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The map label for this gene is zwf [H]

Identifier: 23100393

GI number: 23100393

Start: 3041747

End: 3043222

Strand: Direct

Name: zwf [H]

Synonym: OB2938

Alternate gene names: 23100393

Gene position: 3041747-3043222 (Clockwise)

Preceding gene: 23100392

Following gene: 23100397

Centisome position: 83.78

GC content: 36.99

Gene sequence:

>1476_bases
ATGGAACAAACTATACAGCCAAGAGCCGTTATTGTAATCTTCGGAGCAACTGGAGATTTAGCAAAGCGTAAATTATTCCC
TTCCATTTATCGTTTGTACCGAAGCGGAAAATTAGATGAGCATTTTGCAGTAATTGGTTTAGCACGTCGTCCTTGGACAG
ATGAAGTACTTAGAGAAAATGTGGAAAATTCCATACAAGATGCTCTTTCTCCGGATGAGGATTTATCCGAATTTATTTCC
CATTTCTATTATAAATCTTTTGATGTGACGGAAAAAGAATCGTATCAAGGACTTAATGAAATCATTCAAAACCTTGAAGG
TCAATACCAAACAGAAGGAAATAGACTATTTTATCTGGCAATGGCTCCAGATTTCTTTGGTGCTATTGCAAATCAACTCA
ATGATTATGGATTAAAGAACACGAGTGGTTGGACTAGACTTGTGATCGAAAAACCATTTGGACATGATTTACCTTCTGCT
AAAAAGTTAAACCATGAATTACAAGCCGCATTTCGTGAAGATCAAATTTATCGTATCGACCACTATCTAGGTAAAGAGAT
GGTGCAAAATATTGAAGTAATCCGTTTTGCCAACGGTATTTTTGAACATTTGTGGAATAATCGCTTTATCTCAAACATCC
AAATTACGAGTAGCGAAACGCTTGGAGTAGAGGAACGAGCACGTTATTATGACACTTCTGGTGCTACGCGGGATATGGTT
CAAAATCATATGTTACAAATGGTTGCTCTACTGGCGATGGAACCTCCGATTAGTTTAACAACAGAGGAAGTACGCTCTGA
AAAAATTAAAGTATTGCGTGCCTTAAGAATGATGGAGACAAATGAAATAGATGATTATTTCATTCGCGGTCAATACGGTG
CTGGTACAGTTAAAGGTAATTCTGTTATTGGTTATCAAGACGAAGATGAACAACTAGAAAATTCTCGTACTGAAACATTT
GTAGCTGGAAAACTTCTCATTGACAATTACCGATGGGCAGGCGTTCCTTTCTATATTCGTACAGGAAAGCGCATGACAGA
AAAATCCACAAAAATTGTAATTGAGTTCAAAGACATTCCAATGAATCTTTATTACCAAAAAGATGATCAAAGGAATCCAA
ATTTATTGGTTATTAATATTCAACCAAATGAAGGAATTACGCTTTGCTTGAATGCACGTAAATCAGGTGAAGGTGCACTA
GCAGAGCCAATTCAATTAGCATACCACCAAAATGCTGTATCTGGAATCAATACACCAGAAGCATATGAAAAACTAATTTA
CGATAGTATGCTTGGTGATGCGACTAACTTTACCCATTGGGATGAAGTTGCTTTATCTTGGCAATTTGTCGATAAGATTT
TGGAAAACTGGTCAGAAAATCAACCAGCATTCCCTAATTATCGTTCTGGATCGATGGGACCAGAAGCATCTGATGAACTG
TTGAAAAAAGATGGTTTCCATTGGTGGCCAATCTAA

Upstream 100 bases:

>100_bases
ATTATAGTTCATATGTTTGGTACGTGTTTATCTTTTGGATTATAATGTGAAATGTCTTACAATGAAATTATATTTTGAAA
AAGAATTGAGGAAATTAACG

Downstream 100 bases:

>100_bases
ACGTCCTATATGAAGTAAGATTCCTAAAATCGAACTGTTTTACGAACCATTTTAAAAAGGTATTGTTATTTATAGCATGT
GAGGGTTCCCTACTGTCTAT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD; Vegetative protein 11; VEG11 [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MEQTIQPRAVIVIFGATGDLAKRKLFPSIYRLYRSGKLDEHFAVIGLARRPWTDEVLRENVENSIQDALSPDEDLSEFIS
HFYYKSFDVTEKESYQGLNEIIQNLEGQYQTEGNRLFYLAMAPDFFGAIANQLNDYGLKNTSGWTRLVIEKPFGHDLPSA
KKLNHELQAAFREDQIYRIDHYLGKEMVQNIEVIRFANGIFEHLWNNRFISNIQITSSETLGVEERARYYDTSGATRDMV
QNHMLQMVALLAMEPPISLTTEEVRSEKIKVLRALRMMETNEIDDYFIRGQYGAGTVKGNSVIGYQDEDEQLENSRTETF
VAGKLLIDNYRWAGVPFYIRTGKRMTEKSTKIVIEFKDIPMNLYYQKDDQRNPNLLVINIQPNEGITLCLNARKSGEGAL
AEPIQLAYHQNAVSGINTPEAYEKLIYDSMLGDATNFTHWDEVALSWQFVDKILENWSENQPAFPNYRSGSMGPEASDEL
LKKDGFHWWPI

Sequences:

>Translated_491_residues
MEQTIQPRAVIVIFGATGDLAKRKLFPSIYRLYRSGKLDEHFAVIGLARRPWTDEVLRENVENSIQDALSPDEDLSEFIS
HFYYKSFDVTEKESYQGLNEIIQNLEGQYQTEGNRLFYLAMAPDFFGAIANQLNDYGLKNTSGWTRLVIEKPFGHDLPSA
KKLNHELQAAFREDQIYRIDHYLGKEMVQNIEVIRFANGIFEHLWNNRFISNIQITSSETLGVEERARYYDTSGATRDMV
QNHMLQMVALLAMEPPISLTTEEVRSEKIKVLRALRMMETNEIDDYFIRGQYGAGTVKGNSVIGYQDEDEQLENSRTETF
VAGKLLIDNYRWAGVPFYIRTGKRMTEKSTKIVIEFKDIPMNLYYQKDDQRNPNLLVINIQPNEGITLCLNARKSGEGAL
AEPIQLAYHQNAVSGINTPEAYEKLIYDSMLGDATNFTHWDEVALSWQFVDKILENWSENQPAFPNYRSGSMGPEASDEL
LKKDGFHWWPI
>Mature_491_residues
MEQTIQPRAVIVIFGATGDLAKRKLFPSIYRLYRSGKLDEHFAVIGLARRPWTDEVLRENVENSIQDALSPDEDLSEFIS
HFYYKSFDVTEKESYQGLNEIIQNLEGQYQTEGNRLFYLAMAPDFFGAIANQLNDYGLKNTSGWTRLVIEKPFGHDLPSA
KKLNHELQAAFREDQIYRIDHYLGKEMVQNIEVIRFANGIFEHLWNNRFISNIQITSSETLGVEERARYYDTSGATRDMV
QNHMLQMVALLAMEPPISLTTEEVRSEKIKVLRALRMMETNEIDDYFIRGQYGAGTVKGNSVIGYQDEDEQLENSRTETF
VAGKLLIDNYRWAGVPFYIRTGKRMTEKSTKIVIEFKDIPMNLYYQKDDQRNPNLLVINIQPNEGITLCLNARKSGEGAL
AEPIQLAYHQNAVSGINTPEAYEKLIYDSMLGDATNFTHWDEVALSWQFVDKILENWSENQPAFPNYRSGSMGPEASDEL
LKKDGFHWWPI

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=481, Percent_Identity=37.2141372141372, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI109389365, Length=481, Percent_Identity=37.2141372141372, Blast_Score=328, Evalue=5e-90,
Organism=Homo sapiens, GI52145310, Length=507, Percent_Identity=29.585798816568, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1788158, Length=489, Percent_Identity=37.4233128834356, Blast_Score=342, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17538218, Length=481, Percent_Identity=37.4220374220374, Blast_Score=338, Evalue=5e-93,
Organism=Saccharomyces cerevisiae, GI6324088, Length=496, Percent_Identity=35.2822580645161, Blast_Score=295, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24643350, Length=483, Percent_Identity=33.9544513457557, Blast_Score=285, Evalue=6e-77,
Organism=Drosophila melanogaster, GI24643352, Length=483, Percent_Identity=33.9544513457557, Blast_Score=285, Evalue=6e-77,
Organism=Drosophila melanogaster, GI221513548, Length=482, Percent_Identity=29.4605809128631, Blast_Score=218, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56544; Mature: 56544

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTIQPRAVIVIFGATGDLAKRKLFPSIYRLYRSGKLDEHFAVIGLARRPWTDEVLREN
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHH
VENSIQDALSPDEDLSEFISHFYYKSFDVTEKESYQGLNEIIQNLEGQYQTEGNRLFYLA
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEECCCCEEEEEE
MAPDFFGAIANQLNDYGLKNTSGWTRLVIEKPFGHDLPSAKKLNHELQAAFREDQIYRID
ECCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEHH
HYLGKEMVQNIEVIRFANGIFEHLWNNRFISNIQITSSETLGVEERARYYDTSGATRDMV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCHHHHH
QNHMLQMVALLAMEPPISLTTEEVRSEKIKVLRALRMMETNEIDDYFIRGQYGAGTVKGN
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEECCC
SVIGYQDEDEQLENSRTETFVAGKLLIDNYRWAGVPFYIRTGKRMTEKSTKIVIEFKDIP
EEECCCCCHHHHHCCCCCEEEEEEEEEECCEECCCCEEEECCCHHCCCCCEEEEEEECCC
MNLYYQKDDQRNPNLLVINIQPNEGITLCLNARKSGEGALAEPIQLAYHQNAVSGINTPE
EEEEECCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHH
AYEKLIYDSMLGDATNFTHWDEVALSWQFVDKILENWSENQPAFPNYRSGSMGPEASDEL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHH
LKKDGFHWWPI
HHHCCCEECCC
>Mature Secondary Structure
MEQTIQPRAVIVIFGATGDLAKRKLFPSIYRLYRSGKLDEHFAVIGLARRPWTDEVLREN
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHH
VENSIQDALSPDEDLSEFISHFYYKSFDVTEKESYQGLNEIIQNLEGQYQTEGNRLFYLA
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEECCCCEEEEEE
MAPDFFGAIANQLNDYGLKNTSGWTRLVIEKPFGHDLPSAKKLNHELQAAFREDQIYRID
ECCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEHH
HYLGKEMVQNIEVIRFANGIFEHLWNNRFISNIQITSSETLGVEERARYYDTSGATRDMV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCHHHHH
QNHMLQMVALLAMEPPISLTTEEVRSEKIKVLRALRMMETNEIDDYFIRGQYGAGTVKGN
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEECCC
SVIGYQDEDEQLENSRTETFVAGKLLIDNYRWAGVPFYIRTGKRMTEKSTKIVIEFKDIP
EEECCCCCHHHHHCCCCCEEEEEEEEEECCEECCCCEEEECCCHHCCCCCEEEEEEECCC
MNLYYQKDDQRNPNLLVINIQPNEGITLCLNARKSGEGALAEPIQLAYHQNAVSGINTPE
EEEEECCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHH
AYEKLIYDSMLGDATNFTHWDEVALSWQFVDKILENWSENQPAFPNYRSGSMGPEASDEL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHH
LKKDGFHWWPI
HHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 9298659 [H]