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The map label for this gene is ycgH [H]

Identifier: 23100651

GI number: 23100651

Start: 3326345

End: 3327646

Strand: Reverse

Name: ycgH [H]

Synonym: OB3196

Alternate gene names: 23100651

Gene position: 3327646-3326345 (Counterclockwise)

Preceding gene: 23100652

Following gene: 23100645

Centisome position: 91.66

GC content: 37.79

Gene sequence:

>1302_bases
ATGGTTCGAAAACAAGGAAACATGAAATGGTGGCAATTATCCCTTGTCGGTATTGGTTGTACCATTGGAACAGGTTATTT
CTTAGGGTCAAGTATTGCTATTGAACAATCAGGAGCGGCTGTACTATGGTTATTCCTGTTTGCTGCAATCGGCACGTACT
TTGTTTATGAGTCGTTAGCAAAGTTATCGATAGAATATCCAGATAAGGGTTCGTTTCGCACATATGCCAAGAAAGCATTT
GGTGATTGGGCAGGTTTTAGTAATGGGTGGGTGTATTGTTTGAGCGAGCTGCTCATAATGGGAAGCCAATTAATTGCTTT
AGGAATCTTTACACGCTTTTGGTTTCCGAATTTGCCGTTGTGGCTATGCATGGTCATCTTCGCAGTGTTAGGATTAGCGA
TTATACTTACGGGACTTGCAGGGTTTGAAAAAATGGAAAATATCTTTGGAATAATGAAAGCCTCTGCGATTATCATGTTT
ATATTGGTTGCTGTACTTTTGTTAGTAAAAGGTACAGAGAGTTTAATTAATCCAATCCCCCATATATTTAGTGGTGACTT
ACCATCAATATGGTGGGGTGGCTTTATCTATGCATTTTATGCTTTTGGTGGTATTGAAATAATGGGGCTGGTGGCGACAG
ATTTGAAAAATAAGCAAGAAGCGTTGAAAGCTGGGAGATGGATGTTATTAGGGCTTGGCTCTATTTATATCATCGCATTA
GGATTAGCTTTAGCGTTTATCGATGAGACGAAGATAATTGCAGATGAAAGCCCGTTTATTACAGCATTACAGCCATTTGA
CATACCACTTATTGCGGACGTATTTAATGGAGTGTTTATTATTGCGGGATTTTCCACGATGGTAGCTTCTTTATATGCGA
TTATCACTATATTAGTCTCATTATCTGAAGACCATCATGCTCCAGCCTTTTTGTCTAAAAAGGGAAGGTTGAAAATTCCC
TTCCCAGCTTTTGTTTGTTTAATCGTAGGACTTTTCGTCTCTATATTCATTGCTTTACTATTACCAGATCGCATATTTGA
ATATATAACTACTGCGGCTGGACTTATGCTTTTATATAATTGGTTGTTTATTTTAGCGAGTTTTATGAAATTACAGCGAC
CGACACGCTGGAATTTTATGAAGCCTATTATTGCAGGAGTATTGATCATTATAGCAGTTGCAACTACGTTATTTGCGGAA
ATTAGTAGGATAGGTTTCTTTGTCAGTATAGGTTTTATTATCATGATTGCCATTGCGGTGCTTATGATGAAAGAGAAATG
GCATATTACTTCATCTTCGTAA

Upstream 100 bases:

>100_bases
GAAGTTAAATTTTATCGAAGTAGAAGTTGCCGAATTAGAAAAAGCTGGGGGTGGAATACGGTGTATGACACTTCCTCTTG
TACGTAAGGGATAGGTTAGA

Downstream 100 bases:

>100_bases
GATTGGATATCCTTTGTTTAAAACGAGTGAATGGACATTTACTTAAGGTCTGATCATCATCCCCAATGAAGTATTGTTTC
CATTCGTGATTATCGCTGTT

Product: amino acid transporter

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MVRKQGNMKWWQLSLVGIGCTIGTGYFLGSSIAIEQSGAAVLWLFLFAAIGTYFVYESLAKLSIEYPDKGSFRTYAKKAF
GDWAGFSNGWVYCLSELLIMGSQLIALGIFTRFWFPNLPLWLCMVIFAVLGLAIILTGLAGFEKMENIFGIMKASAIIMF
ILVAVLLLVKGTESLINPIPHIFSGDLPSIWWGGFIYAFYAFGGIEIMGLVATDLKNKQEALKAGRWMLLGLGSIYIIAL
GLALAFIDETKIIADESPFITALQPFDIPLIADVFNGVFIIAGFSTMVASLYAIITILVSLSEDHHAPAFLSKKGRLKIP
FPAFVCLIVGLFVSIFIALLLPDRIFEYITTAAGLMLLYNWLFILASFMKLQRPTRWNFMKPIIAGVLIIIAVATTLFAE
ISRIGFFVSIGFIIMIAIAVLMMKEKWHITSSS

Sequences:

>Translated_433_residues
MVRKQGNMKWWQLSLVGIGCTIGTGYFLGSSIAIEQSGAAVLWLFLFAAIGTYFVYESLAKLSIEYPDKGSFRTYAKKAF
GDWAGFSNGWVYCLSELLIMGSQLIALGIFTRFWFPNLPLWLCMVIFAVLGLAIILTGLAGFEKMENIFGIMKASAIIMF
ILVAVLLLVKGTESLINPIPHIFSGDLPSIWWGGFIYAFYAFGGIEIMGLVATDLKNKQEALKAGRWMLLGLGSIYIIAL
GLALAFIDETKIIADESPFITALQPFDIPLIADVFNGVFIIAGFSTMVASLYAIITILVSLSEDHHAPAFLSKKGRLKIP
FPAFVCLIVGLFVSIFIALLLPDRIFEYITTAAGLMLLYNWLFILASFMKLQRPTRWNFMKPIIAGVLIIIAVATTLFAE
ISRIGFFVSIGFIIMIAIAVLMMKEKWHITSSS
>Mature_433_residues
MVRKQGNMKWWQLSLVGIGCTIGTGYFLGSSIAIEQSGAAVLWLFLFAAIGTYFVYESLAKLSIEYPDKGSFRTYAKKAF
GDWAGFSNGWVYCLSELLIMGSQLIALGIFTRFWFPNLPLWLCMVIFAVLGLAIILTGLAGFEKMENIFGIMKASAIIMF
ILVAVLLLVKGTESLINPIPHIFSGDLPSIWWGGFIYAFYAFGGIEIMGLVATDLKNKQEALKAGRWMLLGLGSIYIIAL
GLALAFIDETKIIADESPFITALQPFDIPLIADVFNGVFIIAGFSTMVASLYAIITILVSLSEDHHAPAFLSKKGRLKIP
FPAFVCLIVGLFVSIFIALLLPDRIFEYITTAAGLMLLYNWLFILASFMKLQRPTRWNFMKPIIAGVLIIIAVATTLFAE
ISRIGFFVSIGFIIMIAIAVLMMKEKWHITSSS

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of The Aromatic Amino Acids (Phenylalanine, Tyrosine, And Tryptophan). [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI87081915, Length=379, Percent_Identity=27.1767810026385, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1786302, Length=379, Percent_Identity=27.1767810026385, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI87081708, Length=458, Percent_Identity=25.5458515283843, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786789, Length=371, Percent_Identity=27.7628032345013, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786602, Length=375, Percent_Identity=25.6, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1790653, Length=383, Percent_Identity=25.065274151436, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1789017, Length=384, Percent_Identity=24.21875, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI48994972, Length=392, Percent_Identity=23.9795918367347, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1788480, Length=401, Percent_Identity=25.9351620947631, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322892, Length=344, Percent_Identity=26.453488372093, Blast_Score=103, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6319542, Length=395, Percent_Identity=23.2911392405063, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320717, Length=405, Percent_Identity=23.7037037037037, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320251, Length=394, Percent_Identity=23.0964467005076, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6320772, Length=398, Percent_Identity=24.6231155778894, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324059, Length=363, Percent_Identity=24.7933884297521, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319824, Length=389, Percent_Identity=22.6221079691517, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324990, Length=408, Percent_Identity=22.3039215686275, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324061, Length=391, Percent_Identity=22.2506393861893, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324553, Length=395, Percent_Identity=23.5443037974684, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322967, Length=327, Percent_Identity=26.2996941896024, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6321629, Length=387, Percent_Identity=21.7054263565891, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324981, Length=392, Percent_Identity=23.9795918367347, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321053, Length=384, Percent_Identity=22.9166666666667, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319543, Length=393, Percent_Identity=24.1730279898219, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 47847; Mature: 47847

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRKQGNMKWWQLSLVGIGCTIGTGYFLGSSIAIEQSGAAVLWLFLFAAIGTYFVYESLA
CCCCCCCCCEEEEEEEEECHHHHCHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
KLSIEYPDKGSFRTYAKKAFGDWAGFSNGWVYCLSELLIMGSQLIALGIFTRFWFPNLPL
HCEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
WLCMVIFAVLGLAIILTGLAGFEKMENIFGIMKASAIIMFILVAVLLLVKGTESLINPIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
HIFSGDLPSIWWGGFIYAFYAFGGIEIMGLVATDLKNKQEALKAGRWMLLGLGSIYIIAL
HHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCEEHHHHHHHHHH
GLALAFIDETKIIADESPFITALQPFDIPLIADVFNGVFIIAGFSTMVASLYAIITILVS
HHHHHHHHCCCEEECCCCCEEEECCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHH
LSEDHHAPAFLSKKGRLKIPFPAFVCLIVGLFVSIFIALLLPDRIFEYITTAAGLMLLYN
HCCCCCCCHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLFILASFMKLQRPTRWNFMKPIIAGVLIIIAVATTLFAEISRIGFFVSIGFIIMIAIAV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMMKEKWHITSSS
HHHHHHCCCCCCC
>Mature Secondary Structure
MVRKQGNMKWWQLSLVGIGCTIGTGYFLGSSIAIEQSGAAVLWLFLFAAIGTYFVYESLA
CCCCCCCCCEEEEEEEEECHHHHCHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
KLSIEYPDKGSFRTYAKKAFGDWAGFSNGWVYCLSELLIMGSQLIALGIFTRFWFPNLPL
HCEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
WLCMVIFAVLGLAIILTGLAGFEKMENIFGIMKASAIIMFILVAVLLLVKGTESLINPIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
HIFSGDLPSIWWGGFIYAFYAFGGIEIMGLVATDLKNKQEALKAGRWMLLGLGSIYIIAL
HHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCEEHHHHHHHHHH
GLALAFIDETKIIADESPFITALQPFDIPLIADVFNGVFIIAGFSTMVASLYAIITILVS
HHHHHHHHCCCEEECCCCCEEEECCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHH
LSEDHHAPAFLSKKGRLKIPFPAFVCLIVGLFVSIFIALLLPDRIFEYITTAAGLMLLYN
HCCCCCCCHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLFILASFMKLQRPTRWNFMKPIIAGVLIIIAVATTLFAEISRIGFFVSIGFIIMIAIAV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMMKEKWHITSSS
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]