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The map label for this gene is fklB [C]

Identifier: 28572603

GI number: 28572603

Start: 490453

End: 491337

Strand: Reverse

Name: fklB [C]

Synonym: TW453

Alternate gene names: 28572603

Gene position: 491337-490453 (Counterclockwise)

Preceding gene: 28572604

Following gene: 28572602

Centisome position: 53.06

GC content: 50.06

Gene sequence:

>885_bases
ATGGTTTCTTTGAAATTTGTGGTTCTGACCTTCGGGCTTGTTGCGCTCTTGTCGGGGTGCGCCGATCAGGGTATCAAGGT
TGATGGTAAATTTGGGACGCCAGTCAGGGTGTCTATTGAGACCGTTGTGAAGGTGAAAGATGTTACCCGCACCGTAATTG
ATGAGGGTGACGGTCCGGAGTTAAAATCAGGCGACCTGGTTGCTTACCAAGTGGCTTATTTCAACGGAACAACAGGGGAT
AGGATAAAGCCAGGGGAGTTTGGCACCGCTAGAGGGATCTCGACGTATACTGTTGGCCAGGGGGCTTATCTTGATAAAAT
CCTCCAGAAAGTAAAAGTACACTCGAGAATTCTCGCGCAGGTTCCGGGGGCTTTGCTGTGGGGGTCTGATTCTCGGCCGG
AAGGTGTTGGTGAGCGAGATAATGCGGTTGTTGTCCTCGATGTTCTAAATGTGATTGCAACAAAGCTTAATGGCCCAAAA
AAGCCTTCTCCACCGGGTTTACCGACTGTTGTTGATTCCGCGAATGGACCAAAGATTCTGCCTGTTACGGCCCCGGCTCC
GCAGGCTCTGTCTGTTGTTACCTTAATAGAGGGGTCGGGACATCCTGTTAAGCCAACTGATAAAGTCACGGTGCATTATG
TTGGTGCTCTTTGGAGTGGCAAAGTGTTTGATTCCTCCTGGAACAGACGCGCCCCTGCGGAATTTCTCCTTGATGGGCTT
ATAAAAGGTGTAAAAGATGGGCTTGTCGGCGCAAAAGTGGGCTCCAGGCTTCTGATTGTCGTTCCCCCTGCCCTTGGTTA
CGGCGATAAAGCGCAGGGTGATATTCCCGCAAACTCGACGCTTATTTTTGTTTTTGATATCCTCATGGCTACTTCCAGGA
ACTAA

Upstream 100 bases:

>100_bases
TACGGATAAGGCAGAAACCTATCCATAAACATAAGTTCGACAAAGATGACATTCCCGCCTGGCTTCCGGAGCAAATAGGC
TAGACTGTTTATATTAGCTA

Downstream 100 bases:

>100_bases
GTCGATGGGTAATGTTTTTAGCGGCTGGCATTTGCTTGTAATACTCTTGGTTATAGTGCTCTTGTTTGGAACTTCGAGGT
TACCAAAGCTATCTAAAAGT

Product: drug-binding lipoprotein

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MVSLKFVVLTFGLVALLSGCADQGIKVDGKFGTPVRVSIETVVKVKDVTRTVIDEGDGPELKSGDLVAYQVAYFNGTTGD
RIKPGEFGTARGISTYTVGQGAYLDKILQKVKVHSRILAQVPGALLWGSDSRPEGVGERDNAVVVLDVLNVIATKLNGPK
KPSPPGLPTVVDSANGPKILPVTAPAPQALSVVTLIEGSGHPVKPTDKVTVHYVGALWSGKVFDSSWNRRAPAEFLLDGL
IKGVKDGLVGAKVGSRLLIVVPPALGYGDKAQGDIPANSTLIFVFDILMATSRN

Sequences:

>Translated_294_residues
MVSLKFVVLTFGLVALLSGCADQGIKVDGKFGTPVRVSIETVVKVKDVTRTVIDEGDGPELKSGDLVAYQVAYFNGTTGD
RIKPGEFGTARGISTYTVGQGAYLDKILQKVKVHSRILAQVPGALLWGSDSRPEGVGERDNAVVVLDVLNVIATKLNGPK
KPSPPGLPTVVDSANGPKILPVTAPAPQALSVVTLIEGSGHPVKPTDKVTVHYVGALWSGKVFDSSWNRRAPAEFLLDGL
IKGVKDGLVGAKVGSRLLIVVPPALGYGDKAQGDIPANSTLIFVFDILMATSRN
>Mature_294_residues
MVSLKFVVLTFGLVALLSGCADQGIKVDGKFGTPVRVSIETVVKVKDVTRTVIDEGDGPELKSGDLVAYQVAYFNGTTGD
RIKPGEFGTARGISTYTVGQGAYLDKILQKVKVHSRILAQVPGALLWGSDSRPEGVGERDNAVVVLDVLNVIATKLNGPK
KPSPPGLPTVVDSANGPKILPVTAPAPQALSVVTLIEGSGHPVKPTDKVTVHYVGALWSGKVFDSSWNRRAPAEFLLDGL
IKGVKDGLVGAKVGSRLLIVVPPALGYGDKAQGDIPANSTLIFVFDILMATSRN

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI87082390, Length=100, Percent_Identity=41, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789745, Length=91, Percent_Identity=43.956043956044, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281363946, Length=103, Percent_Identity=37.8640776699029, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17352457, Length=103, Percent_Identity=37.8640776699029, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 30874; Mature: 30874

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSLKFVVLTFGLVALLSGCADQGIKVDGKFGTPVRVSIETVVKVKDVTRTVIDEGDGPE
CCEEEHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEHHHEEEHHHHHHHHHCCCCCCC
LKSGDLVAYQVAYFNGTTGDRIKPGEFGTARGISTYTVGQGAYLDKILQKVKVHSRILAQ
CCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
VPGALLWGSDSRPEGVGERDNAVVVLDVLNVIATKLNGPKKPSPPGLPTVVDSANGPKIL
CCCEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEEE
PVTAPAPQALSVVTLIEGSGHPVKPTDKVTVHYVGALWSGKVFDSSWNRRAPAEFLLDGL
EEECCCCCCEEEEEEEECCCCCCCCCCCEEEEEEEEEECCCEECCCCCCCCCHHHHHHHH
IKGVKDGLVGAKVGSRLLIVVPPALGYGDKAQGDIPANSTLIFVFDILMATSRN
HHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEHEEHHHHHHCCC
>Mature Secondary Structure
MVSLKFVVLTFGLVALLSGCADQGIKVDGKFGTPVRVSIETVVKVKDVTRTVIDEGDGPE
CCEEEHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEHHHEEEHHHHHHHHHCCCCCCC
LKSGDLVAYQVAYFNGTTGDRIKPGEFGTARGISTYTVGQGAYLDKILQKVKVHSRILAQ
CCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
VPGALLWGSDSRPEGVGERDNAVVVLDVLNVIATKLNGPKKPSPPGLPTVVDSANGPKIL
CCCEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEEE
PVTAPAPQALSVVTLIEGSGHPVKPTDKVTVHYVGALWSGKVFDSSWNRRAPAEFLLDGL
EEECCCCCCEEEEEEEECCCCCCCCCCCEEEEEEEEEECCCEECCCCCCCCCHHHHHHHH
IKGVKDGLVGAKVGSRLLIVVPPALGYGDKAQGDIPANSTLIFVFDILMATSRN
HHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEHEEHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]