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The map label for this gene is gor [H]

Identifier: 27364528

GI number: 27364528

Start: 1104918

End: 1106273

Strand: Reverse

Name: gor [H]

Synonym: VV1_1105

Alternate gene names: 27364528

Gene position: 1106273-1104918 (Counterclockwise)

Preceding gene: 27364529

Following gene: 27364523

Centisome position: 33.71

GC content: 53.39

Gene sequence:

>1356_bases
ATGGCAACGCATTTTGACTATATCTGTATCGGCGGCGGCAGTGGCGGCATCGCTTCAGCAAACCGTGCGGCGATGTATGG
CGCGAAAGTGGCGCTGATCGAAGCAAAAGATCTCGGCGGCACTTGTGTGAACGTTGGTTGTGTACCGAAAAAAGTGATGT
GGCATGGCGCGCAGATCGCAGAAGCGATGAGCCTATACGCTCCTGACTACGGCTTTGATGTGGAAGTGAAAGGCTTCGAC
TGGAGCAAACTGGTTGAGAGCCGCCAAGCGTACATTGGCCGCATCCACCAATCTTACGATCGCGTGCTAGGCAACAACAA
AGTCAACGTGATTAAAGGCTTCGCTAAGTTTGTCGATGAGAAAACCGTGGAAGTAAACGGTGAGCACTACACCGCCGATC
ACATTCTGATCGCTGTGGGTGGCCGCCCGACCATTCCAAACATCCCTGGCGCGGAATACGGCATCGATTCAAACGGCTTC
TTCGACCTTGCAGAGCAACCAAAACGTGTTGCTGTCGTTGGCGCGGGTTACATTGCGGTGGAAATCGCTGGCGTGCTCAA
CGCCCTTGGTACAGAAACCCATCTGTTCTGCCGTAAAGAGTCGCCACTGCGCAGCTTTGACCCAATGATCATCGACACCT
TAGTGGAAGTGATGGCGGCAGAAGGCCCAACACTGCACACCCACTCGGTACCAAAAGAAGTGGTCAAAGAAGCCGATGGC
AGCCTAACGCTTCATCTAGAAAACGGTGAAAGCCAAAACGTTGATCAGCTTATCTGGGCAATCGGCCGTCACCCAGCGAC
TGATGCCATCAACCTGAGCGCAACCGGCGTAGCAACCAACGAGCGCGGCTACATCAAAGTCGATGAGTTCCAAGCAACCA
ACGTTGCTGGCATCTACTGTGTGGGTGACATTATGGAAGGCGGTATCGAGCTCACACCTGTTGCGGTGAAAGCGGGTCGT
CAGCTTTCTGAGCGCCTGTTCAACAACAAACCCAACGCGAAGATGGACTATGACTTGGTCCCAACTGTCGTGTTCAGCCA
CCCACCTATCGGCACCATTGGTCTTTCTGAGCCAGAAGCGATCGCTCAATATGGTGAAGAGAACGTGAAAGTGTACACAT
CAGGCTTTACTGCGATGTACACCGCCGTGACCCAACACCGTCAGCCATGCAAGATGAAGCTCGTATGTGCGGGTGAAGAT
GAGAAAGTGGTTGGCCTGCACGGCATCGGTTTCGCGGTGGACGAAATGATTCAAGGTTTCGGTGTCGCGATGAAGATGGG
TGCAACCAAAGCCGATTTCGACTCGGTTGTGGCTATCCACCCAACCGGTTCGGAAGAATTCGTTACCATGCGCTAA

Upstream 100 bases:

>100_bases
GATTGAGTTCAACCAATCTGTCCTCCATATAAAAATGAAATGAATGAAAAATACGCAGGGAGCACGCGAGTAAATCGCCC
CTGCCAGACAGGAGAAAGTA

Downstream 100 bases:

