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The map label for this gene is pyrD [H]

Identifier: 23501218

GI number: 23501218

Start: 323031

End: 324125

Strand: Reverse

Name: pyrD [H]

Synonym: BR0311

Alternate gene names: 23501218

Gene position: 324125-323031 (Counterclockwise)

Preceding gene: 23501219

Following gene: 23501212

Centisome position: 15.38

GC content: 60.46

Gene sequence:

>1095_bases
ATGAGTGGGCTTTTTGAAACTCTGGGGCGGCGCGCCCTCTTCACCTTCGATGCGGAACAGGCACACGGCCTTTCCATCAC
CGGGCTGAAAACCGGGATCGTCACTTGCCGCACGCCCGAAGATCCGGCCCTTTCGGTGAAGGTGGCGGGGCTGAAATTTC
CCAATCCGCTCGGCATGGCTGCCGGTTACGACAAGAATGCCGAAGTGCCGGATGCGCTGCTGAAGCTTGGATTCGGCTTT
GCGGAAGTCGGCACCCTGACCCCCCGCCCGCAAAGCGGCAATCCGCGCCCGCGCATTTTCCGACTTGTGGACGACAAGGC
CGTCATCAACCGCCTCGGCTTCAACAATGAGGGCCATGAAGCCGCCTTCAAGCGTCTTTCCAGGCGCGCAGGCAAGAGCG
GCATTGTCGGCGTCAACATCGGCGCGAACAAGGATGCCGAAGACCGGATCGCGGATTATGTGGCCGGTATCCGCCGCTTC
TATCAGCTGGCGCGCTATTTCACGGTCAATATTTCCTCACCCAACACGCCGGGGCTGCGCAATCTCCAGGCGCGCGAGGC
CCTGCACGAGCTTTTGAGCCGTGTTCTGGAAGCGCGCGACGAGGAGGGAAATATGTGCACGCTGAAGCGGCCCGTTTTCC
TGAAGATTGCGCCTGATCTCACCGATGAGGAACTGGACGATATCGCCGCCGAAGCAGATGCGCAGAAGCTGGACGGCATC
ATTGTTTCCAACACGACACTATCGCGAAGCGGGCTTAAAAATCCCGAAAACAGCAATGAAACCGGCGGGCTTTCCGGTGC
GCCGCTGTTTGAACGCTCGACCGTGGTTCTGGCGCGGATGCGCGAGCGCGTCGGCCCCGATATGCCGCTGATCGGCGTGG
GCGGCATCGACAGTGCCGAAACGGCGCTGGCCAAGATCAAGGCAGGCGCCGATCTGGTGCAGCTTTATACCGGGCTGATC
TATCGCGGCCCCGGCCTTCCGGGTGAAATCCTGCGCGGCCTTTCCACGGCAATCAAGCATGAAGGCGTTTCCAGCATTGC
TGAATTGCGCGACCGTGACACAAAGGAATGGGCCGCACGCAAACTTATATCTTAA

Upstream 100 bases:

>100_bases
CGCATCTTTATGCGCCTTTGCCGCTTACGGCAGTCGTCAAGGTCGAGCCGTTGCCGCTCGGCCCTGACGATCTTCATATT
TTCCCGGAACTGGAAGACAA

Downstream 100 bases:

>100_bases
ATCAGTGCGCGAATTCCATGCGATAGCGGCGCGGCAGGATCGCCAGAAGCGTAATGCCCCGCACCGACAAAAACAGATTG
ATCGCAAGCCAAAGCCCGTG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSGLFETLGRRALFTFDAEQAHGLSITGLKTGIVTCRTPEDPALSVKVAGLKFPNPLGMAAGYDKNAEVPDALLKLGFGF
AEVGTLTPRPQSGNPRPRIFRLVDDKAVINRLGFNNEGHEAAFKRLSRRAGKSGIVGVNIGANKDAEDRIADYVAGIRRF
YQLARYFTVNISSPNTPGLRNLQAREALHELLSRVLEARDEEGNMCTLKRPVFLKIAPDLTDEELDDIAAEADAQKLDGI
IVSNTTLSRSGLKNPENSNETGGLSGAPLFERSTVVLARMRERVGPDMPLIGVGGIDSAETALAKIKAGADLVQLYTGLI
YRGPGLPGEILRGLSTAIKHEGVSSIAELRDRDTKEWAARKLIS

Sequences:

