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The map label for this gene is fepD [H]

Identifier: 28572240

GI number: 28572240

Start: 60943

End: 61908

Strand: Reverse

Name: fepD [H]

Synonym: TW070

Alternate gene names: 28572240

Gene position: 61908-60943 (Counterclockwise)

Preceding gene: 28572242

Following gene: 28572239

Centisome position: 6.69

GC content: 47.62

Gene sequence:

>966_bases
GTGGCAGGGCCAGTTTTTCGTTTGAGTTTAGTATTCGGCAGCGTCGTTATTGTCGGGCTTTGTTATTTGGCCCTTTTTCT
CGATGGCTCAAGCGTCGGTCAATTGATTGACGCGGTGTTCGGGGGTGGAGACGACTTCAAAGATGTAGTCCTGCGAGATT
TTAGAGTTCCTCGTATCTTGCTGGCAATTCTTGTTGGGGCAGCACTCTCAGTTGCTGGCGCAATTATGCAAGTGGTTACC
CGGAATCCATTGGCCGATCCGGGGCTGCTTGGAATAACTCATGGGGCATATCTTGCGATTGTCCTTGGGTTTTTGGTTGG
CTATGTAACGCCTTTCTGGAATTTGCTGATCGTTCCTCTGTTGGGTGCCTCAATTGCTGCTGGGCTTGTTTATTTTATTG
GGAATATTGTCACTCCGGGGCAATTGATCTTGGTCGGAGTTGCATTAACCGCGCTGATTAGCGGACTGGCACGTTCGGTG
GCGTTAATAAATCAGGATATTTTTGACGTGATCCGCCACTGGGCAGTTGGGTCACTCGATTACAAAAAAATCGACACGGT
GTACATATCATTTCCTCTCATCCTGGCCGGAATACTAATCGCACTTATGATGATGAGCTCACTGAATGTTTTGTCAATTG
ATAAAGACATATCAAAATCGCTTGGCGTTGGAAAAACTGCACTGTGGTCATATATTGCAGTTATAGCGCTTAGCGCAGGA
TCTACCGCGGCAGTCGGTCCGATTAGTTTCTTGGCGCTTGCAGCGGCACATATCTCCCGGGTTATATCAGGACCCAATTT
GCTCAGAATTATTCCTCTTTGTTTGATAACTGGCCCGATTGTGTTACTGACTGCAGACACGCTTGGTCGGGTTCTAACAC
CAACCGGACTAGACGCTGGAGTGGTTGTGCCTTTCTTGGGTGCGCCCATTCTGATTTTCCTGTCAAGAAAGGTAAAAGTC
TTTTGA

Upstream 100 bases:

>100_bases
ATGGGGTGAGACTGCCAAATGACATCTGGCAGTCCATAGCTGCAAGAAAGATTAAAACTCACCCTTTACTTCGTATTACA
CATCAGATAGCCTGAAATGT

Downstream 100 bases:

>100_bases
GGATCATGCCACAGCGGGTGGCGCTGAGAACGTATTGGACAAGTTGCAATCTCGACACTCGTGCTTTGGTGGTCGGGTCT
GTTTTTGCATCTCTATGCGT

Product: iron-siderophore uptake system integral membrane component

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MAGPVFRLSLVFGSVVIVGLCYLALFLDGSSVGQLIDAVFGGGDDFKDVVLRDFRVPRILLAILVGAALSVAGAIMQVVT
RNPLADPGLLGITHGAYLAIVLGFLVGYVTPFWNLLIVPLLGASIAAGLVYFIGNIVTPGQLILVGVALTALISGLARSV
ALINQDIFDVIRHWAVGSLDYKKIDTVYISFPLILAGILIALMMMSSLNVLSIDKDISKSLGVGKTALWSYIAVIALSAG
STAAVGPISFLALAAAHISRVISGPNLLRIIPLCLITGPIVLLTADTLGRVLTPTGLDAGVVVPFLGAPILIFLSRKVKV
F

Sequences:

>Translated_321_residues
MAGPVFRLSLVFGSVVIVGLCYLALFLDGSSVGQLIDAVFGGGDDFKDVVLRDFRVPRILLAILVGAALSVAGAIMQVVT
RNPLADPGLLGITHGAYLAIVLGFLVGYVTPFWNLLIVPLLGASIAAGLVYFIGNIVTPGQLILVGVALTALISGLARSV
ALINQDIFDVIRHWAVGSLDYKKIDTVYISFPLILAGILIALMMMSSLNVLSIDKDISKSLGVGKTALWSYIAVIALSAG
STAAVGPISFLALAAAHISRVISGPNLLRIIPLCLITGPIVLLTADTLGRVLTPTGLDAGVVVPFLGAPILIFLSRKVKV
F
>Mature_320_residues
AGPVFRLSLVFGSVVIVGLCYLALFLDGSSVGQLIDAVFGGGDDFKDVVLRDFRVPRILLAILVGAALSVAGAIMQVVTR
NPLADPGLLGITHGAYLAIVLGFLVGYVTPFWNLLIVPLLGASIAAGLVYFIGNIVTPGQLILVGVALTALISGLARSVA
LINQDIFDVIRHWAVGSLDYKKIDTVYISFPLILAGILIALMMMSSLNVLSIDKDISKSLGVGKTALWSYIAVIALSAGS
TAAVGPISFLALAAAHISRVISGPNLLRIIPLCLITGPIVLLTADTLGRVLTPTGLDAGVVVPFLGAPILIFLSRKVKVF

Specific function: Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786805, Length=291, Percent_Identity=40.5498281786942, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1790740, Length=277, Percent_Identity=35.0180505415162, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790741, Length=306, Percent_Identity=29.7385620915033, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786347, Length=279, Percent_Identity=31.5412186379928, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786804, Length=297, Percent_Identity=27.9461279461279, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788004, Length=288, Percent_Identity=30.5555555555556, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 33466; Mature: 33335

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AGPVFRLSLVFGSVVIVGLCYLALFLDGSSVGQLIDAVFGGGDDFKDVVLRDFRVPRIL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCHHHHH
LAILVGAALSVAGAIMQVVTRNPLADPGLLGITHGAYLAIVLGFLVGYVTPFWNLLIVPL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGASIAAGLVYFIGNIVTPGQLILVGVALTALISGLARSVALINQDIFDVIRHWAVGSLD
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YKKIDTVYISFPLILAGILIALMMMSSLNVLSIDKDISKSLGVGKTALWSYIAVIALSAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHCCCCHHHHHHHHHHHHHCCC
STAAVGPISFLALAAAHISRVISGPNLLRIIPLCLITGPIVLLTADTLGRVLTPTGLDAG
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHEEEHHHHHHHCCCCCCCCC
VVVPFLGAPILIFLSRKVKVF
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1838574; 1787794; 9278503 [H]