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The map label for this gene is hbd [H]

Identifier: 23502817

GI number: 23502817

Start: 1898417

End: 1899292

Strand: Reverse

Name: hbd [H]

Synonym: BR1969

Alternate gene names: 23502817

Gene position: 1899292-1898417 (Counterclockwise)

Preceding gene: 23502818

Following gene: 23502816

Centisome position: 90.11

GC content: 57.31

Gene sequence:

>876_bases
GTGGCAATCAAGACAGTAGGTATCATCGGCGCTGGCCAGATGGGCAGCGGCATCGCCCATGTATGCGCTCTGGCCGGATA
TAACGTGCTTTTGCATGATGCGGCACCAGACCGGCTGGAAAAGGGGATCGCTACCATCAATGGCAATATGGCGCGGCAGG
TCGCTTCCGGAAAATTGCAGGAAGAACAACGCGCTGACGCGATGAAGCTTATCCGCCCGGCAAACTCCATGGAGGATCTG
GCGGGTGTCGATCTTGCCATCGAGGCGGCGACGGAAGACGAAACCATCAAGCGCAAGATTTTCGCGCAGCTTTGCCCGGT
CCTGAACCCGGAAGCCATTCTGGCAACCAATACGTCATCGATTTCCATTACCCGGCTTGCATCCACGACCGATCGCCCTG
AACGCTTCATCGGCATTCACTTCATGAATCCGGTGCCGGTGATGAAGCTCGTCGAACTGGTGCGCAGCATTGCCACGGAA
GAAGATACGTTCCGCAAGTCCAATGATTTCGTCACCGCTCTCGGCAAAACCGTTACGGTGGCCGAAGACTTCCCGGCTTT
CATCGTCAACCGCATCCTGTTGCCGATGATCAACGAAGCAATCTATACGCTCTATGAAGGCGTGGGCAGCGTGGAAGCGA
TCGATACCGCCATGAAGCTTGGCGCGAACCATCCGATGGGGCCGCTGCAATTGGCCGACTTCATCGGCCTCGATACCTGC
CTTTCCATCATGCAGGTGCTGCATGACGGGCTTGCCGATTCCAAATATCGCCCGTGTCCGCTGCTCGTCAAATATGTCGA
GGCTGGCTGGCTTGGGCGCAAGACGGGCCGCGGCTTTTACGACTATCGCGGCGAACATCCCGTGCCGACGCGATAA

Upstream 100 bases:

>100_bases
AAAACCGTTTCATACTTTTGCTGGAAATGCTCTAGTCGCGAAATTTATACACTACCCGACCCGGTTTCGGGTCGGGCGGG
CGGATGAAGGAGTTAAAACG

Downstream 100 bases:

>100_bases
GGCATTTTCATCGGTGGAAATTCGGGGCTGGTTCAGAGGAACCAGCCCTTTTGTTTTTTCAGGATCTGTGCCGCCCCCAA
TAGGTTGGGTCTGTGGAAAA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MAIKTVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQEEQRADAMKLIRPANSMEDL
AGVDLAIEAATEDETIKRKIFAQLCPVLNPEAILATNTSSISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRSIATE
EDTFRKSNDFVTALGKTVTVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLGANHPMGPLQLADFIGLDTC
LSIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRGEHPVPTR

Sequences:

>Translated_291_residues
MAIKTVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQEEQRADAMKLIRPANSMEDL
AGVDLAIEAATEDETIKRKIFAQLCPVLNPEAILATNTSSISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRSIATE
EDTFRKSNDFVTALGKTVTVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLGANHPMGPLQLADFIGLDTC
LSIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRGEHPVPTR
>Mature_290_residues
AIKTVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQEEQRADAMKLIRPANSMEDLA
GVDLAIEAATEDETIKRKIFAQLCPVLNPEAILATNTSSISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRSIATEE
DTFRKSNDFVTALGKTVTVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLGANHPMGPLQLADFIGLDTCL
SIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRGEHPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=42.560553633218, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=41.042345276873, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI261878539, Length=290, Percent_Identity=32.4137931034483, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI68989263, Length=290, Percent_Identity=32.4137931034483, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI20127408, Length=282, Percent_Identity=30.8510638297872, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI115430219, Length=239, Percent_Identity=28.4518828451883, Blast_Score=78, Evalue=8e-15,
Organism=Escherichia coli, GI1787661, Length=285, Percent_Identity=40.3508771929825, Blast_Score=213, Evalue=9e-57,
Organism=Escherichia coli, GI1788682, Length=266, Percent_Identity=34.9624060150376, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1790281, Length=267, Percent_Identity=30.7116104868914, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17553560, Length=292, Percent_Identity=43.4931506849315, Blast_Score=220, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=41.1764705882353, Blast_Score=210, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI17563036, Length=289, Percent_Identity=37.7162629757785, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25144276, Length=283, Percent_Identity=33.2155477031802, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17508951, Length=283, Percent_Identity=33.2155477031802, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17508953, Length=283, Percent_Identity=33.2155477031802, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17558304, Length=283, Percent_Identity=31.8021201413428, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71985923, Length=282, Percent_Identity=28.3687943262411, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=26.0714285714286, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19921000, Length=292, Percent_Identity=34.2465753424658, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24583077, Length=292, Percent_Identity=34.2465753424658, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24583079, Length=292, Percent_Identity=34.2465753424658, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=26.25, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20129993, Length=224, Percent_Identity=25.4464285714286, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31596; Mature: 31465

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKTVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQ
CCEEEEEEEECCCCCCHHHHHHHHHCCCEEEECCCHHHHHHCHHHHCCHHHHHHHHCCHH
EEQRADAMKLIRPANSMEDLAGVDLAIEAATEDETIKRKIFAQLCPVLNPEAILATNTSS
HHHHHHHHHHHCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCC
ISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRSIATEEDTFRKSNDFVTALGKTVTV
EEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHCCEEEE
AEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLGANHPMGPLQLADFIGLDTC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LSIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRGEHPVPTR
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AIKTVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQ
CEEEEEEEECCCCCCHHHHHHHHHCCCEEEECCCHHHHHHCHHHHCCHHHHHHHHCCHH
EEQRADAMKLIRPANSMEDLAGVDLAIEAATEDETIKRKIFAQLCPVLNPEAILATNTSS
HHHHHHHHHHHCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCC
ISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRSIATEEDTFRKSNDFVTALGKTVTV
EEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHCCEEEE
AEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLGANHPMGPLQLADFIGLDTC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LSIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRGEHPVPTR
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]