Click here to switch to the map view.

The map label for this gene is moaA

Identifier: 326424128

GI number: 326424128

Start: 3154954

End: 3155958

Strand: Reverse

Name: moaA

Synonym: NA

Alternate gene names: 326424128

Gene position: 3155958-3154954 (Counterclockwise)

Preceding gene: 27366358

Following gene: 27366355

Centisome position: 96.16

GC content: 45.57

Gene sequence:

>1005_bases
TTGGAAAGGTGTTCCGTGGCGCAACAATTCGAAGATAGATTCCACCGCAAATTCTATTACTTGCGTTTGTCTGTGACGGA
CGTGTGTAATTTCAAATGTACCTATTGTCTGCCTGATGGTTACCAACCTTCGGGGCAGAAAAACTCGTCTTTTTTAAACC
TCTCTGAAATCCGTCGAGTCGTTAAGGCTTTTGCTGACTGTGGCACAAGTAAAGTGCGCATTACTGGCGGAGAGCCAAGT
CTGCGTAAAGATTTTACTGACATTATCCACACGGTCGCATCAACTCAAGGCATTAAGCGAGTTGCCACTACCACCAATGG
CTATCGAATGGAAAAGCATATTGGAGAATGGAAAGAAGCAGGTTTAAACCAAATTAATGTCAGCGTGGATAGCCTTGACC
CACGTATGTTCCATCAAATCACTGGCGAGAATAAATTTCACCAAGTGATGTCGGGGATTGATCGCGCGTTTGAAGTGGGT
TTTGAACAAGTGAAAGTCAACGTTGTGTTGATGAAAGATCTCAACCACAACGAGTTACCTGCTTTTTTGCACTGGATTAA
GCATCGCCCGATCCAATTGCGTTTTATCGAACTGATGCAAACGGGTGAGATGGACACTTTATTCCAACAACATCATGTCT
CCGGTGTGGCGATTCGCAATCATCTGATCGCAAATGGCTGGTTACTGAAAGTGAAGGCGGCTAATGATGGCCCTGCGCAA
GTGTTCGTTCACCCTGATTATCAAGGTGAGATTGGTTTGATCATGCCTTACGAAAAAGACTTTTGTGCGAGCTGTAACCG
CTTACGAGTTTCTGCAAAAGGCAAATTGCATTTGTGTCTATTTGGTGATCGAGGCGTCGAGCTGCGCGACCTGCTGCAAC
AAGACGATCAAGAGTCTGATCTCATTGCCCGAATTCAGTCGGAGTTACAGACTAAATCTGTCAGCCATTTCTTAAACGAA
GGTCAGACGGGCATGACGCCGCACTTAGCATCTATTGGCGGCTAA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:
NA

Sequences:

>Translated_334_residues
MERCSVAQQFEDRFHRKFYYLRLSVTDVCNFKCTYCLPDGYQPSGQKNSSFLNLSEIRRVVKAFADCGTSKVRITGGEPS
LRKDFTDIIHTVASTQGIKRVATTTNGYRMEKHIGEWKEAGLNQINVSVDSLDPRMFHQITGENKFHQVMSGIDRAFEVG
FEQVKVNVVLMKDLNHNELPAFLHWIKHRPIQLRFIELMQTGEMDTLFQQHHVSGVAIRNHLIANGWLLKVKAANDGPAQ
VFVHPDYQGEIGLIMPYEKDFCASCNRLRVSAKGKLHLCLFGDRGVELRDLLQQDDQESDLIARIQSELQTKSVSHFLNE
GQTGMTPHLASIGG
>Mature_334_residues
MERCSVAQQFEDRFHRKFYYLRLSVTDVCNFKCTYCLPDGYQPSGQKNSSFLNLSEIRRVVKAFADCGTSKVRITGGEPS
LRKDFTDIIHTVASTQGIKRVATTTNGYRMEKHIGEWKEAGLNQINVSVDSLDPRMFHQITGENKFHQVMSGIDRAFEVG
FEQVKVNVVLMKDLNHNELPAFLHWIKHRPIQLRFIELMQTGEMDTLFQQHHVSGVAIRNHLIANGWLLKVKAANDGPAQ
VFVHPDYQGEIGLIMPYEKDFCASCNRLRVSAKGKLHLCLFGDRGVELRDLLQQDDQESDLIARIQSELQTKSVSHFLNE
GQTGMTPHLASIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family

