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The map label for this gene is accC [H]

Identifier: 23099340

GI number: 23099340

Start: 1919214

End: 1920581

Strand: Reverse

Name: accC [H]

Synonym: OB1885

Alternate gene names: 23099340

Gene position: 1920581-1919214 (Counterclockwise)

Preceding gene: 23099341

Following gene: 23099339

Centisome position: 52.9

GC content: 38.01

Gene sequence:

>1368_bases
TTGATTAAGAAGCTATTAATAGCTAATAGAGGGGAAATTGCGGTTCGTATTATTCGTGCTTGTAAAGAAATGAATATCGA
AACGGTTGCCATTTACTCAGAAGCCGATAGCGAATCCCTTCATGTACAATTAGCCGATGAAGCATACTGTATTGGGCCCA
AATTAAGTAAAGACAGCTACTTAAACATAACGAATATAATGAGTCTTGCCACACTAACCGAAGTTGATGCTATCCATCCA
GGGTATGGTTTTTTAGCTGAGAATGCTGATTTTGCTGAGATATGCAGAGCTTGTAATATCACCTTCGTTGGCCCTACTCC
AAAAGCAATTCAACAAATGGGAATAAAAGATGTTGCAAAAGAAACAATGAAAAATGCTAATGTACCTGTTGTTCCAGGTT
CTGAAGGTATTGTCGATACAACTGAAGATGCTATCGAAGTAGCTAATAGTATCGGTTATCCTGTTATCATCAAAGCTACT
GCTGGTGGCGGCGGGAAAGGTATTCGCGTTGCTCGCAGCGAAGAAGAGCTTATTAAAGGAATGGAAATAACTCAAAAAGA
AGCAGAAACAGCTTTTGGAAATCCAGGTGTATACCTAGAGAAATTCATTGAGGATTTTCGTCATGTTGAAATTCAAATAC
TTGCTGACACTCACGGGAATGTAATCCATCTTGGAGAGAGAGATTGCTCGATTCAGCGTAGACTACAGAAATTGATTGAA
GAATCACCTTCTCCTGCACTTAATGAATCCATTCGTGCTAAAATGGGAGAAGCCTCTGTAAAAGCGGCTAAAGCCGTAGA
ATATGTTGGTGCTGGTACCATTGAGTATATTTTCGATCGAAAAACGAATGAGTTCTATTTCATGGAAATGAATACTAGAA
TACAAGTAGAGCACCCTGTAACAGAAATGGTAACTGGTGTAGATTTAATTAAAGAACAAATTAATGTTGCAAATGGCGAA
AAGCTATCAGTTAATCAGTCAGATATAACGATGGACGGGTGGGCAATTGAATGTCGGATTAATGCCGAAAATCCATACCA
AAATTTTATGCCATCTGCGGGTGAGATTGAAATGTATTTACCACCTGGTGGATTAGGAGTTCGTATTGATTCTGGTGCAT
ATACTGGATATCGAATTCCACCATATTATGATTCGATGATTGCTAAGCTAATAACATATGCTCCAACGAGAGAAGAAGCA
ATTAGCAAGATGAAGCGAGCATTAGATGAGTTTGTTGTTGAAGGAGTCTTTACAACAATTCCTTTTCACTACCAAATTAT
GAATCACCAAGTATTTCAAGAAGGTGATTTTAATACTAATTTCCTTACTGAATATCCGATTTTGCAGGACACAGATGATT
CCGAATAA

Upstream 100 bases:

>100_bases
GAAGTATCAGGAGAAATCGTAGAAATATTGGTTGAGAATGGTGAGCTTGTTGAGTATGGACAACCATTATTCAGAGTAAA
GAAGTAAGGGGATGGAATAA

Downstream 100 bases:

>100_bases
GGAGTGAATGCAATGAGTGAACAACCATTATTAGAAGTGAGTGATCAGAACGAACTAGGTAAGGTTAAGATTGCACCTGA
AGTATTAGAAGTAATTGCTG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 1; ACC 1 [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MIKKLLIANRGEIAVRIIRACKEMNIETVAIYSEADSESLHVQLADEAYCIGPKLSKDSYLNITNIMSLATLTEVDAIHP
GYGFLAENADFAEICRACNITFVGPTPKAIQQMGIKDVAKETMKNANVPVVPGSEGIVDTTEDAIEVANSIGYPVIIKAT
AGGGGKGIRVARSEEELIKGMEITQKEAETAFGNPGVYLEKFIEDFRHVEIQILADTHGNVIHLGERDCSIQRRLQKLIE
ESPSPALNESIRAKMGEASVKAAKAVEYVGAGTIEYIFDRKTNEFYFMEMNTRIQVEHPVTEMVTGVDLIKEQINVANGE
KLSVNQSDITMDGWAIECRINAENPYQNFMPSAGEIEMYLPPGGLGVRIDSGAYTGYRIPPYYDSMIAKLITYAPTREEA
ISKMKRALDEFVVEGVFTTIPFHYQIMNHQVFQEGDFNTNFLTEYPILQDTDDSE

Sequences:

>Translated_455_residues
MIKKLLIANRGEIAVRIIRACKEMNIETVAIYSEADSESLHVQLADEAYCIGPKLSKDSYLNITNIMSLATLTEVDAIHP
GYGFLAENADFAEICRACNITFVGPTPKAIQQMGIKDVAKETMKNANVPVVPGSEGIVDTTEDAIEVANSIGYPVIIKAT
AGGGGKGIRVARSEEELIKGMEITQKEAETAFGNPGVYLEKFIEDFRHVEIQILADTHGNVIHLGERDCSIQRRLQKLIE
ESPSPALNESIRAKMGEASVKAAKAVEYVGAGTIEYIFDRKTNEFYFMEMNTRIQVEHPVTEMVTGVDLIKEQINVANGE
KLSVNQSDITMDGWAIECRINAENPYQNFMPSAGEIEMYLPPGGLGVRIDSGAYTGYRIPPYYDSMIAKLITYAPTREEA
ISKMKRALDEFVVEGVFTTIPFHYQIMNHQVFQEGDFNTNFLTEYPILQDTDDSE
>Mature_455_residues
MIKKLLIANRGEIAVRIIRACKEMNIETVAIYSEADSESLHVQLADEAYCIGPKLSKDSYLNITNIMSLATLTEVDAIHP
GYGFLAENADFAEICRACNITFVGPTPKAIQQMGIKDVAKETMKNANVPVVPGSEGIVDTTEDAIEVANSIGYPVIIKAT
AGGGGKGIRVARSEEELIKGMEITQKEAETAFGNPGVYLEKFIEDFRHVEIQILADTHGNVIHLGERDCSIQRRLQKLIE
ESPSPALNESIRAKMGEASVKAAKAVEYVGAGTIEYIFDRKTNEFYFMEMNTRIQVEHPVTEMVTGVDLIKEQINVANGE
KLSVNQSDITMDGWAIECRINAENPYQNFMPSAGEIEMYLPPGGLGVRIDSGAYTGYRIPPYYDSMIAKLITYAPTREEA
ISKMKRALDEFVVEGVFTTIPFHYQIMNHQVFQEGDFNTNFLTEYPILQDTDDSE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=445, Percent_Identity=48.7640449438202, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI189095269, Length=446, Percent_Identity=50.4484304932735, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI295821183, Length=446, Percent_Identity=50.4484304932735, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI65506442, Length=446, Percent_Identity=50.4484304932735, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI106049528, Length=452, Percent_Identity=46.6814159292035, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI106049295, Length=452, Percent_Identity=46.6814159292035, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI106049292, Length=452, Percent_Identity=46.6814159292035, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=30.6483300589391, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=30.6483300589391, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=30.6483300589391, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=30.6483300589391, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI38679971, Length=509, Percent_Identity=30.6483300589391, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=29.8039215686275, Blast_Score=228, Evalue=8e-60,
Organism=Escherichia coli, GI1789654, Length=451, Percent_Identity=52.7716186252772, Blast_Score=458, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17567343, Length=446, Percent_Identity=45.9641255605381, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71987519, Length=445, Percent_Identity=46.9662921348315, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=44.4444444444444, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=29.5315682281059, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI71997168, Length=509, Percent_Identity=31.8271119842829, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI71997163, Length=509, Percent_Identity=31.8271119842829, Blast_Score=214, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=43.0493273542601, Blast_Score=380, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6319695, Length=452, Percent_Identity=44.6902654867257, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6321376, Length=452, Percent_Identity=46.2389380530973, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323863, Length=477, Percent_Identity=31.2368972746331, Blast_Score=229, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6324343, Length=518, Percent_Identity=30.8880308880309, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24651757, Length=444, Percent_Identity=45.2702702702703, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24652212, Length=452, Percent_Identity=46.4601769911504, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652210, Length=452, Percent_Identity=46.4601769911504, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652214, Length=452, Percent_Identity=46.4601769911504, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI19921944, Length=452, Percent_Identity=46.4601769911504, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652216, Length=452, Percent_Identity=46.4601769911504, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI281363050, Length=452, Percent_Identity=46.4601769911504, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652224, Length=452, Percent_Identity=46.4601769911504, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652222, Length=452, Percent_Identity=46.4601769911504, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652220, Length=452, Percent_Identity=46.4601769911504, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652218, Length=452, Percent_Identity=46.4601769911504, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24651759, Length=406, Percent_Identity=44.8275862068966, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI161076407, Length=504, Percent_Identity=30.1587301587302, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24586460, Length=504, Percent_Identity=30.1587301587302, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI161076409, Length=504, Percent_Identity=30.1587301587302, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24586458, Length=504, Percent_Identity=30.1587301587302, Blast_Score=219, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50452; Mature: 50452

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKLLIANRGEIAVRIIRACKEMNIETVAIYSEADSESLHVQLADEAYCIGPKLSKDSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCCCCC
LNITNIMSLATLTEVDAIHPGYGFLAENADFAEICRACNITFVGPTPKAIQQMGIKDVAK
CCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHCCEEEECCCHHHHHHCCHHHHHH
ETMKNANVPVVPGSEGIVDTTEDAIEVANSIGYPVIIKATAGGGGKGIRVARSEEELIKG
HHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHHCC
MEITQKEAETAFGNPGVYLEKFIEDFRHVEIQILADTHGNVIHLGERDCSIQRRLQKLIE
CHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHH
ESPSPALNESIRAKMGEASVKAAKAVEYVGAGTIEYIFDRKTNEFYFMEMNTRIQVEHPV
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCEEEECCCH
TEMVTGVDLIKEQINVANGEKLSVNQSDITMDGWAIECRINAENPYQNFMPSAGEIEMYL
HHHHHHHHHHHHHHCCCCCCEEECCCCCEEECCEEEEEEECCCCCHHHHCCCCCCEEEEE
PPGGLGVRIDSGAYTGYRIPPYYDSMIAKLITYAPTREEAISKMKRALDEFVVEGVFTTI
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
PFHYQIMNHQVFQEGDFNTNFLTEYPILQDTDDSE
CEEEEECCCHHHCCCCCCCCEEECCCCCCCCCCCC
>Mature Secondary Structure
MIKKLLIANRGEIAVRIIRACKEMNIETVAIYSEADSESLHVQLADEAYCIGPKLSKDSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCCCCC
LNITNIMSLATLTEVDAIHPGYGFLAENADFAEICRACNITFVGPTPKAIQQMGIKDVAK
CCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHCCEEEECCCHHHHHHCCHHHHHH
ETMKNANVPVVPGSEGIVDTTEDAIEVANSIGYPVIIKATAGGGGKGIRVARSEEELIKG
HHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHHCC
MEITQKEAETAFGNPGVYLEKFIEDFRHVEIQILADTHGNVIHLGERDCSIQRRLQKLIE
CHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHH
ESPSPALNESIRAKMGEASVKAAKAVEYVGAGTIEYIFDRKTNEFYFMEMNTRIQVEHPV
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCEEEECCCH
TEMVTGVDLIKEQINVANGEKLSVNQSDITMDGWAIECRINAENPYQNFMPSAGEIEMYL
HHHHHHHHHHHHHHCCCCCCEEECCCCCEEECCEEEEEEECCCCCHHHHCCCCCCEEEEE
PPGGLGVRIDSGAYTGYRIPPYYDSMIAKLITYAPTREEAISKMKRALDEFVVEGVFTTI
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
PFHYQIMNHQVFQEGDFNTNFLTEYPILQDTDDSE
CEEEEECCCHHHCCCCCCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377 [H]