Click here to switch to the map view.

The map label for this gene is arsC

Identifier: 23099878

GI number: 23099878

Start: 2476584

End: 2477003

Strand: Reverse

Name: arsC

Synonym: OB2423

Alternate gene names: 23099878

Gene position: 2477003-2476584 (Counterclockwise)

Preceding gene: 23099879

Following gene: 23099877

Centisome position: 68.23

GC content: 36.43

Gene sequence:

>420_bases
ATGTCTAAAAAAATTATATATTTCTTATGTACTGGAAATTCATGTCGCAGTCAAATGGCAGAAGGATGGGGAAAGAAAAT
CCTAGGTGAAGAATGGGATGTGTATAGTGCAGGAATTGAAGCACATGGACTTAATCCAAATGCCATAAAAGCAATGAGAG
AAGTAGATATCGATATTACAAATCAAACTTCAGATCAAATTGATAAGGATATCTTAAATAAAGCAGACTTTGTTGTTACT
TTATGTGGGGATGCGAAGGATAAATGTCCAATGACTCCTCCACATGTAAAAAGAGACCATTGGGGATTTGAGGATCCTGC
AAAAGCACAAGGTACTGAAGAAGAAAAGTGGACTGTATTTCAGCAGGTTCGTGATAAAATTGGCGACCGCATAAAAGTGT
TTGCTAAAACAGGAGAATAA

Upstream 100 bases:

>100_bases
TACTTTAAAACCGGAATTGTAATAACAATACCTGTCTTATTTATGACTCTTGCAGGATTGTTTATGTGGTTAATGATTAT
AAATTAAAGGAGTTTTTAAT

Downstream 100 bases:

>100_bases
TTGTCATAGATAGCATGAAGGTAGATGACTACCTTCATGCTTTTTTGTTATATTCAAGTATAAAAACCGTGGATATGTCT
ATGATTTTATTATTGTATAA

Product: arsenate reductase

Products: NA

Alternate protein names: Arsenate reductase; Arsenical pump modifier; Low molecular weight protein-tyrosine-phosphatase

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MSKKIIYFLCTGNSCRSQMAEGWGKKILGEEWDVYSAGIEAHGLNPNAIKAMREVDIDITNQTSDQIDKDILNKADFVVT
LCGDAKDKCPMTPPHVKRDHWGFEDPAKAQGTEEEKWTVFQQVRDKIGDRIKVFAKTGE

Sequences:

>Translated_139_residues
MSKKIIYFLCTGNSCRSQMAEGWGKKILGEEWDVYSAGIEAHGLNPNAIKAMREVDIDITNQTSDQIDKDILNKADFVVT
LCGDAKDKCPMTPPHVKRDHWGFEDPAKAQGTEEEKWTVFQQVRDKIGDRIKVFAKTGE
>Mature_138_residues
SKKIIYFLCTGNSCRSQMAEGWGKKILGEEWDVYSAGIEAHGLNPNAIKAMREVDIDITNQTSDQIDKDILNKADFVVTL
CGDAKDKCPMTPPHVKRDHWGFEDPAKAQGTEEEKWTVFQQVRDKIGDRIKVFAKTGE

Specific function: Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARSC_OCEIH (Q8ENQ5)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693344.1
- ProteinModelPortal:   Q8ENQ5
- SMR:   Q8ENQ5
- GeneID:   1017228
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2423
- NMPDR:   fig|221109.1.peg.2420
- HOGENOM:   HBG730979
- OMA:   NILNRAD
- ProtClustDB:   PRK13530
- BioCyc:   OIHE221109:OB2423-MONOMER
- BRENDA:   3.1.3.48
- HAMAP:   MF_01624
- InterPro:   IPR014064
- InterPro:   IPR017867
- PANTHER:   PTHR11717
- SMART:   SM00226
- TIGRFAMs:   TIGR02691

Pfam domain/function: PF01451 LMWPc; SSF52788 Tyr_Pase_low_mol_wt

EC number: =3.1.3.48

Molecular weight: Translated: 15676; Mature: 15545

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: ACT_SITE 10-10 ACT_SITE 82-82 ACT_SITE 89-89

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKIIYFLCTGNSCRSQMAEGWGKKILGEEWDVYSAGIEAHGLNPNAIKAMREVDIDIT
CCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEECCEECCCCCHHHHHHHHHCCCCCC
NQTSDQIDKDILNKADFVVTLCGDAKDKCPMTPPHVKRDHWGFEDPAKAQGTEEEKWTVF
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
QQVRDKIGDRIKVFAKTGE
HHHHHHHCCEEEEEEECCC
>Mature Secondary Structure 
SKKIIYFLCTGNSCRSQMAEGWGKKILGEEWDVYSAGIEAHGLNPNAIKAMREVDIDIT
CCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEECCEECCCCCHHHHHHHHHCCCCCC
NQTSDQIDKDILNKADFVVTLCGDAKDKCPMTPPHVKRDHWGFEDPAKAQGTEEEKWTVF
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
QQVRDKIGDRIKVFAKTGE
HHHHHHHCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376