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The map label for this gene is yqjC [H]

Identifier: 23099316

GI number: 23099316

Start: 1892155

End: 1892547

Strand: Reverse

Name: yqjC [H]

Synonym: OB1861

Alternate gene names: 23099316

Gene position: 1892547-1892155 (Counterclockwise)

Preceding gene: 23099317

Following gene: 23099315

Centisome position: 52.13

GC content: 36.64

Gene sequence:

>393_bases
ATGCAATTTGATCATATAGGAATTGCCGTATATCAATTACGTCCCGCCATTTCTACATTTACGACGGACTTGGGGTTTCG
CCTTGTGAGCGAAGAGGTTATTTCTGAAGAAGGAATTCGTATAGCAAAATTAATGAATGGAGATGTTTGTATTGAGTTAA
TGGAACCTATAAATGATCATTCCTCAATATCTAATTTTTTAAGTTCACGTGGTGAAGGTATTCATCATTTGGCGTTGAAA
GTCGAAAACTATCTTACTTATGTACTATCCGTATCAAATAGTTCTTTAAAGACAATTATGCCTAATATAAGAGTTGGAGC
CGATCAACGGCGAGTCACGTTCTTACACCCGCGTACTTTGCACGGTGTTTTAGTTGAAATTTGCGATTTGTAA

Upstream 100 bases:

>100_bases
CTTATTTTTTATCTAAAGTATAAAAATATGACTATGTTTGTATTGAAAATCTTATTTACTAATATAATGACTTCATCCAT
GGATAGGCAGGAGGGGTTTT

Downstream 100 bases:

>100_bases
AAGGAGGAAGCAGTCATAGATATCTATAAAAAATTAGAAGAACTTCAGCAAAGAAGAAAAATAGTATTTAGAGGGGGAGG
AAGCGAGAAGCATGCGGAGC

Product: lactoylglutathione lyase

Products: glutathione; methylglyoxal

Alternate protein names: NA

Number of amino acids: Translated: 130; Mature: 130

Protein sequence:

>130_residues
MQFDHIGIAVYQLRPAISTFTTDLGFRLVSEEVISEEGIRIAKLMNGDVCIELMEPINDHSSISNFLSSRGEGIHHLALK
VENYLTYVLSVSNSSLKTIMPNIRVGADQRRVTFLHPRTLHGVLVEICDL

Sequences:

>Translated_130_residues
MQFDHIGIAVYQLRPAISTFTTDLGFRLVSEEVISEEGIRIAKLMNGDVCIELMEPINDHSSISNFLSSRGEGIHHLALK
VENYLTYVLSVSNSSLKTIMPNIRVGADQRRVTFLHPRTLHGVLVEICDL
>Mature_130_residues
MQFDHIGIAVYQLRPAISTFTTDLGFRLVSEEVISEEGIRIAKLMNGDVCIELMEPINDHSSISNFLSSRGEGIHHLALK
VENYLTYVLSVSNSSLKTIMPNIRVGADQRRVTFLHPRTLHGVLVEICDL

Specific function: Unknown

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

Organism=Homo sapiens, GI188035928, Length=127, Percent_Identity=28.3464566929134, Blast_Score=73, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR018146
- InterPro:   IPR017515 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 4.4.1.5

Molecular weight: Translated: 14565; Mature: 14565

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFDHIGIAVYQLRPAISTFTTDLGFRLVSEEVISEEGIRIAKLMNGDVCIELMEPINDH
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCH
SSISNFLSSRGEGIHHLALKVENYLTYVLSVSNSSLKTIMPNIRVGADQRRVTFLHPRTL
HHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCHHHHCCCCEECCCCCEEEEECCHHH
HGVLVEICDL
HHHHHHHHCC
>Mature Secondary Structure
MQFDHIGIAVYQLRPAISTFTTDLGFRLVSEEVISEEGIRIAKLMNGDVCIELMEPINDH
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCH
SSISNFLSSRGEGIHHLALKVENYLTYVLSVSNSSLKTIMPNIRVGADQRRVTFLHPRTL
HHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCHHHHCCCCEECCCCCEEEEECCHHH
HGVLVEICDL
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-S-lactoylglutathione

Specific reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]