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The map label for this gene is serA [H]

Identifier: 23100274

GI number: 23100274

Start: 2898380

End: 2899369

Strand: Reverse

Name: serA [H]

Synonym: OB2819

Alternate gene names: 23100274

Gene position: 2899369-2898380 (Counterclockwise)

Preceding gene: 23100276

Following gene: 23100273

Centisome position: 79.86

GC content: 36.06

Gene sequence:

>990_bases
ATGTTAGAGAAGAAAGTTTTAATAACAGATTGTGATCATGGAAATGTAGATGTTGAAAGCGAAACATTCAAAAAAGCAGA
AATCAGTTTTGATTTGGAACAATGTAAGACAGAAGAGGATCTAATTTCAAAGGGAAAAGGTTTTGAAGTATTTATTAATC
AGTATGCTCCAGTTACAAGAAGCGTTATAGAGAACTTACCTGATCTAAAATTAGTTGTTCGATATGGTGTTGGTGTAGAT
AACGTTGATATAGCTGCAGCAACTGAACATGGTGTGCAGGTGTGTAATGTTCCGGACTATGGAATGAATGAAGTGGCTGA
TCAAGCATTAGCGATGATGTTGAATTTTACTAGAAGTATATCTCGAATGAATAGTTTTGTTCGTAAAGGGGTTTGGGATT
ATCAAAAAAGCATGCCTCTATACCGACATAGTGAGCAAACAGTAGGGGTAATAGGAGTTGGGAGAATCGGCAGTTCTTTT
GCAAAGAAAGTAAAATCCTTAGGTTGTCGTGTGGTGGCCTATGATCCGAAATATTTGGATGAAAAAGCGAAAAAATCACC
CGATTTTATCGATGAATTCTTACCTTTAAATGAATTGTTGGAGCAAGCCGACGTTGTTTCTATTCACTGTCCATTAGATA
AAGCACGTAATTTAATAGATGAAAAAGAATTACAGAAAATGAAGCCAACCGCTTATCTAATCAATGTTTCTAGAGGTGGA
ATTATTAATGAACAAGCCTTAAACAAGGCATTAACTAATCAATGGATTGCTGGCGCAGCAGTCGATGTTGCAGAGAACGA
ACCATTACAACCTGAATCAGCACTACTAGAACATGATAATTTTATCTGTACACCGCATATGGGATGGTATTCAGAGCAAG
CTGCATTAGAGCTGAAAAGAAAAGTTGCAGAGGAATCTATTCGACATTTGAATGGGGATCAAGTACATTATCCAATTAAT
TTTAAAGAAGAAAAGGAGAGTATTCAATGA

Upstream 100 bases:

>100_bases
TTATCTACTATTTAATGATATCGCTTACAATTACTCTCTCTGTTACTTGAAGAGTGAGTCAATCTTATGCATAAGCAATA
AAAAGGAGGAGAGCAATTTT

Downstream 100 bases:

>100_bases
GAGACCTTAAAAAATCATTTTTAATGGTAGTTCTATTCGTTTTTATCCTTGTGTTAGCTGCTTGTGGAAGTGATGGTGCA
ACAGCAGATGGAGAAAGTGG

Product: dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MLEKKVLITDCDHGNVDVESETFKKAEISFDLEQCKTEEDLISKGKGFEVFINQYAPVTRSVIENLPDLKLVVRYGVGVD
NVDIAAATEHGVQVCNVPDYGMNEVADQALAMMLNFTRSISRMNSFVRKGVWDYQKSMPLYRHSEQTVGVIGVGRIGSSF
AKKVKSLGCRVVAYDPKYLDEKAKKSPDFIDEFLPLNELLEQADVVSIHCPLDKARNLIDEKELQKMKPTAYLINVSRGG
IINEQALNKALTNQWIAGAAVDVAENEPLQPESALLEHDNFICTPHMGWYSEQAALELKRKVAEESIRHLNGDQVHYPIN
FKEEKESIQ

Sequences:

>Translated_329_residues
MLEKKVLITDCDHGNVDVESETFKKAEISFDLEQCKTEEDLISKGKGFEVFINQYAPVTRSVIENLPDLKLVVRYGVGVD
NVDIAAATEHGVQVCNVPDYGMNEVADQALAMMLNFTRSISRMNSFVRKGVWDYQKSMPLYRHSEQTVGVIGVGRIGSSF
AKKVKSLGCRVVAYDPKYLDEKAKKSPDFIDEFLPLNELLEQADVVSIHCPLDKARNLIDEKELQKMKPTAYLINVSRGG
IINEQALNKALTNQWIAGAAVDVAENEPLQPESALLEHDNFICTPHMGWYSEQAALELKRKVAEESIRHLNGDQVHYPIN
FKEEKESIQ
>Mature_329_residues
MLEKKVLITDCDHGNVDVESETFKKAEISFDLEQCKTEEDLISKGKGFEVFINQYAPVTRSVIENLPDLKLVVRYGVGVD
NVDIAAATEHGVQVCNVPDYGMNEVADQALAMMLNFTRSISRMNSFVRKGVWDYQKSMPLYRHSEQTVGVIGVGRIGSSF
AKKVKSLGCRVVAYDPKYLDEKAKKSPDFIDEFLPLNELLEQADVVSIHCPLDKARNLIDEKELQKMKPTAYLINVSRGG
IINEQALNKALTNQWIAGAAVDVAENEPLQPESALLEHDNFICTPHMGWYSEQAALELKRKVAEESIRHLNGDQVHYPIN
FKEEKESIQ

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI145580578, Length=322, Percent_Identity=34.472049689441, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4557499, Length=322, Percent_Identity=34.472049689441, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI61743967, Length=322, Percent_Identity=32.9192546583851, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI4557497, Length=322, Percent_Identity=32.9192546583851, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI145580575, Length=322, Percent_Identity=34.7826086956522, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI23308577, Length=328, Percent_Identity=30.7926829268293, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI6912396, Length=249, Percent_Identity=30.1204819277108, Blast_Score=124, Evalue=9e-29,
Organism=Escherichia coli, GI1789279, Length=280, Percent_Identity=30.3571428571429, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787645, Length=221, Percent_Identity=33.0316742081448, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI87082289, Length=234, Percent_Identity=29.9145299145299, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI87081824, Length=246, Percent_Identity=28.4552845528455, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=316, Percent_Identity=31.3291139240506, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=259, Percent_Identity=31.6602316602317, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320925, Length=300, Percent_Identity=27, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=240, Percent_Identity=29.1666666666667, Blast_Score=108, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=300, Percent_Identity=25.6666666666667, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324964, Length=246, Percent_Identity=29.2682926829268, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646446, Length=323, Percent_Identity=34.3653250773994, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24646448, Length=323, Percent_Identity=34.3653250773994, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24646452, Length=323, Percent_Identity=34.3653250773994, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24646450, Length=323, Percent_Identity=34.3653250773994, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI62472511, Length=323, Percent_Identity=34.3653250773994, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI19921140, Length=260, Percent_Identity=37.3076923076923, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28571528, Length=252, Percent_Identity=28.968253968254, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24585516, Length=287, Percent_Identity=25.4355400696864, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45552429, Length=255, Percent_Identity=27.843137254902, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI28574284, Length=255, Percent_Identity=27.843137254902, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585514, Length=255, Percent_Identity=27.843137254902, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574282, Length=255, Percent_Identity=27.843137254902, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45551003, Length=255, Percent_Identity=27.843137254902, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574286, Length=259, Percent_Identity=27.4131274131274, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 37005; Mature: 37005

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKKVLITDCDHGNVDVESETFKKAEISFDLEQCKTEEDLISKGKGFEVFINQYAPVTR
CCCCCEEEEECCCCCCCCCHHHHHHHHHEECHHHHCCHHHHHHCCCCEEEEECCCCHHHH
SVIENLPDLKLVVRYGVGVDNVDIAAATEHGVQVCNVPDYGMNEVADQALAMMLNFTRSI
HHHHCCCCCEEHHHHCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
SRMNSFVRKGVWDYQKSMPLYRHSEQTVGVIGVGRIGSSFAKKVKSLGCRVVAYDPKYLD
HHHHHHHHHHHHHHHHCCCCHHCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEECHHHHH
EKAKKSPDFIDEFLPLNELLEQADVVSIHCPLDKARNLIDEKELQKMKPTAYLINVSRGG
HHHHCCHHHHHHHCCHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCC
IINEQALNKALTNQWIAGAAVDVAENEPLQPESALLEHDNFICTPHMGWYSEQAALELKR
CCCHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHCCCEEECCCCCCCCHHHHHHHHH
KVAEESIRHLNGDQVHYPINFKEEKESIQ
HHHHHHHHHCCCCEEEECCCCHHHHHCCC
>Mature Secondary Structure
MLEKKVLITDCDHGNVDVESETFKKAEISFDLEQCKTEEDLISKGKGFEVFINQYAPVTR
CCCCCEEEEECCCCCCCCCHHHHHHHHHEECHHHHCCHHHHHHCCCCEEEEECCCCHHHH
SVIENLPDLKLVVRYGVGVDNVDIAAATEHGVQVCNVPDYGMNEVADQALAMMLNFTRSI
HHHHCCCCCEEHHHHCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
SRMNSFVRKGVWDYQKSMPLYRHSEQTVGVIGVGRIGSSFAKKVKSLGCRVVAYDPKYLD
HHHHHHHHHHHHHHHHCCCCHHCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEECHHHHH
EKAKKSPDFIDEFLPLNELLEQADVVSIHCPLDKARNLIDEKELQKMKPTAYLINVSRGG
HHHHCCHHHHHHHCCHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCC
IINEQALNKALTNQWIAGAAVDVAENEPLQPESALLEHDNFICTPHMGWYSEQAALELKR
CCCHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHCCCEEECCCCCCCCHHHHHHHHH
KVAEESIRHLNGDQVHYPINFKEEKESIQ
HHHHHHHHHCCCCEEEECCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]