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The map label for this gene is tcyP [H]

Identifier: 23100169

GI number: 23100169

Start: 2784120

End: 2785514

Strand: Direct

Name: tcyP [H]

Synonym: OB2714

Alternate gene names: 23100169

Gene position: 2784120-2785514 (Clockwise)

Preceding gene: 23100168

Following gene: 23100174

Centisome position: 76.69

GC content: 38.64

Gene sequence:

>1395_bases
ATGGATAATTTGTTTATTTTAATCAACGTCGTAGTTTTACTGGCACTTATTGGACTACTAATTTATATGCAGAAAAAACA
TGTATCATTTGCCAAACGAGTATTTACTGGTATGGGTATAGGGATTGTCTTAGGAGCAATTCTGCAAGGGATATATGGTG
AAGGGTCTTCGATTTTAAATGGGACACTCGATTGGTATAGCATTGTTGGTAGTGGATACGTAAGATTCCTTATGGTAATA
GTCGTACCTCTAGTAATGATATCGATTATTCGTGCCATTATAAATCTAGATAAGTCCAAAGAACTTGGAAAAATGGCTGG
TTGGATCATCGGAATACTTATCTCTACAACATTAATTGCCGCATTAGTGGGTATTGGATCAGCATTGGTATTTGATCTAA
GTGCCGAACAAATAGAAGCTGGTCAAGCAGAAACAGATCGTGGGCTTTCAATCGAACAGAGCTTTTCTGAAATGGAAGGA
CAAACAACACCACAACGAATTCTAAACTTTATTCCGAGTAATATATTCTTGGATATGACTGGTGAACGTCCAACTTCTGT
TATTGCTGTAGTAATCTTTTCTGTAATTATCGGTATTGCCACACTCGGTGTTCAACGAAAACAACCAGAGCATGCAGCAA
TATTTACGAAAGGAATTAACGCCATATTCAGTATCATCATGCGAATAGTAACTCTTGTTCTTCGTTTAACACCATTTGGC
GTACTTGCTTTAATGACAAATATGGTTGCGAGTACGAATTATGAAGGAATCATCCAGCTAGGAAAGTTTGTTATCGCGTC
CTACGCTGCATTATTAGTGATGTTCGTGATTCACTTAGTACTTGTTGGTGTATTCGGACTTAATCCGATGACCTATTTAA
AAAAAGTTATTCCAGTCCTTGTTTTTGCATTCACATCACGTTCAAGTGCTGGAACAATTCCATTAAATATCTCAGCGCAA
AAGAATGCACTTGGCGTAGATGATGGGGCAGCAAATATTTCTGCATCATTCGGAGCTACCATGGGGCAAAATGGTTGTGC
GGGTATTTATCCGGCCATGTTAGCCGTGATGATTGCTCCGACAGTGGGAATCGATCCTTTATCTCTTGATTTCATTATTC
AATTGGTGTTAATTACAGCTATCAGTTCATTTGGTGTAGCTGGTGTTGGTGGAGGAGCTACCTTTGCAGCAATTATTGTT
TTATCCTCTATGGGATTACCAGTAGGTCTTGCAGGGTTATTGATCTCGATCGAAGCATTAATTGATATGGGTCGGACCGC
TCTAAATGTTAATGGAAGCATGGTATCCGGAACATTAACTTCAAAAGTGATGCGAAACCTTAATCATGAGAAGTACCAAG
ATAAGAAATCCGTTGTCGAAAACGCAGGAATTTAA

Upstream 100 bases:

>100_bases
CCAAACATTTTTTCTTGATTAAGGCATAGAATCATTGTATAGTTTAATTCGTAGTAAATTAATTGGAATTATATGTTTTT
CACAAGGAGGGTATTTGTTA

Downstream 100 bases:

>100_bases
TATTAAGAATAGAGTAGAAGGGGGCGACTAACCCCCGTCCTCTCACACCACCGTACGTACCGTTCGGTATACGGCGGTTC
AATTAAGTATTACGAATAAA

Product: sodium:glutamate symporter

Products: NA

Alternate protein names: Transporter of cystine tcyP [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MDNLFILINVVVLLALIGLLIYMQKKHVSFAKRVFTGMGIGIVLGAILQGIYGEGSSILNGTLDWYSIVGSGYVRFLMVI
VVPLVMISIIRAIINLDKSKELGKMAGWIIGILISTTLIAALVGIGSALVFDLSAEQIEAGQAETDRGLSIEQSFSEMEG
QTTPQRILNFIPSNIFLDMTGERPTSVIAVVIFSVIIGIATLGVQRKQPEHAAIFTKGINAIFSIIMRIVTLVLRLTPFG
VLALMTNMVASTNYEGIIQLGKFVIASYAALLVMFVIHLVLVGVFGLNPMTYLKKVIPVLVFAFTSRSSAGTIPLNISAQ
KNALGVDDGAANISASFGATMGQNGCAGIYPAMLAVMIAPTVGIDPLSLDFIIQLVLITAISSFGVAGVGGGATFAAIIV
LSSMGLPVGLAGLLISIEALIDMGRTALNVNGSMVSGTLTSKVMRNLNHEKYQDKKSVVENAGI

Sequences:

>Translated_464_residues
MDNLFILINVVVLLALIGLLIYMQKKHVSFAKRVFTGMGIGIVLGAILQGIYGEGSSILNGTLDWYSIVGSGYVRFLMVI
VVPLVMISIIRAIINLDKSKELGKMAGWIIGILISTTLIAALVGIGSALVFDLSAEQIEAGQAETDRGLSIEQSFSEMEG
QTTPQRILNFIPSNIFLDMTGERPTSVIAVVIFSVIIGIATLGVQRKQPEHAAIFTKGINAIFSIIMRIVTLVLRLTPFG
VLALMTNMVASTNYEGIIQLGKFVIASYAALLVMFVIHLVLVGVFGLNPMTYLKKVIPVLVFAFTSRSSAGTIPLNISAQ
KNALGVDDGAANISASFGATMGQNGCAGIYPAMLAVMIAPTVGIDPLSLDFIIQLVLITAISSFGVAGVGGGATFAAIIV
LSSMGLPVGLAGLLISIEALIDMGRTALNVNGSMVSGTLTSKVMRNLNHEKYQDKKSVVENAGI
>Mature_464_residues
MDNLFILINVVVLLALIGLLIYMQKKHVSFAKRVFTGMGIGIVLGAILQGIYGEGSSILNGTLDWYSIVGSGYVRFLMVI
VVPLVMISIIRAIINLDKSKELGKMAGWIIGILISTTLIAALVGIGSALVFDLSAEQIEAGQAETDRGLSIEQSFSEMEG
QTTPQRILNFIPSNIFLDMTGERPTSVIAVVIFSVIIGIATLGVQRKQPEHAAIFTKGINAIFSIIMRIVTLVLRLTPFG
VLALMTNMVASTNYEGIIQLGKFVIASYAALLVMFVIHLVLVGVFGLNPMTYLKKVIPVLVFAFTSRSSAGTIPLNISAQ
KNALGVDDGAANISASFGATMGQNGCAGIYPAMLAVMIAPTVGIDPLSLDFIIQLVLITAISSFGVAGVGGGATFAAIIV
LSSMGLPVGLAGLLISIEALIDMGRTALNVNGSMVSGTLTSKVMRNLNHEKYQDKKSVVENAGI

Specific function: Mediates uptake of L-cystine, the oxidized form of L- cysteine [H]

COG id: COG1823

COG function: function code R; Predicted Na+/dicarboxylate symporter

Gene ontology:

Cell location: Membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI5032093, Length=396, Percent_Identity=26.7676767676768, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI194239697, Length=465, Percent_Identity=22.7956989247312, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI40254478, Length=469, Percent_Identity=23.0277185501066, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI169790839, Length=283, Percent_Identity=26.8551236749117, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI223468566, Length=272, Percent_Identity=27.9411764705882, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI223468564, Length=272, Percent_Identity=27.9411764705882, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI4827012, Length=276, Percent_Identity=24.6376811594203, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI66773030, Length=251, Percent_Identity=27.4900398406374, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI21314632, Length=424, Percent_Identity=22.877358490566, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1788024, Length=448, Percent_Identity=51.1160714285714, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1790514, Length=439, Percent_Identity=26.6514806378132, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1789947, Length=425, Percent_Identity=23.0588235294118, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193206505, Length=459, Percent_Identity=23.9651416122004, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71983099, Length=431, Percent_Identity=22.2737819025522, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71983106, Length=431, Percent_Identity=22.2737819025522, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193206654, Length=457, Percent_Identity=22.7571115973742, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71996953, Length=432, Percent_Identity=25.462962962963, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17537407, Length=451, Percent_Identity=23.5033259423503, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17541374, Length=409, Percent_Identity=23.4718826405868, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24583025, Length=475, Percent_Identity=25.2631578947368, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17137668, Length=475, Percent_Identity=25.2631578947368, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583023, Length=475, Percent_Identity=25.2631578947368, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 48998; Mature: 48998

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNLFILINVVVLLALIGLLIYMQKKHVSFAKRVFTGMGIGIVLGAILQGIYGEGSSILN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHC
GTLDWYSIVGSGYVRFLMVIVVPLVMISIIRAIINLDKSKELGKMAGWIIGILISTTLIA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
ALVGIGSALVFDLSAEQIEAGQAETDRGLSIEQSFSEMEGQTTPQRILNFIPSNIFLDMT
HHHHCCHHHHEECCHHHHHCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCEEEEEC
GERPTSVIAVVIFSVIIGIATLGVQRKQPEHAAIFTKGINAIFSIIMRIVTLVLRLTPFG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLALMTNMVASTNYEGIIQLGKFVIASYAALLVMFVIHLVLVGVFGLNPMTYLKKVIPVL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VFAFTSRSSAGTIPLNISAQKNALGVDDGAANISASFGATMGQNGCAGIYPAMLAVMIAP
HHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHC
TVGIDPLSLDFIIQLVLITAISSFGVAGVGGGATFAAIIVLSSMGLPVGLAGLLISIEAL
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IDMGRTALNVNGSMVSGTLTSKVMRNLNHEKYQDKKSVVENAGI
HHCCCCEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDNLFILINVVVLLALIGLLIYMQKKHVSFAKRVFTGMGIGIVLGAILQGIYGEGSSILN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHC
GTLDWYSIVGSGYVRFLMVIVVPLVMISIIRAIINLDKSKELGKMAGWIIGILISTTLIA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
ALVGIGSALVFDLSAEQIEAGQAETDRGLSIEQSFSEMEGQTTPQRILNFIPSNIFLDMT
HHHHCCHHHHEECCHHHHHCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCEEEEEC
GERPTSVIAVVIFSVIIGIATLGVQRKQPEHAAIFTKGINAIFSIIMRIVTLVLRLTPFG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLALMTNMVASTNYEGIIQLGKFVIASYAALLVMFVIHLVLVGVFGLNPMTYLKKVIPVL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VFAFTSRSSAGTIPLNISAQKNALGVDDGAANISASFGATMGQNGCAGIYPAMLAVMIAP
HHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHC
TVGIDPLSLDFIIQLVLITAISSFGVAGVGGGATFAAIIVLSSMGLPVGLAGLLISIEAL
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IDMGRTALNVNGSMVSGTLTSKVMRNLNHEKYQDKKSVVENAGI
HHCCCCEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA