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The map label for this gene is norM [H]

Identifier: 326424040

GI number: 326424040

Start: 2596582

End: 2598033

Strand: Reverse

Name: norM [H]

Synonym: NA

Alternate gene names: 326424040

Gene position: 2598033-2596582 (Counterclockwise)

Preceding gene: 27365857

Following gene: 27365852

Centisome position: 79.16

GC content: 45.73

Gene sequence:

>1452_bases
GTGGTCTTTGCCGATCGAAAACGTCCCAACGTGCCTCGCACGCTTAGCATATTTATCTTTTTCTTAAACATTGGAGTTAA
CGTGCATCGCTATAAAAAAGAAGCTTCTAATTTGATTAAGCTCGCCACACCAGTTTTGATTGCATCTGTTGCTCAAACCG
GTATGGGTTTTGTGGACACCGTGATGGCGGGTGGCGTCAGTGCAACGGACATGGCTGCAGTTTCTGTCGCAGCAAGTATC
TGGCTGCCTTCTATTTTGTTTGGTATTGGGCTATTGATGGCACTGGTCCCTGTTGTCGCTCAGCTCAATGGTGCAGGCAA
AAGAGAGCAAGTCCCTTTTGAAATTCAACAAGGCGCGGTTATGGCCCTATTGATCAGTATCCCGATCATTGGCGTATTGT
TTCAAACTCAGTGGATACTCGGTTACATGAATGTCGATGCGGTAATGGCGACCAAAACCATTGGTTATATACACGCTGTG
ATGTTTGCCGTACCTGCTTTTCTATTGTTTCAAACACTGCGCAGTTTGACTGATGGTTTGTCTTTAACAAAACCTGCCAT
GGTGATCGGTTTCATTGGCTTACTATTGAATATTCCACTGAACTGGATGTTCGTTTACGGTAAATTGGGTGCGCCAGCCC
TTGGTGGTGTAGGTTGTGGCGTCGCCACAGCCATAGTGTATTGGATCATGTTTTTGTTGCTACTGTTTTATGTGACAACG
TCACATAGACTAAGGCAGGTTCAATTGTTTACTACGTTTCATCCACCACAGCTAAATGCGCAAGTTAAGCTATTTAAACT
TGGCTTTCCGGTCGCTGCCGCACTTTTCTTCGAGGTGACTCTGTTTGCGGTCGTCGCTTTGTTGGTTGCGCCATTGGGTT
CTACTGTCGTTGCAGCACACCAAGTTGCCATTAACTTTTCTTCATTGGTGTTCATGTTACCTATGAGTATTGGCGCAGCA
ACCAGTATCCGTGTTGGGCATATGCTTGGTGAAAAATCGACAGAAGGCGCTCGCATTGCTTCTCATGTCGGTATCTTAGT
TGGTCTTTCAACTGCAGTGTTTACCGCTTTACTGACGGTTATTCTGAGAGAGCAAATCGCTCTCCTCTATACCGATAACC
GAGTGGTTATCACCTTAGCGATGCAGTTGTTGATCTTTACCGCTATTTATCAATGTACCGATGCGATACAAGTTATCGCC
GCTGGTGCGCTACGTGGTTATAAAGACATGCGAGCGATCTTCAACCGAACATTTATCGCCTATTGGTTACTTGGTCTACC
TACTGGTTATGTTCTTGGTCTTACCGATTGGATTGTTGAACCAATGGGGGCACAAGGCTTCTGGATAGGATTCATCGTCG
GCTTATCTTCTGCGGCCGCTATGTTGGGGGTTCGTCTACACTGGCTTCACCGCCAAAATGATGAAATCCAGTTGAATTAT
GAAGCGAGATAA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: Multidrug resistance protein NorM

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter; Na(+)/drug antiporter [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:
NA

Sequences:

>Translated_483_residues
MVFADRKRPNVPRTLSIFIFFLNIGVNVHRYKKEASNLIKLATPVLIASVAQTGMGFVDTVMAGGVSATDMAAVSVAASI
WLPSILFGIGLLMALVPVVAQLNGAGKREQVPFEIQQGAVMALLISIPIIGVLFQTQWILGYMNVDAVMATKTIGYIHAV
MFAVPAFLLFQTLRSLTDGLSLTKPAMVIGFIGLLLNIPLNWMFVYGKLGAPALGGVGCGVATAIVYWIMFLLLLFYVTT
SHRLRQVQLFTTFHPPQLNAQVKLFKLGFPVAAALFFEVTLFAVVALLVAPLGSTVVAAHQVAINFSSLVFMLPMSIGAA
TSIRVGHMLGEKSTEGARIASHVGILVGLSTAVFTALLTVILREQIALLYTDNRVVITLAMQLLIFTAIYQCTDAIQVIA
AGALRGYKDMRAIFNRTFIAYWLLGLPTGYVLGLTDWIVEPMGAQGFWIGFIVGLSSAAAMLGVRLHWLHRQNDEIQLNY
EAR
>Mature_483_residues
MVFADRKRPNVPRTLSIFIFFLNIGVNVHRYKKEASNLIKLATPVLIASVAQTGMGFVDTVMAGGVSATDMAAVSVAASI
WLPSILFGIGLLMALVPVVAQLNGAGKREQVPFEIQQGAVMALLISIPIIGVLFQTQWILGYMNVDAVMATKTIGYIHAV
MFAVPAFLLFQTLRSLTDGLSLTKPAMVIGFIGLLLNIPLNWMFVYGKLGAPALGGVGCGVATAIVYWIMFLLLLFYVTT
SHRLRQVQLFTTFHPPQLNAQVKLFKLGFPVAAALFFEVTLFAVVALLVAPLGSTVVAAHQVAINFSSLVFMLPMSIGAA
TSIRVGHMLGEKSTEGARIASHVGILVGLSTAVFTALLTVILREQIALLYTDNRVVITLAMQLLIFTAIYQCTDAIQVIA
AGALRGYKDMRAIFNRTFIAYWLLGLPTGYVLGLTDWIVEPMGAQGFWIGFIVGLSSAAAMLGVRLHWLHRQNDEIQLNY
EAR

Specific function: Multidrug efflux pump that functions as a Na(+)/drug antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=446, Percent_Identity=26.2331838565022, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI153792564, Length=444, Percent_Identity=24.5495495495495, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI38261960, Length=480, Percent_Identity=23.5416666666667, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI48994890, Length=457, Percent_Identity=54.7045951859956, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI226510954, Length=465, Percent_Identity=23.010752688172, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321821, Length=382, Percent_Identity=24.3455497382199, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320545, Length=423, Percent_Identity=23.8770685579196, Blast_Score=102, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 52364; Mature: 52364

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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ECC
>Mature Secondary Structure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ECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA