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The map label for this gene is gmr [H]

Identifier: 27366411

GI number: 27366411

Start: 3219990

End: 3221963

Strand: Reverse

Name: gmr [H]

Synonym: VV1_3146

Alternate gene names: 27366411

Gene position: 3221963-3219990 (Counterclockwise)

Preceding gene: 326424141

Following gene: 27366409

Centisome position: 98.17

GC content: 45.59

Gene sequence:

>1974_bases
ATGATAAAAAAATTTGGTTGGCTGCTTTCCTGCGTATTCGTTTGGGTATCGTTCAACTGTTGGGCAAAGAGTAAAGAGAT
CACAGTAGCAACGGAAGCGGATGATGTGGTGACGCGGGTTCTGTTTGATGCCATTGCCGAGCAGTTTGCGCTGGACGTCA
CCTATGTGAATATGCCGAGTTTTGATGCTATTCTCGATTCAGTTGCGCGTGGTGAAACAGACTTCGCAGCGAACATTACG
TTTACGCATGAACGTGAAAAAAGATTCAGTTATTCACACCCAACCAACATTGAATATACCTATCTCTATTCTAATACGAC
CAATTCGTTGCGTGATGCGACACGTATTGGCGTACCTCAAGATACCATTTATGGGGAGCTGATTGCGGTAAATCATCCAG
ACATTCAGCTTGTTTCGTACCAAGGCCATGAAGAAGCTTATGCGCTGATCAGTCACGGTCAAGTCGATGGCATTGTGGAT
GCCATCAATCAACTTAAGCCTATGTTGCTTAAAGGAACCAATGCCCATCTTCTCAACGATGAAATATCGATAAAACCCGT
CTCTATCGTCAGTCAAAAAGGGCAACACTTAGAAGAGTTGACTCAATTTGCTCAGTTCATTCACAGCGAGCAGATGCAAA
AAAGGCTTCGTGAAGAAATTACGCAATACCAATTTGCTATTCGAAAACAGGCGCTACAACAGGCTATTGTTCAGGCACCC
CTCGAGCTAGATGAACCATTAACCATCAAACTTGAGCCGATTTACCCTTATGTGATTTACCATCCTGATGGCCACGTGAG
TGGGATTACTGCCGAAGTTCTGCAGCAAAGTTGCGATATTCTTGCCCTTAACTGTCAACTGGTGAGCCGTTCAGATGAAC
GTTGGGGAGAAATGTTACAAGGCTTCATACAGCAAGAGTTTGACCTACTGGCTCCGCTGGCGATGACCAAAGCGAGAGAG
CAGTTTACCTATTACACAAGCCCACACTATGCGCCTCAGTCGGTTATCGTCAAACGTTTGGGGTATAAGCCCAATGTCTA
TTCTCATGTCTCCCAGTTAATTGCAGAGAGAGTCGGGGTGGTTGAGGATGACTACTTTGATGCGTTGTTGACGCAAATGT
TGCCATTGAAAGATCTGAGTCGTTTTTCCGATCACGATGCGATGGTCAGTGCCTTACTTGCCAACCGAGTGGATTACATC
ACGATGGACACGGCAACACTCAACTACTTACTACGAAATGAGTTGAAGCTGGCTATTGAGCAAGATGATGCGATTGGCGT
ATTTGATACGTCGAAAATTTCTATCGGTTTGGCTAACACGGAAAAGGGCAGAGCGCTGGCTCCGTATTTTAGTCGGGCGA
TAGAAATGCTCGATCTCAATAGCATTATCGAACGTTACGATGTTCGTCCTGACTGGCGAAGCTCGTTAGAAATGGAGCAA
AAGTTTGCTGCAAAAACACAAACGCTATTTGCGGCGATGTTATTGCTGGCGTTTGCACTCTCGTATTATCTGCATCGTTT
ATCGAATACGGATAACTTAACTGGGTTAGGCAATCGACGCCAACTACAGAGAAAATATGGCAATGGCATCGCGGGCGACC
TTGCGATTTTGTATATCGACGTTAACAATTTTAAACCGATTAACGACACATATGGTCATCACTGTGGCGACATGGTGCTC
AAAGCCATAGCCCTAGAAATCAAAAGCCATTGGCGTGGCAAAGGTTTCCGCGTGGGCGGCGATGAGTTTATTTTAATTGG
CAAAGCGTCTCAGCAAGAAGTTGAAGAAGCGTTTGATCGTTTTAGCCGAATTCGACTTGAACAGCATATTGCCGGAAAAC
CCTTGATCATCAGTTCTTCGATTGGCTTGTCCGCGAGGAGGGAGCGGGCCATGAGCTTGCAAAAAGCGCTGCATCTGGCT
GATGTCGACATGTATCAGAGCAAGAATGAACAGCGTGAGATGGGGTATTCTTAA

Upstream 100 bases:

>100_bases
TGCATATCAATAAAAATATTTATGCACGTGACAATGAGTTGATATAAGGTTTCTGCTTCATATTTTGACGCTTGTGTGAA
ACCTAGATTAAGTCAGTGAC

Downstream 100 bases:

>100_bases
CCTCCCTCACTTGAAAAGTGGTGTTTTGCACAAGAGTTAAGCATTCGCTCGCCTCATCATGGATTATTGCCGAATTGGGG
TTGCAATCTTGAGGGGGATG

Product: GGDEF domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MIKKFGWLLSCVFVWVSFNCWAKSKEITVATEADDVVTRVLFDAIAEQFALDVTYVNMPSFDAILDSVARGETDFAANIT
FTHEREKRFSYSHPTNIEYTYLYSNTTNSLRDATRIGVPQDTIYGELIAVNHPDIQLVSYQGHEEAYALISHGQVDGIVD
AINQLKPMLLKGTNAHLLNDEISIKPVSIVSQKGQHLEELTQFAQFIHSEQMQKRLREEITQYQFAIRKQALQQAIVQAP
LELDEPLTIKLEPIYPYVIYHPDGHVSGITAEVLQQSCDILALNCQLVSRSDERWGEMLQGFIQQEFDLLAPLAMTKARE
QFTYYTSPHYAPQSVIVKRLGYKPNVYSHVSQLIAERVGVVEDDYFDALLTQMLPLKDLSRFSDHDAMVSALLANRVDYI
TMDTATLNYLLRNELKLAIEQDDAIGVFDTSKISIGLANTEKGRALAPYFSRAIEMLDLNSIIERYDVRPDWRSSLEMEQ
KFAAKTQTLFAAMLLLAFALSYYLHRLSNTDNLTGLGNRRQLQRKYGNGIAGDLAILYIDVNNFKPINDTYGHHCGDMVL
KAIALEIKSHWRGKGFRVGGDEFILIGKASQQEVEEAFDRFSRIRLEQHIAGKPLIISSSIGLSARRERAMSLQKALHLA
DVDMYQSKNEQREMGYS

Sequences:

>Translated_657_residues
MIKKFGWLLSCVFVWVSFNCWAKSKEITVATEADDVVTRVLFDAIAEQFALDVTYVNMPSFDAILDSVARGETDFAANIT
FTHEREKRFSYSHPTNIEYTYLYSNTTNSLRDATRIGVPQDTIYGELIAVNHPDIQLVSYQGHEEAYALISHGQVDGIVD
AINQLKPMLLKGTNAHLLNDEISIKPVSIVSQKGQHLEELTQFAQFIHSEQMQKRLREEITQYQFAIRKQALQQAIVQAP
LELDEPLTIKLEPIYPYVIYHPDGHVSGITAEVLQQSCDILALNCQLVSRSDERWGEMLQGFIQQEFDLLAPLAMTKARE
QFTYYTSPHYAPQSVIVKRLGYKPNVYSHVSQLIAERVGVVEDDYFDALLTQMLPLKDLSRFSDHDAMVSALLANRVDYI
TMDTATLNYLLRNELKLAIEQDDAIGVFDTSKISIGLANTEKGRALAPYFSRAIEMLDLNSIIERYDVRPDWRSSLEMEQ
KFAAKTQTLFAAMLLLAFALSYYLHRLSNTDNLTGLGNRRQLQRKYGNGIAGDLAILYIDVNNFKPINDTYGHHCGDMVL
KAIALEIKSHWRGKGFRVGGDEFILIGKASQQEVEEAFDRFSRIRLEQHIAGKPLIISSSIGLSARRERAMSLQKALHLA
DVDMYQSKNEQREMGYS
>Mature_657_residues
MIKKFGWLLSCVFVWVSFNCWAKSKEITVATEADDVVTRVLFDAIAEQFALDVTYVNMPSFDAILDSVARGETDFAANIT
FTHEREKRFSYSHPTNIEYTYLYSNTTNSLRDATRIGVPQDTIYGELIAVNHPDIQLVSYQGHEEAYALISHGQVDGIVD
AINQLKPMLLKGTNAHLLNDEISIKPVSIVSQKGQHLEELTQFAQFIHSEQMQKRLREEITQYQFAIRKQALQQAIVQAP
LELDEPLTIKLEPIYPYVIYHPDGHVSGITAEVLQQSCDILALNCQLVSRSDERWGEMLQGFIQQEFDLLAPLAMTKARE
QFTYYTSPHYAPQSVIVKRLGYKPNVYSHVSQLIAERVGVVEDDYFDALLTQMLPLKDLSRFSDHDAMVSALLANRVDYI
TMDTATLNYLLRNELKLAIEQDDAIGVFDTSKISIGLANTEKGRALAPYFSRAIEMLDLNSIIERYDVRPDWRSSLEMEQ
KFAAKTQTLFAAMLLLAFALSYYLHRLSNTDNLTGLGNRRQLQRKYGNGIAGDLAILYIDVNNFKPINDTYGHHCGDMVL
KAIALEIKSHWRGKGFRVGGDEFILIGKASQQEVEEAFDRFSRIRLEQHIAGKPLIISSSIGLSARRERAMSLQKALHLA
DVDMYQSKNEQREMGYS

Specific function: Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC/ymaD and adrA (yaic). Activity of this protein is antag

COG id: COG0834

COG function: function code ET; ABC-type amino acid transport/signal transduction systems, periplasmic component/domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=157, Percent_Identity=32.484076433121, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788956, Length=156, Percent_Identity=34.6153846153846, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI87081881, Length=159, Percent_Identity=35.2201257861635, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI145693134, Length=243, Percent_Identity=28.8065843621399, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87081977, Length=160, Percent_Identity=29.375, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1787816, Length=163, Percent_Identity=33.7423312883436, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI87081974, Length=194, Percent_Identity=29.3814432989691, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR000014
- InterPro:   IPR013767 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF00989 PAS [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 74584; Mature: 74584

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKFGWLLSCVFVWVSFNCWAKSKEITVATEADDVVTRVLFDAIAEQFALDVTYVNMPS
CCCHHHHHHHHHHHHHHHCCEECCCEEEEEECHHHHHHHHHHHHHHHHHEEEEEEECCCC
FDAILDSVARGETDFAANITFTHEREKRFSYSHPTNIEYTYLYSNTTNSLRDATRIGVPQ
HHHHHHHHHCCCCCEEEEEEEEECHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCC
DTIYGELIAVNHPDIQLVSYQGHEEAYALISHGQVDGIVDAINQLKPMLLKGTNAHLLND
HHHCCEEEEECCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHCHHHCCCCCCEEECC
EISIKPVSIVSQKGQHLEELTQFAQFIHSEQMQKRLREEITQYQFAIRKQALQQAIVQAP
CCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LELDEPLTIKLEPIYPYVIYHPDGHVSGITAEVLQQSCDILALNCQLVSRSDERWGEMLQ
CCCCCCCEEEEECCCCEEEECCCCCCCCCHHHHHHCCCCEEEEEEEEECCCHHHHHHHHH
GFIQQEFDLLAPLAMTKAREQFTYYTSPHYAPQSVIVKRLGYKPNVYSHVSQLIAERVGV
HHHHHHHHHHHHHHHHHHHHHCEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
VEDDYFDALLTQMLPLKDLSRFSDHDAMVSALLANRVDYITMDTATLNYLLRNELKLAIE
CCCHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHEEEE
QDDAIGVFDTSKISIGLANTEKGRALAPYFSRAIEMLDLNSIIERYDVRPDWRSSLEMEQ
CCCCEEEEECCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
KFAAKTQTLFAAMLLLAFALSYYLHRLSNTDNLTGLGNRRQLQRKYGNGIAGDLAILYID
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEE
VNNFKPINDTYGHHCGDMVLKAIALEIKSHWRGKGFRVGGDEFILIGKASQQEVEEAFDR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEECCCHHHHHHHHHH
FSRIRLEQHIAGKPLIISSSIGLSARRERAMSLQKALHLADVDMYQSKNEQREMGYS
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
>Mature Secondary Structure
MIKKFGWLLSCVFVWVSFNCWAKSKEITVATEADDVVTRVLFDAIAEQFALDVTYVNMPS
CCCHHHHHHHHHHHHHHHCCEECCCEEEEEECHHHHHHHHHHHHHHHHHEEEEEEECCCC
FDAILDSVARGETDFAANITFTHEREKRFSYSHPTNIEYTYLYSNTTNSLRDATRIGVPQ
HHHHHHHHHCCCCCEEEEEEEEECHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCC
DTIYGELIAVNHPDIQLVSYQGHEEAYALISHGQVDGIVDAINQLKPMLLKGTNAHLLND
HHHCCEEEEECCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHCHHHCCCCCCEEECC
EISIKPVSIVSQKGQHLEELTQFAQFIHSEQMQKRLREEITQYQFAIRKQALQQAIVQAP
CCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LELDEPLTIKLEPIYPYVIYHPDGHVSGITAEVLQQSCDILALNCQLVSRSDERWGEMLQ
CCCCCCCEEEEECCCCEEEECCCCCCCCCHHHHHHCCCCEEEEEEEEECCCHHHHHHHHH
GFIQQEFDLLAPLAMTKAREQFTYYTSPHYAPQSVIVKRLGYKPNVYSHVSQLIAERVGV
HHHHHHHHHHHHHHHHHHHHHCEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
VEDDYFDALLTQMLPLKDLSRFSDHDAMVSALLANRVDYITMDTATLNYLLRNELKLAIE
CCCHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHEEEE
QDDAIGVFDTSKISIGLANTEKGRALAPYFSRAIEMLDLNSIIERYDVRPDWRSSLEMEQ
CCCCEEEEECCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
KFAAKTQTLFAAMLLLAFALSYYLHRLSNTDNLTGLGNRRQLQRKYGNGIAGDLAILYID
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEE
VNNFKPINDTYGHHCGDMVLKAIALEIKSHWRGKGFRVGGDEFILIGKASQQEVEEAFDR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEECCCHHHHHHHHHH
FSRIRLEQHIAGKPLIISSSIGLSARRERAMSLQKALHLADVDMYQSKNEQREMGYS
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]