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The map label for this gene is serC

Identifier: 27366096

GI number: 27366096

Start: 2876046

End: 2877140

Strand: Reverse

Name: serC

Synonym: VV1_2813

Alternate gene names: 27366096

Gene position: 2877140-2876046 (Counterclockwise)

Preceding gene: 27366097

Following gene: 27366092

Centisome position: 87.67

GC content: 45.66

Gene sequence:

>1095_bases
ATGGAACAAAATACGGATAACGTATTTAACTTTAGTGCCGGACCAGCAGCACTACCGAAGCCTGTTATGCAGCAGGCGCA
ACAAGAATTGTTGAACTGGCAAGGGCTAGGCACTTCCGTTATGGAAATCAGCCACCGTAGCAAAGAGTTTATTGCAGTCG
CAGAGCAATCTGAGCAAGATCTCCGCGATCTACTGAATATCCCTGATAATTACAAAGTTCTTTTCTGCCAAGGTGGTGCG
CGCGCTCAATTTGCGGCCGTGCCGCTGAATCTGCTAGGTGACGCGACGACGGCGACCTACATTGATGCGGGCTATTGGGC
AGAAAGTGCTGTCGAAGAAGCAAAAAAATACTGTCAGCCGGATGTCTTTGTTGCGAAAGCGGAAAAAGAAGGCAAGCAAG
CGGTACTACCTGCCTCAGAATGGCAAATTCATCCTGATGCGGCTTACGTGCATTTTTGTCCCAATGAAACCATTGATGGC
ATTGAGATCAATGATCTTCCAGTGACGGATAAGCCGATCGTTGCCGATATGTCTTCGACCATTTTGTCGCGTGAAATTGA
TGTATCAAAATACGGTGTGATTTACGCAGGTGCGCAAAAAAATATCGGTCCTTCTGGTATTGCGATTGCCATTGTACGTG
ACGATTTGCTTGGTTTGGCGAAAGAAGTATTGCCAAGTATTCTCAATTACAAAGTGTTGGCAGAACAAGACTCGATGTTT
AACACGCCACCAACTTTTGCCTGGTACTTGTCTGGCCTTGTTTTCAAATGGTTGAAAGCGCAGGGTGGGGTAAAAGCGAT
TGAGCAAGTAAACCGTGAGAAAGCGGCGATTTTGTATAACTACATTGATGAGTCCGATTTTTACATCAACAATGTACATC
CAGATAACCGTTCATTAATGAATGTGCCGTTCCAAATGGTGAAACCAGAGCTAGACGCAAAATTCTTGAAAGAAGCTGAA
GCATTGGGTCTCAAATCACTAAAAGGTCACCGAGTAGTGGGTGGCATGCGCGCCTCCATTTACAACGCAATGCCAATTGA
AGGTGTGAAGGCGTTAGTCGATTTCATGCGCCAATTTGAGCAAGAAAACGCGTAA

Upstream 100 bases:

>100_bases
AAAAAAGAGGTCTTAAGACCTCTTTTCTTGTTTTTCAACAGCGAAAAACGTGATATTACTTGCAGAGTTTTTATTACATC
TAGCAGGAGCAAAGAGCGTC

Downstream 100 bases:

>100_bases
TTTCAGTGCGATAGATGAGAAAAACAAAGGGAAGTGCGTAAGCACTTCCCTTTTTCTTGTTTGCCATTGTCCTATTGATG
GCTGAGTAATACTGCCCAGC

Product: 3-phosphoserine/phosphohydroxythreonine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MEQNTDNVFNFSAGPAALPKPVMQQAQQELLNWQGLGTSVMEISHRSKEFIAVAEQSEQDLRDLLNIPDNYKVLFCQGGA
RAQFAAVPLNLLGDATTATYIDAGYWAESAVEEAKKYCQPDVFVAKAEKEGKQAVLPASEWQIHPDAAYVHFCPNETIDG
IEINDLPVTDKPIVADMSSTILSREIDVSKYGVIYAGAQKNIGPSGIAIAIVRDDLLGLAKEVLPSILNYKVLAEQDSMF
NTPPTFAWYLSGLVFKWLKAQGGVKAIEQVNREKAAILYNYIDESDFYINNVHPDNRSLMNVPFQMVKPELDAKFLKEAE
ALGLKSLKGHRVVGGMRASIYNAMPIEGVKALVDFMRQFEQENA

Sequences:

>Translated_364_residues
MEQNTDNVFNFSAGPAALPKPVMQQAQQELLNWQGLGTSVMEISHRSKEFIAVAEQSEQDLRDLLNIPDNYKVLFCQGGA
RAQFAAVPLNLLGDATTATYIDAGYWAESAVEEAKKYCQPDVFVAKAEKEGKQAVLPASEWQIHPDAAYVHFCPNETIDG
IEINDLPVTDKPIVADMSSTILSREIDVSKYGVIYAGAQKNIGPSGIAIAIVRDDLLGLAKEVLPSILNYKVLAEQDSMF
NTPPTFAWYLSGLVFKWLKAQGGVKAIEQVNREKAAILYNYIDESDFYINNVHPDNRSLMNVPFQMVKPELDAKFLKEAE
ALGLKSLKGHRVVGGMRASIYNAMPIEGVKALVDFMRQFEQENA
>Mature_364_residues
MEQNTDNVFNFSAGPAALPKPVMQQAQQELLNWQGLGTSVMEISHRSKEFIAVAEQSEQDLRDLLNIPDNYKVLFCQGGA
RAQFAAVPLNLLGDATTATYIDAGYWAESAVEEAKKYCQPDVFVAKAEKEGKQAVLPASEWQIHPDAAYVHFCPNETIDG
IEINDLPVTDKPIVADMSSTILSREIDVSKYGVIYAGAQKNIGPSGIAIAIVRDDLLGLAKEVLPSILNYKVLAEQDSMF
NTPPTFAWYLSGLVFKWLKAQGGVKAIEQVNREKAAILYNYIDESDFYINNVHPDNRSLMNVPFQMVKPELDAKFLKEAE
ALGLKSLKGHRVVGGMRASIYNAMPIEGVKALVDFMRQFEQENA

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=361, Percent_Identity=47.3684210526316, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI10863955, Length=357, Percent_Identity=42.296918767507, Blast_Score=286, Evalue=2e-77,
Organism=Escherichia coli, GI1787136, Length=359, Percent_Identity=66.5738161559889, Blast_Score=508, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17506897, Length=361, Percent_Identity=44.0443213296399, Blast_Score=308, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6324758, Length=386, Percent_Identity=43.7823834196891, Blast_Score=285, Evalue=9e-78,
Organism=Drosophila melanogaster, GI21356589, Length=364, Percent_Identity=46.1538461538462, Blast_Score=336, Evalue=1e-92,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_VIBVU (Q8D900)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_761624.1
- ProteinModelPortal:   Q8D900
- SMR:   Q8D900
- GeneID:   1179654
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_2813
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- BioCyc:   VVUL216895:VV1_2813-MONOMER
- BRENDA:   2.6.1.52
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40280; Mature: 40280

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 46-46 BINDING 106-106 BINDING 157-157 BINDING 176-176 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQNTDNVFNFSAGPAALPKPVMQQAQQELLNWQGLGTSVMEISHRSKEFIAVAEQSEQD
CCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHEEEEHHCCHHH
LRDLLNIPDNYKVLFCQGGARAQFAAVPLNLLGDATTATYIDAGYWAESAVEEAKKYCQP
HHHHHCCCCCCEEEEEECCCCCEEEECCHHHHCCCCHHEEEECCHHHHHHHHHHHHHCCC
DVFVAKAEKEGKQAVLPASEWQIHPDAAYVHFCPNETIDGIEINDLPVTDKPIVADMSST
CEEEEECCCCCCEEECCCHHCEECCCCEEEEECCCCCCCCEEECCCCCCCCCHHHHHHHH
ILSREIDVSKYGVIYAGAQKNIGPSGIAIAIVRDDLLGLAKEVLPSILNYKVLAEQDSMF
HHHHCCCCCCCCEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCEEEEECCCCCC
NTPPTFAWYLSGLVFKWLKAQGGVKAIEQVNREKAAILYNYIDESDFYINNVHPDNRSLM
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHEEEECCCCCCEEECCCCCCCCHH
NVPFQMVKPELDAKFLKEAEALGLKSLKGHRVVGGMRASIYNAMPIEGVKALVDFMRQFE
HCCHHHHCCCHHHHHHHHHHHHCHHHCCCCEEECCHHHHHHCCCCHHHHHHHHHHHHHHH
QENA
HCCC
>Mature Secondary Structure
MEQNTDNVFNFSAGPAALPKPVMQQAQQELLNWQGLGTSVMEISHRSKEFIAVAEQSEQD
CCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHEEEEHHCCHHH
LRDLLNIPDNYKVLFCQGGARAQFAAVPLNLLGDATTATYIDAGYWAESAVEEAKKYCQP
HHHHHCCCCCCEEEEEECCCCCEEEECCHHHHCCCCHHEEEECCHHHHHHHHHHHHHCCC
DVFVAKAEKEGKQAVLPASEWQIHPDAAYVHFCPNETIDGIEINDLPVTDKPIVADMSST
CEEEEECCCCCCEEECCCHHCEECCCCEEEEECCCCCCCCEEECCCCCCCCCHHHHHHHH
ILSREIDVSKYGVIYAGAQKNIGPSGIAIAIVRDDLLGLAKEVLPSILNYKVLAEQDSMF
HHHHCCCCCCCCEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCEEEEECCCCCC
NTPPTFAWYLSGLVFKWLKAQGGVKAIEQVNREKAAILYNYIDESDFYINNVHPDNRSLM
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHEEEECCCCCCEEECCCCCCCCHH
NVPFQMVKPELDAKFLKEAEALGLKSLKGHRVVGGMRASIYNAMPIEGVKALVDFMRQFE
HCCHHHHCCCHHHHHHHHHHHHCHHHCCCCEEECCHHHHHHCCCCHHHHHHHHHHHHHHH
QENA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA