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The map label for this gene is pgl [H]

Identifier: 28572614

GI number: 28572614

Start: 500720

End: 501478

Strand: Direct

Name: pgl [H]

Synonym: TW464

Alternate gene names: 28572614

Gene position: 500720-501478 (Clockwise)

Preceding gene: 28572612

Following gene: 28572644

Centisome position: 54.08

GC content: 46.51

Gene sequence:

>759_bases
ATGCTGTCAACGCACTTTCAGGTGCGGGCCTTCCCCAATAAAAGTCTTTTAGTGGAAGAAGTAGCCAATAGATTTTTGCT
TACTCTTGAGAATGTCTTGCAGAAGAAAGCTTCTGCCCATGTTGGCCTTGAGGGCGGTACGATGAGTGAGCTGACCCTGT
CAAGAATCGCGATGTACGCCGCCAGAGCAAAGGTGATCTGGAATAGAGTTCACTTCTGGTGGTCAGATGAACGATATCTT
CCTGATGGAAACTCGCACAGAAATTATGAGCAGGCAAAGAGATGTCTTTTTAGTAGGGTAAAGGTCCCGGAAGGCAATAT
ACATCAGATTCCTTTCATACCCGGTGATATCAATTTAGCTGTTCGTAGATATTCAGATGAACTGGAGAGGCTGTCCCCGG
ATAATGGAAAGGTTCCGGAATTTGACATACTTTTCCTGGGAATGGGCCCTGATGGTCACACTGCATCCCTCTTTCCCAAT
ATGTCGCATCCAAATGTTTCTGTTGTACCCGTCTTTAACGCGCCAAAACCCCCTCCTGAGAGGATATCTATGACCTTGGG
CGCTATAAATAATGCCAACAGAATATGGGTGCAGTTATCAGGATTGGAAAAGGCCAAACCCCTCAAAAGCGCCCTAGAGG
GGGCAGATGTCCTAGAGCTGCCTATAGCTGGTGTAAGGGGAAGGTTAGAGACTATTATCTTTGCAGACAAGGATGCTGCT
AGTTTGATACCTGCAGAGGCTCATACACAGGATTATTAG

Upstream 100 bases:

>100_bases
TTTAAAAGCTTGCAGTGATAAAGACTTGCTGGGCCTGCGTGAAATATACTTAGTGGTACTGCATGCCTTTGTCTGTGCGA
GGCCCCGGTTTGGAGGAATT

Downstream 100 bases:

>100_bases
TTGAAGCGGGATAGGCCTTCTGTGATAATCTCCATGGCCTTATCTTTACCATTCCAGGCACCAAGCTTTACCCATTTACC
TTCTTCTAGATCTTTGTAGT

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MLSTHFQVRAFPNKSLLVEEVANRFLLTLENVLQKKASAHVGLEGGTMSELTLSRIAMYAARAKVIWNRVHFWWSDERYL
PDGNSHRNYEQAKRCLFSRVKVPEGNIHQIPFIPGDINLAVRRYSDELERLSPDNGKVPEFDILFLGMGPDGHTASLFPN
MSHPNVSVVPVFNAPKPPPERISMTLGAINNANRIWVQLSGLEKAKPLKSALEGADVLELPIAGVRGRLETIIFADKDAA
SLIPAEAHTQDY

Sequences:

>Translated_252_residues
MLSTHFQVRAFPNKSLLVEEVANRFLLTLENVLQKKASAHVGLEGGTMSELTLSRIAMYAARAKVIWNRVHFWWSDERYL
PDGNSHRNYEQAKRCLFSRVKVPEGNIHQIPFIPGDINLAVRRYSDELERLSPDNGKVPEFDILFLGMGPDGHTASLFPN
MSHPNVSVVPVFNAPKPPPERISMTLGAINNANRIWVQLSGLEKAKPLKSALEGADVLELPIAGVRGRLETIIFADKDAA
SLIPAEAHTQDY
>Mature_252_residues
MLSTHFQVRAFPNKSLLVEEVANRFLLTLENVLQKKASAHVGLEGGTMSELTLSRIAMYAARAKVIWNRVHFWWSDERYL
PDGNSHRNYEQAKRCLFSRVKVPEGNIHQIPFIPGDINLAVRRYSDELERLSPDNGKVPEFDILFLGMGPDGHTASLFPN
MSHPNVSVVPVFNAPKPPPERISMTLGAINNANRIWVQLSGLEKAKPLKSALEGADVLELPIAGVRGRLETIIFADKDAA
SLIPAEAHTQDY

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912586, Length=243, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI52145310, Length=234, Percent_Identity=27.3504273504274, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI115533058, Length=224, Percent_Identity=29.4642857142857, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI115533060, Length=224, Percent_Identity=29.4642857142857, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324362, Length=183, Percent_Identity=31.1475409836066, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321957, Length=207, Percent_Identity=27.536231884058, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319918, Length=183, Percent_Identity=31.6939890710383, Blast_Score=82, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6321687, Length=259, Percent_Identity=27.027027027027, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641119, Length=226, Percent_Identity=30.5309734513274, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 28116; Mature: 28116

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSTHFQVRAFPNKSLLVEEVANRFLLTLENVLQKKASAHVGLEGGTMSELTLSRIAMYA
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCHHHHHHHHHHHHH
ARAKVIWNRVHFWWSDERYLPDGNSHRNYEQAKRCLFSRVKVPEGNIHQIPFIPGDINLA
HHHHHHEEEEEEEECCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEE
VRRYSDELERLSPDNGKVPEFDILFLGMGPDGHTASLFPNMSHPNVSVVPVFNAPKPPPE
EHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCCCCCEEEEEEECCCCCCHH
RISMTLGAINNANRIWVQLSGLEKAKPLKSALEGADVLELPIAGVRGRLETIIFADKDAA
HEEEEEECCCCCCEEEEEECCCCCCHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCHH
SLIPAEAHTQDY
HCCCCCCCCCCC
>Mature Secondary Structure
MLSTHFQVRAFPNKSLLVEEVANRFLLTLENVLQKKASAHVGLEGGTMSELTLSRIAMYA
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCHHHHHHHHHHHHH
ARAKVIWNRVHFWWSDERYLPDGNSHRNYEQAKRCLFSRVKVPEGNIHQIPFIPGDINLA
HHHHHHEEEEEEEECCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEE
VRRYSDELERLSPDNGKVPEFDILFLGMGPDGHTASLFPNMSHPNVSVVPVFNAPKPPPE
EHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCCCCCEEEEEEECCCCCCHH
RISMTLGAINNANRIWVQLSGLEKAKPLKSALEGADVLELPIAGVRGRLETIIFADKDAA
HEEEEEECCCCCCEEEEEECCCCCCHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCHH
SLIPAEAHTQDY
HCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]