Click here to switch to the map view.

The map label for this gene is lysK [H]

Identifier: 28572242

GI number: 28572242

Start: 62943

End: 64580

Strand: Reverse

Name: lysK [H]

Synonym: TW072

Alternate gene names: 28572242

Gene position: 64580-62943 (Counterclockwise)

Preceding gene: 28572251

Following gene: 28572240

Centisome position: 6.97

GC content: 45.48

Gene sequence:

>1638_bases
ATGACGGCATCAAGAATTGACGCTGCAAGTCCCGAAAAATATGGAAAGCAAGACTGGGTTTCAAAACTTGCCGAGCAGGT
TATACAAGAGCGTAAAGGGGATAAAAAAATTGTTGTAGCGTCTGGAATCAGCCCATCAGGGCAAATCCATTTGGGTAACC
TCAGGGAGGTGATAACCGGACATTTTATTGCCGACGAAATAAGCTCGAGGGGTTTTGATTGCGAACACATACTGTCTTGG
GATGACTTCGATCGTCTGAGAAAAGTACCAGCAAATATCGACAAAGGCTACGAACAATATATCGGGATGCCACTGTGTGA
TGTCCCGCCTCCGGCAGGAAGCAAAAAAAACAGCTGGTCGGAGCATTTTCGGGGAGATTTTGAGAAAACAATGGAAATTC
TCGGAATAAAGGTAAGGCATATAAGCCAGAGTCAAATGTATCGTTCGGGTGCGTATACACACAATATTCTGCTCGCGCTC
GAAAAGCGGCATGAGATTCAGAACATAATTGGCAAATACCAGAGCAAGAAGACCCAACCTGCCGAGTCACCTCGAGAGTA
TTACCCCTATGTTGTATATTGCACACGTTGTAAAAAAGATCTGACACAAATAGAGGATTTTGCGGGGAGTGAGCTCTCAT
ATTCTTGCAAATGCGGGCATTCTGAAACCATTGGCATAGGGGAATTCAACAACGGAAAACTTCCCTGGAAAGTTGACTGG
CCTATGCGGTGGATGTACGAATCAGTTGATTTCGAACCTGGAGGTGTTGATCACTGTTCGCCAGGATCGGCATCGCTATC
AGCCAGTAGTGATATTGCAAATCAAATATTTAATTGGACCCCTCCTTTGACCGTAATGTACTCCTTCGTTGGAGTTCAGG
GGCACGCAAAAATGTCTAGCTCAACGGGTAATGTTCTAACCCCCAATGATGCGCTATCGGTTATGGAGCCAACCCTTCTG
CGGTGGATGTATGCCCGCAGAAAACCCAACCAATCATTCACGGTCGGGTTTGACCAGAGCCTACAAAGACTATATGACGA
ATGGGACAGTCTACCGAATGATCTTACGGGGTGTGAATTGGCATCCTCTTATACCCGCGCAATGTCAACAACCAATAAAA
GATTCAATGCACCGGAGATTCTCATTTCTTTCAGAACACTGGTTTCGCTGATCGACATATCGGCAAGTGATGATTCCCAA
CTGCTAAGGATGGTGAAAAACTTACGCCCTGATATTAGGTCCCTTGCGCAACTCGAGCCAAGATTGAGCTGCGCAAGGAT
CTATAGTAAAAAATTCTCAAACCCAATACATGTTCTGCAAACTCCAAACAAGCAAGTTTTGCATACCGCAGCGCCCAATG
TGAGGGAAATGCTGCGCATCTTCATTGATGGCTTAGATAAGAATTGGTCTATCGAGAAGCTTACGACACTCGCCTACGGA
GTGCCCAAAGTCGTCTTGGGTATAGATCAGTCCTCAAAAGACGTAAGTCAAGAGGTAAAAAATTTACAGAAAGAGTTCTT
TAGGACGATATACCAGTTGGTTATAGGTCAGGACAAGGGTCCGAGGCTTCCAACCTTACTGATGGCAATAGGAAAACAGA
GTACACGAGCACTGCTTTGCAGCTGTGAGACATGCTAG

Upstream 100 bases:

>100_bases
TTTGAGATTCATTGTAAGCTAAGTCTAGTTACGAAGGCTAAATTTAGCCCTATTCCAACTTGAGAGCATACAGTTTGTTT
TTATTTTTTAGAGTAAACGC

Downstream 100 bases:

>100_bases
CATTTTTGAGTCATTCGGTCGGACGTCGTAGGACCTGGCCGAATGTCTTTGGCGAGTTACCCAAGTGGCCAAAGGGATCT
GACTGTAAATCAGCTGTCAT

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MTASRIDAASPEKYGKQDWVSKLAEQVIQERKGDKKIVVASGISPSGQIHLGNLREVITGHFIADEISSRGFDCEHILSW
DDFDRLRKVPANIDKGYEQYIGMPLCDVPPPAGSKKNSWSEHFRGDFEKTMEILGIKVRHISQSQMYRSGAYTHNILLAL
EKRHEIQNIIGKYQSKKTQPAESPREYYPYVVYCTRCKKDLTQIEDFAGSELSYSCKCGHSETIGIGEFNNGKLPWKVDW
PMRWMYESVDFEPGGVDHCSPGSASLSASSDIANQIFNWTPPLTVMYSFVGVQGHAKMSSSTGNVLTPNDALSVMEPTLL
RWMYARRKPNQSFTVGFDQSLQRLYDEWDSLPNDLTGCELASSYTRAMSTTNKRFNAPEILISFRTLVSLIDISASDDSQ
LLRMVKNLRPDIRSLAQLEPRLSCARIYSKKFSNPIHVLQTPNKQVLHTAAPNVREMLRIFIDGLDKNWSIEKLTTLAYG
VPKVVLGIDQSSKDVSQEVKNLQKEFFRTIYQLVIGQDKGPRLPTLLMAIGKQSTRALLCSCETC

Sequences:

>Translated_545_residues
MTASRIDAASPEKYGKQDWVSKLAEQVIQERKGDKKIVVASGISPSGQIHLGNLREVITGHFIADEISSRGFDCEHILSW
DDFDRLRKVPANIDKGYEQYIGMPLCDVPPPAGSKKNSWSEHFRGDFEKTMEILGIKVRHISQSQMYRSGAYTHNILLAL
EKRHEIQNIIGKYQSKKTQPAESPREYYPYVVYCTRCKKDLTQIEDFAGSELSYSCKCGHSETIGIGEFNNGKLPWKVDW
PMRWMYESVDFEPGGVDHCSPGSASLSASSDIANQIFNWTPPLTVMYSFVGVQGHAKMSSSTGNVLTPNDALSVMEPTLL
RWMYARRKPNQSFTVGFDQSLQRLYDEWDSLPNDLTGCELASSYTRAMSTTNKRFNAPEILISFRTLVSLIDISASDDSQ
LLRMVKNLRPDIRSLAQLEPRLSCARIYSKKFSNPIHVLQTPNKQVLHTAAPNVREMLRIFIDGLDKNWSIEKLTTLAYG
VPKVVLGIDQSSKDVSQEVKNLQKEFFRTIYQLVIGQDKGPRLPTLLMAIGKQSTRALLCSCETC
>Mature_544_residues
TASRIDAASPEKYGKQDWVSKLAEQVIQERKGDKKIVVASGISPSGQIHLGNLREVITGHFIADEISSRGFDCEHILSWD
DFDRLRKVPANIDKGYEQYIGMPLCDVPPPAGSKKNSWSEHFRGDFEKTMEILGIKVRHISQSQMYRSGAYTHNILLALE
KRHEIQNIIGKYQSKKTQPAESPREYYPYVVYCTRCKKDLTQIEDFAGSELSYSCKCGHSETIGIGEFNNGKLPWKVDWP
MRWMYESVDFEPGGVDHCSPGSASLSASSDIANQIFNWTPPLTVMYSFVGVQGHAKMSSSTGNVLTPNDALSVMEPTLLR
WMYARRKPNQSFTVGFDQSLQRLYDEWDSLPNDLTGCELASSYTRAMSTTNKRFNAPEILISFRTLVSLIDISASDDSQL
LRMVKNLRPDIRSLAQLEPRLSCARIYSKKFSNPIHVLQTPNKQVLHTAAPNVREMLRIFIDGLDKNWSIEKLTTLAYGV
PKVVLGIDQSSKDVSQEVKNLQKEFFRTIYQLVIGQDKGPRLPTLLMAIGKQSTRALLCSCETC

Specific function: Unknown

COG id: COG1384

COG function: function code J; Lysyl-tRNA synthetase (class I)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008925
- InterPro:   IPR020751
- InterPro:   IPR001412
- InterPro:   IPR002904
- InterPro:   IPR020754
- InterPro:   IPR020756
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01921 tRNA-synt_1f [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 61491; Mature: 61360

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASRIDAASPEKYGKQDWVSKLAEQVIQERKGDKKIVVASGISPSGQIHLGNLREVITG
CCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEECHHHHHHHH
HFIADEISSRGFDCEHILSWDDFDRLRKVPANIDKGYEQYIGMPLCDVPPPAGSKKNSWS
HHHHHHHHCCCCCHHHHCCCCCHHHHHHCCCCHHCCHHHHCCCCCCCCCCCCCCCCCCCH
EHFRGDFEKTMEILGIKVRHISQSQMYRSGAYTHNILLALEKRHEIQNIIGKYQSKKTQP
HHHCCCHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AESPREYYPYVVYCTRCKKDLTQIEDFAGSELSYSCKCGHSETIGIGEFNNGKLPWKVDW
CCCCHHHCCEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCCCCCEEECC
PMRWMYESVDFEPGGVDHCSPGSASLSASSDIANQIFNWTPPLTVMYSFVGVQGHAKMSS
CHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCC
STGNVLTPNDALSVMEPTLLRWMYARRKPNQSFTVGFDQSLQRLYDEWDSLPNDLTGCEL
CCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHCCCCCCCHHHH
ASSYTRAMSTTNKRFNAPEILISFRTLVSLIDISASDDSQLLRMVKNLRPDIRSLAQLEP
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHCH
RLSCARIYSKKFSNPIHVLQTPNKQVLHTAAPNVREMLRIFIDGLDKNWSIEKLTTLAYG
HHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHC
VPKVVLGIDQSSKDVSQEVKNLQKEFFRTIYQLVIGQDKGPRLPTLLMAIGKQSTRALLC
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEE
SCETC
ECCCC
>Mature Secondary Structure 
TASRIDAASPEKYGKQDWVSKLAEQVIQERKGDKKIVVASGISPSGQIHLGNLREVITG
CCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEECHHHHHHHH
HFIADEISSRGFDCEHILSWDDFDRLRKVPANIDKGYEQYIGMPLCDVPPPAGSKKNSWS
HHHHHHHHCCCCCHHHHCCCCCHHHHHHCCCCHHCCHHHHCCCCCCCCCCCCCCCCCCCH
EHFRGDFEKTMEILGIKVRHISQSQMYRSGAYTHNILLALEKRHEIQNIIGKYQSKKTQP
HHHCCCHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AESPREYYPYVVYCTRCKKDLTQIEDFAGSELSYSCKCGHSETIGIGEFNNGKLPWKVDW
CCCCHHHCCEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCCCCCEEECC
PMRWMYESVDFEPGGVDHCSPGSASLSASSDIANQIFNWTPPLTVMYSFVGVQGHAKMSS
CHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCC
STGNVLTPNDALSVMEPTLLRWMYARRKPNQSFTVGFDQSLQRLYDEWDSLPNDLTGCEL
CCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHCCCCCCCHHHH
ASSYTRAMSTTNKRFNAPEILISFRTLVSLIDISASDDSQLLRMVKNLRPDIRSLAQLEP
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHCH
RLSCARIYSKKFSNPIHVLQTPNKQVLHTAAPNVREMLRIFIDGLDKNWSIEKLTTLAYG
HHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHC
VPKVVLGIDQSSKDVSQEVKNLQKEFFRTIYQLVIGQDKGPRLPTLLMAIGKQSTRALLC
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEE
SCETC
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]