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The map label for this gene is gpsA

Identifier: 23099251

GI number: 23099251

Start: 1831719

End: 1832753

Strand: Reverse

Name: gpsA

Synonym: OB1796

Alternate gene names: 23099251

Gene position: 1832753-1831719 (Counterclockwise)

Preceding gene: 23099252

Following gene: 23099250

Centisome position: 50.48

GC content: 37.97

Gene sequence:

>1035_bases
ATGGAAAAAGTTGCTGTACTAGGAGCCGGTAGTTGGGGAACAGCTCTTGCAATTGTATTAGCTGACAATGGTCATGAAGT
TCGATTATGGTCACATAGGAAGGAACATGCAGAAACAATTAATGAAACTCACCGAAATCATAAATATTTAGATGTCGATA
TTCCAAATGAGATTACCGCTTATAGTGATATGCATCAAACAGTCTCTGGGGTAGATGCAGTTGTTATTGTAGTACCAACG
AAAGCAATTCGAGAAGTGTGTAGTGAACTGAATAAATGGATGGATTCAAAAACAACTGTTATCCACGCGACAAAAGGCAT
TGAACCTGTTAGCTTAAAACGGGTCTCTGAGATGATTGAAGAAGAGATGGATATAAAGTACGAAGATATTGTCGTGCTAT
CTGGTCCAAGTCATGCAGAAGAAGTTGCTTTAAGACATCCGACTACAGTTACAACTTCATCTATTAATCTAGAAAAAGCA
AAACATGCACAAGATCTTTTCTCAAGTGATTCATTCCGTGTGTATACAAGCGATGATATTCTAGGAATAGAATTAGGTGG
GGCACTTAAAAACATTATTGCATTGGGAGCAGGAATTTCTGATGGTTTAGGTTTTGGTGATAACGCGAAAGCTGCTTTAA
TTACAAGAGGATTGGCAGAAATTGCTCGATTAGGAACGTCTTTAGGGGCAAACCCGTTAAGTTTTCTTGGATTATCGGGA
GTTGGAGATTTAATTGTTACTTGTACAAGTGTTCATAGCCGAAATTGGCGTGCAGGAAATCTATTGGGTAAAGGTAACCA
GCTTGAGGATGTACTTGAGCAGATGGGAATGGTAGTTGAAGGTGTACGCACCGTTAAAGCTGCCCATCAATTTGCTAAGG
ATCAAAATGTTGATATGCCGATAACAAGCGGAATATTTCAAATTCTATTTGAAAATAAAAATCCCAAAGATGTAGTCGAA
CAACTTATGAACAGAGGAAAAAGAGATGAAATGGATGATTTAGCAGTTCTGCTTAAGGAAAGATATTCAGAATAA

Upstream 100 bases:

>100_bases
AGATTTTTAGAGAATAAAATCCGTGATGCATTTGGATTTGTGGGCACACCTATAAAATTATTCGCTAGAAGACGCCAATA
AATTAGGGAGAGATGATCAC

Downstream 100 bases:

>100_bases
CACGCAAATTACCTCCTTGCATATAATATGATGAATGAAATCGCAAGGAGGAAAAAATGTGAATAATTTTCAAAAAGGCC
TATTTGATAAATTACAGAAG

Product: glycerol-3-phosphate dehydrogenase [NAD(P)H]

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MEKVAVLGAGSWGTALAIVLADNGHEVRLWSHRKEHAETINETHRNHKYLDVDIPNEITAYSDMHQTVSGVDAVVIVVPT
KAIREVCSELNKWMDSKTTVIHATKGIEPVSLKRVSEMIEEEMDIKYEDIVVLSGPSHAEEVALRHPTTVTTSSINLEKA
KHAQDLFSSDSFRVYTSDDILGIELGGALKNIIALGAGISDGLGFGDNAKAALITRGLAEIARLGTSLGANPLSFLGLSG
VGDLIVTCTSVHSRNWRAGNLLGKGNQLEDVLEQMGMVVEGVRTVKAAHQFAKDQNVDMPITSGIFQILFENKNPKDVVE
QLMNRGKRDEMDDLAVLLKERYSE

Sequences:

>Translated_344_residues
MEKVAVLGAGSWGTALAIVLADNGHEVRLWSHRKEHAETINETHRNHKYLDVDIPNEITAYSDMHQTVSGVDAVVIVVPT
KAIREVCSELNKWMDSKTTVIHATKGIEPVSLKRVSEMIEEEMDIKYEDIVVLSGPSHAEEVALRHPTTVTTSSINLEKA
KHAQDLFSSDSFRVYTSDDILGIELGGALKNIIALGAGISDGLGFGDNAKAALITRGLAEIARLGTSLGANPLSFLGLSG
VGDLIVTCTSVHSRNWRAGNLLGKGNQLEDVLEQMGMVVEGVRTVKAAHQFAKDQNVDMPITSGIFQILFENKNPKDVVE
QLMNRGKRDEMDDLAVLLKERYSE
>Mature_344_residues
MEKVAVLGAGSWGTALAIVLADNGHEVRLWSHRKEHAETINETHRNHKYLDVDIPNEITAYSDMHQTVSGVDAVVIVVPT
KAIREVCSELNKWMDSKTTVIHATKGIEPVSLKRVSEMIEEEMDIKYEDIVVLSGPSHAEEVALRHPTTVTTSSINLEKA
KHAQDLFSSDSFRVYTSDDILGIELGGALKNIIALGAGISDGLGFGDNAKAALITRGLAEIARLGTSLGANPLSFLGLSG
VGDLIVTCTSVHSRNWRAGNLLGKGNQLEDVLEQMGMVVEGVRTVKAAHQFAKDQNVDMPITSGIFQILFENKNPKDVVE
QLMNRGKRDEMDDLAVLLKERYSE

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI24307999, Length=343, Percent_Identity=32.0699708454811, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI33695088, Length=346, Percent_Identity=28.9017341040462, Blast_Score=151, Evalue=9e-37,
Organism=Escherichia coli, GI1790037, Length=329, Percent_Identity=41.9452887537994, Blast_Score=274, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI32564399, Length=348, Percent_Identity=29.8850574712644, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI193210136, Length=357, Percent_Identity=29.9719887955182, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32564403, Length=357, Percent_Identity=29.9719887955182, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17507425, Length=358, Percent_Identity=27.9329608938547, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193210134, Length=345, Percent_Identity=26.3768115942029, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320181, Length=357, Percent_Identity=31.9327731092437, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6324513, Length=354, Percent_Identity=29.3785310734463, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17136202, Length=344, Percent_Identity=29.9418604651163, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI17136200, Length=344, Percent_Identity=29.9418604651163, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI17136204, Length=344, Percent_Identity=29.9418604651163, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI22026922, Length=352, Percent_Identity=24.4318181818182, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45551945, Length=291, Percent_Identity=29.2096219931272, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI281362270, Length=291, Percent_Identity=29.2096219931272, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648969, Length=246, Percent_Identity=29.6747967479675, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_OCEIH (Q8EQA9)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692717.1
- ProteinModelPortal:   Q8EQA9
- SMR:   Q8EQA9
- GeneID:   1018290
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1796
- NMPDR:   fig|221109.1.peg.1797
- HOGENOM:   HBG586392
- OMA:   ASVIMEF
- BioCyc:   OIHE221109:OB1796-MONOMER
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 37534; Mature: 37534

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 190-190 BINDING 105-105 BINDING 105-105 BINDING 139-139 BINDING 254-254 BINDING 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVAVLGAGSWGTALAIVLADNGHEVRLWSHRKEHAETINETHRNHKYLDVDIPNEITA
CCCEEEEECCCCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHH
YSDMHQTVSGVDAVVIVVPTKAIREVCSELNKWMDSKTTVIHATKGIEPVSLKRVSEMIE
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHH
EEMDIKYEDIVVLSGPSHAEEVALRHPTTVTTSSINLEKAKHAQDLFSSDSFRVYTSDDI
HHHCCCEEEEEEECCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEECCCE
LGIELGGALKNIIALGAGISDGLGFGDNAKAALITRGLAEIARLGTSLGANPLSFLGLSG
EEEEHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCC
VGDLIVTCTSVHSRNWRAGNLLGKGNQLEDVLEQMGMVVEGVRTVKAAHQFAKDQNVDMP
CCHHHHEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ITSGIFQILFENKNPKDVVEQLMNRGKRDEMDDLAVLLKERYSE
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKVAVLGAGSWGTALAIVLADNGHEVRLWSHRKEHAETINETHRNHKYLDVDIPNEITA
CCCEEEEECCCCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHH
YSDMHQTVSGVDAVVIVVPTKAIREVCSELNKWMDSKTTVIHATKGIEPVSLKRVSEMIE
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHH
EEMDIKYEDIVVLSGPSHAEEVALRHPTTVTTSSINLEKAKHAQDLFSSDSFRVYTSDDI
HHHCCCEEEEEEECCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEECCCE
LGIELGGALKNIIALGAGISDGLGFGDNAKAALITRGLAEIARLGTSLGANPLSFLGLSG
EEEEHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCC
VGDLIVTCTSVHSRNWRAGNLLGKGNQLEDVLEQMGMVVEGVRTVKAAHQFAKDQNVDMP
CCHHHHEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ITSGIFQILFENKNPKDVVEQLMNRGKRDEMDDLAVLLKERYSE
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376