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The map label for this gene is hrcA [H]

Identifier: 23501083

GI number: 23501083

Start: 184226

End: 185350

Strand: Reverse

Name: hrcA [H]

Synonym: BR0172

Alternate gene names: 23501083

Gene position: 185350-184226 (Counterclockwise)

Preceding gene: 23501096

Following gene: 23501082

Centisome position: 8.79

GC content: 59.02

Gene sequence:

>1125_bases
ATGCCGCAGCCTTATATTTATTACATTCAATTCAGAGGGTTCGCAGAACAAGCCATGATGAGACCGCCGGAACACCAGCT
CCTCAGTTCGCTCGACCAGCGCTCGCGCGATATTTTCCGGCTCATCGTCGAAACCTATCTCAATGACGGTGATCCGGTCG
GCTCACGCAATCTCTCGCGGCTTCTGCCGCACACGCTTTCGCCCGCCACGATCCGCAATGTGATGAGCGATCTGGAACAT
CTGGGCCTGATCTATGCGCCGCATATTTCCGCTGGCCGCCTGCCGACGCAGATCGGCCTGCGCTTCTTTGTCGATGCCTT
TCTGGAAGTGGGAGACCTGCCGCCGGAGGAACGCTCCTCCATCGAGGCGCAGGTACGCGCCGCAGGCACCAGCAATTCGG
TGGAAAGCGTCCTGACCGAAGCAAGCCAGGTGCTTTCAGGCCTGTCACGCGGGGCGGGCCTTGTGCTCACCAACAAGACC
GATGTGGCGCTGAAACATATCGAATTCGTGCGCCTTGAACCCATGCGCGCCCTGGCTGTTCTGGTCATGCAGAACGGCGA
TGTGGAAAACCGTGTGATTGATCTTCCGGCGGGCATCAGCACCTCGCAGCTCATCGAAGCCTCCAATTTTCTCAATGCCC
ATATTCATGGCCACACGCTTTCGGAAGCCAAATCCGAATTGAGGAAACTGAGCGAGGAAACACGGCGGGAGCTTGACCAG
CTTTCACAGGAACTGGTGGCGAAGGGACTTGCAGTATGGAGCGGCGCCGGCGCGGACCAGCCCGCACGCCTCATCGTGCG
CGGACGCGCCAATCTTCTGGAAAACGTCCACGCACAGGAAGACATAGAGCGGCTGCGCCATCTCTTCGACGATCTCGAAA
CCAAGGACGGGATGGTGCAGCTTCTGGACCTGGCGGAAGCAGGCTCGGGCGTGCGCATTTTCATCGGTTCGGAAAACAAG
CTTTTCTCGCTTTCCGGCTCGTCGCTGGTGGTTGCCCCCTATCGCGACAGCGAACAACGGGTTATCGGTGCCCTGGGGGT
GATCGGGCCGACCCGGCTCAATTATGCGCGCATCGTTCCGATGGTGGACTATACGGCGCAGATCGTATCGAGGCTGCTGC
GATAA

Upstream 100 bases:

>100_bases
TAGGCATAAATAGAAAGAAATTTCGCATGTCACGAACGGACAAGTGTTATGCGGCGCCACCGGCAAAGGCGCATTCATGC
TCTAAACTCTTTGACGCAAC

Downstream 100 bases:

>100_bases
CTGTCAGATTTGCCGGTGCGCACCAGCCCCCAGAAATTAGACCTTGATTTTAAAGGCACGAAACTCGATATCCGCCCCTA
ACGATCTTCAAGACGGAAGT

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MPQPYIYYIQFRGFAEQAMMRPPEHQLLSSLDQRSRDIFRLIVETYLNDGDPVGSRNLSRLLPHTLSPATIRNVMSDLEH
LGLIYAPHISAGRLPTQIGLRFFVDAFLEVGDLPPEERSSIEAQVRAAGTSNSVESVLTEASQVLSGLSRGAGLVLTNKT
DVALKHIEFVRLEPMRALAVLVMQNGDVENRVIDLPAGISTSQLIEASNFLNAHIHGHTLSEAKSELRKLSEETRRELDQ
LSQELVAKGLAVWSGAGADQPARLIVRGRANLLENVHAQEDIERLRHLFDDLETKDGMVQLLDLAEAGSGVRIFIGSENK
LFSLSGSSLVVAPYRDSEQRVIGALGVIGPTRLNYARIVPMVDYTAQIVSRLLR

Sequences:

>Translated_374_residues
MPQPYIYYIQFRGFAEQAMMRPPEHQLLSSLDQRSRDIFRLIVETYLNDGDPVGSRNLSRLLPHTLSPATIRNVMSDLEH
LGLIYAPHISAGRLPTQIGLRFFVDAFLEVGDLPPEERSSIEAQVRAAGTSNSVESVLTEASQVLSGLSRGAGLVLTNKT
DVALKHIEFVRLEPMRALAVLVMQNGDVENRVIDLPAGISTSQLIEASNFLNAHIHGHTLSEAKSELRKLSEETRRELDQ
LSQELVAKGLAVWSGAGADQPARLIVRGRANLLENVHAQEDIERLRHLFDDLETKDGMVQLLDLAEAGSGVRIFIGSENK
LFSLSGSSLVVAPYRDSEQRVIGALGVIGPTRLNYARIVPMVDYTAQIVSRLLR
>Mature_373_residues
PQPYIYYIQFRGFAEQAMMRPPEHQLLSSLDQRSRDIFRLIVETYLNDGDPVGSRNLSRLLPHTLSPATIRNVMSDLEHL
GLIYAPHISAGRLPTQIGLRFFVDAFLEVGDLPPEERSSIEAQVRAAGTSNSVESVLTEASQVLSGLSRGAGLVLTNKTD
VALKHIEFVRLEPMRALAVLVMQNGDVENRVIDLPAGISTSQLIEASNFLNAHIHGHTLSEAKSELRKLSEETRRELDQL
SQELVAKGLAVWSGAGADQPARLIVRGRANLLENVHAQEDIERLRHLFDDLETKDGMVQLLDLAEAGSGVRIFIGSENKL
FSLSGSSLVVAPYRDSEQRVIGALGVIGPTRLNYARIVPMVDYTAQIVSRLLR

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons [H]

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01628 HrcA [H]

EC number: NA

Molecular weight: Translated: 41299; Mature: 41168

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQPYIYYIQFRGFAEQAMMRPPEHQLLSSLDQRSRDIFRLIVETYLNDGDPVGSRNLSR
CCCCEEEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
LLPHTLSPATIRNVMSDLEHLGLIYAPHISAGRLPTQIGLRFFVDAFLEVGDLPPEERSS
HCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
IEAQVRAAGTSNSVESVLTEASQVLSGLSRGAGLVLTNKTDVALKHIEFVRLEPMRALAV
HHHHHEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCHHHHHHH
LVMQNGDVENRVIDLPAGISTSQLIEASNFLNAHIHGHTLSEAKSELRKLSEETRRELDQ
HHHCCCCCCCEEEECCCCCCHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LSQELVAKGLAVWSGAGADQPARLIVRGRANLLENVHAQEDIERLRHLFDDLETKDGMVQ
HHHHHHHHHHHHCCCCCCCCCHHEEEHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHH
LLDLAEAGSGVRIFIGSENKLFSLSGSSLVVAPYRDSEQRVIGALGVIGPTRLNYARIVP
HHHHHHCCCCEEEEECCCCCEEEECCCEEEEECCCCCHHHHHHHHHCCCCCCCCHHHCCH
MVDYTAQIVSRLLR
HHHHHHHHHHHHHC
>Mature Secondary Structure 
PQPYIYYIQFRGFAEQAMMRPPEHQLLSSLDQRSRDIFRLIVETYLNDGDPVGSRNLSR
CCCEEEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
LLPHTLSPATIRNVMSDLEHLGLIYAPHISAGRLPTQIGLRFFVDAFLEVGDLPPEERSS
HCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
IEAQVRAAGTSNSVESVLTEASQVLSGLSRGAGLVLTNKTDVALKHIEFVRLEPMRALAV
HHHHHEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCHHHHHHH
LVMQNGDVENRVIDLPAGISTSQLIEASNFLNAHIHGHTLSEAKSELRKLSEETRRELDQ
HHHCCCCCCCEEEECCCCCCHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LSQELVAKGLAVWSGAGADQPARLIVRGRANLLENVHAQEDIERLRHLFDDLETKDGMVQ
HHHHHHHHHHHHCCCCCCCCCHHEEEHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHH
LLDLAEAGSGVRIFIGSENKLFSLSGSSLVVAPYRDSEQRVIGALGVIGPTRLNYARIVP
HHHHHHCCCCEEEEECCCCCEEEECCCEEEEECCCCCHHHHHHHHHCCCCCCCCHHHCCH
MVDYTAQIVSRLLR
HHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA