| Definition | Oceanobacillus iheyensis HTE831, complete genome. |
|---|---|
| Accession | NC_004193 |
| Length | 3,630,528 |
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The map label for this gene is lvr [H]
Identifier: 23100172
GI number: 23100172
Start: 2787456
End: 2788220
Strand: Reverse
Name: lvr [H]
Synonym: OB2717
Alternate gene names: 23100172
Gene position: 2788220-2787456 (Counterclockwise)
Preceding gene: 28563944
Following gene: 23100170
Centisome position: 76.8
GC content: 39.61
Gene sequence:
>765_bases TTGGAAGGAAAAGTAGTACTTATTACTGGTGGCGCAGGAGGAATCGGACAAGCAACTGCTAAACTACTATTAGATTATGG GGCGAAGGTAGCTTTAGTAGATATTAATGAAGATTCATTAGTAAAGGCAAAGGAATCACTTCATGTAGAAGATGACCGTG TTTTTACAATTACGGGAAATGTGACAGTGGAAGAAGACGTAGAAAATTATGTGAAACAAACAGTAGATCGTTTTGGAAAG ATTGATGTTTTCTTTAACAATGCAGGAGTTAATGGACCGGTATCACCGATAACAGAATTGGATCAAGCTACATTTGAAAA GATAATGTCCATTAATGTAACCGGGGTATTTTTAGGTTTAAAGCATGTAATGAAACAAATGAAAAAGCAAGGTTACGGGA GTATAGTAAATACAGCTTCCAATGCTGCTTATATTGGTTCAGCAGGTATGGTTAGCTATATTGCTTCCAAGCATGCAGTT GCTGGTATTACAAAAACTGCTGCGTTAGAGGTAGCATCAGACGGGATACGGGTAAATGCTGTAGCTCCAGCTGCAATCGA TACCCAAATGCTTGCTGATATTCAGAATAACCTTACTCCTGGAGAACCTGAAAAATCTGGAGAGGCTTTAAAACAGGGAA TTCCAGCAGGAAGATTTGGAGCTCCAGAAGAAGTTGCTCAGGTGGTAAAGTTTTTAGCCTCTGATGATGCATCCTTTGTG AATGGATCGCTTTACAATGTGGACGGTGGAATGCAGGCTGATTAA
Upstream 100 bases:
>100_bases TAAAATCAAAATACTTGTAATTTTGTAAACGTTTTCATAAAATAAAAGTGACAGATAAGTTACTAAAAAGAAGTAGATTA TTAAAAGGGAGTGGATAATA
Downstream 100 bases:
>100_bases TAAAAAAACAGCAGTGTTGGTTTATGTCAAACTGCTGTTTTTATGTGTGCCCGGCATGGGTGCAGTCTATAGGGTGAGAA TCCCGAACTGTGAAGGCAGA
Product: hypothetical protein
Products: D-Gluconate; Nicotinamide adenine dinucleotide phosphate [C]
Alternate protein names: (6R)-2,2,6-trimethyl-1,4-cyclohexanedione reductase [H]
Number of amino acids: Translated: 254; Mature: 254
Protein sequence:
>254_residues MEGKVVLITGGAGGIGQATAKLLLDYGAKVALVDINEDSLVKAKESLHVEDDRVFTITGNVTVEEDVENYVKQTVDRFGK IDVFFNNAGVNGPVSPITELDQATFEKIMSINVTGVFLGLKHVMKQMKKQGYGSIVNTASNAAYIGSAGMVSYIASKHAV AGITKTAALEVASDGIRVNAVAPAAIDTQMLADIQNNLTPGEPEKSGEALKQGIPAGRFGAPEEVAQVVKFLASDDASFV NGSLYNVDGGMQAD
Sequences:
>Translated_254_residues MEGKVVLITGGAGGIGQATAKLLLDYGAKVALVDINEDSLVKAKESLHVEDDRVFTITGNVTVEEDVENYVKQTVDRFGK IDVFFNNAGVNGPVSPITELDQATFEKIMSINVTGVFLGLKHVMKQMKKQGYGSIVNTASNAAYIGSAGMVSYIASKHAV AGITKTAALEVASDGIRVNAVAPAAIDTQMLADIQNNLTPGEPEKSGEALKQGIPAGRFGAPEEVAQVVKFLASDDASFV NGSLYNVDGGMQAD >Mature_254_residues MEGKVVLITGGAGGIGQATAKLLLDYGAKVALVDINEDSLVKAKESLHVEDDRVFTITGNVTVEEDVENYVKQTVDRFGK IDVFFNNAGVNGPVSPITELDQATFEKIMSINVTGVFLGLKHVMKQMKKQGYGSIVNTASNAAYIGSAGMVSYIASKHAV AGITKTAALEVASDGIRVNAVAPAAIDTQMLADIQNNLTPGEPEKSGEALKQGIPAGRFGAPEEVAQVVKFLASDDASFV NGSLYNVDGGMQAD
Specific function: Catalyzes the regio- and stereoselective reversible NAD- dependent reduction of (6R)-2,2,6-trimethyl-1,4-cyclohexanedione (levodione) to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone (actinol) [H]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI19923817, Length=258, Percent_Identity=37.984496124031, Blast_Score=141, Evalue=6e-34, Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=35.2, Blast_Score=128, Evalue=4e-30, Organism=Homo sapiens, GI31542939, Length=253, Percent_Identity=33.9920948616601, Blast_Score=126, Evalue=1e-29, Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=32.9317269076305, Blast_Score=112, Evalue=4e-25, Organism=Homo sapiens, GI59889578, Length=235, Percent_Identity=31.4893617021277, Blast_Score=110, Evalue=1e-24, Organism=Homo sapiens, GI5031737, Length=242, Percent_Identity=32.2314049586777, Blast_Score=107, Evalue=7e-24, Organism=Homo sapiens, GI4758504, Length=266, Percent_Identity=32.3308270676692, Blast_Score=107, Evalue=9e-24, Organism=Homo sapiens, GI224922801, Length=182, Percent_Identity=36.8131868131868, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI4503817, Length=238, Percent_Identity=32.7731092436975, Blast_Score=105, Evalue=3e-23, Organism=Homo sapiens, GI66933014, Length=259, Percent_Identity=33.2046332046332, Blast_Score=105, Evalue=4e-23, Organism=Homo sapiens, GI15277342, Length=260, Percent_Identity=29.2307692307692, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI7705925, Length=257, Percent_Identity=29.9610894941634, Blast_Score=94, Evalue=9e-20, Organism=Homo sapiens, GI126723750, Length=256, Percent_Identity=30.078125, Blast_Score=94, Evalue=2e-19, Organism=Homo sapiens, GI4504505, Length=257, Percent_Identity=31.1284046692607, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI10190704, Length=252, Percent_Identity=28.968253968254, Blast_Score=92, Evalue=5e-19, Organism=Homo sapiens, GI83715985, Length=266, Percent_Identity=30.4511278195489, Blast_Score=91, Evalue=7e-19, Organism=Homo sapiens, GI33667109, Length=188, Percent_Identity=32.4468085106383, Blast_Score=88, Evalue=7e-18, Organism=Homo sapiens, GI142976729, Length=216, Percent_Identity=29.1666666666667, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI126723191, Length=181, Percent_Identity=33.1491712707182, Blast_Score=84, Evalue=9e-17, Organism=Homo sapiens, GI4503301, Length=252, Percent_Identity=29.3650793650794, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI25282469, Length=246, Percent_Identity=28.0487804878049, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI210032110, Length=206, Percent_Identity=24.7572815533981, Blast_Score=66, Evalue=3e-11, Organism=Homo sapiens, GI302344755, Length=107, Percent_Identity=36.4485981308411, Blast_Score=66, Evalue=3e-11, Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=34.2629482071713, Blast_Score=132, Evalue=2e-32, Organism=Escherichia coli, GI1787335, Length=250, Percent_Identity=34, Blast_Score=132, Evalue=3e-32, Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=32.4110671936759, Blast_Score=125, Evalue=3e-30, Organism=Escherichia coli, GI2367175, Length=261, Percent_Identity=36.3984674329502, Blast_Score=121, Evalue=4e-29, Organism=Escherichia coli, GI87082160, Length=250, Percent_Identity=30.8, Blast_Score=116, Evalue=2e-27, Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=31.496062992126, Blast_Score=115, Evalue=4e-27, Organism=Escherichia coli, GI1786812, Length=258, Percent_Identity=31.3953488372093, Blast_Score=112, Evalue=2e-26, Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=31.6, Blast_Score=109, Evalue=2e-25, Organism=Escherichia coli, GI1788459, Length=254, Percent_Identity=33.4645669291339, Blast_Score=107, Evalue=9e-25, Organism=Escherichia coli, GI1789378, Length=252, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=1e-21, Organism=Escherichia coli, GI1787526, Length=250, Percent_Identity=25.2, Blast_Score=89, Evalue=3e-19, Organism=Escherichia coli, GI2367365, Length=253, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=1e-18, Organism=Escherichia coli, GI1788891, Length=244, Percent_Identity=27.4590163934426, Blast_Score=82, Evalue=2e-17, Organism=Escherichia coli, GI1789057, Length=257, Percent_Identity=23.7354085603113, Blast_Score=74, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=34.6456692913386, Blast_Score=142, Evalue=2e-34, Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=36.8821292775665, Blast_Score=124, Evalue=5e-29, Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=32.0158102766798, Blast_Score=124, Evalue=5e-29, Organism=Caenorhabditis elegans, GI17562906, Length=267, Percent_Identity=32.5842696629214, Blast_Score=115, Evalue=3e-26, Organism=Caenorhabditis elegans, GI17555706, Length=255, Percent_Identity=32.156862745098, Blast_Score=112, Evalue=2e-25, Organism=Caenorhabditis elegans, GI17538182, Length=263, Percent_Identity=31.9391634980989, Blast_Score=112, Evalue=2e-25, Organism=Caenorhabditis elegans, GI25147288, Length=256, Percent_Identity=31.25, Blast_Score=111, Evalue=3e-25, Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=32.5670498084291, Blast_Score=107, Evalue=4e-24, Organism=Caenorhabditis elegans, GI17531453, Length=262, Percent_Identity=32.824427480916, Blast_Score=107, Evalue=7e-24, Organism=Caenorhabditis elegans, GI71994600, Length=263, Percent_Identity=33.8403041825095, Blast_Score=107, Evalue=7e-24, Organism=Caenorhabditis elegans, GI17551412, Length=258, Percent_Identity=31.0077519379845, Blast_Score=104, Evalue=5e-23, Organism=Caenorhabditis elegans, GI17560150, Length=268, Percent_Identity=30.5970149253731, Blast_Score=104, Evalue=5e-23, Organism=Caenorhabditis elegans, GI17562910, Length=258, Percent_Identity=31.7829457364341, Blast_Score=103, Evalue=9e-23, Organism=Caenorhabditis elegans, GI17563726, Length=266, Percent_Identity=32.7067669172932, Blast_Score=103, Evalue=9e-23, Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=30.6513409961686, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=31.5384615384615, Blast_Score=102, Evalue=3e-22, Organism=Caenorhabditis elegans, GI193204405, Length=260, Percent_Identity=30.3846153846154, Blast_Score=100, Evalue=6e-22, Organism=Caenorhabditis elegans, GI115534694, Length=252, Percent_Identity=34.5238095238095, Blast_Score=100, Evalue=7e-22, Organism=Caenorhabditis elegans, GI71994604, Length=261, Percent_Identity=32.5670498084291, Blast_Score=99, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17538486, Length=258, Percent_Identity=31.0077519379845, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=29.811320754717, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17536025, Length=263, Percent_Identity=32.6996197718631, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=30.1526717557252, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17564282, Length=195, Percent_Identity=31.7948717948718, Blast_Score=94, Evalue=9e-20, Organism=Caenorhabditis elegans, GI17536651, Length=263, Percent_Identity=31.9391634980989, Blast_Score=94, Evalue=9e-20, Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=30.3030303030303, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17565030, Length=258, Percent_Identity=29.8449612403101, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17562990, Length=267, Percent_Identity=28.0898876404494, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17568967, Length=277, Percent_Identity=29.9638989169675, Blast_Score=87, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17561272, Length=262, Percent_Identity=31.6793893129771, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17544670, Length=264, Percent_Identity=28.4090909090909, Blast_Score=81, Evalue=4e-16, Organism=Caenorhabditis elegans, GI193203115, Length=220, Percent_Identity=30.4545454545455, Blast_Score=77, Evalue=7e-15, Organism=Caenorhabditis elegans, GI193203117, Length=218, Percent_Identity=30.7339449541284, Blast_Score=77, Evalue=8e-15, Organism=Caenorhabditis elegans, GI17567345, Length=206, Percent_Identity=25.7281553398058, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17508651, Length=248, Percent_Identity=27.0161290322581, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17508895, Length=191, Percent_Identity=27.2251308900524, Blast_Score=75, Evalue=3e-14, Organism=Saccharomyces cerevisiae, GI6324126, Length=262, Percent_Identity=33.206106870229, Blast_Score=105, Evalue=7e-24, Organism=Saccharomyces cerevisiae, GI6322861, Length=258, Percent_Identity=27.906976744186, Blast_Score=84, Evalue=3e-17, Organism=Saccharomyces cerevisiae, GI6322226, Length=213, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=2e-16, Organism=Saccharomyces cerevisiae, GI6322227, Length=217, Percent_Identity=27.1889400921659, Blast_Score=70, Evalue=3e-13, Organism=Drosophila melanogaster, GI23397609, Length=253, Percent_Identity=38.7351778656126, Blast_Score=137, Evalue=5e-33, Organism=Drosophila melanogaster, GI21355319, Length=253, Percent_Identity=33.9920948616601, Blast_Score=136, Evalue=1e-32, Organism=Drosophila melanogaster, GI24639444, Length=258, Percent_Identity=34.1085271317829, Blast_Score=126, Evalue=1e-29, Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=35.6589147286822, Blast_Score=119, Evalue=2e-27, Organism=Drosophila melanogaster, GI17737361, Length=266, Percent_Identity=32.7067669172932, Blast_Score=115, Evalue=3e-26, Organism=Drosophila melanogaster, GI24644337, Length=255, Percent_Identity=36.8627450980392, Blast_Score=114, Evalue=7e-26, Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=34.3873517786561, Blast_Score=110, Evalue=7e-25, Organism=Drosophila melanogaster, GI24643142, Length=254, Percent_Identity=32.2834645669291, Blast_Score=105, Evalue=2e-23, Organism=Drosophila melanogaster, GI28571526, Length=255, Percent_Identity=33.7254901960784, Blast_Score=103, Evalue=2e-22, Organism=Drosophila melanogaster, GI18859837, Length=209, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=5e-15, Organism=Drosophila melanogaster, GI24640492, Length=195, Percent_Identity=27.6923076923077, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI281364892, Length=191, Percent_Identity=26.1780104712042, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI21356301, Length=194, Percent_Identity=30.4123711340206, Blast_Score=71, Evalue=6e-13, Organism=Drosophila melanogaster, GI24665264, Length=205, Percent_Identity=30.7317073170732, Blast_Score=71, Evalue=6e-13, Organism=Drosophila melanogaster, GI281364494, Length=203, Percent_Identity=25.1231527093596, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI24581726, Length=220, Percent_Identity=24.5454545454545, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI21358495, Length=197, Percent_Identity=27.4111675126904, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI24641232, Length=204, Percent_Identity=25.9803921568627, Blast_Score=69, Evalue=3e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.69 [C]
Molecular weight: Translated: 26595; Mature: 26595
Theoretical pI: Translated: 4.54; Mature: 4.54
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEGKVVLITGGAGGIGQATAKLLLDYGAKVALVDINEDSLVKAKESLHVEDDRVFTITGN CCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEEECC VTVEEDVENYVKQTVDRFGKIDVFFNNAGVNGPVSPITELDQATFEKIMSINVTGVFLGL EEEHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH KHVMKQMKKQGYGSIVNTASNAAYIGSAGMVSYIASKHAVAGITKTAALEVASDGIRVNA HHHHHHHHHCCCCCCHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEE VAPAAIDTQMLADIQNNLTPGEPEKSGEALKQGIPAGRFGAPEEVAQVVKFLASDDASFV ECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHH NGSLYNVDGGMQAD CCEEEECCCCCCCC >Mature Secondary Structure MEGKVVLITGGAGGIGQATAKLLLDYGAKVALVDINEDSLVKAKESLHVEDDRVFTITGN CCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEEECC VTVEEDVENYVKQTVDRFGKIDVFFNNAGVNGPVSPITELDQATFEKIMSINVTGVFLGL EEEHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH KHVMKQMKKQGYGSIVNTASNAAYIGSAGMVSYIASKHAVAGITKTAALEVASDGIRVNA HHHHHHHHHCCCCCCHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEE VAPAAIDTQMLADIQNNLTPGEPEKSGEALKQGIPAGRFGAPEEVAQVVKFLASDDASFV ECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHH NGSLYNVDGGMQAD CCEEEECCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NAD+; NADH; NADP+; NADPH [C]
Metal ions: Mn2+ [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 0.02 {NADP+}} 20 {D-gluconate}} 0.006 {NADPH}} 0.9 {5-keto-D-gluconate}} [C]
Substrates: 5-Dehydro-D-gluconate; H+; Nicotinamide adenine dinucleotide phosphate - reduced [C]
Specific reaction: 5-Dehydro-D-gluconate + H+ + Nicotinamide adenine dinucleotide phosphate - reduced <==> D-Gluconate + Nicotinamide adenine dinucleotide phosphate [C]
General reaction: Redox reaction [C]
Inhibitor: Cd2+; Cs2+; Cu2+; Divalent metal ions; Hg2+; Ni2+; p-Chloromercuribenzoate; Sn2+; Sulfhydryl reagents [C]
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11388460; 10508066 [H]