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The map label for this gene is xseA

Identifier: 28572806

GI number: 28572806

Start: 756796

End: 758010

Strand: Direct

Name: xseA

Synonym: TW665

Alternate gene names: 28572806

Gene position: 756796-758010 (Clockwise)

Preceding gene: 28572803

Following gene: 28572807

Centisome position: 81.73

GC content: 44.61

Gene sequence:

>1215_bases
ATGGATATGCAAGCCGACGAGATGTATAGACAAGATCCGCTAGGCTCGTGCGGTAATCCAAGGCAAGTCTCCCATATCAC
GGGCAGGTTATCATCATTGCTCGGCGAGCTACCGGCGACGTGGATAGAGGGTGAGGTAACCCAGTTAAGCCCGAGGAGAA
TAGGTGTTTTTCTAACCCTAAAAGATATGAACGAATCAAAGCACCTCGAATTTTTTCTCCCGTTTGACGCATTTAAAGAC
GAGGTAGAGGTTGGCAACAGGGTAAAAATACACGGAAAATTGGAGTTCTGGGCAACCAGTGGGCAGATCAAGGTAAAGGG
TTTTGAGATCCAGTCGGTTGGAATAGGTGAACTGATTGAACGTATAGCCCGTCTTCGTGTGCAACTTGCCCTTGAAGGGC
TTTATGAGCATAAAAGACCTCTTCCCTTTATTCCAAAACTAATAGGACTTGTAACCGGCCAGAATTCAGATGCAGAAAAA
GATGTTGTAACGAATGTGCTTCTCCGGTGGCCGGCAGCAAAATTCTGCACAATATATGCAAGCATGCAAGGCGCATCATG
TGTTAGTGAAACCATTTCTGCAATACAGAAACTGGACGCTAATAATGATGTCGACGTAATAATTGTTGCCAGAGGTGGTG
GTAGTTTTCACGACCTAATAGGGTTTAGCGACGAGCAAATGATCAGGGCGGTTTTTGCAATAAAAACACCTCTAATATCT
GCAATAGGACATGAAGCTGACAGACCAATATTGGATGAGGTTGCAGATCTTAGAGCATCAACCCCAACAGATGCGGCAAA
AAGGGTTGTGCCAGATATTGCTGACGAGAAACGCCTCATTAAGAGCGCAATGTCTTTCCTTAAAAAGAGTTATGAGCCTG
TAATTGACAAAATCAAGTGTGATACGTTAAGTTGGTCGCAGGCTTTCAGTAACCCATTCGAGACTTTTATTGCGCCAAGA
CGGCGAGAAATAGATTTGTTCTATCAGCAGATGCTGACGGTTGTATGGGCAAATTTTTCTAAGACAGAAACTGAGATCGC
TGCCATAAAAAAGCACCTTCTAGCCATATCCCCTCAAAATACCCTTGTGAGAGGATATGCAATGATCGAGGATGAAACTG
GTCGGATAATAAGTAGCGCAGATAAACTGAGTGCTGGAGATACTGTTACCCTCAGGCTTCATGACGGTCTTGTTAGGGCG
GAAATTACCCAGTGA

Upstream 100 bases:

>100_bases
GCAGCTAAACAATACAACCCGATTAAGATAGGACCCAGAGCACAAACATATAGCAAACACGTACACTGGCAGTTTATTAT
ATTTGACTGGAAAGAGTTAG

Downstream 100 bases:

>100_bases
GACTGTATATTTCGACAAGTTGTTTAGGTGCTGTTATAGGGCAGTATAGTGTTTGCACTGGGAGGAATTGTGTATCTGGA
AAATAATGACAATGTAGGTG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MDMQADEMYRQDPLGSCGNPRQVSHITGRLSSLLGELPATWIEGEVTQLSPRRIGVFLTLKDMNESKHLEFFLPFDAFKD
EVEVGNRVKIHGKLEFWATSGQIKVKGFEIQSVGIGELIERIARLRVQLALEGLYEHKRPLPFIPKLIGLVTGQNSDAEK
DVVTNVLLRWPAAKFCTIYASMQGASCVSETISAIQKLDANNDVDVIIVARGGGSFHDLIGFSDEQMIRAVFAIKTPLIS
AIGHEADRPILDEVADLRASTPTDAAKRVVPDIADEKRLIKSAMSFLKKSYEPVIDKIKCDTLSWSQAFSNPFETFIAPR
RREIDLFYQQMLTVVWANFSKTETEIAAIKKHLLAISPQNTLVRGYAMIEDETGRIISSADKLSAGDTVTLRLHDGLVRA
EITQ

Sequences:

>Translated_404_residues
MDMQADEMYRQDPLGSCGNPRQVSHITGRLSSLLGELPATWIEGEVTQLSPRRIGVFLTLKDMNESKHLEFFLPFDAFKD
EVEVGNRVKIHGKLEFWATSGQIKVKGFEIQSVGIGELIERIARLRVQLALEGLYEHKRPLPFIPKLIGLVTGQNSDAEK
DVVTNVLLRWPAAKFCTIYASMQGASCVSETISAIQKLDANNDVDVIIVARGGGSFHDLIGFSDEQMIRAVFAIKTPLIS
AIGHEADRPILDEVADLRASTPTDAAKRVVPDIADEKRLIKSAMSFLKKSYEPVIDKIKCDTLSWSQAFSNPFETFIAPR
RREIDLFYQQMLTVVWANFSKTETEIAAIKKHLLAISPQNTLVRGYAMIEDETGRIISSADKLSAGDTVTLRLHDGLVRA
EITQ
>Mature_404_residues
MDMQADEMYRQDPLGSCGNPRQVSHITGRLSSLLGELPATWIEGEVTQLSPRRIGVFLTLKDMNESKHLEFFLPFDAFKD
EVEVGNRVKIHGKLEFWATSGQIKVKGFEIQSVGIGELIERIARLRVQLALEGLYEHKRPLPFIPKLIGLVTGQNSDAEK
DVVTNVLLRWPAAKFCTIYASMQGASCVSETISAIQKLDANNDVDVIIVARGGGSFHDLIGFSDEQMIRAVFAIKTPLIS
AIGHEADRPILDEVADLRASTPTDAAKRVVPDIADEKRLIKSAMSFLKKSYEPVIDKIKCDTLSWSQAFSNPFETFIAPR
RREIDLFYQQMLTVVWANFSKTETEIAAIKKHLLAISPQNTLVRGYAMIEDETGRIISSADKLSAGDTVTLRLHDGLVRA
EITQ

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=259, Percent_Identity=30.8880308880309, Blast_Score=128, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_TROW8 (Q83HE6)

Other databases:

- EMBL:   BX251412
- RefSeq:   NP_789586.1
- STRING:   Q83HE6
- GeneID:   1064865
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW665
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   FPALMQG
- ProtClustDB:   PRK00286
- BioCyc:   TWHI218496:TW0631-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 44985; Mature: 44985

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMQADEMYRQDPLGSCGNPRQVSHITGRLSSLLGELPATWIEGEVTQLSPRRIGVFLTL
CCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCEEECCCEEEEEEEE
KDMNESKHLEFFLPFDAFKDEVEVGNRVKIHGKLEFWATSGQIKVKGFEIQSVGIGELIE
ECCCCCCCEEEEECHHHHHHHHCCCCEEEEEEEEEEEEECCEEEEEEEEEECCCHHHHHH
RIARLRVQLALEGLYEHKRPLPFIPKLIGLVTGQNSDAEKDVVTNVLLRWPAAKFCTIYA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHEEH
SMQGASCVSETISAIQKLDANNDVDVIIVARGGGSFHDLIGFSDEQMIRAVFAIKTPLIS
HCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
AIGHEADRPILDEVADLRASTPTDAAKRVVPDIADEKRLIKSAMSFLKKSYEPVIDKIKC
HHCCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
DTLSWSQAFSNPFETFIAPRRREIDLFYQQMLTVVWANFSKTETEIAAIKKHLLAISPQN
CCCCHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCC
TLVRGYAMIEDETGRIISSADKLSAGDTVTLRLHDGLVRAEITQ
CEEEEEEEEECCCCCHHHCCCCCCCCCEEEEEEECCEEEEEECC
>Mature Secondary Structure
MDMQADEMYRQDPLGSCGNPRQVSHITGRLSSLLGELPATWIEGEVTQLSPRRIGVFLTL
CCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCEEECCCEEEEEEEE
KDMNESKHLEFFLPFDAFKDEVEVGNRVKIHGKLEFWATSGQIKVKGFEIQSVGIGELIE
ECCCCCCCEEEEECHHHHHHHHCCCCEEEEEEEEEEEEECCEEEEEEEEEECCCHHHHHH
RIARLRVQLALEGLYEHKRPLPFIPKLIGLVTGQNSDAEKDVVTNVLLRWPAAKFCTIYA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHEEH
SMQGASCVSETISAIQKLDANNDVDVIIVARGGGSFHDLIGFSDEQMIRAVFAIKTPLIS
HCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
AIGHEADRPILDEVADLRASTPTDAAKRVVPDIADEKRLIKSAMSFLKKSYEPVIDKIKC
HHCCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
DTLSWSQAFSNPFETFIAPRRREIDLFYQQMLTVVWANFSKTETEIAAIKKHLLAISPQN
CCCCHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCC
TLVRGYAMIEDETGRIISSADKLSAGDTVTLRLHDGLVRAEITQ
CEEEEEEEEECCCCCHHHCCCCCCCCCEEEEEEECCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12606174