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The map label for this gene is mprA [H]

Identifier: 27363609

GI number: 27363609

Start: 112136

End: 112804

Strand: Reverse

Name: mprA [H]

Synonym: VV1_0126

Alternate gene names: 27363609

Gene position: 112804-112136 (Counterclockwise)

Preceding gene: 27363611

Following gene: 27363608

Centisome position: 3.44

GC content: 47.98

Gene sequence:

>669_bases
ATGAAAATTTTGTTAGTGGATGATAACCACAATGTGGCAGAAACGATTGCCGACTATCTGGAGCTCGAAGGCATCACCAT
CGATTGTGCGTATCATGGTGAAGCGGCGCTGCGATTGATTGAAACGAACCACTACGATGTGATTGTCATGGACATCATGA
TGCCTAAGCTTGACGGCATCAGTACGGTGAAGAAACTCAGAGAAGACTATCTTTGTGGGACGCCCATCCTATTTCTAACT
GCAAAACAGGGCTTGGATGACAAAATCGCGGCTTTTACTGCTGGTGGCGATGATTACCTATTGAAACCTTTTGCGATGCA
GGAACTGAGCTTGCGACTGCACGCATTGGCGAACCGAGGACCAAGACAAGATATTGGTGTGTTGAAATTTGCCGACATCA
CCTTGGATGTCAAAACCGAGCAGGTTGAACGCCAAGGTCAGCAGATCAAACTGAGCCGTATTCAGACGCGAATTTTGAAG
TTATTGATGAAGCGAGCGCCGGCAATCGTGTCACGCGTTGAAGTGATTGAAAGCGTGTGGGGCGATGAACCGCCGGGGAG
TGATGCTCTGCGTAGCCACATTTACGGTTTGCGCACCGCATTGGACAAAGGTTTTTCAGAATCACGATTAGAGACCATTC
ATGGACAAGGTTACCGACTCAAAGCATAG

Upstream 100 bases:

>100_bases
CTTCTTCATCTCTATCTGTACCCTATATGAATGGTGGATGTTTGGTTTTTCGCTATGTTAGGAAATGAGATGTGAAGCGA
TCGTGAAGAGATAAAACTGA

Downstream 100 bases:

>100_bases
CGCCTATCCTAGTATTTACCGCAAGATCCGTTGGAGCTTTGGTGTTCTGACCTTTCTGATGTTCACGCTGTTTTGGAGCT
TGATCTATGTGGCGGAAAAC

Product: putative two-component response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MKILLVDDNHNVAETIADYLELEGITIDCAYHGEAALRLIETNHYDVIVMDIMMPKLDGISTVKKLREDYLCGTPILFLT
AKQGLDDKIAAFTAGGDDYLLKPFAMQELSLRLHALANRGPRQDIGVLKFADITLDVKTEQVERQGQQIKLSRIQTRILK
LLMKRAPAIVSRVEVIESVWGDEPPGSDALRSHIYGLRTALDKGFSESRLETIHGQGYRLKA

Sequences:

>Translated_222_residues
MKILLVDDNHNVAETIADYLELEGITIDCAYHGEAALRLIETNHYDVIVMDIMMPKLDGISTVKKLREDYLCGTPILFLT
AKQGLDDKIAAFTAGGDDYLLKPFAMQELSLRLHALANRGPRQDIGVLKFADITLDVKTEQVERQGQQIKLSRIQTRILK
LLMKRAPAIVSRVEVIESVWGDEPPGSDALRSHIYGLRTALDKGFSESRLETIHGQGYRLKA
>Mature_222_residues
MKILLVDDNHNVAETIADYLELEGITIDCAYHGEAALRLIETNHYDVIVMDIMMPKLDGISTVKKLREDYLCGTPILFLT
AKQGLDDKIAAFTAGGDDYLLKPFAMQELSLRLHALANRGPRQDIGVLKFADITLDVKTEQVERQGQQIKLSRIQTRILK
LLMKRAPAIVSRVEVIESVWGDEPPGSDALRSHIYGLRTALDKGFSESRLETIHGQGYRLKA

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=31.8385650224215, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=32.7354260089686, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=30.8035714285714, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=30.7692307692308, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=30.0448430493274, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=28.125, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=32.15859030837, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=27.8761061946903, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=25.1121076233184, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1788550, Length=110, Percent_Identity=38.1818181818182, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=27.2321428571429, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=26.2222222222222, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=27.5109170305677, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=27.7533039647577, Blast_Score=83, Evalue=1e-17,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24859; Mature: 24859

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILLVDDNHNVAETIADYLELEGITIDCAYHGEAALRLIETNHYDVIVMDIMMPKLDGI
CEEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCEEEEEEECCCCEEEEEEEHHCCCCCH
STVKKLREDYLCGTPILFLTAKQGLDDKIAAFTAGGDDYLLKPFAMQELSLRLHALANRG
HHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCCEEECHHHHHHHHHHHHHHHCCC
PRQDIGVLKFADITLDVKTEQVERQGQQIKLSRIQTRILKLLMKRAPAIVSRVEVIESVW
CCCCCCEEEEEEEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDEPPGSDALRSHIYGLRTALDKGFSESRLETIHGQGYRLKA
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEECC
>Mature Secondary Structure
MKILLVDDNHNVAETIADYLELEGITIDCAYHGEAALRLIETNHYDVIVMDIMMPKLDGI
CEEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCEEEEEEECCCCEEEEEEEHHCCCCCH
STVKKLREDYLCGTPILFLTAKQGLDDKIAAFTAGGDDYLLKPFAMQELSLRLHALANRG
HHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCCEEECHHHHHHHHHHHHHHHCCC
PRQDIGVLKFADITLDVKTEQVERQGQQIKLSRIQTRILKLLMKRAPAIVSRVEVIESVW
CCCCCCEEEEEEEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDEPPGSDALRSHIYGLRTALDKGFSESRLETIHGQGYRLKA
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA