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The map label for this gene is siaT [H]

Identifier: 23100155

GI number: 23100155

Start: 2770483

End: 2771769

Strand: Reverse

Name: siaT [H]

Synonym: OB2700

Alternate gene names: 23100155

Gene position: 2771769-2770483 (Counterclockwise)

Preceding gene: 23100156

Following gene: 23100154

Centisome position: 76.35

GC content: 36.52

Gene sequence:

>1287_bases
ATGGGATTTCTATTATTAGCCATCTTCTTAGTATTAATGGTTATAGGTGTACCAATTGCGTTTGTTATTGGAATAGTTGC
TTTACTTGGGATCAGTGGAATTCCTTATACACCAGAAGCTACAGTAGCAATGAAAATGGTGAATGGTCTTGATTCCTTTG
TCTTATTAGCTGTTCCTTTATTCATTCTAGCAGCAAACTTAATGAATTCAGGTAAAATCTCAGAGAAGCTGATTGAGTTA
GCATTAGCTATTGTTGGGCCAATACGTGGAGGGCTTGCTCATGCAAATGTATTGGTGTCTATGATGTTTGCTGGTGTTTC
TGGAGCAGCACAAGCGGATACTGCTGGTGTAGGGAAAGTTTTAATACCGAGTATGTTACGAAAGGGCTATGATAAAGAAA
CGGCAGTAGGGGTTACTGCAGCATCCTCGACAGTTGGCGTTGTTATTCCCCCAAGTATTCCGATGATTATTTTTGCTGGT
CTTACGAATGCTTCTATCGGTGCTTTATTTTTAGGAGGAATTATCCCTGGTATTCTAATTGGTGTTGGAATGATGGTTCT
TATTTACATCATTGCATTGAAGAGAAACTATCCGAAAGATGCAAAAGTGGAATTTAAAGTATTTTTAAAATTGTTATTGG
AAGCGATTCCAGCATTGCTTACTCCGGTAATCATTATTGGTGGAATTATCACCGGATTTTTTACAGCAACAGAAGCAGCT
GCGGTAGCATCACTTTATACGATTATTATTTGCATGTTTTACTATAAAACTTTGAAACTCAAAGATTTTCCAAAGATATT
ATTCGATACACTAGCACTTAGCTCGTTATCCTTATTTGCTTTAGCAGCTGCGAGTGCATTAGGTGAGTTAATGAGCTATT
ACCAATTAGGAACAATGGCTCAAGAATTTTTTGCGAATAATATTGGGGCAGAGTGGTTATTTATAGTAATTATTATCGTT
TTCTTCTTATTTGTAGGGACATTTATGGATGCAATACCAGCAATGATTTTATTTGTTCCTGTTATTTTACCTACTGCATT
GGAATTTGGAATGGATCCCGTACACTTGGGATTAATTGTCGTCATTACGTTAGCAATTGGATTAATTACACCACCATATG
GATTATGTTTATTGTTGGCTGCGAAAATTGGGAATATGTCGACGGAACGCTCTTTTATAGCAGTCATGCCTTATATTGCG
ATCGTTATAGTAGTCCTGTTATTTATTGCGTTTTTCCCGAATATCGCATTCTATATTCCGAAACTTATTAATCCTAGCTT
ATTCTAA

Upstream 100 bases:

>100_bases
GGTTAGTAATTCCAGTAATGGCTGCTACCATGCTTATATACACTATCTCTCATTTTGTAGAGCACATTCGTGTAATTAAA
GCTAAGGAGGTATTTGAATA

Downstream 100 bases:

>100_bases
TTAGTAGAAAGGAACGATTATAGTGGAATACAGTGATAAACAAATTGCAGCACAAGAAGCGGTAAGGTATATCAAAGATG
GTATGGTTATTGGAATTGGT

Product: C4-dicarboxylate transport system permease large protein

Products: NA

Alternate protein names: N-acetylneuraminic acid permease; N-acetylneuraminic acid transporter; Neu5Ac permease [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MGFLLLAIFLVLMVIGVPIAFVIGIVALLGISGIPYTPEATVAMKMVNGLDSFVLLAVPLFILAANLMNSGKISEKLIEL
ALAIVGPIRGGLAHANVLVSMMFAGVSGAAQADTAGVGKVLIPSMLRKGYDKETAVGVTAASSTVGVVIPPSIPMIIFAG
LTNASIGALFLGGIIPGILIGVGMMVLIYIIALKRNYPKDAKVEFKVFLKLLLEAIPALLTPVIIIGGIITGFFTATEAA
AVASLYTIIICMFYYKTLKLKDFPKILFDTLALSSLSLFALAAASALGELMSYYQLGTMAQEFFANNIGAEWLFIVIIIV
FFLFVGTFMDAIPAMILFVPVILPTALEFGMDPVHLGLIVVITLAIGLITPPYGLCLLLAAKIGNMSTERSFIAVMPYIA
IVIVVLLFIAFFPNIAFYIPKLINPSLF

Sequences:

>Translated_428_residues
MGFLLLAIFLVLMVIGVPIAFVIGIVALLGISGIPYTPEATVAMKMVNGLDSFVLLAVPLFILAANLMNSGKISEKLIEL
ALAIVGPIRGGLAHANVLVSMMFAGVSGAAQADTAGVGKVLIPSMLRKGYDKETAVGVTAASSTVGVVIPPSIPMIIFAG
LTNASIGALFLGGIIPGILIGVGMMVLIYIIALKRNYPKDAKVEFKVFLKLLLEAIPALLTPVIIIGGIITGFFTATEAA
AVASLYTIIICMFYYKTLKLKDFPKILFDTLALSSLSLFALAAASALGELMSYYQLGTMAQEFFANNIGAEWLFIVIIIV
FFLFVGTFMDAIPAMILFVPVILPTALEFGMDPVHLGLIVVITLAIGLITPPYGLCLLLAAKIGNMSTERSFIAVMPYIA
IVIVVLLFIAFFPNIAFYIPKLINPSLF
>Mature_427_residues
GFLLLAIFLVLMVIGVPIAFVIGIVALLGISGIPYTPEATVAMKMVNGLDSFVLLAVPLFILAANLMNSGKISEKLIELA
LAIVGPIRGGLAHANVLVSMMFAGVSGAAQADTAGVGKVLIPSMLRKGYDKETAVGVTAASSTVGVVIPPSIPMIIFAGL
TNASIGALFLGGIIPGILIGVGMMVLIYIIALKRNYPKDAKVEFKVFLKLLLEAIPALLTPVIIIGGIITGFFTATEAAA
VASLYTIIICMFYYKTLKLKDFPKILFDTLALSSLSLFALAAASALGELMSYYQLGTMAQEFFANNIGAEWLFIVIIIVF
FLFVGTFMDAIPAMILFVPVILPTALEFGMDPVHLGLIVVITLAIGLITPPYGLCLLLAAKIGNMSTERSFIAVMPYIAI
VIVVLLFIAFFPNIAFYIPKLINPSLF

Specific function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system siaPT involved in the uptake of sialic acid [H]

COG id: COG1593

COG function: function code G; TRAP-type C4-dicarboxylate transport system, large permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the TRAP transporter large permease family [H]

Homologues:

Organism=Escherichia coli, GI48994950, Length=410, Percent_Identity=33.1707317073171, Blast_Score=191, Evalue=7e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010656
- InterPro:   IPR007387
- InterPro:   IPR004681 [H]

Pfam domain/function: PF06808 DctM; PF04290 DctQ [H]

EC number: NA

Molecular weight: Translated: 45392; Mature: 45261

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFLLLAIFLVLMVIGVPIAFVIGIVALLGISGIPYTPEATVAMKMVNGLDSFVLLAVPL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FILAANLMNSGKISEKLIELALAIVGPIRGGLAHANVLVSMMFAGVSGAAQADTAGVGKV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
LIPSMLRKGYDKETAVGVTAASSTVGVVIPPSIPMIIFAGLTNASIGALFLGGIIPGILI
HHHHHHHCCCCCHHHHEEEECCCCEEEEECCCCCHHHEECCCCCHHHHHHHHHHHHHHHH
GVGMMVLIYIIALKRNYPKDAKVEFKVFLKLLLEAIPALLTPVIIIGGIITGFFTATEAA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVASLYTIIICMFYYKTLKLKDFPKILFDTLALSSLSLFALAAASALGELMSYYQLGTMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEFFANNIGAEWLFIVIIIVFFLFVGTFMDAIPAMILFVPVILPTALEFGMDPVHLGLIV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VITLAIGLITPPYGLCLLLAAKIGNMSTERSFIAVMPYIAIVIVVLLFIAFFPNIAFYIP
HHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLINPSLF
HHCCCCCC
>Mature Secondary Structure 
GFLLLAIFLVLMVIGVPIAFVIGIVALLGISGIPYTPEATVAMKMVNGLDSFVLLAVPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FILAANLMNSGKISEKLIELALAIVGPIRGGLAHANVLVSMMFAGVSGAAQADTAGVGKV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
LIPSMLRKGYDKETAVGVTAASSTVGVVIPPSIPMIIFAGLTNASIGALFLGGIIPGILI
HHHHHHHCCCCCHHHHEEEECCCCEEEEECCCCCHHHEECCCCCHHHHHHHHHHHHHHHH
GVGMMVLIYIIALKRNYPKDAKVEFKVFLKLLLEAIPALLTPVIIIGGIITGFFTATEAA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVASLYTIIICMFYYKTLKLKDFPKILFDTLALSSLSLFALAAASALGELMSYYQLGTMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEFFANNIGAEWLFIVIIIVFFLFVGTFMDAIPAMILFVPVILPTALEFGMDPVHLGLIV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VITLAIGLITPPYGLCLLLAAKIGNMSTERSFIAVMPYIAIVIVVLLFIAFFPNIAFYIP
HHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLINPSLF
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]