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The map label for this gene is engA

Identifier: 23099252

GI number: 23099252

Start: 1832773

End: 1834083

Strand: Reverse

Name: engA

Synonym: OB1797

Alternate gene names: 23099252

Gene position: 1834083-1832773 (Counterclockwise)

Preceding gene: 23099253

Following gene: 23099251

Centisome position: 50.52

GC content: 36.77

Gene sequence:

>1311_bases
ATGAGGAAATCTGTAGTAGCGATTGTTGGTAGACCAAACGTAGGAAAGTCAACCATATTTAATCGCTTAGTAGGAGAAAG
AATTTCAATTGTAGAAGATATCCCTGGTGTAACAAGGGATCGAATATATGCAAATGCAGAATGGCTTAACCATACTTTTA
ATATCATTGATACGGGTGGTATTGAACTGGGTGATGAACCATTGCTCGTGCAAATGAGACAGCAAGCTGAAATTGCAATT
GATGAAGCAGATGTAATTGTATTTTTACTGAATGGAAAAGAAGGCATTACTTCAGCAGATGACGAAGTAGCTAAATTATT
ATTCAAGTCGAATAAACCTGTTGTAGTAGGCGTAAACAAAATGGATAATCCCCAAATGCATGAAACAATTTATGAATATT
ATTCATTAGGATTTGGACAACCATTTCCCATCTCAGGCACACATGGCCTTGGATTGGGTGACTTACTAGATGAAGTCGTA
GGTCACTTTCCTAATGAATCGGAAGAAGAAAAAGATGAAGATACGATATACTTTAGTTTAATCGGTCGACCGAATGTAGG
AAAGTCTTCTCTTGTAAATGCATTATTGAATGAAGATAGAGTGATTGTTAGTGAAATAGAAGGAACCACTCGGGACGCTA
TAGATACGAAATTACATCGTGATGACCAAGACTTTGTAATAATTGATACAGCTGGTATGCGCAAACGAGGAAAAGTATAT
GAATCCACAGAAAAATACAGTGTACTCCGTGCGTTGCGAGCGATAGAACGTTCTGACGTTGTTTTAGTATTAATAGATGC
TGAGACAGGTATTCGTGAACAAGATAAACGTATAGCTGGATATGCCCATGATGCAGGTAGAGCAATAGTTATCGTTGTTA
ATAAATGGGACACTGTCGACTCAAATGAAAAAGCAATGAAAGAATTCGAAAAAAATATTCGAGCACATTTTCAGTATCTA
GATTATGCTCCAGTTGTATTTCTATCAGCGAAAACGAAAAAACGCATGCATACCTTAGTGCCAGCAATAAAATTAGCTAG
TGAAAGCCATACAAAACGTATTCCAACTAATGTATTAAATGATGTAATAATGGATGCTATTGCTATGAATCCAACACCTA
CATTAAAAGGAAAACGCTTGAAAGTGCTCTATGCAACACAAGTTGCTGTCCAACCGCCAAGCTTCGTTGTTTTTGTAAAT
GATCCAGAGTTGATGCACTTTTCATACGAGAGATTTTTAGAGAATAAAATCCGTGATGCATTTGGATTTGTGGGCACACC
TATAAAATTATTCGCTAGAAGACGCCAATAA

Upstream 100 bases:

>100_bases
ATTGTAAAACACTAAATATAGAATTTAATTGTTTATCTTACCTTATTTTGCTAGAATGTATAAAGGCAAATAGACAAAAG
AGAGAGGATGTTCCTTAAAA

Downstream 100 bases:

>100_bases
ATTAGGGAGAGATGATCACATGGAAAAAGTTGCTGTACTAGGAGCCGGTAGTTGGGGAACAGCTCTTGCAATTGTATTAG
CTGACAATGGTCATGAAGTT

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MRKSVVAIVGRPNVGKSTIFNRLVGERISIVEDIPGVTRDRIYANAEWLNHTFNIIDTGGIELGDEPLLVQMRQQAEIAI
DEADVIVFLLNGKEGITSADDEVAKLLFKSNKPVVVGVNKMDNPQMHETIYEYYSLGFGQPFPISGTHGLGLGDLLDEVV
GHFPNESEEEKDEDTIYFSLIGRPNVGKSSLVNALLNEDRVIVSEIEGTTRDAIDTKLHRDDQDFVIIDTAGMRKRGKVY
ESTEKYSVLRALRAIERSDVVLVLIDAETGIREQDKRIAGYAHDAGRAIVIVVNKWDTVDSNEKAMKEFEKNIRAHFQYL
DYAPVVFLSAKTKKRMHTLVPAIKLASESHTKRIPTNVLNDVIMDAIAMNPTPTLKGKRLKVLYATQVAVQPPSFVVFVN
DPELMHFSYERFLENKIRDAFGFVGTPIKLFARRRQ

Sequences:

>Translated_436_residues
MRKSVVAIVGRPNVGKSTIFNRLVGERISIVEDIPGVTRDRIYANAEWLNHTFNIIDTGGIELGDEPLLVQMRQQAEIAI
DEADVIVFLLNGKEGITSADDEVAKLLFKSNKPVVVGVNKMDNPQMHETIYEYYSLGFGQPFPISGTHGLGLGDLLDEVV
GHFPNESEEEKDEDTIYFSLIGRPNVGKSSLVNALLNEDRVIVSEIEGTTRDAIDTKLHRDDQDFVIIDTAGMRKRGKVY
ESTEKYSVLRALRAIERSDVVLVLIDAETGIREQDKRIAGYAHDAGRAIVIVVNKWDTVDSNEKAMKEFEKNIRAHFQYL
DYAPVVFLSAKTKKRMHTLVPAIKLASESHTKRIPTNVLNDVIMDAIAMNPTPTLKGKRLKVLYATQVAVQPPSFVVFVN
DPELMHFSYERFLENKIRDAFGFVGTPIKLFARRRQ
>Mature_436_residues
MRKSVVAIVGRPNVGKSTIFNRLVGERISIVEDIPGVTRDRIYANAEWLNHTFNIIDTGGIELGDEPLLVQMRQQAEIAI
DEADVIVFLLNGKEGITSADDEVAKLLFKSNKPVVVGVNKMDNPQMHETIYEYYSLGFGQPFPISGTHGLGLGDLLDEVV
GHFPNESEEEKDEDTIYFSLIGRPNVGKSSLVNALLNEDRVIVSEIEGTTRDAIDTKLHRDDQDFVIIDTAGMRKRGKVY
ESTEKYSVLRALRAIERSDVVLVLIDAETGIREQDKRIAGYAHDAGRAIVIVVNKWDTVDSNEKAMKEFEKNIRAHFQYL
DYAPVVFLSAKTKKRMHTLVPAIKLASESHTKRIPTNVLNDVIMDAIAMNPTPTLKGKRLKVLYATQVAVQPPSFVVFVN
DPELMHFSYERFLENKIRDAFGFVGTPIKLFARRRQ

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=454, Percent_Identity=37.4449339207048, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1788919, Length=174, Percent_Identity=30.4597701149425, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI2367268, Length=90, Percent_Identity=43.3333333333333, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17507259, Length=89, Percent_Identity=39.3258426966292, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323665, Length=203, Percent_Identity=30.5418719211823, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45550813, Length=203, Percent_Identity=30.0492610837438, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_OCEIH (Q8EQA8)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692718.1
- ProteinModelPortal:   Q8EQA8
- SMR:   Q8EQA8
- GeneID:   1018291
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1797
- NMPDR:   fig|221109.1.peg.1798
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- ProtClustDB:   PRK00093
- BioCyc:   OIHE221109:OB1797-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 48999; Mature: 48999

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKSVVAIVGRPNVGKSTIFNRLVGERISIVEDIPGVTRDRIYANAEWLNHTFNIIDTGG
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHEEECHHHHCCEEEEEECCC
IELGDEPLLVQMRQQAEIAIDEADVIVFLLNGKEGITSADDEVAKLLFKSNKPVVVGVNK
CCCCCCHHHHHHHHHHHEEEECCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEECCC
MDNPQMHETIYEYYSLGFGQPFPISGTHGLGLGDLLDEVVGHFPNESEEEKDEDTIYFSL
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEE
IGRPNVGKSSLVNALLNEDRVIVSEIEGTTRDAIDTKLHRDDQDFVIIDTAGMRKRGKVY
ECCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCH
ESTEKYSVLRALRAIERSDVVLVLIDAETGIREQDKRIAGYAHDAGRAIVIVVNKWDTVD
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCEEECCCCEEEEEEECCCCCC
SNEKAMKEFEKNIRAHFQYLDYAPVVFLSAKTKKRMHTLVPAIKLASESHTKRIPTNVLN
CCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
DVIMDAIAMNPTPTLKGKRLKVLYATQVAVQPPSFVVFVNDPELMHFSYERFLENKIRDA
HHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHH
FGFVGTPIKLFARRRQ
HCCCCCCHHHHHHCCC
>Mature Secondary Structure
MRKSVVAIVGRPNVGKSTIFNRLVGERISIVEDIPGVTRDRIYANAEWLNHTFNIIDTGG
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHEEECHHHHCCEEEEEECCC
IELGDEPLLVQMRQQAEIAIDEADVIVFLLNGKEGITSADDEVAKLLFKSNKPVVVGVNK
CCCCCCHHHHHHHHHHHEEEECCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEECCC
MDNPQMHETIYEYYSLGFGQPFPISGTHGLGLGDLLDEVVGHFPNESEEEKDEDTIYFSL
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEE
IGRPNVGKSSLVNALLNEDRVIVSEIEGTTRDAIDTKLHRDDQDFVIIDTAGMRKRGKVY
ECCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCH
ESTEKYSVLRALRAIERSDVVLVLIDAETGIREQDKRIAGYAHDAGRAIVIVVNKWDTVD
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCEEECCCCEEEEEEECCCCCC
SNEKAMKEFEKNIRAHFQYLDYAPVVFLSAKTKKRMHTLVPAIKLASESHTKRIPTNVLN
CCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
DVIMDAIAMNPTPTLKGKRLKVLYATQVAVQPPSFVVFVNDPELMHFSYERFLENKIRDA
HHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHH
FGFVGTPIKLFARRRQ
HCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376