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The map label for this gene is mutY [H]

Identifier: 326423848

GI number: 326423848

Start: 1490345

End: 1491397

Strand: Reverse

Name: mutY [H]

Synonym: NA

Alternate gene names: 326423848

Gene position: 1491397-1490345 (Counterclockwise)

Preceding gene: 27364890

Following gene: 27364885

Centisome position: 45.44

GC content: 49.1

Gene sequence:

>1053_bases
GTGACACCTTTTGCCAGCGCCATTTTGAAATGGTATGACGCCTACGGAAGAAAAAACCTTCCTTGGCAACACAATAAGAG
CGCCTACAGCGTTTGGTTATCGGAAATTATGCTGCAACAAACGCAAGTTGCGACCGTAATTCCCTATTACCAACGTTTTT
TACAGCGCTTTCCGACCGTAGTTGATCTCGCCAACGCCGAGCAAGATGAAGTGCTTCATCTATGGACGGGGTTAGGCTAC
TACGCTCGCGCACGCAATCTGCACAAAGCCGCGAAAATGGTGGCTGAGCAATATCATGGTGAATTTCCATTGGAACTGGA
GCAGATGAATGCTCTGCCGGGGATTGGCCGCTCTACCGCCGCTGCCGTGCTCTCTTCCGTTCACAAACAGCCACATGCCA
TTCTTGATGGCAATGTGAAACGCACCTTATCTCGCGCCTTTGCCGTTGAAGGTTGGCCTGGGCAAAAAACGGTCGAAAAC
CAATTGTGGCAATTAGCGGAAGCACACACACCCAACACCGATGTCGATAAATACAACCAAGCGATGATGGATATGGGGGC
AATGGTCTGCACACGCAGCAAACCCAAATGCACATTGTGCCCGGTAGCCGAGCTATGCCAAGCCAACAAACAAGGTAACC
CACTGGACTATCCCGGCAAAAAGCCTAAAAAAGAGAAACCCGTCAAAGAGACATGGTTTGCCATGTTGCACTACAACAAT
CAAGTGTGGTTGGAACAAAGGCCACAAAGTGGCATTTGGGGCGGATTGTTTTGCTTTCCGCAAAATGAGCATGCACAACT
TGAAGCACTGCTCGAGAAGCGAGGCATAAAAGAGGGTGACATTCGCACACAAAACACCTTAATTGCTTTTCGCCATACTT
TTAGCCATTACCATCTCGACATCACTCCGATTTTGCTGGACCTATCAAAGCAACCTGACATGGTGATGGAAGCCAGCAAT
GGTCTTTGGTATAACTTAGCCAATCCCGGAGAAGTTGGGTTAGCGGCTCCCGTCAAACAGTTGCTGGAGAGCTTGCCCCA
TGAACTTCGTTAA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:
NA

Sequences:

>Translated_350_residues
MTPFASAILKWYDAYGRKNLPWQHNKSAYSVWLSEIMLQQTQVATVIPYYQRFLQRFPTVVDLANAEQDEVLHLWTGLGY
YARARNLHKAAKMVAEQYHGEFPLELEQMNALPGIGRSTAAAVLSSVHKQPHAILDGNVKRTLSRAFAVEGWPGQKTVEN
QLWQLAEAHTPNTDVDKYNQAMMDMGAMVCTRSKPKCTLCPVAELCQANKQGNPLDYPGKKPKKEKPVKETWFAMLHYNN
QVWLEQRPQSGIWGGLFCFPQNEHAQLEALLEKRGIKEGDIRTQNTLIAFRHTFSHYHLDITPILLDLSKQPDMVMEASN
GLWYNLANPGEVGLAAPVKQLLESLPHELR
>Mature_349_residues
TPFASAILKWYDAYGRKNLPWQHNKSAYSVWLSEIMLQQTQVATVIPYYQRFLQRFPTVVDLANAEQDEVLHLWTGLGYY
ARARNLHKAAKMVAEQYHGEFPLELEQMNALPGIGRSTAAAVLSSVHKQPHAILDGNVKRTLSRAFAVEGWPGQKTVENQ
LWQLAEAHTPNTDVDKYNQAMMDMGAMVCTRSKPKCTLCPVAELCQANKQGNPLDYPGKKPKKEKPVKETWFAMLHYNNQ
VWLEQRPQSGIWGGLFCFPQNEHAQLEALLEKRGIKEGDIRTQNTLIAFRHTFSHYHLDITPILLDLSKQPDMVMEASNG
LWYNLANPGEVGLAAPVKQLLESLPHELR

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=386, Percent_Identity=33.419689119171, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI6912520, Length=384, Percent_Identity=33.59375, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI115298648, Length=384, Percent_Identity=33.59375, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI115298654, Length=384, Percent_Identity=33.59375, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI115298652, Length=384, Percent_Identity=33.59375, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI115298650, Length=384, Percent_Identity=33.59375, Blast_Score=196, Evalue=2e-50,
Organism=Escherichia coli, GI1789331, Length=343, Percent_Identity=58.0174927113703, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1787920, Length=131, Percent_Identity=31.2977099236641, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39774; Mature: 39643

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPFASAILKWYDAYGRKNLPWQHNKSAYSVWLSEIMLQQTQVATVIPYYQRFLQRFPTV
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VDLANAEQDEVLHLWTGLGYYARARNLHKAAKMVAEQYHGEFPLELEQMNALPGIGRSTA
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHH
AAVLSSVHKQPHAILDGNVKRTLSRAFAVEGWPGQKTVENQLWQLAEAHTPNTDVDKYNQ
HHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHH
AMMDMGAMVCTRSKPKCTLCPVAELCQANKQGNPLDYPGKKPKKEKPVKETWFAMLHYNN
HHHHHHHHHHCCCCCCEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
QVWLEQRPQSGIWGGLFCFPQNEHAQLEALLEKRGIKEGDIRTQNTLIAFRHTFSHYHLD
EEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHEEEEEEHHHHEEEE
ITPILLDLSKQPDMVMEASNGLWYNLANPGEVGLAAPVKQLLESLPHELR
EHHHEEECCCCCCEEEECCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TPFASAILKWYDAYGRKNLPWQHNKSAYSVWLSEIMLQQTQVATVIPYYQRFLQRFPTV
CHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VDLANAEQDEVLHLWTGLGYYARARNLHKAAKMVAEQYHGEFPLELEQMNALPGIGRSTA
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHH
AAVLSSVHKQPHAILDGNVKRTLSRAFAVEGWPGQKTVENQLWQLAEAHTPNTDVDKYNQ
HHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHH
AMMDMGAMVCTRSKPKCTLCPVAELCQANKQGNPLDYPGKKPKKEKPVKETWFAMLHYNN
HHHHHHHHHHCCCCCCEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
QVWLEQRPQSGIWGGLFCFPQNEHAQLEALLEKRGIKEGDIRTQNTLIAFRHTFSHYHLD
EEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHEEEEEEHHHHEEEE
ITPILLDLSKQPDMVMEASNGLWYNLANPGEVGLAAPVKQLLESLPHELR
EHHHEEECCCCCCEEEECCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]