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The map label for this gene is folP [H]

Identifier: 28572337

GI number: 28572337

Start: 216584

End: 218881

Strand: Direct

Name: folP [H]

Synonym: TW175

Alternate gene names: 28572337

Gene position: 216584-218881 (Clockwise)

Preceding gene: 28572336

Following gene: 28572338

Centisome position: 23.39

GC content: 46.21

Gene sequence:

>2298_bases
GTGATGAACATGAGCTATACTCCCGACCCATTTCCACCTCCTAATGTAATGGGCATTCTGAATATAACCGATGATTCTTT
CAGTGATGGTGGACTGTTTTTAGACCCCTCTGCTGCCATTACCCAAGGTAGAAAGTTATTTGCTGAGGGTGCTTCAATAA
TCGATGTTGGGGGTGAATCGACACGCCCGGGTGCTGAGCGGATTAGCGTGGAAGAAGAAAAAAAAAGGGTTTTACCCGTA
GTTAGGGAACTTCTATCCGAAGGTATTCATGTAAGTCTTGACACCATGAATGCAGACACAGCAAAAGAGGGCCTTAGCAT
GGGTGTTGCCATTATAAATGACGTATCAGCGGGCAAAGCCGACCCGGACATGCTAAGAGTGATAGCCGATGCAGGCTGTA
AATACATCGCGATGCATTGGCGTGGGCACTCCATGTTTATGGATAGCCTTGCTCATTACGACGATGTTGTGAGTGATGTT
CTTCGAGAGCTTAAGTTTGATATCGAGCGTATTACTGCCGCTGGGGTAAAGAGCGACCAGATCATCCTTGATCCTGGTTT
TGGCTTTTCTAAAACAAGTGACCATAATTGGCAGTTGTTCAGAAACCTTGATTGCTTTGTTAAGCTGGGCTTTCCCGTGC
TGATTGGTCTTTCGCGCAAGAGGTTTTTGAGTCGAGTATTTAAGGGGCATGATTTTTCTCCTAAAGATTCTAAGAATGTT
GGAGGGTTGGATAACCGCGAAATACTTGCGCGCGATCTGCCAAGCGGGATACTGAGTGCTATTGCCATAACACGTGGAGC
ATGGGGCGTGCGTGTACATGATGTTGCCTCAGCTCACACGGCGCTGCGGACTCTACAGCTTGCGCAATACGGCTCGGTAT
ATCAGGCCCACAAACGGGCGGCAAATACCGGAATAGACACCGCAATACCCGGCCAAGGCAACACTGATGACACCACTGCC
TCCAGTAACCACACCAACAATTCTGAAACAGGAGCTTCTTTAAAAAGTGGCGTGAGTCAAGTCCGCAACATGATTGCCCC
GCCCGTTATAAAGATAAGAAGTCTGCGCGTGTATGCATATCATGGGGTGTATCGTTCTGAGCGGGACTACGGTCAGCAAT
TCATTATCGATGCAGATATTCAATTAAAACATTTTCCAGAAGACAAGATTGACTCAACCCTAGACTATGACTCATTGACT
GGAAAGTTTGTGCAATATGCCACCGCATCATCTGTGAATCTTATTGAGACACTCGCTGATCACCTTGCAAAGATTGCCGT
CCTAGATCCAATGGTTGAGTGGGTAAGCCTCAGCATAACAAAGCCAAACCCTCCGCTCGCTTATATGAAACAAAGTAACA
CAGCCGCCTGTCATGCTATGCATAAACCTGATACCAGAGGTGATTATGCTAAAGAACACACAAATCTTACAGGCCTTCAA
TTATCGTGCACGGTTAGGAAAGTGCGTTCCGAAAGTGTAACAAGGGTCTATATAGGCATCGGTGCAAATGTAGGTAATTG
CCTGGATAATGTCCAGCGCGCGATCAAGGATATTGCAGATCATCCAATGATTGAACTTGTCTCACTCGGCAGGCTTTTCC
GAACCACCGCCGTTGTTGGCGAGAGTCTTGATGAATCTCTACCGGTATTTTTGAATACTGCAATCGCAATCGATACTGCT
TTATCCATGCAGGATTTGCTTGCCTTAATGCTTTGTATAGAGAAAAAGCTTGGAAGAACTCGTCACAGTAGAACTCGTCA
CAGTTTATCTTCCGCTCAAGACGCCCACCAGGCTGATTCAACTAGCGATAATCCTAACCAGTTACATTATCCTTGTGCCG
GACGCCAAGGCATCCAACAGCCTTTACATTCGTCAACTTTGGCGCACACTCAGGATGGGTTTGTTAATCGGCATATTGAC
CTTGATATCCTGCTCGCGGAGGGGGTTCAAATTACTGAACACGGGTTATGTATTCCACATCCAAGGCTCAGTAAGAGAGC
CTTTGCGCTTTTGCCACTTGAGAGTATAGATCCTGATCTGCATATCCCCGGACATGGCCCAATTACTGACTTGATACATG
GTCTTCCTGAGGATCAAATAAGCTCTGTTGCTACCCTTCGAGATTCCGGGTATGAATTATTCAGGCACTCTATTACCAGA
CTAAACAATTGTTCAGCGCATAATAAAGCGTATGTTACTCCGTCAGCGGGCCAGAATTATGATTCTGAACAGGATTTTGA
TGCTGGATTGTCACACACAGAATCACGCGGAAAAACAGAGCCACACGGAAAAATATGA

Upstream 100 bases:

>100_bases
GACCTTCGCGCATCGGGGTATAGGAGATGCCGATATCATCTCTTTTATGACAATAATCCGGTAGCGTGTACCTGCTATTT
CGCTTGGGTTAACGTGTATT

Downstream 100 bases:

>100_bases
ATAAAACCGCAGCGCTCGTCGCGGCACTGATTGTTTTTAGTGCTGTAATCGCTGCCCTAGCAAGCCAGGTTCTTTCTGAA
CTTGGATACAGTGTGTTTGT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS 1; Dihydropteroate pyrophosphorylase 1 [H]

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MMNMSYTPDPFPPPNVMGILNITDDSFSDGGLFLDPSAAITQGRKLFAEGASIIDVGGESTRPGAERISVEEEKKRVLPV
VRELLSEGIHVSLDTMNADTAKEGLSMGVAIINDVSAGKADPDMLRVIADAGCKYIAMHWRGHSMFMDSLAHYDDVVSDV
LRELKFDIERITAAGVKSDQIILDPGFGFSKTSDHNWQLFRNLDCFVKLGFPVLIGLSRKRFLSRVFKGHDFSPKDSKNV
GGLDNREILARDLPSGILSAIAITRGAWGVRVHDVASAHTALRTLQLAQYGSVYQAHKRAANTGIDTAIPGQGNTDDTTA
SSNHTNNSETGASLKSGVSQVRNMIAPPVIKIRSLRVYAYHGVYRSERDYGQQFIIDADIQLKHFPEDKIDSTLDYDSLT
GKFVQYATASSVNLIETLADHLAKIAVLDPMVEWVSLSITKPNPPLAYMKQSNTAACHAMHKPDTRGDYAKEHTNLTGLQ
LSCTVRKVRSESVTRVYIGIGANVGNCLDNVQRAIKDIADHPMIELVSLGRLFRTTAVVGESLDESLPVFLNTAIAIDTA
LSMQDLLALMLCIEKKLGRTRHSRTRHSLSSAQDAHQADSTSDNPNQLHYPCAGRQGIQQPLHSSTLAHTQDGFVNRHID
LDILLAEGVQITEHGLCIPHPRLSKRAFALLPLESIDPDLHIPGHGPITDLIHGLPEDQISSVATLRDSGYELFRHSITR
LNNCSAHNKAYVTPSAGQNYDSEQDFDAGLSHTESRGKTEPHGKI

Sequences:

>Translated_765_residues
MMNMSYTPDPFPPPNVMGILNITDDSFSDGGLFLDPSAAITQGRKLFAEGASIIDVGGESTRPGAERISVEEEKKRVLPV
VRELLSEGIHVSLDTMNADTAKEGLSMGVAIINDVSAGKADPDMLRVIADAGCKYIAMHWRGHSMFMDSLAHYDDVVSDV
LRELKFDIERITAAGVKSDQIILDPGFGFSKTSDHNWQLFRNLDCFVKLGFPVLIGLSRKRFLSRVFKGHDFSPKDSKNV
GGLDNREILARDLPSGILSAIAITRGAWGVRVHDVASAHTALRTLQLAQYGSVYQAHKRAANTGIDTAIPGQGNTDDTTA
SSNHTNNSETGASLKSGVSQVRNMIAPPVIKIRSLRVYAYHGVYRSERDYGQQFIIDADIQLKHFPEDKIDSTLDYDSLT
GKFVQYATASSVNLIETLADHLAKIAVLDPMVEWVSLSITKPNPPLAYMKQSNTAACHAMHKPDTRGDYAKEHTNLTGLQ
LSCTVRKVRSESVTRVYIGIGANVGNCLDNVQRAIKDIADHPMIELVSLGRLFRTTAVVGESLDESLPVFLNTAIAIDTA
LSMQDLLALMLCIEKKLGRTRHSRTRHSLSSAQDAHQADSTSDNPNQLHYPCAGRQGIQQPLHSSTLAHTQDGFVNRHID
LDILLAEGVQITEHGLCIPHPRLSKRAFALLPLESIDPDLHIPGHGPITDLIHGLPEDQISSVATLRDSGYELFRHSITR
LNNCSAHNKAYVTPSAGQNYDSEQDFDAGLSHTESRGKTEPHGKI
>Mature_765_residues
MMNMSYTPDPFPPPNVMGILNITDDSFSDGGLFLDPSAAITQGRKLFAEGASIIDVGGESTRPGAERISVEEEKKRVLPV
VRELLSEGIHVSLDTMNADTAKEGLSMGVAIINDVSAGKADPDMLRVIADAGCKYIAMHWRGHSMFMDSLAHYDDVVSDV
LRELKFDIERITAAGVKSDQIILDPGFGFSKTSDHNWQLFRNLDCFVKLGFPVLIGLSRKRFLSRVFKGHDFSPKDSKNV
GGLDNREILARDLPSGILSAIAITRGAWGVRVHDVASAHTALRTLQLAQYGSVYQAHKRAANTGIDTAIPGQGNTDDTTA
SSNHTNNSETGASLKSGVSQVRNMIAPPVIKIRSLRVYAYHGVYRSERDYGQQFIIDADIQLKHFPEDKIDSTLDYDSLT
GKFVQYATASSVNLIETLADHLAKIAVLDPMVEWVSLSITKPNPPLAYMKQSNTAACHAMHKPDTRGDYAKEHTNLTGLQ
LSCTVRKVRSESVTRVYIGIGANVGNCLDNVQRAIKDIADHPMIELVSLGRLFRTTAVVGESLDESLPVFLNTAIAIDTA
LSMQDLLALMLCIEKKLGRTRHSRTRHSLSSAQDAHQADSTSDNPNQLHYPCAGRQGIQQPLHSSTLAHTQDGFVNRHID
LDILLAEGVQITEHGLCIPHPRLSKRAFALLPLESIDPDLHIPGHGPITDLIHGLPEDQISSVATLRDSGYELFRHSITR
LNNCSAHNKAYVTPSAGQNYDSEQDFDAGLSHTESRGKTEPHGKI

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=274, Percent_Identity=37.5912408759124, Blast_Score=174, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324073, Length=328, Percent_Identity=33.5365853658537, Blast_Score=137, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 83692; Mature: 83692

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNMSYTPDPFPPPNVMGILNITDDSFSDGGLFLDPSAAITQGRKLFAEGASIIDVGGES
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCHHHHHHHHHHHHCCCCEEECCCCC
TRPGAERISVEEEKKRVLPVVRELLSEGIHVSLDTMNADTAKEGLSMGVAIINDVSAGKA
CCCCHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCHHHEECCCCCCC
DPDMLRVIADAGCKYIAMHWRGHSMFMDSLAHYDDVVSDVLRELKFDIERITAAGVKSDQ
CHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
IILDPGFGFSKTSDHNWQLFRNLDCFVKLGFPVLIGLSRKRFLSRVFKGHDFSPKDSKNV
EEECCCCCCCCCCCCCHHHHHCCCEEEEECCHHEECCHHHHHHHHHHCCCCCCCCCCCCC
GGLDNREILARDLPSGILSAIAITRGAWGVRVHDVASAHTALRTLQLAQYGSVYQAHKRA
CCCCCHHHHHHHCCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANTGIDTAIPGQGNTDDTTASSNHTNNSETGASLKSGVSQVRNMIAPPVIKIRSLRVYAY
HCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEE
HGVYRSERDYGQQFIIDADIQLKHFPEDKIDSTLDYDSLTGKFVQYATASSVNLIETLAD
ECCHHCCHHCCCEEEEECCCEEEECCCHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
HLAKIAVLDPMVEWVSLSITKPNPPLAYMKQSNTAACHAMHKPDTRGDYAKEHTNLTGLQ
HHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHCCCCCEE
LSCTVRKVRSESVTRVYIGIGANVGNCLDNVQRAIKDIADHPMIELVSLGRLFRTTAVVG
EEHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ESLDESLPVFLNTAIAIDTALSMQDLLALMLCIEKKLGRTRHSRTRHSLSSAQDAHQADS
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TSDNPNQLHYPCAGRQGIQQPLHSSTLAHTQDGFVNRHIDLDILLAEGVQITEHGLCIPH
CCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEECCCCEEEEEECCCEEECCCCCCCC
PRLSKRAFALLPLESIDPDLHIPGHGPITDLIHGLPEDQISSVATLRDSGYELFRHSITR
CCCCCCEEEEEEHHHCCCCEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LNNCSAHNKAYVTPSAGQNYDSEQDFDAGLSHTESRGKTEPHGKI
HCCCCCCCCEEECCCCCCCCCCCCCHHCCCCCHHHCCCCCCCCCC
>Mature Secondary Structure
MMNMSYTPDPFPPPNVMGILNITDDSFSDGGLFLDPSAAITQGRKLFAEGASIIDVGGES
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCHHHHHHHHHHHHCCCCEEECCCCC
TRPGAERISVEEEKKRVLPVVRELLSEGIHVSLDTMNADTAKEGLSMGVAIINDVSAGKA
CCCCHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCHHHEECCCCCCC
DPDMLRVIADAGCKYIAMHWRGHSMFMDSLAHYDDVVSDVLRELKFDIERITAAGVKSDQ
CHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
IILDPGFGFSKTSDHNWQLFRNLDCFVKLGFPVLIGLSRKRFLSRVFKGHDFSPKDSKNV
EEECCCCCCCCCCCCCHHHHHCCCEEEEECCHHEECCHHHHHHHHHHCCCCCCCCCCCCC
GGLDNREILARDLPSGILSAIAITRGAWGVRVHDVASAHTALRTLQLAQYGSVYQAHKRA
CCCCCHHHHHHHCCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANTGIDTAIPGQGNTDDTTASSNHTNNSETGASLKSGVSQVRNMIAPPVIKIRSLRVYAY
HCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEE
HGVYRSERDYGQQFIIDADIQLKHFPEDKIDSTLDYDSLTGKFVQYATASSVNLIETLAD
ECCHHCCHHCCCEEEEECCCEEEECCCHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
HLAKIAVLDPMVEWVSLSITKPNPPLAYMKQSNTAACHAMHKPDTRGDYAKEHTNLTGLQ
HHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHCCCCCEE
LSCTVRKVRSESVTRVYIGIGANVGNCLDNVQRAIKDIADHPMIELVSLGRLFRTTAVVG
EEHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ESLDESLPVFLNTAIAIDTALSMQDLLALMLCIEKKLGRTRHSRTRHSLSSAQDAHQADS
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TSDNPNQLHYPCAGRQGIQQPLHSSTLAHTQDGFVNRHIDLDILLAEGVQITEHGLCIPH
CCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEECCCCEEEEEECCCEEECCCCCCCC
PRLSKRAFALLPLESIDPDLHIPGHGPITDLIHGLPEDQISSVATLRDSGYELFRHSITR
CCCCCCEEEEEEHHHCCCCEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LNNCSAHNKAYVTPSAGQNYDSEQDFDAGLSHTESRGKTEPHGKI
HCCCCCCCCEEECCCCCCCCCCCCCHHCCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10474189; 10542185; 11234002 [H]