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The map label for this gene is wecC [H]

Identifier: 27364228

GI number: 27364228

Start: 789450

End: 790721

Strand: Reverse

Name: wecC [H]

Synonym: VV1_0779

Alternate gene names: 27364228

Gene position: 790721-789450 (Counterclockwise)

Preceding gene: 326423768

Following gene: 326423767

Centisome position: 24.09

GC content: 43.71

Gene sequence:

>1272_bases
ATGTCTTTTGAAACCATTTCAGTAATCGGCTTAGGCTACATTGGTTTACCTACAGCGGCGATGTTTGCATCGCGTAAAAA
GAAAGTGATTGGTGTGGATGTTAACCAACACGCTGTTGATACCATTAATCAAGGTAAGATTCATATTGTAGAGCCAGATC
TCGATATGATGGTGCATGCTGCAGTCAGCGGCGGCTACTTAAAAGCAACCACTACACCAGAAGCGGCCGATGCCTTTTTG
ATTGCCGTGCCAACACCATTTTTACCTTGTGCAGAGGGCGAAATCCCAGCACCTGATCTTTCTTACATTGAAGCAGCTAG
TAAAGCGATTGCCCCTGTACTGAAAAAAGGTGACTTGGTGATTCTAGAATCGACCTCACCCGTTGGTGCAACCGAGCAAA
TGGCAGCTTGGCTCGCTGAAGCTCGTTCAGATCTTACCTTCCCGCAAGCCCACGGTGAAGACGCGGATGTGAACATTGCC
CATTGCCCCGAGCGCGTTTTGCCTGGCCATGTAGTTCGTGAGCTAGTTGAAAACGACCGAGTAATTGGTGGTTTAACAGC
TAAGTGTTCGGCGCGTGCGGTTGAACTCTATAAAACTTTTGTTCAAGGTGAATGCGTAGTAACCAACGCGCGTACCGCGG
AAATGGCGAAACTTACCGAAAATAGCTCTCGCGATGTACAAATTGCCTTTGCCAATGAACTATCTATTATTTGTGACAAG
CTAGACATCAACGTATGGGAGCTAATCGCTCTGGCAAACCGCCATCCTCGTGTCAACATTCTCCAGCCTGGCCCAGGTGT
AGGCGGTCACTGTATTGCTGTTGACCCTTGGTTTATTGTGTCAAAAACACCAGAAGAAGCACAAATTATTCATACGGCAC
GCAAAGTCAATGATAGCAAACCGCAGTGGGTGATTAACAAAGTAAAATTAGCAATTGCAGACTTTTTACAAGCCAACCCA
GACAAAACCGCTAAAGATGTGACTATTGCATGCTATGGTTTAGCATTTAAACCAGATATTGATGACTTACGTGAAAGTCC
AGCAATGGCAATAACACAAAAAATTGCTGAAATGCATAATGGAAGAGTTATAGCAATCGAGCCAAATATAGATGTAGTAC
CTAAAAAATTAGAAAATGTAGAATTAACTAGTTTAGATTTTGCAAAACTTGAAGCTAGCATCCATGTGATGCTGGTTGAT
CATACTAACTTTAAAGTATCAGATATACCTAGCAATGGAATCGTAGTCGATACAAAGGGTGTATGGGGTTGA

Upstream 100 bases:

>100_bases
GAACCTAGAACCTAGAACCTAGAACCTAGAACCTAGAACCTAGAACCTAGAACCTAGAACCTAGAACTAAATTTATAAAA
TAACATTAGGACTCACAAAA

Downstream 100 bases:

>100_bases
GATAATAGGCACTCCTCTTTTTAGGGGAGTGAAATTTAAATGAAAAAGATCATTTTGTTTGTAATTTCGCTAGGAGTGCC
ACAAGCCATAACGATGTTTG

Product: UDP-N-acetyl-D-mannosamine dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MSFETISVIGLGYIGLPTAAMFASRKKKVIGVDVNQHAVDTINQGKIHIVEPDLDMMVHAAVSGGYLKATTTPEAADAFL
IAVPTPFLPCAEGEIPAPDLSYIEAASKAIAPVLKKGDLVILESTSPVGATEQMAAWLAEARSDLTFPQAHGEDADVNIA
HCPERVLPGHVVRELVENDRVIGGLTAKCSARAVELYKTFVQGECVVTNARTAEMAKLTENSSRDVQIAFANELSIICDK
LDINVWELIALANRHPRVNILQPGPGVGGHCIAVDPWFIVSKTPEEAQIIHTARKVNDSKPQWVINKVKLAIADFLQANP
DKTAKDVTIACYGLAFKPDIDDLRESPAMAITQKIAEMHNGRVIAIEPNIDVVPKKLENVELTSLDFAKLEASIHVMLVD
HTNFKVSDIPSNGIVVDTKGVWG

Sequences:

>Translated_423_residues
MSFETISVIGLGYIGLPTAAMFASRKKKVIGVDVNQHAVDTINQGKIHIVEPDLDMMVHAAVSGGYLKATTTPEAADAFL
IAVPTPFLPCAEGEIPAPDLSYIEAASKAIAPVLKKGDLVILESTSPVGATEQMAAWLAEARSDLTFPQAHGEDADVNIA
HCPERVLPGHVVRELVENDRVIGGLTAKCSARAVELYKTFVQGECVVTNARTAEMAKLTENSSRDVQIAFANELSIICDK
LDINVWELIALANRHPRVNILQPGPGVGGHCIAVDPWFIVSKTPEEAQIIHTARKVNDSKPQWVINKVKLAIADFLQANP
DKTAKDVTIACYGLAFKPDIDDLRESPAMAITQKIAEMHNGRVIAIEPNIDVVPKKLENVELTSLDFAKLEASIHVMLVD
HTNFKVSDIPSNGIVVDTKGVWG
>Mature_422_residues
SFETISVIGLGYIGLPTAAMFASRKKKVIGVDVNQHAVDTINQGKIHIVEPDLDMMVHAAVSGGYLKATTTPEAADAFLI
AVPTPFLPCAEGEIPAPDLSYIEAASKAIAPVLKKGDLVILESTSPVGATEQMAAWLAEARSDLTFPQAHGEDADVNIAH
CPERVLPGHVVRELVENDRVIGGLTAKCSARAVELYKTFVQGECVVTNARTAEMAKLTENSSRDVQIAFANELSIICDKL
DINVWELIALANRHPRVNILQPGPGVGGHCIAVDPWFIVSKTPEEAQIIHTARKVNDSKPQWVINKVKLAIADFLQANPD
KTAKDVTIACYGLAFKPDIDDLRESPAMAITQKIAEMHNGRVIAIEPNIDVVPKKLENVELTSLDFAKLEASIHVMLVDH
TNFKVSDIPSNGIVVDTKGVWG

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=375, Percent_Identity=26.6666666666667, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI296040438, Length=278, Percent_Identity=25.8992805755396, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI48994968, Length=425, Percent_Identity=68.4705882352941, Blast_Score=580, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI17560350, Length=369, Percent_Identity=29.2682926829268, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI17136908, Length=370, Percent_Identity=27.5675675675676, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 45663; Mature: 45532

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFETISVIGLGYIGLPTAAMFASRKKKVIGVDVNQHAVDTINQGKIHIVEPDLDMMVHA
CCCEEEEEEEECCHHHHHHHHHHHCCCEEEEECCCCHHHCCCCCCEEEEECCCHHHEEEE
AVSGGYLKATTTPEAADAFLIAVPTPFLPCAEGEIPAPDLSYIEAASKAIAPVLKKGDLV
EECCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEE
ILESTSPVGATEQMAAWLAEARSDLTFPQAHGEDADVNIAHCPERVLPGHVVRELVENDR
EEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEHHCCCCCCCCHHHHHHHHHCCC
VIGGLTAKCSARAVELYKTFVQGECVVTNARTAEMAKLTENSSRDVQIAFANELSIICDK
EEEEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEEEEECCEEEEEEE
LDINVWELIALANRHPRVNILQPGPGVGGHCIAVDPWFIVSKTPEEAQIIHTARKVNDSK
CCCCHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHCCCCC
PQWVINKVKLAIADFLQANPDKTAKDVTIACYGLAFKPDIDDLRESPAMAITQKIAEMHN
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHHC
GRVIAIEPNIDVVPKKLENVELTSLDFAKLEASIHVMLVDHTNFKVSDIPSNGIVVDTKG
CEEEEECCCCCCCCHHCCCEEEEECHHEEEEEEEEEEEEECCCEEEEECCCCCEEEECCC
VWG
CCC
>Mature Secondary Structure 
SFETISVIGLGYIGLPTAAMFASRKKKVIGVDVNQHAVDTINQGKIHIVEPDLDMMVHA
CCEEEEEEEECCHHHHHHHHHHHCCCEEEEECCCCHHHCCCCCCEEEEECCCHHHEEEE
AVSGGYLKATTTPEAADAFLIAVPTPFLPCAEGEIPAPDLSYIEAASKAIAPVLKKGDLV
EECCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEE
ILESTSPVGATEQMAAWLAEARSDLTFPQAHGEDADVNIAHCPERVLPGHVVRELVENDR
EEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEHHCCCCCCCCHHHHHHHHHCCC
VIGGLTAKCSARAVELYKTFVQGECVVTNARTAEMAKLTENSSRDVQIAFANELSIICDK
EEEEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEEEEECCEEEEEEE
LDINVWELIALANRHPRVNILQPGPGVGGHCIAVDPWFIVSKTPEEAQIIHTARKVNDSK
CCCCHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHCCCCC
PQWVINKVKLAIADFLQANPDKTAKDVTIACYGLAFKPDIDDLRESPAMAITQKIAEMHN
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHHC
GRVIAIEPNIDVVPKKLENVELTSLDFAKLEASIHVMLVDHTNFKVSDIPSNGIVVDTKG
CEEEEECCCCCCCCHHCCCEEEEECHHEEEEEEEEEEEEECCCEEEEECCCCCEEEECCC
VWG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]