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The map label for this gene is gluP [H]

Identifier: 23099378

GI number: 23099378

Start: 1950531

End: 1952087

Strand: Reverse

Name: gluP [H]

Synonym: OB1923

Alternate gene names: 23099378

Gene position: 1952087-1950531 (Counterclockwise)

Preceding gene: 23099379

Following gene: 23099376

Centisome position: 53.77

GC content: 30.31

Gene sequence:

>1557_bases
ATGTACATAAACGATGTATATGTGGAGTACCAGTTAGCTTATCAATTACTTGAACAAGGGTTTGAATTAATTAATAAGAA
CGAGGAAACAGATGAGCTTTGGTTTGAAAAGTTTAAAAACAATACTTCAGTCATCATTCGATTAATACCAAAAAGGTTTG
ATTGGGACAATCAACTTAAACAAGATGTAACAAATACATATCAACGAATTCATCAAATGAGAAAGATGTTTAAAGGAAAA
CATATTGAAGCAATTACGATTTATACATCAAGTGAGGAACCAATTGGTGATGATTGGCAAACATTAAAGAAACCAATTAC
TTCAAATGCAAAAAAACCATTTACGATGAATGTCTATTTTTTACATGAATCTACGTTTTCTGATGAAATTGAACGGTTAC
GGGAGAAAATAGGGTTAGATTTATCTATGGATGAACTAAATGAATTGGATGATGAACAAAAAGAAAGTAAAGTTAATTAT
TTTAAGCAAACCATATTTCATGATTATAATAATCGAATCGAAAAAAGAAGAAAAGTATTTTCAAATGGAAAACCATTATT
TACATATATTTTAATAGCACTTAATCTATTTTTTTTCTTACAACAAATAAATAATGGCGGCAGTGAAAATATCGATACGC
TTATACAAATGGGTGCAAAATATAATCCATTAATCATGGAAGGAGAATGGTGGCGTCTATTGACTTCGATGTTCCTGCAT
ATAGGGTTTGTTCATATCTTAATGAACATGGTTGCTTTATTCTATTTAGGAACAGCAGTTGAAAGGATATTTGGCAGAAC
GAGATTTTTAGTTATTTACTTTCTAGGTGGAATTGCTGGTTCTATAGCGAGCTTCGCTACATCTATTAGTATTTCAGCCG
GTGCGTCTGGAGCAATATTTGGATTGTTTGGTGCCTTGTTATTCTTTGGATTAATCTATAAAGATGTCTTTAAGGATACA
ATGGGTATGAATATTGTATTTATACTTGTAGTGAATCTTGTTATCGGTTTTTCTATACCGGAAATAGATATGGGTGCTCA
TCTCGGTGGATTACTTGGAGGCTTTCTAATAGCAGCTTGTCTTTATGTACCAGGTAAAAAGAATGGTAAATATCAATTAG
GAGCAATTATTGCATTTATTATTTTATGTTCTGGATTATTAATGTACGGTTTTGATAATAATGCTTCTTCTTTAGAATTT
AAATTAATTGAAGTAGAAGAGAAATTATCTGACAATCAATTTGAAGAAGCAATTGACCTATCTACCAATGCTTTAAATGA
ATTAAAATCAACGAACGATAATGAGCTGGTTCCTTATTTTCTATTCCATCGTTCATATGCATATTTACAGCAGGATGAAA
TTGAATTAGCACAAGCTGATCTAGAAGAAAGTTTAAACTACGATGAAACGATCCCTGAAGCATACAATAATTTAACTATT
ATCTATGCAAATAATTTTGAATTTGATAAGGCAAATGAAATAATAGATGAAGGTTTAGAACGTTTTCCTGAAAATCAAGA
ATTATTAGATCTTCAACAAGACTTATCCAATTATTAA

Upstream 100 bases:

>100_bases
TTTACACTTATCTTCTAAGGTTTTTTAGATACCTGGATTATGGTAATTCTGTGCAAAAAATATTCCCGTTTGGTATGATA
TTTATTGGGGAGGTTGGTGT

Downstream 100 bases:

>100_bases
TCACTAAGAGTAGCTTTTGGCAATCGCTGAATGAGCTGCTCTTTTTTTCCATTAAGTTCGAACAGCACGAGTAAGTGCTT
TGCTTCTTTGTCAATTAAAA

Product: hypothetical protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MYINDVYVEYQLAYQLLEQGFELINKNEETDELWFEKFKNNTSVIIRLIPKRFDWDNQLKQDVTNTYQRIHQMRKMFKGK
HIEAITIYTSSEEPIGDDWQTLKKPITSNAKKPFTMNVYFLHESTFSDEIERLREKIGLDLSMDELNELDDEQKESKVNY
FKQTIFHDYNNRIEKRRKVFSNGKPLFTYILIALNLFFFLQQINNGGSENIDTLIQMGAKYNPLIMEGEWWRLLTSMFLH
IGFVHILMNMVALFYLGTAVERIFGRTRFLVIYFLGGIAGSIASFATSISISAGASGAIFGLFGALLFFGLIYKDVFKDT
MGMNIVFILVVNLVIGFSIPEIDMGAHLGGLLGGFLIAACLYVPGKKNGKYQLGAIIAFIILCSGLLMYGFDNNASSLEF
KLIEVEEKLSDNQFEEAIDLSTNALNELKSTNDNELVPYFLFHRSYAYLQQDEIELAQADLEESLNYDETIPEAYNNLTI
IYANNFEFDKANEIIDEGLERFPENQELLDLQQDLSNY

Sequences:

>Translated_518_residues
MYINDVYVEYQLAYQLLEQGFELINKNEETDELWFEKFKNNTSVIIRLIPKRFDWDNQLKQDVTNTYQRIHQMRKMFKGK
HIEAITIYTSSEEPIGDDWQTLKKPITSNAKKPFTMNVYFLHESTFSDEIERLREKIGLDLSMDELNELDDEQKESKVNY
FKQTIFHDYNNRIEKRRKVFSNGKPLFTYILIALNLFFFLQQINNGGSENIDTLIQMGAKYNPLIMEGEWWRLLTSMFLH
IGFVHILMNMVALFYLGTAVERIFGRTRFLVIYFLGGIAGSIASFATSISISAGASGAIFGLFGALLFFGLIYKDVFKDT
MGMNIVFILVVNLVIGFSIPEIDMGAHLGGLLGGFLIAACLYVPGKKNGKYQLGAIIAFIILCSGLLMYGFDNNASSLEF
KLIEVEEKLSDNQFEEAIDLSTNALNELKSTNDNELVPYFLFHRSYAYLQQDEIELAQADLEESLNYDETIPEAYNNLTI
IYANNFEFDKANEIIDEGLERFPENQELLDLQQDLSNY
>Mature_518_residues
MYINDVYVEYQLAYQLLEQGFELINKNEETDELWFEKFKNNTSVIIRLIPKRFDWDNQLKQDVTNTYQRIHQMRKMFKGK
HIEAITIYTSSEEPIGDDWQTLKKPITSNAKKPFTMNVYFLHESTFSDEIERLREKIGLDLSMDELNELDDEQKESKVNY
FKQTIFHDYNNRIEKRRKVFSNGKPLFTYILIALNLFFFLQQINNGGSENIDTLIQMGAKYNPLIMEGEWWRLLTSMFLH
IGFVHILMNMVALFYLGTAVERIFGRTRFLVIYFLGGIAGSIASFATSISISAGASGAIFGLFGALLFFGLIYKDVFKDT
MGMNIVFILVVNLVIGFSIPEIDMGAHLGGLLGGFLIAACLYVPGKKNGKYQLGAIIAFIILCSGLLMYGFDNNASSLEF
KLIEVEEKLSDNQFEEAIDLSTNALNELKSTNDNELVPYFLFHRSYAYLQQDEIELAQADLEESLNYDETIPEAYNNLTI
IYANNFEFDKANEIIDEGLERFPENQELLDLQQDLSNY

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Caenorhabditis elegans, GI133901888, Length=132, Percent_Identity=30.3030303030303, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24641333, Length=184, Percent_Identity=26.6304347826087, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17933592, Length=184, Percent_Identity=26.6304347826087, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 59697; Mature: 59697

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS50005 TPR L=RR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYINDVYVEYQLAYQLLEQGFELINKNEETDELWFEKFKNNTSVIIRLIPKRFDWDNQLK
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHH
QDVTNTYQRIHQMRKMFKGKHIEAITIYTSSEEPIGDDWQTLKKPITSNAKKPFTMNVYF
HHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEEE
LHESTFSDEIERLREKIGLDLSMDELNELDDEQKESKVNYFKQTIFHDYNNRIEKRRKVF
EECCHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNGKPLFTYILIALNLFFFLQQINNGGSENIDTLIQMGAKYNPLIMEGEWWRLLTSMFLH
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEECCHHHHHHHHHHHH
IGFVHILMNMVALFYLGTAVERIFGRTRFLVIYFLGGIAGSIASFATSISISAGASGAIF
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHH
GLFGALLFFGLIYKDVFKDTMGMNIVFILVVNLVIGFSIPEIDMGAHLGGLLGGFLIAAC
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
LYVPGKKNGKYQLGAIIAFIILCSGLLMYGFDNNASSLEFKLIEVEEKLSDNQFEEAIDL
HHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHHCCHHHHHHHHH
STNALNELKSTNDNELVPYFLFHRSYAYLQQDEIELAQADLEESLNYDETIPEAYNNLTI
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCEEE
IYANNFEFDKANEIIDEGLERFPENQELLDLQQDLSNY
EEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MYINDVYVEYQLAYQLLEQGFELINKNEETDELWFEKFKNNTSVIIRLIPKRFDWDNQLK
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHH
QDVTNTYQRIHQMRKMFKGKHIEAITIYTSSEEPIGDDWQTLKKPITSNAKKPFTMNVYF
HHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEEE
LHESTFSDEIERLREKIGLDLSMDELNELDDEQKESKVNYFKQTIFHDYNNRIEKRRKVF
EECCHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNGKPLFTYILIALNLFFFLQQINNGGSENIDTLIQMGAKYNPLIMEGEWWRLLTSMFLH
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEECCHHHHHHHHHHHH
IGFVHILMNMVALFYLGTAVERIFGRTRFLVIYFLGGIAGSIASFATSISISAGASGAIF
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHH
GLFGALLFFGLIYKDVFKDTMGMNIVFILVVNLVIGFSIPEIDMGAHLGGLLGGFLIAAC
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
LYVPGKKNGKYQLGAIIAFIILCSGLLMYGFDNNASSLEFKLIEVEEKLSDNQFEEAIDL
HHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHHCCHHHHHHHHH
STNALNELKSTNDNELVPYFLFHRSYAYLQQDEIELAQADLEESLNYDETIPEAYNNLTI
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCEEE
IYANNFEFDKANEIIDEGLERFPENQELLDLQQDLSNY
EEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]