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The map label for this gene is hemC [H]

Identifier: 23502739

GI number: 23502739

Start: 1821553

End: 1822497

Strand: Reverse

Name: hemC [H]

Synonym: BR1887

Alternate gene names: 23502739

Gene position: 1822497-1821553 (Counterclockwise)

Preceding gene: 23502745

Following gene: 23502738

Centisome position: 86.46

GC content: 62.54

Gene sequence:

>945_bases
ATGCAAACAGCATCCTTCAAGAATGGCACGTTGAAGATCGGCACCAGGGGCAGCAAGCTGGCTCTGGCACAGGCTTACCT
CACGCGCCGCCTTTTGCAGGAGGCTCATGGTTTGCCGGAAGATGCGATTGAAATCCTGCCCATGTCCACCGCAGGCGACC
GCATTCAGGACCGCCCGCTTTCGGAAGTTGGCGGCAAGGGGCTGTTTACGGAGGAAATCGAGCAGGCGCTGAAGGATGGG
CGAATCGATATTGCCGTCCACTCGACCAAGGATATGCCCACCGTCTTGCCAGAGGGGCTTCACCTTTCCGTTTTTCTGGA
GCGTGAGGACCCGCGCGACGCTTTCATCGGGCGCAGCGCAAGGCGTTTCATGGATTTGCCGCAGGGCGCCACCGTTGGCT
CGTCCTCGCTGCGCCGTCAGGCGCTTATTCGCCGTCTTCGCCCGGATATCGAGGTGGTGATGTATCGCGGCAATGTGGAT
ACCCGCCTGCGCAAGCTCGATGCGGGCGAAGTGGATGGCACTTTCCTTGCCTGTGCCGGTTTGCGCCGGCTCGGCCTTGC
CGATGTCATCACCGATCTTCTCGATCCATCCGTTTTCCCGCCTGCGCCGGGGCAGGGCGCAATCGGCATTGAAAGCCGCA
TTGGCGACGAGCGGATCGATGTGCTTCTTGCGCCGCTCGCCCATCGCGAAACGCAAATTGCGCTTGCCTGCGAGCGGGCC
TTTCTCGGCGCTCTCGACGGTTCCTGCCGTACGCCTATTGCCGGTCTTGCAACGGTCGAGGGCGACCGGTTGTCCTTCCG
GGGGATGATCCTGACGCCGGATGGCCGGCAGGCCCATGAAGTGACGGCCGAAGGGGTTGTCTCGGATGCAGCCGCGCTCG
GCACAGATGCGGCAAACCGCGTGCGCGCCATGGCGGGCCCGCATTTCTTTGATGGGTGGCAGTAG

Upstream 100 bases:

>100_bases
TGGCTCATATTGGCGCATGTTCAGCAAAAGTGGAAACCGGTTTTGCCTTTGGACATGCATGAAAACGAATGATGAAACCC
GGTACCATGGACGAGGCAAT

Downstream 100 bases:

>100_bases
CATTGTCGGAGCGGTGAAACCGGATGAAGCGGGTTCTTGTTACACGGCCTGAGCCGGCAGCAGCGCAAACCGCAGCAAAG
CTTCGCGCGGCGGGCTATGA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MQTASFKNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGKGLFTEEIEQALKDG
RIDIAVHSTKDMPTVLPEGLHLSVFLEREDPRDAFIGRSARRFMDLPQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVD
TRLRKLDAGEVDGTFLACAGLRRLGLADVITDLLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERA
FLGALDGSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRVRAMAGPHFFDGWQ

Sequences:

>Translated_314_residues
MQTASFKNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGKGLFTEEIEQALKDG
RIDIAVHSTKDMPTVLPEGLHLSVFLEREDPRDAFIGRSARRFMDLPQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVD
TRLRKLDAGEVDGTFLACAGLRRLGLADVITDLLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERA
FLGALDGSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRVRAMAGPHFFDGWQ
>Mature_314_residues
MQTASFKNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGKGLFTEEIEQALKDG
RIDIAVHSTKDMPTVLPEGLHLSVFLEREDPRDAFIGRSARRFMDLPQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVD
TRLRKLDAGEVDGTFLACAGLRRLGLADVITDLLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERA
FLGALDGSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRVRAMAGPHFFDGWQ

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=290, Percent_Identity=38.6206896551724, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI66933009, Length=285, Percent_Identity=38.5964912280702, Blast_Score=182, Evalue=4e-46,
Organism=Escherichia coli, GI48994974, Length=294, Percent_Identity=45.578231292517, Blast_Score=235, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6319996, Length=317, Percent_Identity=35.6466876971609, Blast_Score=174, Evalue=1e-44,
Organism=Drosophila melanogaster, GI20130425, Length=266, Percent_Identity=40.2255639097744, Blast_Score=188, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33880; Mature: 33880

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTASFKNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPL
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCHHCCCH
SEVGGKGLFTEEIEQALKDGRIDIAVHSTKDMPTVLPEGLHLSVFLEREDPRDAFIGRSA
HHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHCHHH
RRFMDLPQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLDAGEVDGTFLACAG
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHCCCCCCCCHHHHHHH
LRRLGLADVITDLLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERA
HHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHH
FLGALDGSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANR
HHHHCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHH
VRAMAGPHFFDGWQ
HHHHCCCCCCCCCC
>Mature Secondary Structure
MQTASFKNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPL
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCHHCCCH
SEVGGKGLFTEEIEQALKDGRIDIAVHSTKDMPTVLPEGLHLSVFLEREDPRDAFIGRSA
HHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHCHHH
RRFMDLPQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLDAGEVDGTFLACAG
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHCCCCCCCCHHHHHHH
LRRLGLADVITDLLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERA
HHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHH
FLGALDGSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANR
HHHHCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHH
VRAMAGPHFFDGWQ
HHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA