BacMap

Definition	Tropheryma whipplei TW08/27, complete genome.
Accession	NC_004551
Length	925,938

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The map label for this gene is fabG [H]

Identifier: 28572609

GI number: 28572609

Start: 496060

End: 496776

Strand: Reverse

Name: fabG [H]

Synonym: TW459

Alternate gene names: 28572609

Gene position: 496776-496060 (Counterclockwise)

Preceding gene: 28572610

Following gene: 28572608

Centisome position: 53.65

GC content: 44.77

Gene sequence:

>717_bases
ATGTCTAGCAAGAGAACAGTTTTTATAACCGGGGGAAACCGGGGGATAGGTCGCGCAATTGCTGAAAAGTTCAAGAGCTT
CAACTACAATGTCGCGATTGGAGTAAGGCAACCTGAAGCTTTCAAGGATGCTGGCTGCCTTGCAGTTGAGTGCGATGTAA
CCGTCTCTAGCTCGCTTACAAAAGCTTTCAAAGAGGTAGAAGAGAGATTCGGTTTTGTTGATGTGGCGATTGCAAATGCT
GGAATTATCAGGGACACACTTGTTCTACGGATGAAAGAGGATGATTTTCAACATATCCTTGATACCAATCTGACAGGCGC
GTGGAGGCTTGCCAAACTTGCGAGTAGATCGATGATGCGAAATAAGTTTGGTCGCATAGTTTTTATATCAAGTGTTTCTG
CTGGGATGGGTGGTATTGGTCAGACAAATTATTCAGCATCTAAGGCTGGAATGATAGGCCTTGCTAGAGCTTTAACCCGT
GAGCTTGCAAGTTTTGGCATTACTGTGAATGTTGTAGCTCCCGGAATAGTGCAGACGGATATGGTATCGTCAATCCCTGA
CAATTTGAGAGAGGAATTGATACAAAGGGTGCCAATACGTCGAATTGGTCTGCCAGAGGAAGTTGCTAATGCCGTTTTTT
GGCTTTCCAGTGATGAGGCAAGTTATGTATCCGGAGTTGTATTGCCTGTGGACGGTGGCTTATCAATGGGTTTTTAA

Upstream 100 bases:

>100_bases
ACGCAGGTCCTTGGAAATTGTTGCGGAACACGAAATAGACCGCACAATAGATGCGTTTGAGCGGCTGTATGCAGGCTCTC
AAGTATCCTGCAACTAGTCT

Downstream 100 bases:

>100_bases
CCCCCGCGGGTTGCAGAATCCTGTCCGTCCTGCTTTCTGTGTCACATGCAGTTCAAGCAGTTTTTATTTCTCGCTTCAGA
ATATTCTGTGTTTAGACTAG

Product: 3-oxoacyl-[acyl-carrier protein] reductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MSSKRTVFITGGNRGIGRAIAEKFKSFNYNVAIGVRQPEAFKDAGCLAVECDVTVSSSLTKAFKEVEERFGFVDVAIANA
GIIRDTLVLRMKEDDFQHILDTNLTGAWRLAKLASRSMMRNKFGRIVFISSVSAGMGGIGQTNYSASKAGMIGLARALTR
ELASFGITVNVVAPGIVQTDMVSSIPDNLREELIQRVPIRRIGLPEEVANAVFWLSSDEASYVSGVVLPVDGGLSMGF

Sequences:

>Translated_238_residues
MSSKRTVFITGGNRGIGRAIAEKFKSFNYNVAIGVRQPEAFKDAGCLAVECDVTVSSSLTKAFKEVEERFGFVDVAIANA
GIIRDTLVLRMKEDDFQHILDTNLTGAWRLAKLASRSMMRNKFGRIVFISSVSAGMGGIGQTNYSASKAGMIGLARALTR
ELASFGITVNVVAPGIVQTDMVSSIPDNLREELIQRVPIRRIGLPEEVANAVFWLSSDEASYVSGVVLPVDGGLSMGF
>Mature_237_residues
SSKRTVFITGGNRGIGRAIAEKFKSFNYNVAIGVRQPEAFKDAGCLAVECDVTVSSSLTKAFKEVEERFGFVDVAIANAG
IIRDTLVLRMKEDDFQHILDTNLTGAWRLAKLASRSMMRNKFGRIVFISSVSAGMGGIGQTNYSASKAGMIGLARALTRE
LASFGITVNVVAPGIVQTDMVSSIPDNLREELIQRVPIRRIGLPEEVANAVFWLSSDEASYVSGVVLPVDGGLSMGF

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=234, Percent_Identity=40.5982905982906, Blast_Score=158, Evalue=4e-39,
Organism=Homo sapiens, GI15277342, Length=247, Percent_Identity=31.5789473684211, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI4758504, Length=248, Percent_Identity=32.258064516129, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI19923817, Length=250, Percent_Identity=28.8, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI4504505, Length=238, Percent_Identity=30.672268907563, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI83715985, Length=248, Percent_Identity=30.241935483871, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI59889578, Length=204, Percent_Identity=30.3921568627451, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI66933014, Length=192, Percent_Identity=29.6875, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI10190704, Length=247, Percent_Identity=28.3400809716599, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=27.0161290322581, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI5031737, Length=248, Percent_Identity=30.6451612903226, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI31542939, Length=252, Percent_Identity=27.3809523809524, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI7705925, Length=237, Percent_Identity=27.0042194092827, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI7706318, Length=192, Percent_Identity=26.0416666666667, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI4503301, Length=190, Percent_Identity=27.3684210526316, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI126723750, Length=250, Percent_Identity=27.2, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI20149619, Length=190, Percent_Identity=26.8421052631579, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4503817, Length=223, Percent_Identity=26.457399103139, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI33667109, Length=194, Percent_Identity=30.4123711340206, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI7657478, Length=192, Percent_Identity=30.7291666666667, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI50726952, Length=194, Percent_Identity=30.4123711340206, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=239, Percent_Identity=43.5146443514644, Blast_Score=198, Evalue=3e-52,
Organism=Escherichia coli, GI87082100, Length=249, Percent_Identity=35.3413654618474, Blast_Score=143, Evalue=9e-36,
Organism=Escherichia coli, GI87082160, Length=243, Percent_Identity=32.5102880658436, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI2367365, Length=237, Percent_Identity=36.2869198312236, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI2367175, Length=242, Percent_Identity=31.8181818181818, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790717, Length=241, Percent_Identity=29.045643153527, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1788459, Length=243, Percent_Identity=29.6296296296296, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789208, Length=239, Percent_Identity=27.1966527196653, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786812, Length=247, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787905, Length=239, Percent_Identity=31.3807531380753, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789057, Length=198, Percent_Identity=32.3232323232323, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=28.4, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=244, Percent_Identity=34.4262295081967, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25147288, Length=248, Percent_Identity=33.0645161290323, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17560676, Length=246, Percent_Identity=30.8943089430894, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17561402, Length=247, Percent_Identity=28.3400809716599, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17538182, Length=246, Percent_Identity=28.8617886178862, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI115534694, Length=249, Percent_Identity=31.3253012048193, Blast_Score=93, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17536651, Length=250, Percent_Identity=28.4, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17536025, Length=246, Percent_Identity=26.8292682926829, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17568967, Length=138, Percent_Identity=35.5072463768116, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=245, Percent_Identity=28.1632653061224, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=29.277566539924, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17561272, Length=234, Percent_Identity=26.4957264957265, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=244, Percent_Identity=27.0491803278689, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=257, Percent_Identity=25.2918287937743, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=263, Percent_Identity=27.3764258555133, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=263, Percent_Identity=26.2357414448669, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=26.5384615384615, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=28.8973384030418, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=25.8555133079848, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=27.7566539923954, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17507613, Length=200, Percent_Identity=30.5, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI32563809, Length=200, Percent_Identity=30.5, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=198, Percent_Identity=28.2828282828283, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=27.7566539923954, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=27.9693486590038, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=26.2357414448669, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=193, Percent_Identity=25.3886010362694, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=248, Percent_Identity=22.9838709677419, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=260, Percent_Identity=24.6153846153846, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=261, Percent_Identity=25.6704980842912, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=24.5283018867925, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=190, Percent_Identity=23.6842105263158, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=247, Percent_Identity=31.5789473684211, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324126, Length=245, Percent_Identity=28.9795918367347, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320089, Length=197, Percent_Identity=26.9035532994924, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639444, Length=240, Percent_Identity=33.3333333333333, Blast_Score=150, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24644339, Length=248, Percent_Identity=31.4516129032258, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI17737361, Length=248, Percent_Identity=29.8387096774194, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355319, Length=244, Percent_Identity=29.0983606557377, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI23397609, Length=243, Percent_Identity=30.8641975308642, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=28.6852589641434, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357041, Length=245, Percent_Identity=26.9387755102041, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI18859837, Length=239, Percent_Identity=29.2887029288703, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24641232, Length=216, Percent_Identity=30.5555555555556, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24643142, Length=245, Percent_Identity=28.1632653061224, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644337, Length=178, Percent_Identity=32.5842696629214, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI116007236, Length=233, Percent_Identity=28.3261802575107, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571387, Length=245, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24581726, Length=196, Percent_Identity=28.0612244897959, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656154, Length=232, Percent_Identity=28.0172413793103, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI19922628, Length=232, Percent_Identity=28.0172413793103, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 25660; Mature: 25529

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKRTVFITGGNRGIGRAIAEKFKSFNYNVAIGVRQPEAFKDAGCLAVECDVTVSSSLT
CCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCEEEEECCCHHHHHH
KAFKEVEERFGFVDVAIANAGIIRDTLVLRMKEDDFQHILDTNLTGAWRLAKLASRSMMR
HHHHHHHHHCCEEEEEECCCCHHHHHEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHH
NKFGRIVFISSVSAGMGGIGQTNYSASKAGMIGLARALTRELASFGITVNVVAPGIVQTD
HHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHH
MVSSIPDNLREELIQRVPIRRIGLPEEVANAVFWLSSDEASYVSGVVLPVDGGLSMGF
HHHHCCHHHHHHHHHHCCHHHCCCHHHHHHEEEEECCCCCHHHCEEEEEECCCCCCCC
>Mature Secondary Structure 
SSKRTVFITGGNRGIGRAIAEKFKSFNYNVAIGVRQPEAFKDAGCLAVECDVTVSSSLT
CCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCEEEEECCCHHHHHH
KAFKEVEERFGFVDVAIANAGIIRDTLVLRMKEDDFQHILDTNLTGAWRLAKLASRSMMR
HHHHHHHHHCCEEEEEECCCCHHHHHEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHH
NKFGRIVFISSVSAGMGGIGQTNYSASKAGMIGLARALTRELASFGITVNVVAPGIVQTD
HHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHH
MVSSIPDNLREELIQRVPIRRIGLPEEVANAVFWLSSDEASYVSGVVLPVDGGLSMGF
HHHHCCHHHHHHHHHHCCHHHCCCHHHHHHEEEEECCCCCHHHCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA