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The map label for this gene is siaT [H]

Identifier: 23100315

GI number: 23100315

Start: 2945050

End: 2946354

Strand: Reverse

Name: siaT [H]

Synonym: OB2860

Alternate gene names: 23100315

Gene position: 2946354-2945050 (Counterclockwise)

Preceding gene: 23100316

Following gene: 23100314

Centisome position: 81.15

GC content: 37.09

Gene sequence:

>1305_bases
ATGAGCCCAGAACTTATTGGATTTTTAGGTATTATAGCTATTTTGATACTGTTTTTCCTGAAGATTCCAATTGCTGTATC
TCTTATTCTTGTTAGTTTACTAGGAACAAGTTTCATTAGAGGGTGGGAGGTAGCCTTTGCACAGTTGGGGAGAACCCCTT
TTGATACATCTAGTAATTATTCACTAAGTGTTATTCCGTTATTTATTCTGATGGGTATGATTCTTTCTTATACAGGAATT
GGTAAAGATTTGTATAGATTGGTAGACACTTGGATTGGCCATTTACGGGGTGGTCTTGCGATGGCTACCATTGGCACGGC
AGCTATATTCTCATCCATTTCGGGTTCTTTAAATGCTACTACTGCAACAGTAGCAAAAATCGCATTGCCAGAAATGGACA
AATATAATTATAAACCAGGGCTTTCGACTTCTAGTGTTGCAGCAGGAGGCACACTAGGGATTTTAATCCCTCCAAGTGTA
ATTTTAATTTTGTACGGAATTCTGACAAGAGAACCCATAGGTGCGTTATTAATTTCCGGCATTATTCCTGGTGTTTTGCA
GATCACTATATTTATCATTACGATTTATATTCTTGTTCGTAAAGATCCTTCCATTGCACCGCCAAGGGAAGAGAAAGCAA
GTATTCTTGAGAAGTTACATTCGCTTAAAAATATTTGGCCGTTTATGGGGCTATTTTTAGTAAGTATTGGCGGTATATAT
TTAGGTATTTTCACGCCGACTGAAGCAGCTGGAGTAGGTGCGTTTGGTGCTCTATTGTTTGCATTAATTTCCAGAAAACT
TACGTGGGAAACTTTGAAAGACTCACTAAGTGAATCTATTCGCTTGACTGCGTTTATTTTCTTTATTTTAATTGGTGCCA
ATTTATTTGGACAATTCTTGGCAATCAGCAGAATTCCTGTCATGCTTACGACGTATGTCGGAAATCTTGACTTGCACGCA
TATATCATCCTTATCGGTATTCTTGCTGTGTTACTTGTGCTTGGTTGTTTCATTGAAAGTTTAGCTTTAATCGTTATCAC
ATTGCCCATTCTGTATCCAATTATTACGGAATTAGGATTTAACGGTATTTGGTTTGGAGTAATTATGATTATGGTTATTA
ATATCGGTGCATTAACACCACCGTTAGGAATAAGTGTCTACGTTATTAAAGGAGTAGCTAGAAATATTCCAATACAGTCA
ATCTTCAGAGGGGTCGTTCCAATGATTATCGCAATGATTGTATGTGTGGCAATTCTAGTTGTTTTTCCGCAGATAGTTAC
TGTATTGCCAGATTTAATGAAATGA

Upstream 100 bases:

>100_bases
CAATTTACTTATTCGCTGCAGTGTCAGGAATTGGTGCAATTGTATTTGCTTTAACTGCCTTAATGTTAGCCATCAAATAC
TTTGCAAGGGTGGGTGAAAA

Downstream 100 bases:

>100_bases
TTTATCAACCGTTGTTTGGAGTATTGCTAATACATGAAGTCTTACAGAACATCATAATTAAATATAGTTTTTATATTTTT
TTGAAAAGGATAGAGATGAG

Product: C4-dicarboxylate transporter

Products: NA

Alternate protein names: N-acetylneuraminic acid permease; N-acetylneuraminic acid transporter; Neu5Ac permease [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSPELIGFLGIIAILILFFLKIPIAVSLILVSLLGTSFIRGWEVAFAQLGRTPFDTSSNYSLSVIPLFILMGMILSYTGI
GKDLYRLVDTWIGHLRGGLAMATIGTAAIFSSISGSLNATTATVAKIALPEMDKYNYKPGLSTSSVAAGGTLGILIPPSV
ILILYGILTREPIGALLISGIIPGVLQITIFIITIYILVRKDPSIAPPREEKASILEKLHSLKNIWPFMGLFLVSIGGIY
LGIFTPTEAAGVGAFGALLFALISRKLTWETLKDSLSESIRLTAFIFFILIGANLFGQFLAISRIPVMLTTYVGNLDLHA
YIILIGILAVLLVLGCFIESLALIVITLPILYPIITELGFNGIWFGVIMIMVINIGALTPPLGISVYVIKGVARNIPIQS
IFRGVVPMIIAMIVCVAILVVFPQIVTVLPDLMK

Sequences:

>Translated_434_residues
MSPELIGFLGIIAILILFFLKIPIAVSLILVSLLGTSFIRGWEVAFAQLGRTPFDTSSNYSLSVIPLFILMGMILSYTGI
GKDLYRLVDTWIGHLRGGLAMATIGTAAIFSSISGSLNATTATVAKIALPEMDKYNYKPGLSTSSVAAGGTLGILIPPSV
ILILYGILTREPIGALLISGIIPGVLQITIFIITIYILVRKDPSIAPPREEKASILEKLHSLKNIWPFMGLFLVSIGGIY
LGIFTPTEAAGVGAFGALLFALISRKLTWETLKDSLSESIRLTAFIFFILIGANLFGQFLAISRIPVMLTTYVGNLDLHA
YIILIGILAVLLVLGCFIESLALIVITLPILYPIITELGFNGIWFGVIMIMVINIGALTPPLGISVYVIKGVARNIPIQS
IFRGVVPMIIAMIVCVAILVVFPQIVTVLPDLMK
>Mature_433_residues
SPELIGFLGIIAILILFFLKIPIAVSLILVSLLGTSFIRGWEVAFAQLGRTPFDTSSNYSLSVIPLFILMGMILSYTGIG
KDLYRLVDTWIGHLRGGLAMATIGTAAIFSSISGSLNATTATVAKIALPEMDKYNYKPGLSTSSVAAGGTLGILIPPSVI
LILYGILTREPIGALLISGIIPGVLQITIFIITIYILVRKDPSIAPPREEKASILEKLHSLKNIWPFMGLFLVSIGGIYL
GIFTPTEAAGVGAFGALLFALISRKLTWETLKDSLSESIRLTAFIFFILIGANLFGQFLAISRIPVMLTTYVGNLDLHAY
IILIGILAVLLVLGCFIESLALIVITLPILYPIITELGFNGIWFGVIMIMVINIGALTPPLGISVYVIKGVARNIPIQSI
FRGVVPMIIAMIVCVAILVVFPQIVTVLPDLMK

Specific function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system siaPT involved in the uptake of sialic acid [H]

COG id: COG1593

COG function: function code G; TRAP-type C4-dicarboxylate transport system, large permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the TRAP transporter large permease family [H]

Homologues:

Organism=Escherichia coli, GI48994950, Length=413, Percent_Identity=31.2348668280872, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010656
- InterPro:   IPR007387
- InterPro:   IPR004681 [H]

Pfam domain/function: PF06808 DctM; PF04290 DctQ [H]

EC number: NA

Molecular weight: Translated: 46689; Mature: 46558

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPELIGFLGIIAILILFFLKIPIAVSLILVSLLGTSFIRGWEVAFAQLGRTPFDTSSNY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SLSVIPLFILMGMILSYTGIGKDLYRLVDTWIGHLRGGLAMATIGTAAIFSSISGSLNAT
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHH
TATVAKIALPEMDKYNYKPGLSTSSVAAGGTLGILIPPSVILILYGILTREPIGALLISG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCHHHHHHHHH
IIPGVLQITIFIITIYILVRKDPSIAPPREEKASILEKLHSLKNIWPFMGLFLVSIGGIY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGIFTPTEAAGVGAFGALLFALISRKLTWETLKDSLSESIRLTAFIFFILIGANLFGQFL
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AISRIPVMLTTYVGNLDLHAYIILIGILAVLLVLGCFIESLALIVITLPILYPIITELGF
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NGIWFGVIMIMVINIGALTPPLGISVYVIKGVARNIPIQSIFRGVVPMIIAMIVCVAILV
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VFPQIVTVLPDLMK
HHHHHHHHHHHHCC
>Mature Secondary Structure 
SPELIGFLGIIAILILFFLKIPIAVSLILVSLLGTSFIRGWEVAFAQLGRTPFDTSSNY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SLSVIPLFILMGMILSYTGIGKDLYRLVDTWIGHLRGGLAMATIGTAAIFSSISGSLNAT
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHH
TATVAKIALPEMDKYNYKPGLSTSSVAAGGTLGILIPPSVILILYGILTREPIGALLISG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCHHHHHHHHH
IIPGVLQITIFIITIYILVRKDPSIAPPREEKASILEKLHSLKNIWPFMGLFLVSIGGIY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGIFTPTEAAGVGAFGALLFALISRKLTWETLKDSLSESIRLTAFIFFILIGANLFGQFL
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AISRIPVMLTTYVGNLDLHAYIILIGILAVLLVLGCFIESLALIVITLPILYPIITELGF
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NGIWFGVIMIMVINIGALTPPLGISVYVIKGVARNIPIQSIFRGVVPMIIAMIVCVAILV
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VFPQIVTVLPDLMK
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]