>100_bases
GGCGCGAAGCACAGTGACAATCAAAGTAAGATGGCGGCCTTTTTGGCGGCCATTTTTTATTGGGGCGGCTAAAATGAAAC
ACGGAGATCCATTTTCATAA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MATHFDYICIGGGSGGIASANRAAMYGAKVALIEAKDLGGTCVNVGCVPKKVMWHGAQIAEAMSLYAPDYGFDVEVKGFD
WSKLVESRQAYIGRIHQSYDRVLGNNKVNVIKGFAKFVDEKTVEVNGEHYTADHILIAVGGRPTIPNIPGAEYGIDSNGF
FDLAEQPKRVAVVGAGYIAVEIAGVLNALGTETHLFCRKESPLRSFDPMIIDTLVEVMAAEGPTLHTHSVPKEVVKEADG
SLTLHLENGESQNVDQLIWAIGRHPATDAINLSATGVATNERGYIKVDEFQATNVAGIYCVGDIMEGGIELTPVAVKAGR
QLSERLFNNKPNAKMDYDLVPTVVFSHPPIGTIGLSEPEAIAQYGEENVKVYTSGFTAMYTAVTQHRQPCKMKLVCAGED
EKVVGLHGIGFAVDEMIQGFGVAMKMGATKADFDSVVAIHPTGSEEFVTMR

Sequences:

>Translated_451_residues
MATHFDYICIGGGSGGIASANRAAMYGAKVALIEAKDLGGTCVNVGCVPKKVMWHGAQIAEAMSLYAPDYGFDVEVKGFD
WSKLVESRQAYIGRIHQSYDRVLGNNKVNVIKGFAKFVDEKTVEVNGEHYTADHILIAVGGRPTIPNIPGAEYGIDSNGF
FDLAEQPKRVAVVGAGYIAVEIAGVLNALGTETHLFCRKESPLRSFDPMIIDTLVEVMAAEGPTLHTHSVPKEVVKEADG
SLTLHLENGESQNVDQLIWAIGRHPATDAINLSATGVATNERGYIKVDEFQATNVAGIYCVGDIMEGGIELTPVAVKAGR
QLSERLFNNKPNAKMDYDLVPTVVFSHPPIGTIGLSEPEAIAQYGEENVKVYTSGFTAMYTAVTQHRQPCKMKLVCAGED
EKVVGLHGIGFAVDEMIQGFGVAMKMGATKADFDSVVAIHPTGSEEFVTMR
>Mature_450_residues
ATHFDYICIGGGSGGIASANRAAMYGAKVALIEAKDLGGTCVNVGCVPKKVMWHGAQIAEAMSLYAPDYGFDVEVKGFDW
SKLVESRQAYIGRIHQSYDRVLGNNKVNVIKGFAKFVDEKTVEVNGEHYTADHILIAVGGRPTIPNIPGAEYGIDSNGFF
DLAEQPKRVAVVGAGYIAVEIAGVLNALGTETHLFCRKESPLRSFDPMIIDTLVEVMAAEGPTLHTHSVPKEVVKEADGS
LTLHLENGESQNVDQLIWAIGRHPATDAINLSATGVATNERGYIKVDEFQATNVAGIYCVGDIMEGGIELTPVAVKAGRQ
LSERLFNNKPNAKMDYDLVPTVVFSHPPIGTIGLSEPEAIAQYGEENVKVYTSGFTAMYTAVTQHRQPCKMKLVCAGEDE
KVVGLHGIGFAVDEMIQGFGVAMKMGATKADFDSVVAIHPTGSEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=52.4945770065076, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI22035672, Length=459, Percent_Identity=40.0871459694989, Blast_Score=290, Evalue=3e-78,
Organism=Homo sapiens, GI148277071, Length=456, Percent_Identity=36.8421052631579, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI33519430, Length=455, Percent_Identity=36.4835164835165, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI33519428, Length=455, Percent_Identity=36.4835164835165, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI33519426, Length=455, Percent_Identity=36.4835164835165, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI148277065, Length=456, Percent_Identity=36.8421052631579, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI291045266, Length=458, Percent_Identity=33.1877729257642, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI291045268, Length=458, Percent_Identity=29.6943231441048, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI91199540, Length=463, Percent_Identity=28.5097192224622, Blast_Score=145, Evalue=9e-35,
Organism=Escherichia coli, GI1789915, Length=451, Percent_Identity=71.840354767184, Blast_Score=661, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=449, Percent_Identity=27.8396436525612, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI87082354, Length=467, Percent_Identity=26.5524625267666, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87081717, Length=460, Percent_Identity=25.6521739130435, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1787114, Length=200, Percent_Identity=30.5, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71983429, Length=449, Percent_Identity=54.7884187082405, Blast_Score=437, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI71983419, Length=449, Percent_Identity=54.7884187082405, Blast_Score=437, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=36.228813559322, Blast_Score=291, Evalue=5e-79,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=34.5114345114345, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI32565766, Length=457, Percent_Identity=29.7592997811816, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=51.5021459227468, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6321091, Length=465, Percent_Identity=26.6666666666667, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6325240, Length=480, Percent_Identity=23.9583333333333, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=40.5117270788913, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=40.5117270788913, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=40.5117270788913, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI17737741, Length=471, Percent_Identity=37.5796178343949, Blast_Score=269, Evalue=3e-72,
Organism=Drosophila melanogaster, GI21358499, Length=465, Percent_Identity=30.1075268817204, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48458; Mature: 48327

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATHFDYICIGGGSGGIASANRAAMYGAKVALIEAKDLGGTCVNVGCVPKKVMWHGAQIA
CCCEEEEEEEECCCCCCCCCCCCEEECCEEEEEEECCCCCEEEEECCCCHHHHHCCHHHH
EAMSLYAPDYGFDVEVKGFDWSKLVESRQAYIGRIHQSYDRVLGNNKVNVIKGFAKFVDE
HHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
KTVEVNGEHYTADHILIAVGGRPTIPNIPGAEYGIDSNGFFDLAEQPKRVAVVGAGYIAV
CEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHEE
EIAGVLNALGTETHLFCRKESPLRSFDPMIIDTLVEVMAAEGPTLHTHSVPKEVVKEADG
HHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHCCC
SLTLHLENGESQNVDQLIWAIGRHPATDAINLSATGVATNERGYIKVDEFQATNVAGIYC
CEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCEEEECCCCCCCEEEEE
VGDIMEGGIELTPVAVKAGRQLSERLFNNKPNAKMDYDLVPTVVFSHPPIGTIGLSEPEA
EEEHHHCCEEEEEHHHHHHHHHHHHHHCCCCCCEECCCCCCEEEECCCCCCCCCCCCCHH
IAQYGEENVKVYTSGFTAMYTAVTQHRQPCKMKLVCAGEDEKVVGLHGIGFAVDEMIQGF
HHHCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHC
GVAMKMGATKADFDSVVAIHPTGSEEFVTMR
CCEEECCCCCCCCCCEEEEECCCCCCEEEEC
>Mature Secondary Structure 
ATHFDYICIGGGSGGIASANRAAMYGAKVALIEAKDLGGTCVNVGCVPKKVMWHGAQIA
CCEEEEEEEECCCCCCCCCCCCEEECCEEEEEEECCCCCEEEEECCCCHHHHHCCHHHH
EAMSLYAPDYGFDVEVKGFDWSKLVESRQAYIGRIHQSYDRVLGNNKVNVIKGFAKFVDE
HHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
KTVEVNGEHYTADHILIAVGGRPTIPNIPGAEYGIDSNGFFDLAEQPKRVAVVGAGYIAV
CEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHEE
EIAGVLNALGTETHLFCRKESPLRSFDPMIIDTLVEVMAAEGPTLHTHSVPKEVVKEADG
HHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHCCC
SLTLHLENGESQNVDQLIWAIGRHPATDAINLSATGVATNERGYIKVDEFQATNVAGIYC
CEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCEEEECCCCCCCEEEEE
VGDIMEGGIELTPVAVKAGRQLSERLFNNKPNAKMDYDLVPTVVFSHPPIGTIGLSEPEA
EEEHHHCCEEEEEHHHHHHHHHHHHHHCCCCCCEECCCCCCEEEECCCCCCCCCCCCCHH
IAQYGEENVKVYTSGFTAMYTAVTQHRQPCKMKLVCAGEDEKVVGLHGIGFAVDEMIQGF
HHHCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHC
GVAMKMGATKADFDSVVAIHPTGSEEFVTMR
CCEEECCCCCCCCCCEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]