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The map label for this gene is gntZ [H]

Identifier: 23100642

GI number: 23100642

Start: 3316142

End: 3317539

Strand: Reverse

Name: gntZ [H]

Synonym: OB3187

Alternate gene names: 23100642

Gene position: 3317539-3316142 (Counterclockwise)

Preceding gene: 23100643

Following gene: 23100640

Centisome position: 91.38

GC content: 38.13

Gene sequence:

>1398_bases
ATGAATTCTATTGGAGTATTTGGACTAGGTGTGATGGGTGCAAATCTTGCGATGAACATGGCAAATAAAGGAGAAAAAGT
TGCCGTTTATAACTATACATCTGACCTAACAGAAAAATTTAAATCCAATTTTACAAGTGATAATGCAGAGGCACATTATG
ACTTAGAGCGTTTTGTAAATTCATTAGAAAAACCAAGAAAAGTATTTTTAATGGTAACAGCAGGTCCCGTTATTGATTCG
GTTATTGATTCCTTAGTACCTCTACTAGATAAAGATGACATTATGATGGACGGAGGAAATTCTAATTTTAATGATTCGAA
CCGTCGTTATCATCGCTTAAAAGAAGCTGGTATACATTTTGTCAGTGTAGGTGTTTCTGGTGGAGAAGAAGGAGCGCTTC
ATGGACCAGCACTTATGCCGAGTGGTGATGAAAAAGTATATCAAGAAGTTGCACCTATCTTAGAAAAAATAGCAGCACAA
GTTGATGGTAAAGCATGTTGTGGTTATTTAGGTAAAGAAGGTTCTGGACATTATGTGAAAATGGTGCATAACGGCATTGA
ATATGCTGATATGCAGCTGATCACAGAGGCTTATCAGTTCTTGCGTGAAAGACTGGGTCTATCAGTTGAAGAAATCGCAA
CTACATTTCGTGAGTGGAATGAAGGAGAACTAGAAAGCTATTTAATGGAAATAACGAGTGATATTTTAACGCATGTCGAT
GAAGAAACGAATAAGCCAATGGTTGATGTTATTTTAGATAAATCCGGTCAAAAAGGTACTGGGAAATGGACAAGCCAAAA
TGCATTGGATGTAGGTGTTCCGTTATCTATTATTACAGAATCAGTATTTGCACGATTCTTATCGGGCTTAAAAGAAGAAC
GTGTACGGGCGGATCAAATGTTGTCAGGTCCAACGAAACTAGACCAAGACCTCGATAAGCAAGCGTGGTTAGAACTTGTG
AGAAAAGCACTGTTTATGGGCAAAATATGTGCGTATGCACAAGGGTTTCACCAATATAAGCAAGCATCTGAAGCCTATGG
TTGGGATTTAAAACTAGAAGAAATTGCGTTGATATTTAGAGGTGGATGCATTATCCGAGCTGGTATTCTGAATGAAATTA
GTGATGCATTTAAAGCAGATAAACAACTACCGAACTTATTGCTATCGCCATTCTTCCAAGAGAAGATGAATGACTATCAA
GCTTCATTACGTAAAGTTGTTATAAAAGGGATGGAAAGTGGACTTTCCTTACCAAGTTTAGGAGCATCTTTAACTTACTA
TGATGGGTACCGCTCTTCTCAAAGTGGCGCCAATATGATTCAAGCACAGCGGGACTATTTTGGTGCACATACGTATGAGC
GAGTGGATAAAAAAGGAACTTTCCATACAGCGTGGTAA

Upstream 100 bases:

>100_bases
GCGTTTCCAACAGGGAGTGAGTGATATTAGAAGGTCCCCTTGACATGTGTCTTTTCACCGGATGTTTTGAACAACCTCAA
TGAAGGAAGTGTCAAAAAGA

Downstream 100 bases:

>100_bases
GTGTTAAGAACAAAAGGGGTTAAATAATAAAGGTCGTATCTTTATGTGGATACGACTTTTTGTTATTCATTTTTCTTGTA
TTCCATATCAATATAGTAAT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MNSIGVFGLGVMGANLAMNMANKGEKVAVYNYTSDLTEKFKSNFTSDNAEAHYDLERFVNSLEKPRKVFLMVTAGPVIDS
VIDSLVPLLDKDDIMMDGGNSNFNDSNRRYHRLKEAGIHFVSVGVSGGEEGALHGPALMPSGDEKVYQEVAPILEKIAAQ
VDGKACCGYLGKEGSGHYVKMVHNGIEYADMQLITEAYQFLRERLGLSVEEIATTFREWNEGELESYLMEITSDILTHVD
EETNKPMVDVILDKSGQKGTGKWTSQNALDVGVPLSIITESVFARFLSGLKEERVRADQMLSGPTKLDQDLDKQAWLELV
RKALFMGKICAYAQGFHQYKQASEAYGWDLKLEEIALIFRGGCIIRAGILNEISDAFKADKQLPNLLLSPFFQEKMNDYQ
ASLRKVVIKGMESGLSLPSLGASLTYYDGYRSSQSGANMIQAQRDYFGAHTYERVDKKGTFHTAW

Sequences:

>Translated_465_residues
MNSIGVFGLGVMGANLAMNMANKGEKVAVYNYTSDLTEKFKSNFTSDNAEAHYDLERFVNSLEKPRKVFLMVTAGPVIDS
VIDSLVPLLDKDDIMMDGGNSNFNDSNRRYHRLKEAGIHFVSVGVSGGEEGALHGPALMPSGDEKVYQEVAPILEKIAAQ
VDGKACCGYLGKEGSGHYVKMVHNGIEYADMQLITEAYQFLRERLGLSVEEIATTFREWNEGELESYLMEITSDILTHVD
EETNKPMVDVILDKSGQKGTGKWTSQNALDVGVPLSIITESVFARFLSGLKEERVRADQMLSGPTKLDQDLDKQAWLELV
RKALFMGKICAYAQGFHQYKQASEAYGWDLKLEEIALIFRGGCIIRAGILNEISDAFKADKQLPNLLLSPFFQEKMNDYQ
ASLRKVVIKGMESGLSLPSLGASLTYYDGYRSSQSGANMIQAQRDYFGAHTYERVDKKGTFHTAW
>Mature_465_residues
MNSIGVFGLGVMGANLAMNMANKGEKVAVYNYTSDLTEKFKSNFTSDNAEAHYDLERFVNSLEKPRKVFLMVTAGPVIDS
VIDSLVPLLDKDDIMMDGGNSNFNDSNRRYHRLKEAGIHFVSVGVSGGEEGALHGPALMPSGDEKVYQEVAPILEKIAAQ
VDGKACCGYLGKEGSGHYVKMVHNGIEYADMQLITEAYQFLRERLGLSVEEIATTFREWNEGELESYLMEITSDILTHVD
EETNKPMVDVILDKSGQKGTGKWTSQNALDVGVPLSIITESVFARFLSGLKEERVRADQMLSGPTKLDQDLDKQAWLELV
RKALFMGKICAYAQGFHQYKQASEAYGWDLKLEEIALIFRGGCIIRAGILNEISDAFKADKQLPNLLLSPFFQEKMNDYQ
ASLRKVVIKGMESGLSLPSLGASLTYYDGYRSSQSGANMIQAQRDYFGAHTYERVDKKGTFHTAW

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=465, Percent_Identity=48.1720430107527, Blast_Score=432, Evalue=1e-121,
Organism=Escherichia coli, GI1788341, Length=463, Percent_Identity=54.4276457883369, Blast_Score=524, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17542558, Length=467, Percent_Identity=47.3233404710921, Blast_Score=444, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6321695, Length=464, Percent_Identity=45.9051724137931, Blast_Score=434, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6321977, Length=451, Percent_Identity=47.6718403547672, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24639279, Length=464, Percent_Identity=47.198275862069, Blast_Score=412, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51686; Mature: 51686

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSIGVFGLGVMGANLAMNMANKGEKVAVYNYTSDLTEKFKSNFTSDNAEAHYDLERFVN
CCCCCEEHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHHH
SLEKPRKVFLMVTAGPVIDSVIDSLVPLLDKDDIMMDGGNSNFNDSNRRYHRLKEAGIHF
HHCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCCEE
VSVGVSGGEEGALHGPALMPSGDEKVYQEVAPILEKIAAQVDGKACCGYLGKEGSGHYVK
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEH
MVHNGIEYADMQLITEAYQFLRERLGLSVEEIATTFREWNEGELESYLMEITSDILTHVD
HHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
EETNKPMVDVILDKSGQKGTGKWTSQNALDVGVPLSIITESVFARFLSGLKEERVRADQM
HHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LSGPTKLDQDLDKQAWLELVRKALFMGKICAYAQGFHQYKQASEAYGWDLKLEEIALIFR
HCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GGCIIRAGILNEISDAFKADKQLPNLLLSPFFQEKMNDYQASLRKVVIKGMESGLSLPSL
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GASLTYYDGYRSSQSGANMIQAQRDYFGAHTYERVDKKGTFHTAW
CCCEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNSIGVFGLGVMGANLAMNMANKGEKVAVYNYTSDLTEKFKSNFTSDNAEAHYDLERFVN
CCCCCEEHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHHH
SLEKPRKVFLMVTAGPVIDSVIDSLVPLLDKDDIMMDGGNSNFNDSNRRYHRLKEAGIHF
HHCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCCEE
VSVGVSGGEEGALHGPALMPSGDEKVYQEVAPILEKIAAQVDGKACCGYLGKEGSGHYVK
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEH
MVHNGIEYADMQLITEAYQFLRERLGLSVEEIATTFREWNEGELESYLMEITSDILTHVD
HHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
EETNKPMVDVILDKSGQKGTGKWTSQNALDVGVPLSIITESVFARFLSGLKEERVRADQM
HHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LSGPTKLDQDLDKQAWLELVRKALFMGKICAYAQGFHQYKQASEAYGWDLKLEEIALIFR
HCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GGCIIRAGILNEISDAFKADKQLPNLLLSPFFQEKMNDYQASLRKVVIKGMESGLSLPSL
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GASLTYYDGYRSSQSGANMIQAQRDYFGAHTYERVDKKGTFHTAW
CCCEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3020045; 7584049; 9384377; 1659648 [H]