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The map label for this gene is glcR [H]

Identifier: 23100263

GI number: 23100263

Start: 2888403

End: 2889182

Strand: Direct

Name: glcR [H]

Synonym: OB2808

Alternate gene names: 23100263

Gene position: 2888403-2889182 (Clockwise)

Preceding gene: 23100262

Following gene: 23100264

Centisome position: 79.56

GC content: 34.1

Gene sequence:

>780_bases
TTGTATCAAGAAGAAAGATTGATCTCTATACTGGACTATTTGAAAGAGAATAAGAGAATTTCCGTTGAACAAATTTGTAC
ACTTTTCAATATATCTCGAGATACTGCGAGAAGAGATCTAGTAAAACTAGAAGAAGAAAGCAAAATAGTACGTACTCGCG
GTGGGGCTCTCCTCCCTTCCATTCATACGGAAATTAAAAACTACTCGCATCGATTAAATATTGTTTCAGATGAAAAAAAG
GTGATTGGTAAAAAAGCAGCATCTCTAATTTATCCAGGAGACAGGATTATTTTAGATGCTTCAACTACGGTACAATCCTG
TGCCGAGCAAATTAACAATACTGAATGTACGATAATCACCAATTCTATCAACCAAGCAGATGTATTATCCTCTAATTCAA
ATATAAATATTCAGTTATTAGGTGGTATTTTGGAAAAAGAGCATCGATATGTGTATGGCTCTTCCGTTATAGATAAGCTC
TCCGAATACAATGTGGATAAAGCTTTTATCGGAGTTGTAGGTATATCTGAAAGTGGTTTAACAATTGCCCATGAAGAAGA
TGGTGCAGTAAAAAGAAAAATGATACAGCAAGCTAAGCAAGTAATTGCATTAGCTGACAACACAAAATTAGGTAATACGG
ATTTTTTCCGATTTGCGAATTTGCAAGATATTGATTTATTAATAACTGATAAAACACCACCACAATCATTTAGAGAACTG
TTAGATAAACATCATGTTGAACTTTTAACAGCAGAGAATGGTGACCAAGGAGATGATTAA

Upstream 100 bases:

>100_bases
TCAATCTGCATACAATTTTAACCAAAACACTTATTTTTACTTATTTATAATTACAAATGCTTATTTTTGTTGTATAATTA
CTTAAAAGGAGGAGATATCT

Downstream 100 bases:

>100_bases
TATGGTGAAATTAATTGCCATAGATTTAGATGGTACATTACTTAATGAACGAAATGAAATTAGTAACACAAACCTAGAGT
CGATTAAAGATGCACAGGCC

Product: transcriptional repressor of phosphotransferase system

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MYQEERLISILDYLKENKRISVEQICTLFNISRDTARRDLVKLEEESKIVRTRGGALLPSIHTEIKNYSHRLNIVSDEKK
VIGKKAASLIYPGDRIILDASTTVQSCAEQINNTECTIITNSINQADVLSSNSNINIQLLGGILEKEHRYVYGSSVIDKL
SEYNVDKAFIGVVGISESGLTIAHEEDGAVKRKMIQQAKQVIALADNTKLGNTDFFRFANLQDIDLLITDKTPPQSFREL
LDKHHVELLTAENGDQGDD

Sequences:

>Translated_259_residues
MYQEERLISILDYLKENKRISVEQICTLFNISRDTARRDLVKLEEESKIVRTRGGALLPSIHTEIKNYSHRLNIVSDEKK
VIGKKAASLIYPGDRIILDASTTVQSCAEQINNTECTIITNSINQADVLSSNSNINIQLLGGILEKEHRYVYGSSVIDKL
SEYNVDKAFIGVVGISESGLTIAHEEDGAVKRKMIQQAKQVIALADNTKLGNTDFFRFANLQDIDLLITDKTPPQSFREL
LDKHHVELLTAENGDQGDD
>Mature_259_residues
MYQEERLISILDYLKENKRISVEQICTLFNISRDTARRDLVKLEEESKIVRTRGGALLPSIHTEIKNYSHRLNIVSDEKK
VIGKKAASLIYPGDRIILDASTTVQSCAEQINNTECTIITNSINQADVLSSNSNINIQLLGGILEKEHRYVYGSSVIDKL
SEYNVDKAFIGVVGISESGLTIAHEEDGAVKRKMIQQAKQVIALADNTKLGNTDFFRFANLQDIDLLITDKTPPQSFREL
LDKHHVELLTAENGDQGDD

Specific function: Plays a role in carbon catabolite repression (CCR). Specifically required for transcriptional repression of the levanase operon by glucose but not by other sugars [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI226510968, Length=254, Percent_Identity=32.6771653543307, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789829, Length=251, Percent_Identity=29.4820717131474, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789519, Length=252, Percent_Identity=30.1587301587302, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789059, Length=253, Percent_Identity=30.4347826086957, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1788069, Length=252, Percent_Identity=28.5714285714286, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082344, Length=244, Percent_Identity=27.0491803278689, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790753, Length=250, Percent_Identity=24.8, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1790635, Length=253, Percent_Identity=25.296442687747, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789170, Length=228, Percent_Identity=26.7543859649123, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787063, Length=254, Percent_Identity=24.4094488188976, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787540, Length=228, Percent_Identity=26.7543859649123, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 29017; Mature: 29017

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQEERLISILDYLKENKRISVEQICTLFNISRDTARRDLVKLEEESKIVRTRGGALLPS
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEECHH
IHTEIKNYSHRLNIVSDEKKVIGKKAASLIYPGDRIILDASTTVQSCAEQINNTECTIIT
HHHHHHHHHHEEEEECCHHHHHHHHHHHEECCCCEEEEECCHHHHHHHHHHCCCEEEEEE
NSINQADVLSSNSNINIQLLGGILEKEHRYVYGSSVIDKLSEYNVDKAFIGVVGISESGL
CCCCCHHHCCCCCCEEEEEECCHHHHCCCEEECHHHHHHHHHCCCCEEEEEEEEECCCCC
TIAHEEDGAVKRKMIQQAKQVIALADNTKLGNTDFFRFANLQDIDLLITDKTPPQSFREL
EEEECCCCHHHHHHHHHHHHHEECCCCCCCCCCCCEEECCCCCEEEEEECCCCHHHHHHH
LDKHHVELLTAENGDQGDD
HHHHCEEEEEECCCCCCCC
>Mature Secondary Structure
MYQEERLISILDYLKENKRISVEQICTLFNISRDTARRDLVKLEEESKIVRTRGGALLPS
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEECHH
IHTEIKNYSHRLNIVSDEKKVIGKKAASLIYPGDRIILDASTTVQSCAEQINNTECTIIT
HHHHHHHHHHEEEEECCHHHHHHHHHHHEECCCCEEEEECCHHHHHHHHHHCCCEEEEEE
NSINQADVLSSNSNINIQLLGGILEKEHRYVYGSSVIDKLSEYNVDKAFIGVVGISESGL
CCCCCHHHCCCCCCEEEEEECCHHHHCCCEEECHHHHHHHHHCCCCEEEEEEEEECCCCC
TIAHEEDGAVKRKMIQQAKQVIALADNTKLGNTDFFRFANLQDIDLLITDKTPPQSFREL
EEEECCCCHHHHHHHHHHHHHEECCCCCCCCCCCCEEECCCCCEEEEEECCCCHHHHHHH
LDKHHVELLTAENGDQGDD
HHHHCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]