Homologues:

Organism=Homo sapiens, GI116734668, Length=309, Percent_Identity=36.2459546925566, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI22027536, Length=309, Percent_Identity=36.2459546925566, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1786999, Length=329, Percent_Identity=64.1337386018237, Blast_Score=466, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI32566331, Length=334, Percent_Identity=36.2275449101796, Blast_Score=208, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI32566329, Length=310, Percent_Identity=37.741935483871, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17561210, Length=319, Percent_Identity=37.3040752351097, Blast_Score=207, Evalue=5e-54,
Organism=Drosophila melanogaster, GI28574488, Length=332, Percent_Identity=33.7349397590361, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI28574490, Length=314, Percent_Identity=33.4394904458599, Blast_Score=194, Evalue=9e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAA_VIBVU (Q8D894)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_761884.1
- ProteinModelPortal:   Q8D894
- SMR:   Q8D894
- GeneID:   1179918
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_3088
- HOGENOM:   HBG529885
- OMA:   KIATRAK
- ProtClustDB:   PRK00164
- BioCyc:   VVUL216895:VV1_3088-MONOMER
- HAMAP:   MF_01225_B
- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR010505
- InterPro:   IPR007197
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00729
- TIGRFAMs:   TIGR02666

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM

EC number: NA

Molecular weight: Translated: 37922; Mature: 37922

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: BINDING 22-22 BINDING 35-35 BINDING 73-73 BINDING 77-77 BINDING 104-104 BINDING 128-128 BINDING 165-165 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERCSVAQQFEDRFHRKFYYLRLSVTDVCNFKCTYCLPDGYQPSGQKNSSFLNLSEIRRV
CCCCHHHHHHHHHHHHEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCEECHHHHHHH
VKAFADCGTSKVRITGGEPSLRKDFTDIIHTVASTQGIKRVATTTNGYRMEKHIGEWKEA
HHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEHHHHHHHHHHC
GLNQINVSVDSLDPRMFHQITGENKFHQVMSGIDRAFEVGFEQVKVNVVLMKDLNHNELP
CCCEEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHEEEEEEEEECCCCCCHH
AFLHWIKHRPIQLRFIELMQTGEMDTLFQQHHVSGVAIRNHLIANGWLLKVKAANDGPAQ
HHHHHHHCCCEEEEEEHHHHCCCHHHHHHHHCCCCCHHHHEEEECCEEEEEEECCCCCEE
VFVHPDYQGEIGLIMPYEKDFCASCNRLRVSAKGKLHLCLFGDRGVELRDLLQQDDQESD
EEECCCCCCCEEEEECCCCHHHCCCCEEEEECCCCEEEEEECCCCCHHHHHHHCCCCHHH
LIARIQSELQTKSVSHFLNEGQTGMTPHLASIGG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCC
>Mature Secondary Structure
MERCSVAQQFEDRFHRKFYYLRLSVTDVCNFKCTYCLPDGYQPSGQKNSSFLNLSEIRRV
CCCCHHHHHHHHHHHHEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCEECHHHHHHH
VKAFADCGTSKVRITGGEPSLRKDFTDIIHTVASTQGIKRVATTTNGYRMEKHIGEWKEA
HHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEHHHHHHHHHHC
GLNQINVSVDSLDPRMFHQITGENKFHQVMSGIDRAFEVGFEQVKVNVVLMKDLNHNELP
CCCEEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHEEEEEEEEECCCCCCHH
AFLHWIKHRPIQLRFIELMQTGEMDTLFQQHHVSGVAIRNHLIANGWLLKVKAANDGPAQ
HHHHHHHCCCEEEEEEHHHHCCCHHHHHHHHCCCCCHHHHEEEECCEEEEEEECCCCCEE
VFVHPDYQGEIGLIMPYEKDFCASCNRLRVSAKGKLHLCLFGDRGVELRDLLQQDDQESD
EEECCCCCCCEEEEECCCCHHHCCCCEEEEECCCCEEEEEECCCCCHHHHHHHCCCCHHH
LIARIQSELQTKSVSHFLNEGQTGMTPHLASIGG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA