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The map label for this gene is proA

Identifier: 23502696

GI number: 23502696

Start: 1773983

End: 1775248

Strand: Reverse

Name: proA

Synonym: BR1843

Alternate gene names: 23502696

Gene position: 1775248-1773983 (Counterclockwise)

Preceding gene: 23502697

Following gene: 23502695

Centisome position: 84.22

GC content: 61.37

Gene sequence:

>1266_bases
ATGACGAAGGATATTGCGCAAGTGATGGCGGAGGTTGGCCGCAAGGCAAAAGCCGCTGCGGCTCCTCTCTCCATTGCCAC
GAGCGAGCAGAAGAACAAGGCGCTGAATGCCGCTGCCGATGCAATCCTTGAAGCGCGCGCCGATATTCTTGAAGCCAACA
GGCTTGATCTGGCCAATGCGGAAAAGAACGGCATGGCCGCTTCCTTCGTGGACCGGCTGACGCTCAACGAAGCGCGCATT
GACGCGATTGCGGAAGATATCCGCGCCATTGCCACACTGCCCGACCCGGTTGGTGAAGTGATTGCCGAATGGGACCGCCC
CAACGGCCTGCATATCGAACGTGTGCGCACGCCGCTTGGCGTGATCGGTGTCATCTATGAAAGCCGCCCCAATGTGACCG
CCGATGCCGGCGCGCTGTGCCTCAAGGCGGGCAATGCCGTCATCCTGCGTGGCGGCTCGGATTCGGCGCATTCCTCGGCT
GCCATTCACAAGGCGCTGGTCAAGGGGCTTGAAGCCGCCAATCTGCCGGCCGATGCAATCCAGATCGTGCCGGTGACGGA
CAGGGCTGCCGTTGGTGAAATGCTCAAAGGTCTTGGCGGCGCGATTGATGTCATTGTGCCGCGCGGCGGCAAAAGCCTCG
TTGCCCGCGTGCAATCGGAAGCGCGGGTGCCGGTTTTCGCGCATCTGGAAGGCATCTGCCATCTTTATATCGACAAGTCG
GCTGATCTGGACATGGCGCGCAGGATTGCGCTCGATGCCAAGATGCGGCGCACCGGCATTTGCGGGGCTGCGGAAACGCT
GCTGGTGGATCGTGCTGTAGCTTCGACGCATCTGGCGCCGATCCTCGGCGATCTGGCTGCCGGGGGCTGCGAAATTCGCG
GCAGCGCGGAGGTGCTGGCGCTCTATCCGGCGGCAAAGCCTGCGACGGAGGAGGACTGGTCAACCGAATATCTCGACGCG
ATCATTTCCGTGGCGCTGGTTGACGGCATTTCGGGTGCGATAGACCATATCAACCGCTATTCTTCGCATCACACCGAAGC
CATCGTGGCCGAGGATGCGCAGACCGTTGCGCGTTTCTTCAACGAGATCGATTCAGCCATTTTGCTGCACAATGCCTCCA
CGCAATTTGCCGATGGCGGCGAGTTCGGCATGGGCGCGGAAATCGGCATCGCCACCGGTAAGATGCATGCGCGCGGGCCG
GTTGGCGTCGAGCAGCTGACCTCGTTCAAATATCGTGTGCGCGGCAGCGGCCAGGTTCGGGGTTAA

Upstream 100 bases:

>100_bases
TGATGCCCGCGCGGCGATGATCCATCGCAACGATCTGGTGGTGCGGGCCGCCAGCGATGCGAAAGCCGCATAGGGGGATA
GGATGTTGGTCAAGGCGGAT

Downstream 100 bases:

>100_bases
TGAAATTCGGCTTCGGGCTTTCTGCGCTCAAGGAACAATATCCCGGCGTTGATGCGCATTATCTGCGTATGCCGCATGTC
GAAAAGGGCATGACGGTGGG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MTKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANRLDLANAEKNGMAASFVDRLTLNEARI
DAIAEDIRAIATLPDPVGEVIAEWDRPNGLHIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSDSAHSSA
AIHKALVKGLEAANLPADAIQIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICHLYIDKS
ADLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRGSAEVLALYPAAKPATEEDWSTEYLDA
IISVALVDGISGAIDHINRYSSHHTEAIVAEDAQTVARFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGP
VGVEQLTSFKYRVRGSGQVRG

Sequences:

>Translated_421_residues
MTKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANRLDLANAEKNGMAASFVDRLTLNEARI
DAIAEDIRAIATLPDPVGEVIAEWDRPNGLHIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSDSAHSSA
AIHKALVKGLEAANLPADAIQIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICHLYIDKS
ADLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRGSAEVLALYPAAKPATEEDWSTEYLDA
IISVALVDGISGAIDHINRYSSHHTEAIVAEDAQTVARFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGP
VGVEQLTSFKYRVRGSGQVRG
>Mature_420_residues
TKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANRLDLANAEKNGMAASFVDRLTLNEARID
AIAEDIRAIATLPDPVGEVIAEWDRPNGLHIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSDSAHSSAA
IHKALVKGLEAANLPADAIQIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICHLYIDKSA
DLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRGSAEVLALYPAAKPATEEDWSTEYLDAI
ISVALVDGISGAIDHINRYSSHHTEAIVAEDAQTVARFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPV
GVEQLTSFKYRVRGSGQVRG

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=410, Percent_Identity=36.8292682926829, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI62912457, Length=410, Percent_Identity=36.8292682926829, Blast_Score=259, Evalue=3e-69,
Organism=Escherichia coli, GI1786438, Length=416, Percent_Identity=39.9038461538462, Blast_Score=314, Evalue=8e-87,
Organism=Caenorhabditis elegans, GI17569967, Length=416, Percent_Identity=35.5769230769231, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17569969, Length=416, Percent_Identity=35.5769230769231, Blast_Score=249, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6324899, Length=431, Percent_Identity=34.5707656612529, Blast_Score=259, Evalue=6e-70,
Organism=Drosophila melanogaster, GI21357643, Length=419, Percent_Identity=36.7541766109785, Blast_Score=240, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_BRUC2 (A9M880)

Other databases:

- EMBL:   CP000872
- RefSeq:   YP_001593649.1
- ProteinModelPortal:   A9M880
- SMR:   A9M880
- GeneID:   5784302
- GenomeReviews:   CP000872_GR
- KEGG:   bcs:BCAN_A1881
- HOGENOM:   HBG318080
- OMA:   ITHINRY
- ProtClustDB:   PRK00197
- BioCyc:   BCAN483179:BCAN_A1881-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44100; Mature: 43969

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANRLDLANA
CCHHHHHHHHHHCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EKNGMAASFVDRLTLNEARIDAIAEDIRAIATLPDPVGEVIAEWDRPNGLHIERVRTPLG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEHHHHHCCHH
VIGVIYESRPNVTADAGALCLKAGNAVILRGGSDSAHSSAAIHKALVKGLEAANLPADAI
EEEEEEECCCCCCCCCCHHEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
QIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICHLYIDKS
EEEECCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHCCEEEEEECCC
ADLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRGSAEVLA
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEE
LYPAAKPATEEDWSTEYLDAIISVALVDGISGAIDHINRYSSHHTEAIVAEDAQTVARFF
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHH
NEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRVRGSGQVR
HHHCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCCCEEECCCCCCC
G
C
>Mature Secondary Structure 
TKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANRLDLANA
CHHHHHHHHHHCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EKNGMAASFVDRLTLNEARIDAIAEDIRAIATLPDPVGEVIAEWDRPNGLHIERVRTPLG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEHHHHHCCHH
VIGVIYESRPNVTADAGALCLKAGNAVILRGGSDSAHSSAAIHKALVKGLEAANLPADAI
EEEEEEECCCCCCCCCCHHEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
QIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICHLYIDKS
EEEECCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHCCEEEEEECCC
ADLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRGSAEVLA
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEE
LYPAAKPATEEDWSTEYLDAIISVALVDGISGAIDHINRYSSHHTEAIVAEDAQTVARFF
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHH
NEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRVRGSGQVR
HHHCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCCCEEECCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA