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The map label for this gene is hisD [H]

Identifier: 27366197

GI number: 27366197

Start: 2984883

End: 2986178

Strand: Reverse

Name: hisD [H]

Synonym: VV1_2919

Alternate gene names: 27366197

Gene position: 2986178-2984883 (Counterclockwise)

Preceding gene: 161501801

Following gene: 27366196

Centisome position: 90.99

GC content: 47.15

Gene sequence:

>1296_bases
ATGAGAACGGTTGTTTGGCAATCTCTTAGTGAGACGCAACAAGACGCTATTTTGGAACGTCCAGCGATAACAGAAGGTGC
GAATATTACCGCTGCAGTAGCAGAAGTGATTGCGAAAGTCAGAGCAGAAGGCGATGCGGCGCTGTTCGAACTGACGGAAA
AGTTTGATCGCGTTAAACCAGAATCGATTCGAGTGACTGAACAAGAAATCGAGGAGGCTTCTGCTCGCTTAACTGCAAAA
ATGAAGCAAGCGCTTGAGCAGGCTTACGCCAATATCGCGAAGTTCCACAATGCCCAGAAACCGACGCCAATTAAAGTCGA
AACACAACCGGGTGTGGTGTGTGAACAAGTCACTCGCCCGATACAAAAAGTGGGTTTATACATTCCTGGTGGCAGTGCAC
CGCTGCCTTCAACGGTATTGATGTTGGGTGTTCCTGCGCAAATCGCGGGTTGCCGTAAAGTGGTTTTATGTTCACCGCCA
CCGATTGCCGATGAAATTCTCTATGTGGCAAAGCTTTGTAATATAGATGAAGTTTACAATGTCGGTGGTGGGCAAGCGGT
AGCGGCGATGGCTTATGGGACAGAAAGTGTCACTAAGGTGGATAAAATATTTGGTCCTGGCAACGCGTATGTCACAGAAG
CAAAACGCCAAGTGAGCAATGATTTTCGTGGTGCCGCTATTGATATGCCCGCTGGGCCATCAGAAGTGTTGGTGATTGCT
GATGAAACTGCAGATGCCGATTTTATCGCCGCCGATTTACTTAGCCAAGCTGAGCACGGACCAGACTCTCAAGTGGTTTT
GGTGACTCCATCAGTATTGATTGCAGATCAAGTAACGGATGCTGTGCAGAAACAGTTGAAGCAATTATCGCGTGCCTCAA
TTGCTGAAAAAGCACTAGCGTCGAGCTTGATTATTATTGCTGACTCCTTGACCCAAGCGGTTTCTATTTCAAATTATTAC
GGTCCAGAGCATTTAATTGTTCAAACCAAAAATCCTCGAGAGTTGTTGCCATTGCTGGATAACGCAGGTTCCATTTTCTT
GGGTGATTGGTCGCCTGAATCGGCGGGTGATTATGCGTCAGGAACCAACCACGTATTGCCGACGTATGGGTACACCCGTA
CGTATTCAAGTTTAGGTTTGGCTGATTTTTCAAAACGTATGACGATTCAAGAACTATCGGCTGAAGGTTTAAAAACACTG
GCACCTACGGTTGTTACAATGGCAGAAGCGGAAGGGTTGGATGCGCACAAACGTGCGGTGACCATTCGTGTCGAAAAGCT
GAATGCACGTGGATAA

Upstream 100 bases:

>100_bases
GTACAGAAAACCTATTCTGGGAAACGATGGAACAGCTCAAAGAACTTGGCGCGAGCTCTATTCTTGTTCTACCAATTGAA
AAAATGATGGAGTAAGGCTC

Downstream 100 bases:

>100_bases
GGAGAGAGAGAAAATGGAAAAACTTGCTCGAAAAAGTGTACAGAAACTGACTCCTTACCTTTCGGCGCGCCGTATCGGTG
GAACCGGCGATGTTTGGTTG

Product: bifunctional histidinal dehydrogenase/ histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MRTVVWQSLSETQQDAILERPAITEGANITAAVAEVIAKVRAEGDAALFELTEKFDRVKPESIRVTEQEIEEASARLTAK
MKQALEQAYANIAKFHNAQKPTPIKVETQPGVVCEQVTRPIQKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPP
PIADEILYVAKLCNIDEVYNVGGGQAVAAMAYGTESVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DETADADFIAADLLSQAEHGPDSQVVLVTPSVLIADQVTDAVQKQLKQLSRASIAEKALASSLIIIADSLTQAVSISNYY
GPEHLIVQTKNPRELLPLLDNAGSIFLGDWSPESAGDYASGTNHVLPTYGYTRTYSSLGLADFSKRMTIQELSAEGLKTL
APTVVTMAEAEGLDAHKRAVTIRVEKLNARG

