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The map label for this gene is cobC [H]

Identifier: 23502171

GI number: 23502171

Start: 1255543

End: 1256541

Strand: Reverse

Name: cobC [H]

Synonym: BR1295

Alternate gene names: 23502171

Gene position: 1256541-1255543 (Counterclockwise)

Preceding gene: 23502172

Following gene: 23502170

Centisome position: 59.61

GC content: 60.76

Gene sequence:

>999_bases
GTGAGCGTGGAAATCGAGCATGGTGGCGCGCTGGACCGGGCCATCGCGCGCTTTGGCGGCTCGGCGCAGGACTGGCTCGA
TCTTTCAACGGGCATCAATCCCGAACATTTTCCGCTACCCGAATTTTCACCGGAAATCTGGAATCGCCTGCCCGATGAGG
GGCTGTTGCAAACCACGCTGGCGCTTGCACGCCGCTACTATCGCATCGGTGAAAACGCACCCATCGTGGCCGCGCCCGGT
ACGCAGGCCCTGATCCAGCTCATGCCCATGCTGGCTGCCCCTTCCACCGTCGCCATTCTGGGGCCGACCTATCAGGAACA
CGCGGCGGCTTTTGCGGCAGCTAGTTGGAACGTGGTTTCCTGTGCCACAATCGACGATATTCCCGCCAGTGCGACGGTTG
CCGTCATCGTCAATCCAAATAACCCGGATGGCCGCGTTATCGCCCGCGATGCGCTGCTGGCGCTTGCGAATAGGCTTGGC
GAGCGAGGCGGATTTCTTGTCGTGGACGAAGCTTTTGCCGATGCGCATGAAGCGGTGAGCATTGCTTGCGAAGCAGAAGC
TGCGCCGCTTGTCGTGCTCAAATCTTTCGGCAAGTTCTTTGGGCTGGCCGGGATTCGGCTGGGCTTCGCTGTTGCGAATG
CCGATTATGCCGCTCGCTTGCGGTTGCGGCTTGGCCCGTGGGCGGTGTCCGGTCCGGCACTTGCCATTGCCAACAGCGCC
TTCGCAAATGCTGCCGTCGTCACGGATTTCCGCGCCCGGATCGATCTTCGCCGGCTTGCCCTTTCCGCAGTGCTGGAGCG
GGCAGGCCTGACGGAAGTTGGCGGCACGGCGCTGTTTTCACTGGTTGAACATATCGATGCGCACAGCCTTTATAATGCCT
TGTGCGAAAGGCATATTCTCGTTCGCAAGTTCGATTATGCGCCGGATTGGCTGCGTATCGGCCTTGCGCATGACGACGCT
GCCCTGGCGCGGCTGGAACAAGCATTGTGCGACATGTGA

Upstream 100 bases:

>100_bases
TGCGCGATGCATCGGGCGAGAACCTTGGCGAAGCGGGCTTGCGGGTTGGTTCCGTCTCCGGCTCCTTCATGCATGTCATT
GATTTTAGCGGAGAAGCGGC

Downstream 100 bases:

>100_bases
AGTTGAAATTTTGATTCAGGTTTTTTGGCCAACTCCATGGAAATAAAACTTATTGTCCTTTCGCTGGCGCTCCTTCTCGA
CCGCTTCATCGGTGATCCAC

Product: cobC protein

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSVEIEHGGALDRAIARFGGSAQDWLDLSTGINPEHFPLPEFSPEIWNRLPDEGLLQTTLALARRYYRIGENAPIVAAPG
TQALIQLMPMLAAPSTVAILGPTYQEHAAAFAAASWNVVSCATIDDIPASATVAVIVNPNNPDGRVIARDALLALANRLG
ERGGFLVVDEAFADAHEAVSIACEAEAAPLVVLKSFGKFFGLAGIRLGFAVANADYAARLRLRLGPWAVSGPALAIANSA
FANAAVVTDFRARIDLRRLALSAVLERAGLTEVGGTALFSLVEHIDAHSLYNALCERHILVRKFDYAPDWLRIGLAHDDA
ALARLEQALCDM

Sequences:

>Translated_332_residues
MSVEIEHGGALDRAIARFGGSAQDWLDLSTGINPEHFPLPEFSPEIWNRLPDEGLLQTTLALARRYYRIGENAPIVAAPG
TQALIQLMPMLAAPSTVAILGPTYQEHAAAFAAASWNVVSCATIDDIPASATVAVIVNPNNPDGRVIARDALLALANRLG
ERGGFLVVDEAFADAHEAVSIACEAEAAPLVVLKSFGKFFGLAGIRLGFAVANADYAARLRLRLGPWAVSGPALAIANSA
FANAAVVTDFRARIDLRRLALSAVLERAGLTEVGGTALFSLVEHIDAHSLYNALCERHILVRKFDYAPDWLRIGLAHDDA
ALARLEQALCDM
>Mature_331_residues
SVEIEHGGALDRAIARFGGSAQDWLDLSTGINPEHFPLPEFSPEIWNRLPDEGLLQTTLALARRYYRIGENAPIVAAPGT
QALIQLMPMLAAPSTVAILGPTYQEHAAAFAAASWNVVSCATIDDIPASATVAVIVNPNNPDGRVIARDALLALANRLGE
RGGFLVVDEAFADAHEAVSIACEAEAAPLVVLKSFGKFFGLAGIRLGFAVANADYAARLRLRLGPWAVSGPALAIANSAF
ANAAVVTDFRARIDLRRLALSAVLERAGLTEVGGTALFSLVEHIDAHSLYNALCERHILVRKFDYAPDWLRIGLAHDDAA
LARLEQALCDM

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 35408; Mature: 35277

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVEIEHGGALDRAIARFGGSAQDWLDLSTGINPEHFPLPEFSPEIWNRLPDEGLLQTTL
CEEEECCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHH
ALARRYYRIGENAPIVAAPGTQALIQLMPMLAAPSTVAILGPTYQEHAAAFAAASWNVVS
HHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCEEE
CATIDDIPASATVAVIVNPNNPDGRVIARDALLALANRLGERGGFLVVDEAFADAHEAVS
EEEECCCCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHHCCCCCEEEEEHHHHCHHHHEE
IACEAEAAPLVVLKSFGKFFGLAGIRLGFAVANADYAARLRLRLGPWAVSGPALAIANSA
EEECCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCEEECCCHHEEECHH
FANAAVVTDFRARIDLRRLALSAVLERAGLTEVGGTALFSLVEHIDAHSLYNALCERHIL
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VRKFDYAPDWLRIGLAHDDAALARLEQALCDM
HHCCCCCCCCEEEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVEIEHGGALDRAIARFGGSAQDWLDLSTGINPEHFPLPEFSPEIWNRLPDEGLLQTTL
EEEECCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHH
ALARRYYRIGENAPIVAAPGTQALIQLMPMLAAPSTVAILGPTYQEHAAAFAAASWNVVS
HHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCEEE
CATIDDIPASATVAVIVNPNNPDGRVIARDALLALANRLGERGGFLVVDEAFADAHEAVS
EEEECCCCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHHCCCCCEEEEEHHHHCHHHHEE
IACEAEAAPLVVLKSFGKFFGLAGIRLGFAVANADYAARLRLRLGPWAVSGPALAIANSA
EEECCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCEEECCCHHEEECHH
FANAAVVTDFRARIDLRRLALSAVLERAGLTEVGGTALFSLVEHIDAHSLYNALCERHIL
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VRKFDYAPDWLRIGLAHDDAALARLEQALCDM
HHCCCCCCCCEEEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211520 [H]