Click here to switch to the map view.

The map label for this gene is cvrA [H]

Identifier: 27363962

GI number: 27363962

Start: 496172

End: 497968

Strand: Reverse

Name: cvrA [H]

Synonym: VV1_0498

Alternate gene names: 27363962

Gene position: 497968-496172 (Counterclockwise)

Preceding gene: 27363963

Following gene: 27363960

Centisome position: 15.17

GC content: 50.08

Gene sequence:

>1797_bases
ATGCAAACCGAAACAACCGCATTATGGCTTGCTGGTATAGGGGTAATAGGGCTTGCTTGTCAGTGGTTTGCTTGGCGGTT
AAAACTGCCTGCAATTCTATTTTTATTGGTGGCGGGCTTATTGGTTGGGCCGGTGAGTGGCTGGCTTCAGCCAGAGCTGC
TTTTGGGAGATTTGCTTTTTCCTATGGTGTCATTAGCGGTCGCTGTGATTCTGTTTGAAGGCAGCTTAACGCTGAACTTT
CGCGAAATACGCGGTGTCAGTAACACCGTTTGGAGCATAGTTACACTCGGTGCGGTGGTTTCATGGGGGTTAACCAGTAC
CGCAACTCACTATCTGCTGGGGTTTGATTGGCCGCTTGCGTTGTTGTTTGGTAGCTTGACCGTGGTCACCGGACCAACGG
TGATTGTGCCGCTGCTGCGCACCGTTAGGCCATCGACGCGCCTCTCCAATATTTTACGTTGGGAAGGGATTTTAATCGAT
CCGCTCGGTGCTCTGTTTGTGGTGATGGTGTATGAGTTCATTGTCTCCAGCAGTGAAACGCACAGTTTGGTGGTATTGGC
GTGGATTCTGGCCATTGGCCTTGGATTAGGCGTTCTGTTTGGTCAGTTTCTCGCGGTGGTACTGCGCCGTGGCTGGCTGC
CTGAATACCTACAACCGTTTGCCGTTTTAAGCTTAGTGCTGGGCGTGTTTGCGCTCTCGAATCATCTGGAGCATGAATCG
GGTTTATTAACGGTCACTGTGATGGGGATGTGGTTAGCCAACTCCAAAGGGGTGGATATCAAGCATATTCTTCACTTTAA
AGAGCATCTCACCATTCTCTTCATTACTGGCTTGTTCATTTTGTTGGCGGCGCGTATCCAGCCGGAAGACTTTTACACAC
TCGGCATCAGCGCCTTGGTCTTATTCGCGTTTATTCAGTTTGTCTCTCGCCCGGTCTCTATCTATCTTGCGACGCTGCGC
AGCTCGCTTAATGGTAAGGAAAAGGCCTTTCTGGCTTGGGTGGCACCGCGTGGCATTGTCGCCGCGTCCATTTCGTCGTT
ATTTGCGATCAAGTTAGAATCACTCGGCATGTCTGAGGCTGCGTTGTTAGTGCCACTTACCTTTATGGTGATTATTGGCA
CTGTGGTGCTGCAAAGTGCAACGGCTCGGCCAGTGGCGGTGGCACTAGGGGTGTCAGAACCCGCTCCAAAAGGTTTCTTG
ATCATCGGTGCGAACGATGTCGCGCGTACATTAGCGCAGGCAATCAACAAGTACGATTGCCGCGTGGTGTTAACGGATTC
GAACTGGGATTACATTCGTCAAGCACGCATGGCAGGCTTGGATCACTACTTTGGGAATCCGGTATCGAGCCATGCTGATG
AGTACCTCAACTTAATTGGCATCGGGCATGTGGTGGCGCTGAGTCCTGATCGCTACTTCAACATTATGGCGTGTATGCAC
TTTCTCAACGACTTCAGTGATAAGCGGATTTTCTGTTTATACGATAAGTCCAATGGCAATGGCTCGGGTGACAAACATTC
GGTGTCCGATGGTTACAAGGGGCTGCCATTCTTAGATGAAGCGATCAGTTATAAAAAGTTAGCCAGTCTGATCAATCAAG
GGGCGGAAGTGCGTCACACCAAGATCAGTGAAAACTACACGTACGCAGATTATCGTGAGACGCACGCGAATAATTACGTA
TTGCCGCTGTTTGTGGTGGATACCAATGGGCGTGTGCAAATTTGCCACAACAGTGCGAACTTCTCGCCAAAAGAAGGCGA
GACGATAGTCTCTTTGATCAAGGTGCAAGAAGCCTAA

Upstream 100 bases:

>100_bases
TTTGTGAAGGGACAGAGCAAGCACAAAAATTCCGCATGGAATGGCAGCGTGGTTGGAATGAATACCAAAACTAATTAACC
CAACGGATGAGGCAACGGAT

Downstream 100 bases:

>100_bases
TTTCACGCGGTGACAGGCATCGACCCGTCACCGCATTTCATCTAGGCTTTGGAATAGAGTACACCGAGGCTTGCCAAGCG
GCTCGCGCCAGTCACTTCGG

Product: NhaP-type Na+/H+ and K+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MQTETTALWLAGIGVIGLACQWFAWRLKLPAILFLLVAGLLVGPVSGWLQPELLLGDLLFPMVSLAVAVILFEGSLTLNF
REIRGVSNTVWSIVTLGAVVSWGLTSTATHYLLGFDWPLALLFGSLTVVTGPTVIVPLLRTVRPSTRLSNILRWEGILID
PLGALFVVMVYEFIVSSSETHSLVVLAWILAIGLGLGVLFGQFLAVVLRRGWLPEYLQPFAVLSLVLGVFALSNHLEHES
GLLTVTVMGMWLANSKGVDIKHILHFKEHLTILFITGLFILLAARIQPEDFYTLGISALVLFAFIQFVSRPVSIYLATLR
SSLNGKEKAFLAWVAPRGIVAASISSLFAIKLESLGMSEAALLVPLTFMVIIGTVVLQSATARPVAVALGVSEPAPKGFL
IIGANDVARTLAQAINKYDCRVVLTDSNWDYIRQARMAGLDHYFGNPVSSHADEYLNLIGIGHVVALSPDRYFNIMACMH
FLNDFSDKRIFCLYDKSNGNGSGDKHSVSDGYKGLPFLDEAISYKKLASLINQGAEVRHTKISENYTYADYRETHANNYV
LPLFVVDTNGRVQICHNSANFSPKEGETIVSLIKVQEA

Sequences:

>Translated_598_residues
MQTETTALWLAGIGVIGLACQWFAWRLKLPAILFLLVAGLLVGPVSGWLQPELLLGDLLFPMVSLAVAVILFEGSLTLNF
REIRGVSNTVWSIVTLGAVVSWGLTSTATHYLLGFDWPLALLFGSLTVVTGPTVIVPLLRTVRPSTRLSNILRWEGILID
PLGALFVVMVYEFIVSSSETHSLVVLAWILAIGLGLGVLFGQFLAVVLRRGWLPEYLQPFAVLSLVLGVFALSNHLEHES
GLLTVTVMGMWLANSKGVDIKHILHFKEHLTILFITGLFILLAARIQPEDFYTLGISALVLFAFIQFVSRPVSIYLATLR
SSLNGKEKAFLAWVAPRGIVAASISSLFAIKLESLGMSEAALLVPLTFMVIIGTVVLQSATARPVAVALGVSEPAPKGFL
IIGANDVARTLAQAINKYDCRVVLTDSNWDYIRQARMAGLDHYFGNPVSSHADEYLNLIGIGHVVALSPDRYFNIMACMH
FLNDFSDKRIFCLYDKSNGNGSGDKHSVSDGYKGLPFLDEAISYKKLASLINQGAEVRHTKISENYTYADYRETHANNYV
LPLFVVDTNGRVQICHNSANFSPKEGETIVSLIKVQEA
>Mature_598_residues
MQTETTALWLAGIGVIGLACQWFAWRLKLPAILFLLVAGLLVGPVSGWLQPELLLGDLLFPMVSLAVAVILFEGSLTLNF
REIRGVSNTVWSIVTLGAVVSWGLTSTATHYLLGFDWPLALLFGSLTVVTGPTVIVPLLRTVRPSTRLSNILRWEGILID
PLGALFVVMVYEFIVSSSETHSLVVLAWILAIGLGLGVLFGQFLAVVLRRGWLPEYLQPFAVLSLVLGVFALSNHLEHES
GLLTVTVMGMWLANSKGVDIKHILHFKEHLTILFITGLFILLAARIQPEDFYTLGISALVLFAFIQFVSRPVSIYLATLR
SSLNGKEKAFLAWVAPRGIVAASISSLFAIKLESLGMSEAALLVPLTFMVIIGTVVLQSATARPVAVALGVSEPAPKGFL
IIGANDVARTLAQAINKYDCRVVLTDSNWDYIRQARMAGLDHYFGNPVSSHADEYLNLIGIGHVVALSPDRYFNIMACMH
FLNDFSDKRIFCLYDKSNGNGSGDKHSVSDGYKGLPFLDEAISYKKLASLINQGAEVRHTKISENYTYADYRETHANNYV
LPLFVVDTNGRVQICHNSANFSPKEGETIVSLIKVQEA

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=335, Percent_Identity=25.9701492537313, Blast_Score=86, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 65464; Mature: 65464

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTETTALWLAGIGVIGLACQWFAWRLKLPAILFLLVAGLLVGPVSGWLQPELLLGDLLF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
PMVSLAVAVILFEGSLTLNFREIRGVSNTVWSIVTLGAVVSWGLTSTATHYLLGFDWPLA
HHHHHHHHHHHCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHEECCHHHH
LLFGSLTVVTGPTVIVPLLRTVRPSTRLSNILRWEGILIDPLGALFVVMVYEFIVSSSET
HHHCCHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHCCCCC
HSLVVLAWILAIGLGLGVLFGQFLAVVLRRGWLPEYLQPFAVLSLVLGVFALSNHLEHES
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GLLTVTVMGMWLANSKGVDIKHILHFKEHLTILFITGLFILLAARIQPEDFYTLGISALV
CEEEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LFAFIQFVSRPVSIYLATLRSSLNGKEKAFLAWVAPRGIVAASISSLFAIKLESLGMSEA
HHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHH
ALLVPLTFMVIIGTVVLQSATARPVAVALGVSEPAPKGFLIIGANDVARTLAQAINKYDC
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHCCCCC
RVVLTDSNWDYIRQARMAGLDHYFGNPVSSHADEYLNLIGIGHVVALSPDRYFNIMACMH
EEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECEEEEECCCHHHHHHHHHH
FLNDFSDKRIFCLYDKSNGNGSGDKHSVSDGYKGLPFLDEAISYKKLASLINQGAEVRHT
HHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEE
KISENYTYADYRETHANNYVLPLFVVDTNGRVQICHNSANFSPKEGETIVSLIKVQEA
ECCCCCCCCCHHHHCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MQTETTALWLAGIGVIGLACQWFAWRLKLPAILFLLVAGLLVGPVSGWLQPELLLGDLLF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
PMVSLAVAVILFEGSLTLNFREIRGVSNTVWSIVTLGAVVSWGLTSTATHYLLGFDWPLA
HHHHHHHHHHHCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHEECCHHHH
LLFGSLTVVTGPTVIVPLLRTVRPSTRLSNILRWEGILIDPLGALFVVMVYEFIVSSSET
HHHCCHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHCCCCC
HSLVVLAWILAIGLGLGVLFGQFLAVVLRRGWLPEYLQPFAVLSLVLGVFALSNHLEHES
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GLLTVTVMGMWLANSKGVDIKHILHFKEHLTILFITGLFILLAARIQPEDFYTLGISALV
CEEEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LFAFIQFVSRPVSIYLATLRSSLNGKEKAFLAWVAPRGIVAASISSLFAIKLESLGMSEA
HHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHH
ALLVPLTFMVIIGTVVLQSATARPVAVALGVSEPAPKGFLIIGANDVARTLAQAINKYDC
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHCCCCC
RVVLTDSNWDYIRQARMAGLDHYFGNPVSSHADEYLNLIGIGHVVALSPDRYFNIMACMH
EEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECEEEEECCCHHHHHHHHHH
FLNDFSDKRIFCLYDKSNGNGSGDKHSVSDGYKGLPFLDEAISYKKLASLINQGAEVRHT
HHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEE
KISENYTYADYRETHANNYVLPLFVVDTNGRVQICHNSANFSPKEGETIVSLIKVQEA
ECCCCCCCCCHHHHCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]