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The map label for this gene is pdhB [H]

Identifier: 23100331

GI number: 23100331

Start: 2962267

End: 2963262

Strand: Reverse

Name: pdhB [H]

Synonym: OB2876

Alternate gene names: 23100331

Gene position: 2963262-2962267 (Counterclockwise)

Preceding gene: 23100332

Following gene: 23100330

Centisome position: 81.62

GC content: 43.07

Gene sequence:

>996_bases
ATGATAACCATAACGAAAACGAAACAATTGACCCTTATTCAGGCAATCACGGACGGAATGCGTACAATGCTTCACGAAAG
AGAAGAAGTCGTTGTATTAGGAGAAGATGTCGGCAAAAATGGTGGGGTCTTTCGAGCAACCGATGGATTGCAGGAGGAGT
TTGGTGAGAAGAGGGTTTTTGATACACCGTTGAGTGAAGCTGGAATCATCGGGTCCTCTATTGGGATGGCAATCAACGGA
CTGCTTCCGGTAGCAGAAATTCAGTTTTCAGGTTTTATTTATCCTGCATATGAACAAATTATGACGCATGCAACAAGAAT
GCGTTACCGTACCAAAGGTGTTTTTACTGTACCACTTGTAATTCGTGCACCATATGGAGCGGGAGTACGTGCCCCGGAAA
TTCATTCGGATAGCATGGAAGCATTATTTACCCATATGCCAGGGATAAAAGTCGTTTGTCCATCTAGTCCCTACGATGCA
AAAGGGCTTCTTATTTCTGCAATCGAGGATCCAGATCCGGTACTATTTCTTGAGCCATTAAAATTATATCGTGCAGTTAG
AGGCGAAGTACCAGAAGAAAAATATGAAATTGAAATCGGAAAAGGTAAGTATTTGCGCGAGGGGGATGATGTAACGGTGA
TTGCCTGGGGAGCAATGGTACCCGTAGCGATGAAGGCAGCCGAACAGGCAGCGGAAAAAGGTATTACCTGTGAAGTTATC
GATTTACGCACCCTGTATCCGATTGATAGAGCTATTATCGCCGAATCAGTTCAGAAAACCGGACGCTGTGTAGTTGTTCA
TGAAGCACCAGCTACCGGAGGACTGGGAAATGATATTATTTCGATTGTTAATGATACTTCATTCTTATATATGAAATCAC
CGATTGAGCGTGTTACTGGTGCCGATGTTCATGTTCCATTTTGGGCTTTGGAAGAACATAATATCCCAACACCAGCACGT
GTAATGGATGCGATTAACCAAGTGATTAATTTTTAA

Upstream 100 bases:

>100_bases
CGATGTAAATGATATTTATGATTATATGTTCGAAAAACCGACATGGACGATTGAACAGCAAAAAGAAGAATATATAAAAC
ATTTGCGAGGGGTGAAATAG

Downstream 100 bases:

>100_bases
GGGAGGTGGAACGAATGGTAGAAGTTAAATTGCATGATATTGGAGAAGGGATGACAGAGGGGGATATCCTGACTTATTTT
ATTCAAGAAGGGGATCAGGT

Product: pyruvate dehydrogenase E1 beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MITITKTKQLTLIQAITDGMRTMLHEREEVVVLGEDVGKNGGVFRATDGLQEEFGEKRVFDTPLSEAGIIGSSIGMAING
LLPVAEIQFSGFIYPAYEQIMTHATRMRYRTKGVFTVPLVIRAPYGAGVRAPEIHSDSMEALFTHMPGIKVVCPSSPYDA
KGLLISAIEDPDPVLFLEPLKLYRAVRGEVPEEKYEIEIGKGKYLREGDDVTVIAWGAMVPVAMKAAEQAAEKGITCEVI
DLRTLYPIDRAIIAESVQKTGRCVVVHEAPATGGLGNDIISIVNDTSFLYMKSPIERVTGADVHVPFWALEEHNIPTPAR
VMDAINQVINF

Sequences:

>Translated_331_residues
MITITKTKQLTLIQAITDGMRTMLHEREEVVVLGEDVGKNGGVFRATDGLQEEFGEKRVFDTPLSEAGIIGSSIGMAING
LLPVAEIQFSGFIYPAYEQIMTHATRMRYRTKGVFTVPLVIRAPYGAGVRAPEIHSDSMEALFTHMPGIKVVCPSSPYDA
KGLLISAIEDPDPVLFLEPLKLYRAVRGEVPEEKYEIEIGKGKYLREGDDVTVIAWGAMVPVAMKAAEQAAEKGITCEVI
DLRTLYPIDRAIIAESVQKTGRCVVVHEAPATGGLGNDIISIVNDTSFLYMKSPIERVTGADVHVPFWALEEHNIPTPAR
VMDAINQVINF
>Mature_331_residues
MITITKTKQLTLIQAITDGMRTMLHEREEVVVLGEDVGKNGGVFRATDGLQEEFGEKRVFDTPLSEAGIIGSSIGMAING
LLPVAEIQFSGFIYPAYEQIMTHATRMRYRTKGVFTVPLVIRAPYGAGVRAPEIHSDSMEALFTHMPGIKVVCPSSPYDA
KGLLISAIEDPDPVLFLEPLKLYRAVRGEVPEEKYEIEIGKGKYLREGDDVTVIAWGAMVPVAMKAAEQAAEKGITCEVI
DLRTLYPIDRAIIAESVQKTGRCVVVHEAPATGGLGNDIISIVNDTSFLYMKSPIERVTGADVHVPFWALEEHNIPTPAR
VMDAINQVINF

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=328, Percent_Identity=45.7317073170732, Blast_Score=294, Evalue=7e-80,
Organism=Homo sapiens, GI34101272, Length=328, Percent_Identity=45.7317073170732, Blast_Score=294, Evalue=7e-80,
Organism=Homo sapiens, GI156564403, Length=328, Percent_Identity=37.1951219512195, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI291084858, Length=328, Percent_Identity=35.6707317073171, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17506935, Length=336, Percent_Identity=44.9404761904762, Blast_Score=263, Evalue=7e-71,
Organism=Caenorhabditis elegans, GI17538422, Length=326, Percent_Identity=36.8098159509202, Blast_Score=209, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6319698, Length=335, Percent_Identity=34.0298507462687, Blast_Score=202, Evalue=6e-53,
Organism=Drosophila melanogaster, GI160714828, Length=326, Percent_Identity=42.638036809816, Blast_Score=277, Evalue=6e-75,
Organism=Drosophila melanogaster, GI160714832, Length=326, Percent_Identity=42.638036809816, Blast_Score=277, Evalue=8e-75,
Organism=Drosophila melanogaster, GI21358145, Length=328, Percent_Identity=36.890243902439, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24650940, Length=328, Percent_Identity=36.890243902439, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24650943, Length=93, Percent_Identity=34.4086021505376, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24650945, Length=93, Percent_Identity=34.4086021505376, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36270; Mature: 36270

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITITKTKQLTLIQAITDGMRTMLHEREEVVVLGEDVGKNGGVFRATDGLQEEFGEKRVF
CEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCHHHHHCCCCCC
DTPLSEAGIIGSSIGMAINGLLPVAEIQFSGFIYPAYEQIMTHATRMRYRTKGVFTVPLV
CCCCCCCCCCHHHHHHHHHCCCEEEEEEECCEECHHHHHHHHHHHHHHHHCCCEEEEEEE
IRAPYGAGVRAPEIHSDSMEALFTHMPGIKVVCPSSPYDAKGLLISAIEDPDPVLFLEPL
EECCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCEEEEECCCCCCEEEECHH
KLYRAVRGEVPEEKYEIEIGKGKYLREGDDVTVIAWGAMVPVAMKAAEQAAEKGITCEVI
HHHHHHHCCCCCCCEEEEECCCCEEECCCCEEEEEECHHHHHHHHHHHHHHHCCCEEEEE
DLRTLYPIDRAIIAESVQKTGRCVVVHEAPATGGLGNDIISIVNDTSFLYMKSPIERVTG
ECHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHCCCEEEEECCCHHHHCC
ADVHVPFWALEEHNIPTPARVMDAINQVINF
CCEECEEEEEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MITITKTKQLTLIQAITDGMRTMLHEREEVVVLGEDVGKNGGVFRATDGLQEEFGEKRVF
CEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCHHHHHCCCCCC
DTPLSEAGIIGSSIGMAINGLLPVAEIQFSGFIYPAYEQIMTHATRMRYRTKGVFTVPLV
CCCCCCCCCCHHHHHHHHHCCCEEEEEEECCEECHHHHHHHHHHHHHHHHCCCEEEEEEE
IRAPYGAGVRAPEIHSDSMEALFTHMPGIKVVCPSSPYDAKGLLISAIEDPDPVLFLEPL
EECCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCEEEEECCCCCCEEEECHH
KLYRAVRGEVPEEKYEIEIGKGKYLREGDDVTVIAWGAMVPVAMKAAEQAAEKGITCEVI
HHHHHHHCCCCCCCEEEEECCCCEEECCCCEEEEEECHHHHHHHHHHHHHHHCCCEEEEE
DLRTLYPIDRAIIAESVQKTGRCVVVHEAPATGGLGNDIISIVNDTSFLYMKSPIERVTG
ECHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHCCCEEEEECCCHHHHCC
ADVHVPFWALEEHNIPTPARVMDAINQVINF
CCEECEEEEEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1735725 [H]