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The map label for this gene is aroC

Identifier: 28572550

GI number: 28572550

Start: 433349

End: 434551

Strand: Direct

Name: aroC

Synonym: TW397

Alternate gene names: 28572550

Gene position: 433349-434551 (Clockwise)

Preceding gene: 28572549

Following gene: 28572551

Centisome position: 46.8

GC content: 47.3

Gene sequence:

>1203_bases
ATGTTACGTTGGTTTACTGCTGGCGAGTCACACGGGATGGAGCTTGTTGCCATCCTTGAGGGGCTACCGGCAGGCATACC
GGTTTCTCTCGAGCACATAGGCAATGAACTGTCAAGGCGCAGGCTGGGATTTGGGCGCAGTGCAAGGCAAAAATTTGAGA
AAGATCTAGTTACGCTATCGGCCGGTGTGTTACATGGCTCAACCCTTGGTAGTCCAGTTGCGATTAGGATAACTAATTCT
GAGTGGGGTAAATGGGAAAAGATTATGACCCCGGAAGTGCCTTGTAAATCAGATATGTCTGATGCAAAAAGGGCTCAGGG
TCTCTATAAGCCGCGGCCAGGCCATGCCGATCTGGTCGGTATGCAAAAATATGGTTTTCAAAATTCACGTCTTGTTCTTG
AAAGAGCCAGCGCTCGCGAGACAGCCGCGAGGGTTGCATGTGGGGCCGTTGCAAAGGCCTTTTTGCAACAACTGGACATT
TTTATCCTAAGCCACGTAAAGCAAATTGGTTCCATAAAAATTGATTATGAACAGGGCGCGTATCCGAGATTTTGTGATTT
AGAAGCAATAGACTCTAGTCCTGTTCGGTGTTTTGACAAGAACACATCTGAGAAAATGAAAGATGAGCTTCACCGAATCA
AGCGGTGTGGCGATACCCTTGGTGGTGTTTTTGAAGTTTTGGCCTATGGCCTCCCTCCCGGCCTGGGAAGCTATGTGCAT
TGGGATAGACGCCTTGACGCGATGCTTTCAGCAGCTATTATGAGCATTCAAGCAGTAAAAGCGGTTGAGATTGGTGACGG
ACTTGCGATCTCCGCTCTGCCTGGGTCAGAGGCACATGATCAAATTGTGCTTGAGAGTGGTTTACTAACGCGCATGTCAA
ATCACAGCGGGGGAGTTGAGGGTGGTGTAACAACCGGATCTGCTTTGAGGATCAGTGGCAGCATGAAACCTATATCGACT
GTCCCTCGTGCACTAAAAACTGTTGATATTTCTACACGCCAACCGGCTAATGCCGATCATCAAAGATCTGATATTTGTGC
TGTTCCTGCGGCGGCAGTTGTTGGAGAATCAATGGTTGCACTCACGATATCTTGCGCAATCTTGGATAAATTTGGCGGAG
ATTCGCTTTGTGAAATAAAGCGGAATTTCTCTGGTTATCTTAACTCTATTCCAAAAAATCTCATGTCTGTCATAGAAAGA
TAG

Upstream 100 bases:

>100_bases
TCCAGGTTTATTCATCCCAGGATTGCAAGTATTTTTATGACTCACTCTGAATTACCAAATATCTTCGCCGGATAAGTTAC
ATCACGATAAACTTATTGCA

Downstream 100 bases:

>100_bases
CTTCGGCCGTAATCGGATTAATTGGAATCAATGGCTATCGTACTAATTGGTCCTCCTGCCGTCGGGAAAACCCTTTTGGG
GGGTCTTGTTGCAAAGCGCC

Product: chorismate synthase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate phospholyase

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MLRWFTAGESHGMELVAILEGLPAGIPVSLEHIGNELSRRRLGFGRSARQKFEKDLVTLSAGVLHGSTLGSPVAIRITNS
EWGKWEKIMTPEVPCKSDMSDAKRAQGLYKPRPGHADLVGMQKYGFQNSRLVLERASARETAARVACGAVAKAFLQQLDI
FILSHVKQIGSIKIDYEQGAYPRFCDLEAIDSSPVRCFDKNTSEKMKDELHRIKRCGDTLGGVFEVLAYGLPPGLGSYVH
WDRRLDAMLSAAIMSIQAVKAVEIGDGLAISALPGSEAHDQIVLESGLLTRMSNHSGGVEGGVTTGSALRISGSMKPIST
VPRALKTVDISTRQPANADHQRSDICAVPAAAVVGESMVALTISCAILDKFGGDSLCEIKRNFSGYLNSIPKNLMSVIER

Sequences:

>Translated_400_residues
MLRWFTAGESHGMELVAILEGLPAGIPVSLEHIGNELSRRRLGFGRSARQKFEKDLVTLSAGVLHGSTLGSPVAIRITNS
EWGKWEKIMTPEVPCKSDMSDAKRAQGLYKPRPGHADLVGMQKYGFQNSRLVLERASARETAARVACGAVAKAFLQQLDI
FILSHVKQIGSIKIDYEQGAYPRFCDLEAIDSSPVRCFDKNTSEKMKDELHRIKRCGDTLGGVFEVLAYGLPPGLGSYVH
WDRRLDAMLSAAIMSIQAVKAVEIGDGLAISALPGSEAHDQIVLESGLLTRMSNHSGGVEGGVTTGSALRISGSMKPIST
VPRALKTVDISTRQPANADHQRSDICAVPAAAVVGESMVALTISCAILDKFGGDSLCEIKRNFSGYLNSIPKNLMSVIER
>Mature_400_residues
MLRWFTAGESHGMELVAILEGLPAGIPVSLEHIGNELSRRRLGFGRSARQKFEKDLVTLSAGVLHGSTLGSPVAIRITNS
EWGKWEKIMTPEVPCKSDMSDAKRAQGLYKPRPGHADLVGMQKYGFQNSRLVLERASARETAARVACGAVAKAFLQQLDI
FILSHVKQIGSIKIDYEQGAYPRFCDLEAIDSSPVRCFDKNTSEKMKDELHRIKRCGDTLGGVFEVLAYGLPPGLGSYVH
WDRRLDAMLSAAIMSIQAVKAVEIGDGLAISALPGSEAHDQIVLESGLLTRMSNHSGGVEGGVTTGSALRISGSMKPIST
VPRALKTVDISTRQPANADHQRSDICAVPAAAVVGESMVALTISCAILDKFGGDSLCEIKRNFSGYLNSIPKNLMSVIER

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; seventh step. [C]

COG id: COG0082

COG function: function code E; Chorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chorismate synthase family

Homologues:

Organism=Escherichia coli, GI1788669, Length=369, Percent_Identity=33.6043360433604, Blast_Score=168, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6321290, Length=378, Percent_Identity=34.3915343915344, Blast_Score=183, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROC_TROW8 (Q83HU6)

Other databases:

- EMBL:   BX251411
- RefSeq:   NP_789330.1
- HSSP:   O66493
- ProteinModelPortal:   Q83HU6
- SMR:   Q83HU6
- STRING:   Q83HU6
- GeneID:   1064683
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW397
- eggNOG:   COG0082
- HOGENOM:   HBG292336
- OMA:   GSEAHDE
- ProtClustDB:   PRK05382
- BioCyc:   TWHI218496:TW0375-MONOMER
- HAMAP:   MF_00300_B
- InterPro:   IPR000453
- InterPro:   IPR020541
- PANTHER:   PTHR21085
- PIRSF:   PIRSF001456
- TIGRFAMs:   TIGR00033

Pfam domain/function: PF01264 Chorismate_synt; SSF103263 Chorismate_synth

EC number: =4.2.3.5

Molecular weight: Translated: 43174; Mature: 43174

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS00787 CHORISMATE_SYNTHASE_1; PS00788 CHORISMATE_SYNTHASE_2; PS00789 CHORISMATE_SYNTHASE_3; PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRWFTAGESHGMELVAILEGLPAGIPVSLEHIGNELSRRRLGFGRSARQKFEKDLVTLS
CCEEEECCCCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AGVLHGSTLGSPVAIRITNSEWGKWEKIMTPEVPCKSDMSDAKRAQGLYKPRPGHADLVG
HHHEECCCCCCCEEEEEECCCCCCHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEE
MQKYGFQNSRLVLERASARETAARVACGAVAKAFLQQLDIFILSHVKQIGSIKIDYEQGA
HHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
YPRFCDLEAIDSSPVRCFDKNTSEKMKDELHRIKRCGDTLGGVFEVLAYGLPPGLGSYVH
CCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
WDRRLDAMLSAAIMSIQAVKAVEIGDGLAISALPGSEAHDQIVLESGLLTRMSNHSGGVE
HHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCEEHHHHHHHHHCCCCCCCC
GGVTTGSALRISGSMKPISTVPRALKTVDISTRQPANADHQRSDICAVPAAAVVGESMVA
CCCCCCCEEEECCCCCCHHHHHHHHHEECCCCCCCCCCCCCCCCHHHCCHHHHHCCHHHH
LTISCAILDKFGGDSLCEIKRNFSGYLNSIPKNLMSVIER
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLRWFTAGESHGMELVAILEGLPAGIPVSLEHIGNELSRRRLGFGRSARQKFEKDLVTLS
CCEEEECCCCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AGVLHGSTLGSPVAIRITNSEWGKWEKIMTPEVPCKSDMSDAKRAQGLYKPRPGHADLVG
HHHEECCCCCCCEEEEEECCCCCCHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEE
MQKYGFQNSRLVLERASARETAARVACGAVAKAFLQQLDIFILSHVKQIGSIKIDYEQGA
HHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
YPRFCDLEAIDSSPVRCFDKNTSEKMKDELHRIKRCGDTLGGVFEVLAYGLPPGLGSYVH
CCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
WDRRLDAMLSAAIMSIQAVKAVEIGDGLAISALPGSEAHDQIVLESGLLTRMSNHSGGVE
HHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCEEHHHHHHHHHCCCCCCCC
GGVTTGSALRISGSMKPISTVPRALKTVDISTRQPANADHQRSDICAVPAAAVVGESMVA
CCCCCCCEEEECCCCCCHHHHHHHHHEECCCCCCCCCCCCCCCCHHHCCHHHHHCCHHHH
LTISCAILDKFGGDSLCEIKRNFSGYLNSIPKNLMSVIER
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12606174