Click here to switch to the map view.

The map label for this gene is envZ [H]

Identifier: 27363524

GI number: 27363524

Start: 40895

End: 42331

Strand: Reverse

Name: envZ [H]

Synonym: VV1_0036

Alternate gene names: 27363524

Gene position: 42331-40895 (Counterclockwise)

Preceding gene: 27363525

Following gene: 27363523

Centisome position: 1.29

GC content: 50.73

Gene sequence:

>1437_bases
ATGAAGAGGTTTCGCCCCAACTCCTTGGTTGCCAGAACGCTGTTGCTCACCTTGCTCGCGGTGGTGATAGCTCAAGGGAT
CGCCACCGCTATCTGGTATAGCGAGTCCAAACAGAAAGAGCTGCAAGGCATTCGCTCTGCGTCGGAAAGCATGGCGGGCA
TGTTTGCCTCGACGGTGACCTTTTTCCAATCCTTACCCGTGCGTTATCGTCATATCGTGCTGGATCAGATCCGCAATATG
GGCGGCACGCGCTTTTTCGTCTCTTTCAATAAACAGAAGCTGACTGTTGAGCCGATTGCCGATACACCGTTAAAACTGGC
TTCGGTGCTGGCTGTCGAAAGCGTGCTGCAGCAAAAACTCACCAAGGTTGCCTCAATCTCCGTTGACTTCTCGCATCCGC
AAAATTTACGTTTGCTGAAAGACGATATCTATCTGCATGACCTACCCAAATCGTGGGCGCACCACACGCTTACTTTGGAG
CCGATCAATCCCCCCGTGTTGGTGGTGCAAATTGAGTTAGAAAGTCACGAGTGGATCTACATTGCCGCGCTGCTTCCCGC
ACCTTATTTGACCTTAGATGACACCATTTTAGGGCGTGAGCAGATCTTGTTTCTCTTCTTCTCAACCACGCTATTGTTAG
TGTTGACTTACACCATGATCCGTCGCCAGGTGAAGCCGCTCAAGCGCTTAGCCAAAGCGGCCAATGAAATGAGCATCAAT
ATCGAGCAGCCGCCGTTGCAAGAGGAAGGAGCGAGTGAGCTGGTGACAGCCACGCGCGCGTTTAATCGCATGCAGCAGCG
TATTCGCCGTTATGTGGCAGACCGAGAGCATCTTTTTTCCGCCATTTCTCACGATCTCAAAACGCCGATCACCCGTTTGC
GCATTCGAGCCGAGTTGCTCGAAGATGACACCAAACGCAGCAAGTTCAATCGCGATCTCGATGATTTAGAGATGATGGTC
AAAGGGGCGCTGCAGTGTGTGCGCGATACCGATTTGCATGAGAACAACGACTACATCGATCTCAATGCGATGATCGAGCA
TGTGATTGATACCTATAATCAGCACGATACTAAGGTCCATTTTCGTCCTATCATCATGGAGCCTATGGTGGCCAAGCCTC
TGGCGATAAAGCGAGTGCTCACCAATTTGATCGACAACGCGGTGAAATATGGTGAACAAGCGGTGGTGACACTCGAACAC
AGTGAGGAGTGGATTTACGTCACCATTGATGACCAAGGGCCGGGAATTGCGGAAGCGCAATTAGAGGCCGTGTTTGAACC
TTATTTCCGCTTAGCAAAGGACAGTGAAGGGCATGGATTAGGCTTAGGTATCTGCCGAAACATCTTACACGGACATGGTG
GAGATCTCATTATTAGCAATCTGCCGCAGGGTGGTTTACGTGCGCAAGTGCTGATTCCTAAAGGGCTGGAAGTGTAA

Upstream 100 bases:

>100_bases
TGGGCGACAGTGCACGCTACCCACACTACATCAAAACCATGCGCGGTAATGGCTATATTTTATCGGTGCCTGTTAGCTAC
GAACATTGAGGTGATTGGAG

Downstream 100 bases:

>100_bases
TGTAACAAAGGTGTTACTTTGTGGTTACGGTTTGTTGCAATGCTTATCTCCAGTTATGGATAGACTGCTCAATATCAGGC
ACGACCTGATCTGTCTAATC

Product: signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MKRFRPNSLVARTLLLTLLAVVIAQGIATAIWYSESKQKELQGIRSASESMAGMFASTVTFFQSLPVRYRHIVLDQIRNM
GGTRFFVSFNKQKLTVEPIADTPLKLASVLAVESVLQQKLTKVASISVDFSHPQNLRLLKDDIYLHDLPKSWAHHTLTLE
PINPPVLVVQIELESHEWIYIAALLPAPYLTLDDTILGREQILFLFFSTTLLLVLTYTMIRRQVKPLKRLAKAANEMSIN
IEQPPLQEEGASELVTATRAFNRMQQRIRRYVADREHLFSAISHDLKTPITRLRIRAELLEDDTKRSKFNRDLDDLEMMV
KGALQCVRDTDLHENNDYIDLNAMIEHVIDTYNQHDTKVHFRPIIMEPMVAKPLAIKRVLTNLIDNAVKYGEQAVVTLEH
SEEWIYVTIDDQGPGIAEAQLEAVFEPYFRLAKDSEGHGLGLGICRNILHGHGGDLIISNLPQGGLRAQVLIPKGLEV

Sequences:

>Translated_478_residues
MKRFRPNSLVARTLLLTLLAVVIAQGIATAIWYSESKQKELQGIRSASESMAGMFASTVTFFQSLPVRYRHIVLDQIRNM
GGTRFFVSFNKQKLTVEPIADTPLKLASVLAVESVLQQKLTKVASISVDFSHPQNLRLLKDDIYLHDLPKSWAHHTLTLE
PINPPVLVVQIELESHEWIYIAALLPAPYLTLDDTILGREQILFLFFSTTLLLVLTYTMIRRQVKPLKRLAKAANEMSIN
IEQPPLQEEGASELVTATRAFNRMQQRIRRYVADREHLFSAISHDLKTPITRLRIRAELLEDDTKRSKFNRDLDDLEMMV
KGALQCVRDTDLHENNDYIDLNAMIEHVIDTYNQHDTKVHFRPIIMEPMVAKPLAIKRVLTNLIDNAVKYGEQAVVTLEH
SEEWIYVTIDDQGPGIAEAQLEAVFEPYFRLAKDSEGHGLGLGICRNILHGHGGDLIISNLPQGGLRAQVLIPKGLEV
>Mature_478_residues
MKRFRPNSLVARTLLLTLLAVVIAQGIATAIWYSESKQKELQGIRSASESMAGMFASTVTFFQSLPVRYRHIVLDQIRNM
GGTRFFVSFNKQKLTVEPIADTPLKLASVLAVESVLQQKLTKVASISVDFSHPQNLRLLKDDIYLHDLPKSWAHHTLTLE
PINPPVLVVQIELESHEWIYIAALLPAPYLTLDDTILGREQILFLFFSTTLLLVLTYTMIRRQVKPLKRLAKAANEMSIN
IEQPPLQEEGASELVTATRAFNRMQQRIRRYVADREHLFSAISHDLKTPITRLRIRAELLEDDTKRSKFNRDLDDLEMMV
KGALQCVRDTDLHENNDYIDLNAMIEHVIDTYNQHDTKVHFRPIIMEPMVAKPLAIKRVLTNLIDNAVKYGEQAVVTLEH
SEEWIYVTIDDQGPGIAEAQLEAVFEPYFRLAKDSEGHGLGLGICRNILHGHGGDLIISNLPQGGLRAQVLIPKGLEV

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=280, Percent_Identity=31.7857142857143, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1790346, Length=269, Percent_Identity=29.7397769516729, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787894, Length=307, Percent_Identity=27.0358306188925, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=32.5991189427313, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1788393, Length=280, Percent_Identity=23.2142857142857, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790436, Length=200, Percent_Identity=28, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790551, Length=283, Percent_Identity=24.7349823321555, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790861, Length=298, Percent_Identity=24.8322147651007, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI87081816, Length=325, Percent_Identity=24, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786783, Length=232, Percent_Identity=25.8620689655172, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788549, Length=238, Percent_Identity=23.9495798319328, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789403, Length=289, Percent_Identity=24.5674740484429, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI48994928, Length=231, Percent_Identity=23.3766233766234, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788279, Length=273, Percent_Identity=22.7106227106227, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87082128, Length=283, Percent_Identity=24.7349823321555, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54203; Mature: 54203

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRFRPNSLVARTLLLTLLAVVIAQGIATAIWYSESKQKELQGIRSASESMAGMFASTVT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
FFQSLPVRYRHIVLDQIRNMGGTRFFVSFNKQKLTVEPIADTPLKLASVLAVESVLQQKL
HHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
TKVASISVDFSHPQNLRLLKDDIYLHDLPKSWAHHTLTLEPINPPVLVVQIELESHEWIY
HHHHHEEEECCCCCCCEEECCCHHEECCCHHHCCCEEEEECCCCCEEEEEEEECCCCEEE
IAALLPAPYLTLDDTILGREQILFLFFSTTLLLVLTYTMIRRQVKPLKRLAKAANEMSIN
EEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEE
IEQPPLQEEGASELVTATRAFNRMQQRIRRYVADREHLFSAISHDLKTPITRLRIRAELL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
EDDTKRSKFNRDLDDLEMMVKGALQCVRDTDLHENNDYIDLNAMIEHVIDTYNQHDTKVH
HCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHCCCCCCEEE
FRPIIMEPMVAKPLAIKRVLTNLIDNAVKYGEQAVVTLEHSEEWIYVTIDDQGPGIAEAQ
EEEEECCCHHCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCCHHHHH
LEAVFEPYFRLAKDSEGHGLGLGICRNILHGHGGDLIISNLPQGGLRAQVLIPKGLEV
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MKRFRPNSLVARTLLLTLLAVVIAQGIATAIWYSESKQKELQGIRSASESMAGMFASTVT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
FFQSLPVRYRHIVLDQIRNMGGTRFFVSFNKQKLTVEPIADTPLKLASVLAVESVLQQKL
HHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
TKVASISVDFSHPQNLRLLKDDIYLHDLPKSWAHHTLTLEPINPPVLVVQIELESHEWIY
HHHHHEEEECCCCCCCEEECCCHHEECCCHHHCCCEEEEECCCCCEEEEEEEECCCCEEE
IAALLPAPYLTLDDTILGREQILFLFFSTTLLLVLTYTMIRRQVKPLKRLAKAANEMSIN
EEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEE
IEQPPLQEEGASELVTATRAFNRMQQRIRRYVADREHLFSAISHDLKTPITRLRIRAELL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
EDDTKRSKFNRDLDDLEMMVKGALQCVRDTDLHENNDYIDLNAMIEHVIDTYNQHDTKVH
HCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHCCCCCCEEE
FRPIIMEPMVAKPLAIKRVLTNLIDNAVKYGEQAVVTLEHSEEWIYVTIDDQGPGIAEAQ
EEEEECCCHHCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCCHHHHH
LEAVFEPYFRLAKDSEGHGLGLGICRNILHGHGGDLIISNLPQGGLRAQVLIPKGLEV
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]