Sequences:

>Translated_431_residues
MRTVVWQSLSETQQDAILERPAITEGANITAAVAEVIAKVRAEGDAALFELTEKFDRVKPESIRVTEQEIEEASARLTAK
MKQALEQAYANIAKFHNAQKPTPIKVETQPGVVCEQVTRPIQKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPP
PIADEILYVAKLCNIDEVYNVGGGQAVAAMAYGTESVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DETADADFIAADLLSQAEHGPDSQVVLVTPSVLIADQVTDAVQKQLKQLSRASIAEKALASSLIIIADSLTQAVSISNYY
GPEHLIVQTKNPRELLPLLDNAGSIFLGDWSPESAGDYASGTNHVLPTYGYTRTYSSLGLADFSKRMTIQELSAEGLKTL
APTVVTMAEAEGLDAHKRAVTIRVEKLNARG
>Mature_431_residues
MRTVVWQSLSETQQDAILERPAITEGANITAAVAEVIAKVRAEGDAALFELTEKFDRVKPESIRVTEQEIEEASARLTAK
MKQALEQAYANIAKFHNAQKPTPIKVETQPGVVCEQVTRPIQKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPP
PIADEILYVAKLCNIDEVYNVGGGQAVAAMAYGTESVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DETADADFIAADLLSQAEHGPDSQVVLVTPSVLIADQVTDAVQKQLKQLSRASIAEKALASSLIIIADSLTQAVSISNYY
GPEHLIVQTKNPRELLPLLDNAGSIFLGDWSPESAGDYASGTNHVLPTYGYTRTYSSLGLADFSKRMTIQELSAEGLKTL
APTVVTMAEAEGLDAHKRAVTIRVEKLNARG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=422, Percent_Identity=63.9810426540284, Blast_Score=558, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6319819, Length=419, Percent_Identity=52.2673031026253, Blast_Score=416, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46039; Mature: 46039

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTVVWQSLSETQQDAILERPAITEGANITAAVAEVIAKVRAEGDAALFELTEKFDRVKP
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
ESIRVTEQEIEEASARLTAKMKQALEQAYANIAKFHNAQKPTPIKVETQPGVVCEQVTRP
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHH
IQKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPPPIADEILYVAKLCNIDEVYN
HHHCCEEECCCCCCCCCEEEEECCCHHHCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHC
VGGGQAVAAMAYGTESVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
CCCCCEEEEEHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEE
DETADADFIAADLLSQAEHGPDSQVVLVTPSVLIADQVTDAVQKQLKQLSRASIAEKALA
ECCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLIIIADSLTQAVSISNYYGPEHLIVQTKNPRELLPLLDNAGSIFLGDWSPESAGDYAS
HHHHEEEHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCEEEECCCCCCCCCCCC
GTNHVLPTYGYTRTYSSLGLADFSKRMTIQELSAEGLKTLAPTVVTMAEAEGLDAHKRAV
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
TIRVEKLNARG
EEEEEECCCCC
>Mature Secondary Structure
MRTVVWQSLSETQQDAILERPAITEGANITAAVAEVIAKVRAEGDAALFELTEKFDRVKP
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
ESIRVTEQEIEEASARLTAKMKQALEQAYANIAKFHNAQKPTPIKVETQPGVVCEQVTRP
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHH
IQKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPPPIADEILYVAKLCNIDEVYN
HHHCCEEECCCCCCCCCEEEEECCCHHHCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHC
VGGGQAVAAMAYGTESVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
CCCCCEEEEEHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEE
DETADADFIAADLLSQAEHGPDSQVVLVTPSVLIADQVTDAVQKQLKQLSRASIAEKALA
ECCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLIIIADSLTQAVSISNYYGPEHLIVQTKNPRELLPLLDNAGSIFLGDWSPESAGDYAS
HHHHEEEHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCEEEECCCCCCCCCCCC
GTNHVLPTYGYTRTYSSLGLADFSKRMTIQELSAEGLKTLAPTVVTMAEAEGLDAHKRAV
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
TIRVEKLNARG
EEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]