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The map label for this gene is hmrR [H]

Identifier: 23501128

GI number: 23501128

Start: 232958

End: 233407

Strand: Reverse

Name: hmrR [H]

Synonym: BR0221

Alternate gene names: 23501128

Gene position: 233407-232958 (Counterclockwise)

Preceding gene: 23501129

Following gene: 23501125

Centisome position: 11.07

GC content: 58.67

Gene sequence:

>450_bases
ATGAATATCGGCCAGGCAGCAGCCGCATCGGGCATATCGGCAAAGATGATCCGCCATTATGAAACCATCGGACTTATTGA
AGCCGCCGACAGAACCAGTTCCGGCTATCGCATCTATACGCAAAAGGATGTCGAGACGCTGCGCTTCATTCGCCGCAGCC
GCGACCTCGGTTTTCAGGTGGAGCAGATCAAGGAACTGCTGGCGCTCTGGCGCGACCGCAACCGCGCTTCCGCCGATGTG
AAGAAGGTGGCGCTCGGCCATATCGAGGAACTGGAAGCAAAAATGCGCCAGCTTCAGGAAATGGCCGATACGCTGCGCTA
TCTGGCCAGGAATTGCCATGGTGATAACCGCCCCGATTGCCCGATCATCCACCAGCTTGCCGAGCCGGGGCCGGAGGCGC
GCAAGCCTCCTCAACCCCGGAAAGGCGAATTACTGCACGGCAAGACGTAA

Upstream 100 bases:

>100_bases
CTCGCTGACCAGCCTCCCTGCCCTGCCTTCCTGACTGGCCCTTTGAATAGATTTCCCAACTCCCTATATGGTGCCAAACA
GCAAGCGAGCGAGGCAAGGG

Downstream 100 bases:

>100_bases
GCGCCGCAGCCGCAAGGCATTGCTCAGAACGAAGATGCTTGAAAGCGCCATGGCGCCCGCAGCCAGAACCGGCGACAGCA
AGGTTCCGGTGAAGGGATAG

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MNIGQAAAASGISAKMIRHYETIGLIEAADRTSSGYRIYTQKDVETLRFIRRSRDLGFQVEQIKELLALWRDRNRASADV
KKVALGHIEELEAKMRQLQEMADTLRYLARNCHGDNRPDCPIIHQLAEPGPEARKPPQPRKGELLHGKT

Sequences:

>Translated_149_residues
MNIGQAAAASGISAKMIRHYETIGLIEAADRTSSGYRIYTQKDVETLRFIRRSRDLGFQVEQIKELLALWRDRNRASADV
KKVALGHIEELEAKMRQLQEMADTLRYLARNCHGDNRPDCPIIHQLAEPGPEARKPPQPRKGELLHGKT
>Mature_149_residues
MNIGQAAAASGISAKMIRHYETIGLIEAADRTSSGYRIYTQKDVETLRFIRRSRDLGFQVEQIKELLALWRDRNRASADV
KKVALGHIEELEAKMRQLQEMADTLRYLARNCHGDNRPDCPIIHQLAEPGPEARKPPQPRKGELLHGKT

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=127, Percent_Identity=42.5196850393701, Blast_Score=109, Evalue=7e-26,
Organism=Escherichia coli, GI1789687, Length=127, Percent_Identity=33.8582677165354, Blast_Score=77, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 16915; Mature: 16915

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGQAAAASGISAKMIRHYETIGLIEAADRTSSGYRIYTQKDVETLRFIRRSRDLGFQV
CCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCH
EQIKELLALWRDRNRASADVKKVALGHIEELEAKMRQLQEMADTLRYLARNCHGDNRPDC
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PIIHQLAEPGPEARKPPQPRKGELLHGKT
HHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNIGQAAAASGISAKMIRHYETIGLIEAADRTSSGYRIYTQKDVETLRFIRRSRDLGFQV
CCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCH
EQIKELLALWRDRNRASADVKKVALGHIEELEAKMRQLQEMADTLRYLARNCHGDNRPDC
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PIIHQLAEPGPEARKPPQPRKGELLHGKT
HHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]