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The map label for this gene is glcD [H]

Identifier: 23502281

GI number: 23502281

Start: 1362445

End: 1363851

Strand: Reverse

Name: glcD [H]

Synonym: BR1410

Alternate gene names: 23502281

Gene position: 1363851-1362445 (Counterclockwise)

Preceding gene: 23502282

Following gene: 23502280

Centisome position: 64.71

GC content: 59.56

Gene sequence:

>1407_bases
ATGTCACTGGAAAATGTGGTTGCACTTGCGCGTAACGAAGCCGGTATTGCGGCAGCGGTGGGTATCCTGAAACAGCGTTT
CGGCGAGCGCGCCCAGACGGGACAGGCTATTCGCGAGCAGCACGGCCACACCACCACCTATGTGCCGACGCAGGCGCCCG
ACATCGTTGTTTTTGCTGAAAATACGCAGGATGTGCAGGATGTGGTGCGTATCTGCGCCGAGCATCGCGTACCGGTGGTT
GCCTTTGGTGCGGGCTCCTCACTTGAAGGGCAGGTGAATGCGCCAGCGGGCGGTGTGTCGCTGGACATGACCCATATGAA
CCGGGTGATTGCCGTTCACGCGGAAGATCTGGATTGCGTCGTGGAGCCGGGCGTGACGCGGCGCGCGTTGAATGAATATT
TGCGCGATACCGGCCTGTTCTTCCCGATCGATCCGGGTGCAAACGCAACGCTTGGCGGAATGGCTTCCACGCGCGCCTCC
GGCACCAATGCGGTGCGCTATGGCACGATGCGCGAAAACGTACTGGCGCTGAAGGCCGTCATGCCGGATGGCCGCCTGAT
CGAAACATCGAAGCGGGTGAAAAAGACCGCCGCAGGCTACGACCTCACGCGGTTGCTCATCGGCGCGGAAGGAACGCTCG
GCATTATCACCGAATTGACAATGAAATTGCAGGGCATTCCGCAGGCAATTTCCGGTGGCATCTGCCCATTCCCGGACGTG
GATTCGGCCTGCCGCACGGTGATCGAAACGATCCAGATGGGCATTCCGGTGGCGCGTATCGAACTCGTCAACACGCTGCA
AATGCAGGCGCTTATCATGCATTCCAAGCTGCCTTACGAGGCGCAACCCTATCTCTTCGTGGAATTCCACGGCACGGAAA
GCGGTGTTGGTGAGCAGGCGGAACTGTTCGGCGAGATTGCCGCCGGTCATGGCGGCGGTGCATTCCAATGGACGCATGAT
GCCGAAGAACGCGACCGGCTGTGGCGGGCGCGGCACGAGGCATATCTTGCCTCGTTCCTCCTTCGTCCGGGCTGCAAGGG
CGTTTCCACCGATGTCTGCGTTCCGATCTCGCGCCTTGCCGACTGTATCGGCGAGACGGAAAAGGACCTTGCCGAAACCG
GTCTTATCGCGCCGATTGTAGGGCATGTCGGGGACGGTAATTTCCATCTTCTCCTGCTGCTCGATACCGACGATGCGTCG
GAAATGGAGCGGGCGGAAGCCTTCATGGATCGCCTTGCCAAACGTGCCATCGCCATGGAAGGTACCTGCACCGGCGAGCA
CGGCATCGGGCAAGGCAAGATGAAGTATCTGGCCATGGAGCTTGGCACGGCGACGGACTATATGCGTGCTATCAAGAAAG
CGCTTGATCCGGACAACATCATGAACCCCGGCAAAATACTGATTTGA

Upstream 100 bases:

>100_bases
TCACAATCTCGTCGTGCGCGCTGTTGCCGAACATGTGGGGCAGGACCCGGTTGCGCTGGCGCTGCCTGCGGCCTGAAAAT
CTGAATACGGAGAATGAACC

Downstream 100 bases:

>100_bases
TGATTCAAATCAGCCATTTGGATGGGTTTGCCGAGAAACTGATTCAGATGGACGTGCATATTGATGCGGCGGTGATGCAA
TTTGCCTTGTTGTCGGCGGA

Product: FAD-binding oxidoreductase

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSLENVVALARNEAGIAAAVGILKQRFGERAQTGQAIREQHGHTTTYVPTQAPDIVVFAENTQDVQDVVRICAEHRVPVV
AFGAGSSLEGQVNAPAGGVSLDMTHMNRVIAVHAEDLDCVVEPGVTRRALNEYLRDTGLFFPIDPGANATLGGMASTRAS
GTNAVRYGTMRENVLALKAVMPDGRLIETSKRVKKTAAGYDLTRLLIGAEGTLGIITELTMKLQGIPQAISGGICPFPDV
DSACRTVIETIQMGIPVARIELVNTLQMQALIMHSKLPYEAQPYLFVEFHGTESGVGEQAELFGEIAAGHGGGAFQWTHD
AEERDRLWRARHEAYLASFLLRPGCKGVSTDVCVPISRLADCIGETEKDLAETGLIAPIVGHVGDGNFHLLLLLDTDDAS
EMERAEAFMDRLAKRAIAMEGTCTGEHGIGQGKMKYLAMELGTATDYMRAIKKALDPDNIMNPGKILI

Sequences:

>Translated_468_residues
MSLENVVALARNEAGIAAAVGILKQRFGERAQTGQAIREQHGHTTTYVPTQAPDIVVFAENTQDVQDVVRICAEHRVPVV
AFGAGSSLEGQVNAPAGGVSLDMTHMNRVIAVHAEDLDCVVEPGVTRRALNEYLRDTGLFFPIDPGANATLGGMASTRAS
GTNAVRYGTMRENVLALKAVMPDGRLIETSKRVKKTAAGYDLTRLLIGAEGTLGIITELTMKLQGIPQAISGGICPFPDV
DSACRTVIETIQMGIPVARIELVNTLQMQALIMHSKLPYEAQPYLFVEFHGTESGVGEQAELFGEIAAGHGGGAFQWTHD
AEERDRLWRARHEAYLASFLLRPGCKGVSTDVCVPISRLADCIGETEKDLAETGLIAPIVGHVGDGNFHLLLLLDTDDAS
EMERAEAFMDRLAKRAIAMEGTCTGEHGIGQGKMKYLAMELGTATDYMRAIKKALDPDNIMNPGKILI
>Mature_467_residues
SLENVVALARNEAGIAAAVGILKQRFGERAQTGQAIREQHGHTTTYVPTQAPDIVVFAENTQDVQDVVRICAEHRVPVVA
FGAGSSLEGQVNAPAGGVSLDMTHMNRVIAVHAEDLDCVVEPGVTRRALNEYLRDTGLFFPIDPGANATLGGMASTRASG
TNAVRYGTMRENVLALKAVMPDGRLIETSKRVKKTAAGYDLTRLLIGAEGTLGIITELTMKLQGIPQAISGGICPFPDVD
SACRTVIETIQMGIPVARIELVNTLQMQALIMHSKLPYEAQPYLFVEFHGTESGVGEQAELFGEIAAGHGGGAFQWTHDA
EERDRLWRARHEAYLASFLLRPGCKGVSTDVCVPISRLADCIGETEKDLAETGLIAPIVGHVGDGNFHLLLLLDTDDASE
MERAEAFMDRLAKRAIAMEGTCTGEHGIGQGKMKYLAMELGTATDYMRAIKKALDPDNIMNPGKILI

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=444, Percent_Identity=50, Blast_Score=464, Evalue=1e-131,
Organism=Homo sapiens, GI37595754, Length=467, Percent_Identity=47.5374732334047, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI119964728, Length=429, Percent_Identity=27.972027972028, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI4501993, Length=460, Percent_Identity=25.6521739130435, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1789351, Length=418, Percent_Identity=28.7081339712919, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1787977, Length=498, Percent_Identity=27.710843373494, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI48994907, Length=443, Percent_Identity=23.4762979683973, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI48994914, Length=173, Percent_Identity=27.1676300578035, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71992373, Length=441, Percent_Identity=45.3514739229025, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71992381, Length=441, Percent_Identity=44.2176870748299, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71992392, Length=376, Percent_Identity=48.6702127659575, Blast_Score=373, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17556096, Length=481, Percent_Identity=24.3243243243243, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17534361, Length=439, Percent_Identity=22.5512528473804, Blast_Score=105, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6320027, Length=473, Percent_Identity=38.6892177589852, Blast_Score=303, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6320764, Length=446, Percent_Identity=25.5605381165919, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6320023, Length=449, Percent_Identity=27.1714922048998, Blast_Score=130, Evalue=6e-31,
Organism=Drosophila melanogaster, GI18921117, Length=418, Percent_Identity=27.2727272727273, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24639277, Length=418, Percent_Identity=27.2727272727273, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24639275, Length=418, Percent_Identity=27.2727272727273, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24653753, Length=455, Percent_Identity=26.3736263736264, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 50317; Mature: 50186

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLENVVALARNEAGIAAAVGILKQRFGERAQTGQAIREQHGHTTTYVPTQAPDIVVFAE
CCHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEC
NTQDVQDVVRICAEHRVPVVAFGAGSSLEGQVNAPAGGVSLDMTHMNRVIAVHAEDLDCV
CCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEHHHCCEEEEEEECCCCEE
VEPGVTRRALNEYLRDTGLFFPIDPGANATLGGMASTRASGTNAVRYGTMRENVLALKAV
ECCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCEEECCHHHHHEEEEEE
MPDGRLIETSKRVKKTAAGYDLTRLLIGAEGTLGIITELTMKLQGIPQAISGGICPFPDV
CCCCCEEHHHHHHHHHHCCCCHHHHEECCCCCHHHHHHHHHHHCCCCHHHCCCCCCCCCC
DSACRTVIETIQMGIPVARIELVNTLQMQALIMHSKLPYEAQPYLFVEFHGTESGVGEQA
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCHHH
ELFGEIAAGHGGGAFQWTHDAEERDRLWRARHEAYLASFLLRPGCKGVSTDVCVPISRLA
HHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
DCIGETEKDLAETGLIAPIVGHVGDGNFHLLLLLDTDDASEMERAEAFMDRLAKRAIAME
HHHCCHHHHHHHCCCHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
GTCTGEHGIGQGKMKYLAMELGTATDYMRAIKKALDPDNIMNPGKILI
CCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEC
>Mature Secondary Structure 
SLENVVALARNEAGIAAAVGILKQRFGERAQTGQAIREQHGHTTTYVPTQAPDIVVFAE
CHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEC
NTQDVQDVVRICAEHRVPVVAFGAGSSLEGQVNAPAGGVSLDMTHMNRVIAVHAEDLDCV
CCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEHHHCCEEEEEEECCCCEE
VEPGVTRRALNEYLRDTGLFFPIDPGANATLGGMASTRASGTNAVRYGTMRENVLALKAV
ECCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCEEECCHHHHHEEEEEE
MPDGRLIETSKRVKKTAAGYDLTRLLIGAEGTLGIITELTMKLQGIPQAISGGICPFPDV
CCCCCEEHHHHHHHHHHCCCCHHHHEECCCCCHHHHHHHHHHHCCCCHHHCCCCCCCCCC
DSACRTVIETIQMGIPVARIELVNTLQMQALIMHSKLPYEAQPYLFVEFHGTESGVGEQA
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCHHH
ELFGEIAAGHGGGAFQWTHDAEERDRLWRARHEAYLASFLLRPGCKGVSTDVCVPISRLA
HHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
DCIGETEKDLAETGLIAPIVGHVGDGNFHLLLLLDTDDASEMERAEAFMDRLAKRAIAME
HHHCCHHHHHHHCCCHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
GTCTGEHGIGQGKMKYLAMELGTATDYMRAIKKALDPDNIMNPGKILI
CCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]