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The map label for this gene is panC

Identifier: 28572243

GI number: 28572243

Start: 64669

End: 65535

Strand: Direct

Name: panC

Synonym: TW073

Alternate gene names: 28572243

Gene position: 64669-65535 (Clockwise)

Preceding gene: 28572241

Following gene: 28572244

Centisome position: 6.98

GC content: 46.02

Gene sequence:

>867_bases
ATGAATCTCAAATTGGCTTCTTCTCCGCATGAGCTACGGACATGCTTGGCCGGCAGGGCATTTGTGCTGGTCCCCACCAT
GGGGGCTTTGCATGAGGGACATATCTGGCTTGTGGACATGGCAAGGCGATGCAATCTCCCTGTTGTTGTATCGATTTTTG
TGAACCCCCTACAATTCGATGACAGTCTTGATTTGGATACTTATCCCAGGACTCTGGAACAGGATTTAGAAAAGTTAGAG
GGCAAGGCTTTTGCAGTTTATTCGCCTAGCGTCGAAACAATGTATCCAAACGGTCTCGACTCTATCCGTATTGACCCAGG
GCCAATAGGAAGAATTCTAGAAGGCGCCATTCGTCCGGGGTTCTTTGATGGGATTCTCACAATTGTTGCAAAATTATTGC
TACAAACCGCACCTGAACGAGTTTTTTTTAGCAAAAAAGATGCCCAACAGGCCTTTTTAGTGAGGCGCATGGTGCGTGAA
CTCGCCTTTCCTGTCAGGGTTGAAGTTACAGGATTTCTACGTGATAAATTTTCCCTGCCTTATTCCTCACGTAATCGTAA
GTTAGGGGTAGATGCGAGAGAAAAGGCTCAAAGATTATCCCAAGGATTACTCTCTGTTGTAAATAATGGTCCGCTTACTG
TGCGGGATTGTATCGACAAAATAACAGATCTAGCAAATTCAATTGGTGTCGATTTGGGCTATGCGCAGATTCTGGATGAA
AATTTTTGCGAAATTGCTTCGGATAGAATGGTTACGCGGGCATTCCACTCGGAGGCCTGTATTGGGCTCAATACCCCACT
TTTTCTGCTTGCTGCCCGTGTACACGGGGTTCGGGTAGTCGACAATGTTGATCTCGTAGTTGTTTAG

Upstream 100 bases:

>100_bases
TGATGCCGTCATGCGTTTACTCTAAAAAATAAAAACAAACTGTATGCTCTCAAGTTGGAATAGGGCTAAATTTAGCCTTC
GTAACTAGACTTAGCTTACA

Downstream 100 bases:

>100_bases
TCGGATGCCTGTCGTTGTCCATTACAGGTTGCTGTTTTGGGGGTTTGCATCTTGGGTTGGAACGGTTGGGCTGCCTTGCT
TCCATCTATCTGCCTTGCGC

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MNLKLASSPHELRTCLAGRAFVLVPTMGALHEGHIWLVDMARRCNLPVVVSIFVNPLQFDDSLDLDTYPRTLEQDLEKLE
GKAFAVYSPSVETMYPNGLDSIRIDPGPIGRILEGAIRPGFFDGILTIVAKLLLQTAPERVFFSKKDAQQAFLVRRMVRE
LAFPVRVEVTGFLRDKFSLPYSSRNRKLGVDAREKAQRLSQGLLSVVNNGPLTVRDCIDKITDLANSIGVDLGYAQILDE
NFCEIASDRMVTRAFHSEACIGLNTPLFLLAARVHGVRVVDNVDLVVV

Sequences:

>Translated_288_residues
MNLKLASSPHELRTCLAGRAFVLVPTMGALHEGHIWLVDMARRCNLPVVVSIFVNPLQFDDSLDLDTYPRTLEQDLEKLE
GKAFAVYSPSVETMYPNGLDSIRIDPGPIGRILEGAIRPGFFDGILTIVAKLLLQTAPERVFFSKKDAQQAFLVRRMVRE
LAFPVRVEVTGFLRDKFSLPYSSRNRKLGVDAREKAQRLSQGLLSVVNNGPLTVRDCIDKITDLANSIGVDLGYAQILDE
NFCEIASDRMVTRAFHSEACIGLNTPLFLLAARVHGVRVVDNVDLVVV
>Mature_288_residues
MNLKLASSPHELRTCLAGRAFVLVPTMGALHEGHIWLVDMARRCNLPVVVSIFVNPLQFDDSLDLDTYPRTLEQDLEKLE
GKAFAVYSPSVETMYPNGLDSIRIDPGPIGRILEGAIRPGFFDGILTIVAKLLLQTAPERVFFSKKDAQQAFLVRRMVRE
LAFPVRVEVTGFLRDKFSLPYSSRNRKLGVDAREKAQRLSQGLLSVVNNGPLTVRDCIDKITDLANSIGVDLGYAQILDE
NFCEIASDRMVTRAFHSEACIGLNTPLFLLAARVHGVRVVDNVDLVVV

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=217, Percent_Identity=42.3963133640553, Blast_Score=150, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6322046, Length=230, Percent_Identity=35.6521739130435, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_TROW8 (Q83ID9)

Other databases:

- EMBL:   BX251410
- RefSeq:   NP_789023.1
- HSSP:   P0A5R0
- ProteinModelPortal:   Q83ID9
- SMR:   Q83ID9
- STRING:   Q83ID9
- GeneID:   1065020
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW073
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   ASSKENH
- ProtClustDB:   CLSK229453
- BioCyc:   TWHI218496:TW0068-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31993; Mature: 31993

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: ACT_SITE 34-34 BINDING 58-58 BINDING 58-58 BINDING 150-150 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKLASSPHELRTCLAGRAFVLVPTMGALHEGHIWLVDMARRCNLPVVVSIFVNPLQFD
CCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEHHHHCCCCEEEEEEECCCCCC
DSLDLDTYPRTLEQDLEKLEGKAFAVYSPSVETMYPNGLDSIRIDPGPIGRILEGAIRPG
CCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEECCCCCCCEEECCCCHHHHHHHHCCCC
FFDGILTIVAKLLLQTAPERVFFSKKDAQQAFLVRRMVRELAFPVRVEVTGFLRDKFSLP
HHHHHHHHHHHHHHHHCCHHHEECCCHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHCCC
YSSRNRKLGVDAREKAQRLSQGLLSVVNNGPLTVRDCIDKITDLANSIGVDLGYAQILDE
CCCCCCEECCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHH
NFCEIASDRMVTRAFHSEACIGLNTPLFLLAARVHGVRVVDNVDLVVV
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEECCCCEEEC
>Mature Secondary Structure
MNLKLASSPHELRTCLAGRAFVLVPTMGALHEGHIWLVDMARRCNLPVVVSIFVNPLQFD
CCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEHHHHCCCCEEEEEEECCCCCC
DSLDLDTYPRTLEQDLEKLEGKAFAVYSPSVETMYPNGLDSIRIDPGPIGRILEGAIRPG
CCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEECCCCCCCEEECCCCHHHHHHHHCCCC
FFDGILTIVAKLLLQTAPERVFFSKKDAQQAFLVRRMVRELAFPVRVEVTGFLRDKFSLP
HHHHHHHHHHHHHHHHCCHHHEECCCHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHCCC
YSSRNRKLGVDAREKAQRLSQGLLSVVNNGPLTVRDCIDKITDLANSIGVDLGYAQILDE
CCCCCCEECCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHH
NFCEIASDRMVTRAFHSEACIGLNTPLFLLAARVHGVRVVDNVDLVVV
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEECCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174