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The map label for this gene is zitB [H]

Identifier: 28572502

GI number: 28572502

Start: 379342

End: 380280

Strand: Direct

Name: zitB [H]

Synonym: TW348

Alternate gene names: 28572502

Gene position: 379342-380280 (Clockwise)

Preceding gene: 28572501

Following gene: 28572505

Centisome position: 40.97

GC content: 42.39

Gene sequence:

>939_bases
TTGTTTGGGGTCCTTTTGCATGGTCATACGCATTCTTCTTTTGATGTACATATAAACGTATCTATTTATAAACGTTTATT
TATTGCTCTTTGTCTCACCGTTGGCTTTACGCTTATTGAGCTACTTGCCGTGTATCTTAGCGCGTCAGTTACTTTGGCAT
CCGATGCGGGGCATATGTTTATAGATTCACTTGGCCTTTTTAATGCACTTATTGCGGCAAGGCTTGTTGCCAAATCAAAT
AGAAATTCACATAGGACTTATGGGCTCTATAGAGTTGAGGTGTTTTCTGCCGGAGTGAGTATTTTGATTATGTTTTTTCT
GGCTTTTCTTATAGCAAAAGAGTCGATTATGCGTCTTGTGTATCCTGAAGAACATATATCAGGATGGGTGATTTTTGTAA
CGGGTATTGCAGGTCTCTTGGTGAATCTTTCTGCCGTCCTCGTGTTGCATTCTGCCAAACAAAAGGGGATTAATCTCAGA
GCCGCATACATGGAAGTGCTTTCTGACGCCATTGCGTCTGTCAGCGTTATGTTGTCGGCAATACTCATTATTCTGACAGG
GCTAACTATTATTGATTCAATAGCTGCGATTGCCATAGTTCTCTTTATTTGCTACCGTGCGGCAAAACTTGGCAAAGAGG
TTATTAGAATCCTTTTGCAAGCTTCACCTGTTGATATACAAGAGGTGGAAAGCAGTTTGCTTGGAATTGATGGTGTGATT
TCAGTCGATCACCTGCATGCGTGGACCTTATCGGACGAAAAGCACATTGCGACGGCGAATATTCTAATTCACAAGCAGAC
AGATCAGAACAAAGTCCTAGTGGAAGCGGAAAGAATTCTTTATGAGCAATACGGCATCTTGCATACGACCCTGCAAATAT
CTCCGATGCGACTCGAGAGCAGATTGGCATGCGGAGGACCCGTTATTTCGCATCGATGA

Upstream 100 bases:

>100_bases
TGGTCAGAAGGTGCTTGTTGAGGTATCAAAGATCGACGATAGGGGTAAATTGTGCCTTGTCGCTGTCAAGTAGCCGCGCT
CCTGCTTTGGCGCTAGTTTC

Downstream 100 bases:

>100_bases
GGACCCGTTTTATAAGTACGACGATACTTGCTGCGGCTGGAACAGCCACCACAGCACCAGGAACACCTGCCAGCATTCCA
CCTGCTAGGGCTGATATAAC

Product: cation efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MFGVLLHGHTHSSFDVHINVSIYKRLFIALCLTVGFTLIELLAVYLSASVTLASDAGHMFIDSLGLFNALIAARLVAKSN
RNSHRTYGLYRVEVFSAGVSILIMFFLAFLIAKESIMRLVYPEEHISGWVIFVTGIAGLLVNLSAVLVLHSAKQKGINLR
AAYMEVLSDAIASVSVMLSAILIILTGLTIIDSIAAIAIVLFICYRAAKLGKEVIRILLQASPVDIQEVESSLLGIDGVI
SVDHLHAWTLSDEKHIATANILIHKQTDQNKVLVEAERILYEQYGILHTTLQISPMRLESRLACGGPVISHR

Sequences:

>Translated_312_residues
MFGVLLHGHTHSSFDVHINVSIYKRLFIALCLTVGFTLIELLAVYLSASVTLASDAGHMFIDSLGLFNALIAARLVAKSN
RNSHRTYGLYRVEVFSAGVSILIMFFLAFLIAKESIMRLVYPEEHISGWVIFVTGIAGLLVNLSAVLVLHSAKQKGINLR
AAYMEVLSDAIASVSVMLSAILIILTGLTIIDSIAAIAIVLFICYRAAKLGKEVIRILLQASPVDIQEVESSLLGIDGVI
SVDHLHAWTLSDEKHIATANILIHKQTDQNKVLVEAERILYEQYGILHTTLQISPMRLESRLACGGPVISHR
>Mature_312_residues
MFGVLLHGHTHSSFDVHINVSIYKRLFIALCLTVGFTLIELLAVYLSASVTLASDAGHMFIDSLGLFNALIAARLVAKSN
RNSHRTYGLYRVEVFSAGVSILIMFFLAFLIAKESIMRLVYPEEHISGWVIFVTGIAGLLVNLSAVLVLHSAKQKGINLR
AAYMEVLSDAIASVSVMLSAILIILTGLTIIDSIAAIAIVLFICYRAAKLGKEVIRILLQASPVDIQEVESSLLGIDGVI
SVDHLHAWTLSDEKHIATANILIHKQTDQNKVLVEAERILYEQYGILHTTLQISPMRLESRLACGGPVISHR

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21361112, Length=307, Percent_Identity=26.7100977198697, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI52352805, Length=324, Percent_Identity=24.3827160493827, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI21359890, Length=312, Percent_Identity=24.6794871794872, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI20070323, Length=313, Percent_Identity=24.6006389776358, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI289803013, Length=293, Percent_Identity=24.5733788395904, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI289803009, Length=293, Percent_Identity=24.5733788395904, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI289803007, Length=293, Percent_Identity=24.5733788395904, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI289803003, Length=293, Percent_Identity=24.5733788395904, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI64762489, Length=293, Percent_Identity=24.5733788395904, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI14210520, Length=232, Percent_Identity=25, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI52351208, Length=128, Percent_Identity=33.59375, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI222080086, Length=126, Percent_Identity=34.1269841269841, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI40255009, Length=126, Percent_Identity=34.1269841269841, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1786966, Length=288, Percent_Identity=32.6388888888889, Blast_Score=117, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17555794, Length=320, Percent_Identity=24.0625, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17555796, Length=303, Percent_Identity=24.4224422442244, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI193210990, Length=324, Percent_Identity=24.0740740740741, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI32564488, Length=313, Percent_Identity=25.5591054313099, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=148, Percent_Identity=31.0810810810811, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323899, Length=155, Percent_Identity=30.9677419354839, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24583858, Length=342, Percent_Identity=25.4385964912281, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24645863, Length=140, Percent_Identity=30, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585900, Length=187, Percent_Identity=25.668449197861, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24585898, Length=187, Percent_Identity=25.668449197861, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24585896, Length=187, Percent_Identity=25.668449197861, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19921672, Length=187, Percent_Identity=25.668449197861, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34167; Mature: 34167

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGVLLHGHTHSSFDVHINVSIYKRLFIALCLTVGFTLIELLAVYLSASVTLASDAGHMF
CCEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHH
IDSLGLFNALIAARLVAKSNRNSHRTYGLYRVEVFSAGVSILIMFFLAFLIAKESIMRLV
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHC
YPEEHISGWVIFVTGIAGLLVNLSAVLVLHSAKQKGINLRAAYMEVLSDAIASVSVMLSA
CCHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ILIILTGLTIIDSIAAIAIVLFICYRAAKLGKEVIRILLQASPVDIQEVESSLLGIDGVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEE
SVDHLHAWTLSDEKHIATANILIHKQTDQNKVLVEAERILYEQYGILHTTLQISPMRLES
EECCEEEEECCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEECHHHHHH
RLACGGPVISHR
HHCCCCCCCCCC
>Mature Secondary Structure
MFGVLLHGHTHSSFDVHINVSIYKRLFIALCLTVGFTLIELLAVYLSASVTLASDAGHMF
CCEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHH
IDSLGLFNALIAARLVAKSNRNSHRTYGLYRVEVFSAGVSILIMFFLAFLIAKESIMRLV
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHC
YPEEHISGWVIFVTGIAGLLVNLSAVLVLHSAKQKGINLRAAYMEVLSDAIASVSVMLSA
CCHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ILIILTGLTIIDSIAAIAIVLFICYRAAKLGKEVIRILLQASPVDIQEVESSLLGIDGVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEE
SVDHLHAWTLSDEKHIATANILIHKQTDQNKVLVEAERILYEQYGILHTTLQISPMRLES
EECCEEEEECCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEECHHHHHH
RLACGGPVISHR
HHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]