA [H]

Identifier: 28572850

GI number: 28572850

Start: 802594

End: 803229

Strand: Direct

Name: ribA [H]

Synonym: TW709

Alternate gene names: 28572850

Gene position: 802594-803229 (Clockwise)

Preceding gene: 28572849

Following gene: 28572851

Centisome position: 86.68

GC content: 44.18

Gene sequence:

>636_bases
ATGATGGGGAATATGGATAAGGGTCTAGATTCGCAAAAACAAGAAACTGCTCGCAGCTGCAGATTTGAGGTTGAAACAAA
TCTTCCAACAAAATTTGGAACCCTCAGGGTACGTGGCTATCGGGATATAAAAAATAACGAGCATATCGCACTGATTACAA
AGCAAATTAAGAGTGAGGATGTTTTGCTCAGAATTCACTCAGAATGTATAACGGGAGAAGTATTTATGTCTCTGAAGTGT
GATTGTCATGGGCAATTGCACAAAGCCCTTGAGCGGATCAGTGCAGAAGGCGGACTTGTTATATATATGAGGGGGCACGA
AGGTCGCGGTATAGGTATCTTGAATAAATTGCGAGCATACAGATTGCAAGAGCAGGGCCTTGATACATTCGACTCAAACG
TGAAGCTGGGCCTTCCTGTTGATGCCAGGGATTATGGACCTGCTGCAGAAATACTGCACGATCTGGGTGTGCGCTCAGTA
AGGCTTCTAAGTAATAATCCAGATAAACAGCTGCAACTTGAACAATCCGGGATACGCGTCACGGGGGTGCTGCCCTGGCA
AGTTGGGCTTGGTAAATGCAATCATGAATACCTTAAAGTAAAACGCGACAAAATGGGTCATAAAATCGAGTTATAG

Upstream 100 bases:

>100_bases
GTAGAAATAAGTCAAATAATTGAATATATGAAAATGTCTGATCTAAAGGACATAAGTATGAATCTAAATCGCGACTGCCT
CTGAGCGAGGGCTAAAAAGT

Downstream 100 bases:

>100_bases
CATTCTGTGCAGAATGAGTAGAAATGGGTAAAGACAGAAATCTCAGCCTAAATTCCCCAGAAAGTATACAGAGTGTGATT
GGGGATACGGATATTAAAAT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MMGNMDKGLDSQKQETARSCRFEVETNLPTKFGTLRVRGYRDIKNNEHIALITKQIKSEDVLLRIHSECITGEVFMSLKC
DCHGQLHKALERISAEGGLVIYMRGHEGRGIGILNKLRAYRLQEQGLDTFDSNVKLGLPVDARDYGPAAEILHDLGVRSV
RLLSNNPDKQLQLEQSGIRVTGVLPWQVGLGKCNHEYLKVKRDKMGHKIEL

Sequences:

>Translated_211_residues
MMGNMDKGLDSQKQETARSCRFEVETNLPTKFGTLRVRGYRDIKNNEHIALITKQIKSEDVLLRIHSECITGEVFMSLKC
DCHGQLHKALERISAEGGLVIYMRGHEGRGIGILNKLRAYRLQEQGLDTFDSNVKLGLPVDARDYGPAAEILHDLGVRSV
RLLSNNPDKQLQLEQSGIRVTGVLPWQVGLGKCNHEYLKVKRDKMGHKIEL
>Mature_211_residues
MMGNMDKGLDSQKQETARSCRFEVETNLPTKFGTLRVRGYRDIKNNEHIALITKQIKSEDVLLRIHSECITGEVFMSLKC
DCHGQLHKALERISAEGGLVIYMRGHEGRGIGILNKLRAYRLQEQGLDTFDSNVKLGLPVDARDYGPAAEILHDLGVRSV
RLLSNNPDKQLQLEQSGIRVTGVLPWQVGLGKCNHEYLKVKRDKMGHKIEL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=187, Percent_Identity=44.3850267379679, Blast_Score=154, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=41.1764705882353, Blast_Score=107, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 23819; Mature: 23819

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGNMDKGLDSQKQETARSCRFEVETNLPTKFGTLRVRGYRDIKNNEHIALITKQIKSED
CCCCCCCCCCHHHHHHHHHCEEEEECCCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCC
VLLRIHSECITGEVFMSLKCDCHGQLHKALERISAEGGLVIYMRGHEGRGIGILNKLRAY
EEEEEECHHCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHH
RLQEQGLDTFDSNVKLGLPVDARDYGPAAEILHDLGVRSVRLLSNNPDKQLQLEQSGIRV
HHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCEEEEECCCEEE
TGVLPWQVGLGKCNHEYLKVKRDKMGHKIEL
EEEEEEECCCCCCCHHHHHEEHHHCCCCCCC
>Mature Secondary Structure
MMGNMDKGLDSQKQETARSCRFEVETNLPTKFGTLRVRGYRDIKNNEHIALITKQIKSED
CCCCCCCCCCHHHHHHHHHCEEEEECCCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCC
VLLRIHSECITGEVFMSLKCDCHGQLHKALERISAEGGLVIYMRGHEGRGIGILNKLRAY
EEEEEECHHCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHH
RLQEQGLDTFDSNVKLGLPVDARDYGPAAEILHDLGVRSVRLLSNNPDKQLQLEQSGIRV
HHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCEEEEECCCEEE
TGVLPWQVGLGKCNHEYLKVKRDKMGHKIEL
EEEEEEECCCCCCCHHHHHEEHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA