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The map label for this gene is cobQ [H]

Identifier: 23502187

GI number: 23502187

Start: 1270943

End: 1272394

Strand: Reverse

Name: cobQ [H]

Synonym: BR1311

Alternate gene names: 23502187

Gene position: 1272394-1270943 (Counterclockwise)

Preceding gene: 23502188

Following gene: 23502186

Centisome position: 60.37

GC content: 60.61

Gene sequence:

>1452_bases
ATGGCTCGTGCGATCATGTTTCAGGGAACCGGCTCGGATGTCGGCAAGAGTGTTCTTGTCGCCGGGCTTTGCCGCGTTGC
GCGCAATCGCGGCCTGAAGGTGCGCCCGTTCAAGCCGCAGAATATGTCGAACAATGCCGCCGTCAGTGATGATGGGGGCG
AGATCGGTCGCGCGCAATGGCTTCAGGCGCTTGCCTGCGGCGTGCCGTCTTCGGTGCATATGAACCCGGTTCTGCTCAAA
CCCCAGACGGATATGGGCAGTCAGCTTATTGTGCAGGGGCAGGTGCGCGGTGAGGCGCGCGGGCGTTATTATCAGGAATT
GAAGCCGCAGCTCATGGCGGCGGTGATGGAGTCTTTTGCAAAGGTTGGTGACGGCGCCGATCTGGTGCTGGTGGAAGGCG
CGGGTTCTCCGGCTGAAATCAATCTTCGCGCGGGCGATATAGCCAATATGGGCTTTGCCACCCATGCAGATGTTCCGGTC
GTTCTGGTTGGTGATATCGACCGGGGCGGGGTGATTGCCTCTCTGGTTGGCACGCACACGATTTTGCCGCAGGAAGACCG
CGCCATGGTGCGGGGCTTTCTCATCAACAAGTTTCGCGGCGATATTTCCCTTTTTGATGATGGTCTTGCGGCGATCACGC
GGTTTACCGGCTGGCGCTCTTTCGGTGTGGTGCCGTGGCTGAAGGCGGTGTCGCGTCTGCCAGCGGAGGATTCCGTCGTT
CTGGAGCGCGCGGTGCGCGGGGACAAAAAAGCGCTCATCGTGGCCGTGCCCATGCTGCCGCGCATCGCCAATTTTGACGA
TCTCGATCCTTTGAAGGCGGAGCCTGCGGTCGAGGTGGTGATGGTGCCGCCGGGCTCCAGCCTGCCTGCGGATGCGGGGC
TTGTCGTGTTGCCCGGCACCAAATCCACGATTGCCGATCTGCTGGCGCTGCGTGAAAACGGCTGGGACCGCGAATTGGTC
GCCCATGTGAAGCGGGGCGGGCATGTGCTTGGTATTTGCGGCGGGTTTCAAATGCTTGGACGGCGGATCAGTGACCCGGC
GGGTATTGAAGGCAATGTGCGCGATATCGAGGGGCTGGGCCTTCTCGATATCGAGACGATGATGGAGCCGGAAAAAGTGG
TTCGCAATGTTGAGGCGGTGTCGCTGCTGCATGATGAGCCGCTGGAGGGCTATGAAATCCACATCGGGCGCACCAGCGGG
CCGGATATGGCGCGGCCATTTGCGCGTATCGGCGATCATGATGATGGGGCCGTCTCGCCCGATGGTCGTATCATGGGAAC
CTATCTCCACGGTGTTTTCAGTGCGGATCGTTTCCGCCACCACTTTTTGCGCGCGCTGGGTGTGGAAGGCGGCCAGATGA
ATTATCGCGAGAGCGTCGAAGAGGCTCTGGACGAACTGGCTGAAGGGCTGGAAGCCTCGCTGGATATTGATGGCCTGTTT
GCGCTGGCATGA

Upstream 100 bases:

>100_bases
GTTCCGGTTAAAGCGGAACCGCTCTCACTATTTGTTTTGTCGCATTATCCTACGCAAAACCGCTTCGCACTTTTGCTGGA
AATGCTCTAGGCAGGCTCCC

Downstream 100 bases:

>100_bases
TTGACGCCGCGAAGCCGAAAGCCTAGTGTCAAACCATGTGACAGGTTTTGCCGGAACGAATCCCCGGCAATACCAAAAGG
GAATGCGACGGACGGACCCA

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MARAIMFQGTGSDVGKSVLVAGLCRVARNRGLKVRPFKPQNMSNNAAVSDDGGEIGRAQWLQALACGVPSSVHMNPVLLK
PQTDMGSQLIVQGQVRGEARGRYYQELKPQLMAAVMESFAKVGDGADLVLVEGAGSPAEINLRAGDIANMGFATHADVPV
VLVGDIDRGGVIASLVGTHTILPQEDRAMVRGFLINKFRGDISLFDDGLAAITRFTGWRSFGVVPWLKAVSRLPAEDSVV
LERAVRGDKKALIVAVPMLPRIANFDDLDPLKAEPAVEVVMVPPGSSLPADAGLVVLPGTKSTIADLLALRENGWDRELV
AHVKRGGHVLGICGGFQMLGRRISDPAGIEGNVRDIEGLGLLDIETMMEPEKVVRNVEAVSLLHDEPLEGYEIHIGRTSG
PDMARPFARIGDHDDGAVSPDGRIMGTYLHGVFSADRFRHHFLRALGVEGGQMNYRESVEEALDELAEGLEASLDIDGLF
ALA

Sequences:

>Translated_483_residues
MARAIMFQGTGSDVGKSVLVAGLCRVARNRGLKVRPFKPQNMSNNAAVSDDGGEIGRAQWLQALACGVPSSVHMNPVLLK
PQTDMGSQLIVQGQVRGEARGRYYQELKPQLMAAVMESFAKVGDGADLVLVEGAGSPAEINLRAGDIANMGFATHADVPV
VLVGDIDRGGVIASLVGTHTILPQEDRAMVRGFLINKFRGDISLFDDGLAAITRFTGWRSFGVVPWLKAVSRLPAEDSVV
LERAVRGDKKALIVAVPMLPRIANFDDLDPLKAEPAVEVVMVPPGSSLPADAGLVVLPGTKSTIADLLALRENGWDRELV
AHVKRGGHVLGICGGFQMLGRRISDPAGIEGNVRDIEGLGLLDIETMMEPEKVVRNVEAVSLLHDEPLEGYEIHIGRTSG
PDMARPFARIGDHDDGAVSPDGRIMGTYLHGVFSADRFRHHFLRALGVEGGQMNYRESVEEALDELAEGLEASLDIDGLF
ALA
>Mature_482_residues
ARAIMFQGTGSDVGKSVLVAGLCRVARNRGLKVRPFKPQNMSNNAAVSDDGGEIGRAQWLQALACGVPSSVHMNPVLLKP
QTDMGSQLIVQGQVRGEARGRYYQELKPQLMAAVMESFAKVGDGADLVLVEGAGSPAEINLRAGDIANMGFATHADVPVV
LVGDIDRGGVIASLVGTHTILPQEDRAMVRGFLINKFRGDISLFDDGLAAITRFTGWRSFGVVPWLKAVSRLPAEDSVVL
ERAVRGDKKALIVAVPMLPRIANFDDLDPLKAEPAVEVVMVPPGSSLPADAGLVVLPGTKSTIADLLALRENGWDRELVA
HVKRGGHVLGICGGFQMLGRRISDPAGIEGNVRDIEGLGLLDIETMMEPEKVVRNVEAVSLLHDEPLEGYEIHIGRTSGP
DMARPFARIGDHDDGAVSPDGRIMGTYLHGVFSADRFRHHFLRALGVEGGQMNYRESVEEALDELAEGLEASLDIDGLFA
LA

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 51706; Mature: 51575

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARAIMFQGTGSDVGKSVLVAGLCRVARNRGLKVRPFKPQNMSNNAAVSDDGGEIGRAQW
CCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEECCCCCCCCHHHH
LQALACGVPSSVHMNPVLLKPQTDMGSQLIVQGQVRGEARGRYYQELKPQLMAAVMESFA
HHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
KVGDGADLVLVEGAGSPAEINLRAGDIANMGFATHADVPVVLVGDIDRGGVIASLVGTHT
HHCCCCCEEEEECCCCCCEEEEECCCCCCCCCEECCCCCEEEEECCCCCCCHHHHHHHHC
ILPQEDRAMVRGFLINKFRGDISLFDDGLAAITRFTGWRSFGVVPWLKAVSRLPAEDSVV
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHH
LERAVRGDKKALIVAVPMLPRIANFDDLDPLKAEPAVEVVMVPPGSSLPADAGLVVLPGT
HHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCC
KSTIADLLALRENGWDRELVAHVKRGGHVLGICGGFQMLGRRISDPAGIEGNVRDIEGLG
HHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCC
LLDIETMMEPEKVVRNVEAVSLLHDEPLEGYEIHIGRTSGPDMARPFARIGDHDDGAVSP
EEEHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCC
DGRIMGTYLHGVFSADRFRHHFLRALGVEGGQMNYRESVEEALDELAEGLEASLDIDGLF
CCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEE
ALA
ECC
>Mature Secondary Structure 
ARAIMFQGTGSDVGKSVLVAGLCRVARNRGLKVRPFKPQNMSNNAAVSDDGGEIGRAQW
CCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEECCCCCCCCHHHH
LQALACGVPSSVHMNPVLLKPQTDMGSQLIVQGQVRGEARGRYYQELKPQLMAAVMESFA
HHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
KVGDGADLVLVEGAGSPAEINLRAGDIANMGFATHADVPVVLVGDIDRGGVIASLVGTHT
HHCCCCCEEEEECCCCCCEEEEECCCCCCCCCEECCCCCEEEEECCCCCCCHHHHHHHHC
ILPQEDRAMVRGFLINKFRGDISLFDDGLAAITRFTGWRSFGVVPWLKAVSRLPAEDSVV
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHH
LERAVRGDKKALIVAVPMLPRIANFDDLDPLKAEPAVEVVMVPPGSSLPADAGLVVLPGT
HHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCC
KSTIADLLALRENGWDRELVAHVKRGGHVLGICGGFQMLGRRISDPAGIEGNVRDIEGLG
HHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCC
LLDIETMMEPEKVVRNVEAVSLLHDEPLEGYEIHIGRTSGPDMARPFARIGDHDDGAVSP
EEEHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCC
DGRIMGTYLHGVFSADRFRHHFLRALGVEGGQMNYRESVEEALDELAEGLEASLDIDGLF
CCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEE
ALA
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA