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The map label for this gene is capL [H]

Identifier: 23099535

GI number: 23099535

Start: 2110177

End: 2111499

Strand: Direct

Name: capL [H]

Synonym: OB2080

Alternate gene names: 23099535

Gene position: 2110177-2111499 (Clockwise)

Preceding gene: 23099526

Following gene: 23099536

Centisome position: 58.12

GC content: 32.96

Gene sequence:

>1323_bases
ATGAAAAAAACAAACAATACAACAAACACTCCCTACGTAAATTCAAAAGTAGGTGTAATTGGCATGGGTTATGTCGGACT
TCCTCTAGCTTTATTATTCTTAAAAAAAGGATATCAAGTTACTGGAATTGATATTAATCAATCTAAAATTAGCCAATTAC
AAAACGGAAAAAGTTATATTCCAGATATTAAAGACAACGAACTACAGGATGCGCTAAAAACGGATAGTATTATATTTACT
TCCAACTATGATGTCATAAGTCAATTAGATATTATCGTAATATGCGTTCCAACACCTTTAACAAAAGAGCAAATTCCTGA
TCTTAGTTATATCAAAAATGTAAGTGAAGAAATATATCCAAGACTGCAAATTAATCAGTTAGTTATTTTGGAAAGTTCCA
CTTATCCAGGAACAACACGTGATATTCTCCTACCAATATTAGAAAAAAGCGATCTACAAATTGGTTCAGAGTTCTATCTA
GGTTATTCTCCAGAGAGAATTGACCCTGGAAATAACACGTTAAAAGTAGAAGAAATTCCTAAAGTAGTTGGCGGTATATC
AGAGGGTTGCCTGCAACATATAACTGATTTCTATCAAAATGTATTTGATGAAATAATTCCAACTTCTTCTGTTGAAATAG
CTGAACTATGTAAATTAGTGGAGAATAGTTATCGTTTTATTAATGTATCCTTTATAAACGAATTGGCAATGCTCTGCGAT
CAATTAAATATTAATTTATGGGAAGCAATTGATGCTGCTAGTTCAAAACCATATGGTTTTCAACCGTTTTACCCGGGACC
TGGAATCGGAGGACATTGCATTCCGATTGATCCACTATATTTGTCATGGATAGGACAACAACATGGATTTAATAACCAAT
TTCTAGCTCTTGCAGAGCAAAAAAACAAAGATATAAGTCAGTATGTAATCAATCAGATTAATAATATCGTTCATGCAGAA
AAACCTATTAATGAGGCAAATATTCTTATCTGTGGTGTATCATACAAAAAAGATTCCAATGATGTTCGAACGTCTCCGCC
TTTAGACATCATGAAAACGTTAGTAAAAAGTTACAAAAGTTTGGTGTACTTTGATCCAGCTGTTCCAACTGTTGAAATCA
ACCAACAAACATATCACAGTACGGAGATAACTCCCCAACTATTAAAAAAAATGGATATAGTTGTCATATTAGTCGACCAT
TCTGCCATTCCTGTCCAGGACATACTAAACCATGCAAAAATAGTATATGATACCAAGAATGTAACTGCTGGATTAACCGG
AAGTGCTAAATTATTCTTGTTAGGTAACGGAAATATATCTTAG

Upstream 100 bases:

>100_bases
ATTCAGTGCTGCCAATAGGTAGCAGCCGTTCCTTATTCAATTAAAATTCTATAAAATACAGCAGCTGATTAATTGAATGT
ATATTTTTAGGAGGTCAACT

Downstream 100 bases:

>100_bases
TTGGTGACCTTTATGATATCAATCATTACTTGTACGAATCGAGATCATATGATGGAAAATATATTCCTTAACTATAGTTC
ACAGACTATAGAGAACAAGG

Product: UDP-glucose:GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MKKTNNTTNTPYVNSKVGVIGMGYVGLPLALLFLKKGYQVTGIDINQSKISQLQNGKSYIPDIKDNELQDALKTDSIIFT
SNYDVISQLDIIVICVPTPLTKEQIPDLSYIKNVSEEIYPRLQINQLVILESSTYPGTTRDILLPILEKSDLQIGSEFYL
GYSPERIDPGNNTLKVEEIPKVVGGISEGCLQHITDFYQNVFDEIIPTSSVEIAELCKLVENSYRFINVSFINELAMLCD
QLNINLWEAIDAASSKPYGFQPFYPGPGIGGHCIPIDPLYLSWIGQQHGFNNQFLALAEQKNKDISQYVINQINNIVHAE
KPINEANILICGVSYKKDSNDVRTSPPLDIMKTLVKSYKSLVYFDPAVPTVEINQQTYHSTEITPQLLKKMDIVVILVDH
SAIPVQDILNHAKIVYDTKNVTAGLTGSAKLFLLGNGNIS

Sequences:

>Translated_440_residues
MKKTNNTTNTPYVNSKVGVIGMGYVGLPLALLFLKKGYQVTGIDINQSKISQLQNGKSYIPDIKDNELQDALKTDSIIFT
SNYDVISQLDIIVICVPTPLTKEQIPDLSYIKNVSEEIYPRLQINQLVILESSTYPGTTRDILLPILEKSDLQIGSEFYL
GYSPERIDPGNNTLKVEEIPKVVGGISEGCLQHITDFYQNVFDEIIPTSSVEIAELCKLVENSYRFINVSFINELAMLCD
QLNINLWEAIDAASSKPYGFQPFYPGPGIGGHCIPIDPLYLSWIGQQHGFNNQFLALAEQKNKDISQYVINQINNIVHAE
KPINEANILICGVSYKKDSNDVRTSPPLDIMKTLVKSYKSLVYFDPAVPTVEINQQTYHSTEITPQLLKKMDIVVILVDH
SAIPVQDILNHAKIVYDTKNVTAGLTGSAKLFLLGNGNIS
>Mature_440_residues
MKKTNNTTNTPYVNSKVGVIGMGYVGLPLALLFLKKGYQVTGIDINQSKISQLQNGKSYIPDIKDNELQDALKTDSIIFT
SNYDVISQLDIIVICVPTPLTKEQIPDLSYIKNVSEEIYPRLQINQLVILESSTYPGTTRDILLPILEKSDLQIGSEFYL
GYSPERIDPGNNTLKVEEIPKVVGGISEGCLQHITDFYQNVFDEIIPTSSVEIAELCKLVENSYRFINVSFINELAMLCD
QLNINLWEAIDAASSKPYGFQPFYPGPGIGGHCIPIDPLYLSWIGQQHGFNNQFLALAEQKNKDISQYVINQINNIVHAE
KPINEANILICGVSYKKDSNDVRTSPPLDIMKTLVKSYKSLVYFDPAVPTVEINQQTYHSTEITPQLLKKMDIVVILVDH
SAIPVQDILNHAKIVYDTKNVTAGLTGSAKLFLLGNGNIS

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=386, Percent_Identity=25.6476683937824, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI48994968, Length=423, Percent_Identity=29.7872340425532, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1788340, Length=369, Percent_Identity=26.0162601626016, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17560350, Length=380, Percent_Identity=25.7894736842105, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136908, Length=399, Percent_Identity=25.062656641604, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48977; Mature: 48977

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTNNTTNTPYVNSKVGVIGMGYVGLPLALLFLKKGYQVTGIDINQSKISQLQNGKSYI
CCCCCCCCCCCEECCCCCEEEECHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCC
PDIKDNELQDALKTDSIIFTSNYDVISQLDIIVICVPTPLTKEQIPDLSYIKNVSEEIYP
CCCCCCHHHHHHCCCCEEEECCCCHHCCCCEEEEEECCCCCHHHCCCHHHHHHHHHHHCC
RLQINQLVILESSTYPGTTRDILLPILEKSDLQIGSEFYLGYSPERIDPGNNTLKVEEIP
CEEECEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCEEEHHHHH
KVVGGISEGCLQHITDFYQNVFDEIIPTSSVEIAELCKLVENSYRFINVSFINELAMLCD
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHH
QLNINLWEAIDAASSKPYGFQPFYPGPGIGGHCIPIDPLYLSWIGQQHGFNNQFLALAEQ
HCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCCCCCEEEEECC
KNKDISQYVINQINNIVHAEKPINEANILICGVSYKKDSNDVRTSPPLDIMKTLVKSYKS
CCCCHHHHHHHHHHHHEECCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
LVYFDPAVPTVEINQQTYHSTEITPQLLKKMDIVVILVDHSAIPVQDILNHAKIVYDTKN
EEEECCCCCEEEECCCCCCCCCCCHHHHHCCCEEEEEECCCCCCHHHHHCCCEEEEECCC
VTAGLTGSAKLFLLGNGNIS
CEECCCCCEEEEEEECCCCC
>Mature Secondary Structure
MKKTNNTTNTPYVNSKVGVIGMGYVGLPLALLFLKKGYQVTGIDINQSKISQLQNGKSYI
CCCCCCCCCCCEECCCCCEEEECHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCC
PDIKDNELQDALKTDSIIFTSNYDVISQLDIIVICVPTPLTKEQIPDLSYIKNVSEEIYP
CCCCCCHHHHHHCCCCEEEECCCCHHCCCCEEEEEECCCCCHHHCCCHHHHHHHHHHHCC
RLQINQLVILESSTYPGTTRDILLPILEKSDLQIGSEFYLGYSPERIDPGNNTLKVEEIP
CEEECEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCEEEHHHHH
KVVGGISEGCLQHITDFYQNVFDEIIPTSSVEIAELCKLVENSYRFINVSFINELAMLCD
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHH
QLNINLWEAIDAASSKPYGFQPFYPGPGIGGHCIPIDPLYLSWIGQQHGFNNQFLALAEQ
HCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCCCCCEEEEECC
KNKDISQYVINQINNIVHAEKPINEANILICGVSYKKDSNDVRTSPPLDIMKTLVKSYKS
CCCCHHHHHHHHHHHHEECCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
LVYFDPAVPTVEINQQTYHSTEITPQLLKKMDIVVILVDHSAIPVQDILNHAKIVYDTKN
EEEECCCCCEEEECCCCCCCCCCCHHHHHCCCEEEEEECCCCCCHHHHHCCCEEEEECCC
VTAGLTGSAKLFLLGNGNIS
CEECCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]