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The map label for this gene is pgm

Identifier: 28572819

GI number: 28572819

Start: 767545

End: 768210

Strand: Reverse

Name: pgm

Synonym: TW678

Alternate gene names: 28572819

Gene position: 768210-767545 (Counterclockwise)

Preceding gene: 28572820

Following gene: 28572818

Centisome position: 82.97

GC content: 49.4

Gene sequence:

>666_bases
ATGGATAATCTAGTTTTGCTACGTCACGGGAATAGCCTATGGAATCAAGAGAATCTTTTTACTGGCTGGGTTGATGTTCG
CCTGAGTGAACTTGGCGAGAAAGAGGCGAAAACTGCCGGGCAACTCTTGCGTGAAGCCAACAGATACCCTGATGTCTTGT
TCACCTCTCTGCTAACCCGTTCTATTCAAACGGCTCATATAGCACTCATGGAGATCGATCGTGTTTGGCTGCCAACTTTT
CGTAGTTGGCGATTGAACGAGAGACATTACGGAAGCTTACAGGGTAAAAATAAAGCCCAGGTACTGGAGGAGTTTGGTGA
AGAGCAGTTCAATTCCTGGCGCCGTGGTTACGATACACCCCCGCCACCGCTGCACAGCCAAGCTGATGACCCCCGCTATG
AGGAGCCACCACCCCTTTCAGAGTCACTGAAGGACGTACAGAATAGACTTCTGCCTTATTGGCAGGGTGTGATTCTTCCG
CATCTTGTTGCCGGAAAGGTTGTTCTTGTGGTTGCTCACGGAAATTCTTTGCGTGCCCTTGTGAAACACCTCGAGTGCAT
ATCGGATACAGACGTGTGTCAGCTCAATATTCCGACTGGCATACCCCTTGTGTATTCTATTGACCCTTCGGGTTGTGCAA
CACATCCCGGTAGATATTTGCCCTAG

Upstream 100 bases:

>100_bases
GTCTCCAGATTCCGGGTCTGTTGCATCTGTGCCGCGCATGAAAAGGCTAACATAACTTGTGTGACCCGAGTAAGCAAATT
GTCACTAGACTTGGTGGGGT

Downstream 100 bases:

>100_bases
CAGTCTCCGCCCCCTTGGGCAGGGTTTCTGATGTATATAATTTTTTGCTAGGCTTTTTGTCGCTGGTGCGCAAGTGGGTG
TGCTGTTTGTATTTGCGCTT

Product: phosphoglycerate mutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MDNLVLLRHGNSLWNQENLFTGWVDVRLSELGEKEAKTAGQLLREANRYPDVLFTSLLTRSIQTAHIALMEIDRVWLPTF
RSWRLNERHYGSLQGKNKAQVLEEFGEEQFNSWRRGYDTPPPPLHSQADDPRYEEPPPLSESLKDVQNRLLPYWQGVILP
HLVAGKVVLVVAHGNSLRALVKHLECISDTDVCQLNIPTGIPLVYSIDPSGCATHPGRYLP

Sequences:

>Translated_221_residues
MDNLVLLRHGNSLWNQENLFTGWVDVRLSELGEKEAKTAGQLLREANRYPDVLFTSLLTRSIQTAHIALMEIDRVWLPTF
RSWRLNERHYGSLQGKNKAQVLEEFGEEQFNSWRRGYDTPPPPLHSQADDPRYEEPPPLSESLKDVQNRLLPYWQGVILP
HLVAGKVVLVVAHGNSLRALVKHLECISDTDVCQLNIPTGIPLVYSIDPSGCATHPGRYLP
>Mature_221_residues
MDNLVLLRHGNSLWNQENLFTGWVDVRLSELGEKEAKTAGQLLREANRYPDVLFTSLLTRSIQTAHIALMEIDRVWLPTF
RSWRLNERHYGSLQGKNKAQVLEEFGEEQFNSWRRGYDTPPPPLHSQADDPRYEEPPPLSESLKDVQNRLLPYWQGVILP
HLVAGKVVLVVAHGNSLRALVKHLECISDTDVCQLNIPTGIPLVYSIDPSGCATHPGRYLP

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=228, Percent_Identity=47.8070175438597, Blast_Score=217, Evalue=6e-57,
Organism=Homo sapiens, GI4505753, Length=229, Percent_Identity=48.471615720524, Blast_Score=205, Evalue=2e-53,
Organism=Homo sapiens, GI4502445, Length=230, Percent_Identity=45.6521739130435, Blast_Score=205, Evalue=3e-53,
Organism=Homo sapiens, GI40353764, Length=230, Percent_Identity=45.6521739130435, Blast_Score=205, Evalue=3e-53,
Organism=Homo sapiens, GI71274132, Length=229, Percent_Identity=45.8515283842795, Blast_Score=190, Evalue=9e-49,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=49.0683229813665, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1786970, Length=214, Percent_Identity=51.8691588785047, Blast_Score=225, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6322697, Length=229, Percent_Identity=58.9519650655022, Blast_Score=275, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6320183, Length=268, Percent_Identity=35.0746268656716, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324516, Length=262, Percent_Identity=32.824427480916, Blast_Score=136, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24646216, Length=219, Percent_Identity=51.1415525114155, Blast_Score=227, Evalue=4e-60,
Organism=Drosophila melanogaster, GI85725270, Length=218, Percent_Identity=46.7889908256881, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI85725272, Length=218, Percent_Identity=46.7889908256881, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24650981, Length=218, Percent_Identity=46.7889908256881, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI28571815, Length=219, Percent_Identity=41.0958904109589, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI28571817, Length=219, Percent_Identity=41.0958904109589, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24648979, Length=219, Percent_Identity=41.0958904109589, Blast_Score=159, Evalue=1e-39,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_TROW8 (Q83HD5)

Other databases:

- EMBL:   BX251412
- RefSeq:   NP_789599.1
- ProteinModelPortal:   Q83HD5
- SMR:   Q83HD5
- STRING:   Q83HD5
- GeneID:   1064878
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW678
- eggNOG:   COG0588
- HOGENOM:   HBG658938
- OMA:   FDICLTS
- PhylomeDB:   Q83HD5
- ProtClustDB:   CLSK2516684
- BioCyc:   TWHI218496:TW0644-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 25123; Mature: 25123

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNLVLLRHGNSLWNQENLFTGWVDVRLSELGEKEAKTAGQLLREANRYPDVLFTSLLTR
CCCEEEEECCCCCCCCCCCEEHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
SIQTAHIALMEIDRVWLPTFRSWRLNERHYGSLQGKNKAQVLEEFGEEQFNSWRRGYDTP
HHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
PPPLHSQADDPRYEEPPPLSESLKDVQNRLLPYWQGVILPHLVAGKVVLVVAHGNSLRAL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHH
VKHLECISDTDVCQLNIPTGIPLVYSIDPSGCATHPGRYLP
HHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MDNLVLLRHGNSLWNQENLFTGWVDVRLSELGEKEAKTAGQLLREANRYPDVLFTSLLTR
CCCEEEEECCCCCCCCCCCEEHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
SIQTAHIALMEIDRVWLPTFRSWRLNERHYGSLQGKNKAQVLEEFGEEQFNSWRRGYDTP
HHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
PPPLHSQADDPRYEEPPPLSESLKDVQNRLLPYWQGVILPHLVAGKVVLVVAHGNSLRAL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHH
VKHLECISDTDVCQLNIPTGIPLVYSIDPSGCATHPGRYLP
HHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174