>Translated_364_residues
MSGLFETLGRRALFTFDAEQAHGLSITGLKTGIVTCRTPEDPALSVKVAGLKFPNPLGMAAGYDKNAEVPDALLKLGFGF
AEVGTLTPRPQSGNPRPRIFRLVDDKAVINRLGFNNEGHEAAFKRLSRRAGKSGIVGVNIGANKDAEDRIADYVAGIRRF
YQLARYFTVNISSPNTPGLRNLQAREALHELLSRVLEARDEEGNMCTLKRPVFLKIAPDLTDEELDDIAAEADAQKLDGI
IVSNTTLSRSGLKNPENSNETGGLSGAPLFERSTVVLARMRERVGPDMPLIGVGGIDSAETALAKIKAGADLVQLYTGLI
YRGPGLPGEILRGLSTAIKHEGVSSIAELRDRDTKEWAARKLIS
>Mature_363_residues
SGLFETLGRRALFTFDAEQAHGLSITGLKTGIVTCRTPEDPALSVKVAGLKFPNPLGMAAGYDKNAEVPDALLKLGFGFA
EVGTLTPRPQSGNPRPRIFRLVDDKAVINRLGFNNEGHEAAFKRLSRRAGKSGIVGVNIGANKDAEDRIADYVAGIRRFY
QLARYFTVNISSPNTPGLRNLQAREALHELLSRVLEARDEEGNMCTLKRPVFLKIAPDLTDEELDDIAAEADAQKLDGII
VSNTTLSRSGLKNPENSNETGGLSGAPLFERSTVVLARMRERVGPDMPLIGVGGIDSAETALAKIKAGADLVQLYTGLIY
RGPGLPGEILRGLSTAIKHEGVSSIAELRDRDTKEWAARKLIS

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=343, Percent_Identity=45.4810495626822, Blast_Score=277, Evalue=1e-74,
Organism=Escherichia coli, GI1787177, Length=337, Percent_Identity=44.8071216617211, Blast_Score=273, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17509475, Length=370, Percent_Identity=41.0810810810811, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI281361352, Length=363, Percent_Identity=43.2506887052342, Blast_Score=288, Evalue=3e-78,
Organism=Drosophila melanogaster, GI17137316, Length=363, Percent_Identity=43.2506887052342, Blast_Score=288, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 39272; Mature: 39141

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLFETLGRRALFTFDAEQAHGLSITGLKTGIVTCRTPEDPALSVKVAGLKFPNPLGMA
CCCHHHHHCCCEEEEECCCCCCCCEEEEEEECEEEEECCCCCCEEEEEECCCCCCCCCCC
AGYDKNAEVPDALLKLGFGFAEVGTLTPRPQSGNPRPRIFRLVDDKAVINRLGFNNEGHE
CCCCCCCCHHHHHHHHCCCHHHHCCCCCCCCCCCCCCEEEEEECHHHHHHHHCCCCCCHH
AAFKRLSRRAGKSGIVGVNIGANKDAEDRIADYVAGIRRFYQLARYFTVNISSPNTPGLR
HHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCC
NLQAREALHELLSRVLEARDEEGNMCTLKRPVFLKIAPDLTDEELDDIAAEADAQKLDGI
CHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCCHHHHHHHHHHCCHHHHCCE
IVSNTTLSRSGLKNPENSNETGGLSGAPLFERSTVVLARMRERVGPDMPLIGVGGIDSAE
EEECCEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHH
TALAKIKAGADLVQLYTGLIYRGPGLPGEILRGLSTAIKHEGVSSIAELRDRDTKEWAAR
HHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHH
KLIS
HHCC
>Mature Secondary Structure 
SGLFETLGRRALFTFDAEQAHGLSITGLKTGIVTCRTPEDPALSVKVAGLKFPNPLGMA
CCHHHHHCCCEEEEECCCCCCCCEEEEEEECEEEEECCCCCCEEEEEECCCCCCCCCCC
AGYDKNAEVPDALLKLGFGFAEVGTLTPRPQSGNPRPRIFRLVDDKAVINRLGFNNEGHE
CCCCCCCCHHHHHHHHCCCHHHHCCCCCCCCCCCCCCEEEEEECHHHHHHHHCCCCCCHH
AAFKRLSRRAGKSGIVGVNIGANKDAEDRIADYVAGIRRFYQLARYFTVNISSPNTPGLR
HHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCC
NLQAREALHELLSRVLEARDEEGNMCTLKRPVFLKIAPDLTDEELDDIAAEADAQKLDGI
CHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCCHHHHHHHHHHCCHHHHCCE
IVSNTTLSRSGLKNPENSNETGGLSGAPLFERSTVVLARMRERVGPDMPLIGVGGIDSAE
EEECCEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHH
TALAKIKAGADLVQLYTGLIYRGPGLPGEILRGLSTAIKHEGVSSIAELRDRDTKEWAAR
HHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHH
KLIS
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA