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The map label for this gene is neuC [H]

Identifier: 27364256

GI number: 27364256

Start: 815100

End: 816263

Strand: Reverse

Name: neuC [H]

Synonym: VV1_0807

Alternate gene names: 27364256

Gene position: 816263-815100 (Counterclockwise)

Preceding gene: 27364257

Following gene: 326423771

Centisome position: 24.87

GC content: 44.42

Gene sequence:

>1164_bases
ATGCGTAAAATCTGTGTAGTCACCGCCACGCGAGCGGAATATGGCTTACTGAAATGTTTGCTGGATGATATTCAAAATGA
TCCGCAACTTGAGTTACAAATCATCTCTACTGGCAGCCATTTGTCGCCAGAGTTTGGTTACACCAATCAGCAAATCTTGG
ATGATGGTTTTCGTGTTAACAAGCAAATTGAGATCTTACTCTCTTCAGATACCCCAGTGGGAGTGAGTAAAAGTATGGGC
TTGGCCCAAATCAGTTTTGCTGAAGCCTTTGAAGAGTTGCGACCGGATTTAGTCGTGGTACTTGGTGACCGTTACGAGTT
GATCCCGATTGTGTCGGCGGCCAATATTGCGCGTATTCCAGTCGCTCACCTCAATGGCGGCGAGTTAACAGAAGGGGCGA
TTGATGAACTCATTCGTCATGCGATCACCAAACTGTCGCAACTGCATTTCACTGCGATGGAAGAATACTCTCGACGTGTC
ATTCAAATGGGTGAAAGTCCAGATCGAGTGTTTAATATTGGTGAAGTGGGTTTGGATAACATTCTAAGAATGGAGTTGCT
CTCTAAGAGTGCCTTTGAAGAGTCTATTGGCGTGAAGTTAAAAAAGAAAAATCTGCTGTTTACCTATCATCCGGAAACAA
CCCAATCAGTTGATGAGATTGAAGCGGATTTTAACCATATCCTTGCGGCATTAGATACTCTTGATGATTGTTTGATCATT
TTCACTAAAGCGAATGCAGATGTGGGTGGCCGTCTGATCAACAAAATGATTGATCAGTACGTGGTCGACCATAAAGACAA
GTCAGTGGCGTTTACCTCGTTGGGGCAGTTGCGCTATTTGTCTGCTCTGCAATATGTCGATGCGGTGGTCGGGAATTCGT
CGAGTGGTATCGTAGAAGCCCCTTCATTTAGAATAGCGTCGATTAATATCGGCTCTCGTCAAAAAGGGCGAGTACGAGCT
GATAGCACCATTGACGTTGAGGTTGAAAAGCAGCAGATTATCGACGCCATTGCTACTATCTATACAGATGCTTTCCAAGA
GCGACTCCACACGGTCATTAATCCTTACGGCCAGGGCAACAGTTCGCAAAAGTTGGTGAGTATCATTAAGTCAGTCGACT
TGAGCAAATTGAAATCCAAGAAGTTCTATGATGTCGAATACTAA

Upstream 100 bases:

>100_bases
TAGAAATTAAACGTCCAGGTAATGGTATTTCTCCAACGCGTTGGGATGAAGTGGTTGGCTCTATAGCGAAGAAAGATTAC
CAGATTGGAGAGCTGATCTA

Downstream 100 bases:

>100_bases
TCAAAAAACGATTGGTGGTGAGCAAGAGCTGCTATCGGACCATCTTCATTATGGGGTCACCAACTCTGGGCGCTCATCGT
TACGATGGGCGCTTGAGTCA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MRKICVVTATRAEYGLLKCLLDDIQNDPQLELQIISTGSHLSPEFGYTNQQILDDGFRVNKQIEILLSSDTPVGVSKSMG
LAQISFAEAFEELRPDLVVVLGDRYELIPIVSAANIARIPVAHLNGGELTEGAIDELIRHAITKLSQLHFTAMEEYSRRV
IQMGESPDRVFNIGEVGLDNILRMELLSKSAFEESIGVKLKKKNLLFTYHPETTQSVDEIEADFNHILAALDTLDDCLII
FTKANADVGGRLINKMIDQYVVDHKDKSVAFTSLGQLRYLSALQYVDAVVGNSSSGIVEAPSFRIASINIGSRQKGRVRA
DSTIDVEVEKQQIIDAIATIYTDAFQERLHTVINPYGQGNSSQKLVSIIKSVDLSKLKSKKFYDVEY

Sequences:

>Translated_387_residues
MRKICVVTATRAEYGLLKCLLDDIQNDPQLELQIISTGSHLSPEFGYTNQQILDDGFRVNKQIEILLSSDTPVGVSKSMG
LAQISFAEAFEELRPDLVVVLGDRYELIPIVSAANIARIPVAHLNGGELTEGAIDELIRHAITKLSQLHFTAMEEYSRRV
IQMGESPDRVFNIGEVGLDNILRMELLSKSAFEESIGVKLKKKNLLFTYHPETTQSVDEIEADFNHILAALDTLDDCLII
FTKANADVGGRLINKMIDQYVVDHKDKSVAFTSLGQLRYLSALQYVDAVVGNSSSGIVEAPSFRIASINIGSRQKGRVRA
DSTIDVEVEKQQIIDAIATIYTDAFQERLHTVINPYGQGNSSQKLVSIIKSVDLSKLKSKKFYDVEY
>Mature_387_residues
MRKICVVTATRAEYGLLKCLLDDIQNDPQLELQIISTGSHLSPEFGYTNQQILDDGFRVNKQIEILLSSDTPVGVSKSMG
LAQISFAEAFEELRPDLVVVLGDRYELIPIVSAANIARIPVAHLNGGELTEGAIDELIRHAITKLSQLHFTAMEEYSRRV
IQMGESPDRVFNIGEVGLDNILRMELLSKSAFEESIGVKLKKKNLLFTYHPETTQSVDEIEADFNHILAALDTLDDCLII
FTKANADVGGRLINKMIDQYVVDHKDKSVAFTSLGQLRYLSALQYVDAVVGNSSSGIVEAPSFRIASINIGSRQKGRVRA
DSTIDVEVEKQQIIDAIATIYTDAFQERLHTVINPYGQGNSSQKLVSIIKSVDLSKLKSKKFYDVEY

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI190014632, Length=389, Percent_Identity=27.7634961439589, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI298566312, Length=389, Percent_Identity=27.7634961439589, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4885285, Length=389, Percent_Identity=27.7634961439589, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI298566325, Length=357, Percent_Identity=26.890756302521, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI298566315, Length=339, Percent_Identity=25.6637168141593, Blast_Score=99, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 42969; Mature: 42969

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKICVVTATRAEYGLLKCLLDDIQNDPQLELQIISTGSHLSPEFGYTNQQILDDGFRVN
CCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHCCCCCCC
KQIEILLSSDTPVGVSKSMGLAQISFAEAFEELRPDLVVVLGDRYELIPIVSAANIARIP
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEECCCCCCCE
VAHLNGGELTEGAIDELIRHAITKLSQLHFTAMEEYSRRVIQMGESPDRVFNIGEVGLDN
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECCHHCHHH
ILRMELLSKSAFEESIGVKLKKKNLLFTYHPETTQSVDEIEADFNHILAALDTLDDCLII
HHHHHHHHHHHHHHHHCCEEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEE
FTKANADVGGRLINKMIDQYVVDHKDKSVAFTSLGQLRYLSALQYVDAVVGNSSSGIVEA
EEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
PSFRIASINIGSRQKGRVRADSTIDVEVEKQQIIDAIATIYTDAFQERLHTVINPYGQGN
CCEEEEEEECCCCCCCCEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SSQKLVSIIKSVDLSKLKSKKFYDVEY
CHHHHHHHHHHCCHHHHCCCCCCCCCC
>Mature Secondary Structure
MRKICVVTATRAEYGLLKCLLDDIQNDPQLELQIISTGSHLSPEFGYTNQQILDDGFRVN
CCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHCCCCCCC
KQIEILLSSDTPVGVSKSMGLAQISFAEAFEELRPDLVVVLGDRYELIPIVSAANIARIP
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEECCCCCCCE
VAHLNGGELTEGAIDELIRHAITKLSQLHFTAMEEYSRRVIQMGESPDRVFNIGEVGLDN
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECCHHCHHH
ILRMELLSKSAFEESIGVKLKKKNLLFTYHPETTQSVDEIEADFNHILAALDTLDDCLII
HHHHHHHHHHHHHHHHCCEEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEE
FTKANADVGGRLINKMIDQYVVDHKDKSVAFTSLGQLRYLSALQYVDAVVGNSSSGIVEA
EEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
PSFRIASINIGSRQKGRVRADSTIDVEVEKQQIIDAIATIYTDAFQERLHTVINPYGQGN
CCEEEEEEECCCCCCCCEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SSQKLVSIIKSVDLSKLKSKKFYDVEY
CHHHHHHHHHHCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]